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A Preliminary Study on qEEG in Burn Patients With Chronic Pruritus
Fiorella K. Miraval,Vivian L. Shie,Leon Morales-Quezada,Carolina Santiago,Bianca Fernandes-Marcondes,Deborah Nadler,Colleen M. Ryan,Jeffrey C. Schneider,Felipe Fregni 대한재활의학회 2017 Annals of Rehabilitation Medicine Vol.41 No.4
Objective To explore and determine the reorganizational changes in the cortical neural circuits associated with pruritis, this study was undertaken to compare the electroencephalography (EEG) changes in burn patients having primary symptoms of chronic itching (pruritis) and their paired healthy subjects. Methods Eight subjects were recruited for this exploratory pilot study: 4 patients with pruritus after burn injury matched by gender and age with 4 healthy subjects. EEG recordings were analyzed for absolute alpha, low beta, high beta, and theta power for both groups. Results The mean age of the burn patients was 41.75 years; while the mean age for the matched healthy subjects was 41.5 years. All subjects were male. A decreased alpha activity was observed in the occipital channels (0.82 vs. 1.4; p=0.01) and a decreased low beta activity in the frontal area (0.22 vs. 0.4; p=0.049) in eyes closed conditions. An overall decreased theta trend was observed in both the eyes open and eyes closed conditions in burn patients, compared to healthy individuals.Conclusion This preliminary study presents initial evidence that chronic pruritus in burn subjects may be associated with brain reorganizational changes at the cortical level characterized by an EEG pattern.
Meneghetti, Fiorella,Villa, Stefania,Masciocchi, Daniela,Barlocco, Daniela,Toma, Lucio,Han, Dong‐,Cho,Kwon, Byoung‐,Mog,Ogo, Naohisa,Asai, Akira,Legnani, Laura,Gelain, Arianna WILEY‐VCH Verlag 2015 EUROPEAN JOURNAL OF ORGANIC CHEMISTRY Vol.2015 No.22
<P><B>Abstract</B></P><P>Three new ureido‐pyridazinone derivatives, which are structurally related to the known STAT3 inhibitor <B>AVS‐0288</B>, were designed by taking into account the structure–activity relationships determined for several ureido‐oxadiazole derivatives previously studied by our group. Their synthesis was first attempted through suitable 5‐aminopyridazinone intermediates (<B>6a</B> and <B>6b</B>), which molecular structures were confirmed by means of X‐ray diffraction data on <B>6a</B>. Amine functionalization was unsuccessful, therefore, an alternative method was devised. Dual‐luciferase and AlphaScreen‐based assays were used to test their activity. The obtained data were rationalized on the basis of a modeling study, which focused our attention on the geometrical preferences of the ureido moiety. Computational results seem to indicate that both the 1,2,5‐oxadiazole ring and the extended <I>ZZ</I> arrangement are essential and probably act in a synergistic way to confer significant activity against STAT3.</P>
Giulia Baldelli,Mauro De Santi,Daniele Fraternale,Giorgio Brandi,Mirco Fanelli,Giuditta Fiorella Schiavano 한국식품영양과학회 2019 Journal of medicinal food Vol.22 No.6
This study focused on the evaluation of the chemopreventive potential of tissue in vitro culture of the “Mela Rosa Marchigiana” apple (MRM callus) that allows the amplification of secondary metabolites. The MRM pulp and MRM callus chemopreventive potential was evaluated in terms of antiproliferative activity, inhibition of tumorigenesis in soft agar cultures, cell cycle and western blotting analyses in CaCo2 and LoVo colon cancer cell lines and in JB6 promotion-sensitive (JB6 P+) cells. MRM callus induced a strong concentration-dependent inhibition of colon cancer cell proliferation and suppressed 12-o-tetra-decanoyl-phorbol-13-acetate-induced tumorigenesis of JB6 P+ cells in soft agar cultures. MRM callus inhibited the phosphorylation of JNK, p38, and eIF2alpha. Our data indicate that the MRM callus exerts a good antiproliferative and antitumorigenic potential through the MAP kinase inhibition and could provide natural compounds with chemopreventive properties.
Three Months Monitored Metabolic Fitness Modulates Cardiovascular Risk Factors in Diabetic Patients
Ilenia Cirilli,Sonia Silvestri,Fabio Marcheggiani,Fabiola Olivieri,Roberta Galeazzi,Roberto Antonicelli,Rina Recchioni,Fiorella Marcheselli,Tiziana Bacchetti,Luca Tiano,Patrick Orlando 대한당뇨병학회 2019 Diabetes and Metabolism Journal Vol.43 No.6
Cardiovascular diseases represent the leading cause of death and moderate physical exercise is associated with a reduction in cardiovascular risk. The aim of the study was to evaluate the correlation between the amount of exercise recorded daily by a wearable gravitometer for 3 months and selected biochemical and clinical parameters. Nineteen sedentary type 2 diabetics were recruited and distributed into three homogenous groups, low, medium, and high exercise, according to the level of physical exercise monitored and expressed as MOVEs. Data showed an inverse correlation between MOVEs and oxidative stress indexes and a significant improvement in paraoxonase-1 activities and endothelial functionality. Decrease of visceral/total adipose tissue ratio, systolic blood pressure and a down-regulation of the inflammatory microRNA-146a in high exercise group were observed. Finally, a decrease of glycosylated hemoglobin and an up-regulation of the angiogenic microRNA-130a in medium exercise one was obtained. In this study, precise daily monitoring permitted to underline the importance of the amount of physical activity to counteract some cardiovascular risk factors persisting in diabetes. Finally, it identifies new microRNA biomarkers for future investigation on the same topic.