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( Kevin Finneran ) 대한지질공학회 2019 대한지질공학회 학술발표회논문집 Vol.2019 No.2
Data are collected during environmental remediation projects - some data are complex, and some are simple. For example, the groundwater pH is an example of a datum collected over time that could be considered simple. But, the site pH influences microbial metabolism and phylogeny, speciation of metals and sometimes organics, and rates of reactions. Very often the “why” of data is not considered during analyses and interpretation. The problem arises when the data are not used effectively to design the remedial strategy, because it often leads to selecting the wrong approach, and maintaining that approach irrespective of whether additional data indicate it is time to move in another direction. We have developed remediation strategies for both organic and inorganic compounds, and the technologies selected range from passive (monitored natural attenuation, MNA) to highly engineered systems. We will highlight the use of data analyses and interpretation to guide remediation, with examples from both the lab and field. The contaminants highlighted will include explosives and insensitive munitions, chlorinated organic compounds, metals, and petroleum hydrocarbons. The data presented will range from the simplest (pH, organic carbon, low molecular mass organics acids), to complex (dissolved hydrogen, high throughout molecular phylogeny, and compounds specific isotope analyses). We will detail how all data were collected, organized, and interpreted in the aggregate to develop successful in situ and ex situ remediation approaches. We will also highlight similarities and differences amongst lab and field data, as a guide to understanding when lab/field data do (and do not) correlate.
John J. Finneran IV,Rodney A. Gabriel,Matthew W. Swisher,Allison E. Berndtson,Abhijit Nair,Todd W. Costantini,Brian M. Ilfeld 대한마취통증의학회 2020 Korean Journal of Anesthesiology Vol.73 No.5
Background: Rib fractures are a common injury in trauma patients and account for significant morbidity and mortality within this population. Local anesthetic-based nerve blocks have been demonstrated to provide significant pain relief and reduce complications. However, the analgesia provided by these blocks is limited to hours for single injection blocks or days for continuous infusions, while the duration of this pain often lasts weeks. Case: This case series describes five patients with rib fractures whose pain was successfully treated with cryoneurolysis. Conclusions: Ultrasound-guided percutaneous cryoneurolysis is a modality that has the potential to provide analgesia matching the duration of pain following rib fractures.
Burton Brittany N.,Finneran John J.,Angerstein Aaron,Ross Evelyn,Mitchell Ana,Waterman Ruth S.,Elsharydah Ahmad,Said Engy T.,Gabriel Rodney A. 대한마취통증의학회 2021 Korean Journal of Anesthesiology Vol.74 No.1
Background: Same-day discharge, defined as discharge from the hospital within 24 h of surgery, has been shown to be safe for joint arthroplasty. We examined demographic and clinical factors associated with same-day discharge and unplanned readmission following shoulder arthroplasty in adult patients.Methods: Utilizing data from the American College of Surgeons National Surgical Quality Improvement Program database, we extracted information of all patients that underwent shoulder arthroplasty. The primary and secondary outcome of interest was same-day discharge and 30-day unplanned readmission, respectively. We utilized multivariable logistic regression to identify covariates associated with these outcomes. Results: There were 17,011 patients analyzed when identifying predictors for same-day discharge. There was an increase in same-day discharge from 2007 to 2016. The odds of same-day discharge were significantly better for males (P < 0.001). The odds of same-day discharge was significantly decreased for every 10-year increase in age and for patients with insulin dependent diabetes, poor functional status, chronic obstructive pulmonary disease, congestive heart failure, bleeding disorder, and comorbidity burden (all P < 0.001). There were 14,276 patients analyzed for hospital readmission. The odds of unplanned readmission were significantly higher for every 10-year increase in age and for patients with poor functional status, congestive heart failure, bleeding disorder, and higher comorbidity burden (all P < 0.001). Conclusions: The results of this study show that preoperative comorbidities and advanced age reduce the odds of same-day discharge. Risk stratification, preoperative optimization, and coordinated care after surgery may be helpful to optimize patients for same-day discharge.
Rodney A. Gabriel,John J. Finneran,Matthew W. Swisher,Engy T. Said,Jacklynn F. Sztain,Bahareh Khatibi,Anne M. Wallace,Ava Hosseini,Andrea M. Trescot,Brian M. Ilfeld 대한마취통증의학회 2020 Korean Journal of Anesthesiology Vol.73 No.2
Background: Acute post-mastectomy pain is frequently challenging to adequately treat with local anesthetic-based regional anesthesia techniques due to its relatively long duration measured in multiple weeks. Case: We report three cases in which preoperative ultrasound-guided percutaneous intercostal nerve cryoneurolysis was performed to treat pain following mastectomy. Across all postoperative days and all three patients, the mean pain score on the numeric rating scale was 0 for each day. Similarly, no patient required any supplemental opioid analgesics during the entire postoperative period; and, no patient reported insomnia or awakenings due to pain at any time point. This was a significant improvement over historic cohorts. Conclusions: Ultrasound-guided percutaneous cryoanalgesia is a potential novel analgesic modality for acute pain management which has a duration that better-matches mastectomy than other currently-described techniques. Appropriately powered randomized, controlled clinical trials are required to demonstrate and quantify both potential benefits and risks.