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- 저자 : Findikcioglu (검색결과 6 건)
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Sibar, Serhat,Findikcioglu, Kemal,Erdal, Ayhan Isik,Barut, Ismail,Ozmen, Selahattin Korean Society of Plastic and Reconstructive Surge 2016 Archives of Plastic Surgery Vol.43 No.4
Background Xeroderma pigmentosum (XP) is an autosomal recessive disorder characterized by xerosis, ultraviolet light sensitivity, and cutaneous dyspigmentation. Due to defects in their DNA repair mechanism, genetic mutations and carcinogenesis inevitably occurs in almost all patients. In these patients, reconstruction of cutaneous malignancies in the head and neck area is associated with some challenges such as likelihood of recurrence and an aggressive clinical course. The aim of this study is to discuss the therapeutic options and challenges commonly seen during the course of treatment. Methods Between 2005 and 2015, 11 XP patients with head and neck cutaneous malignancies were included in this study. Demographic data and treatment options of the patients were evaluated. Results The mean age of the patients was 32 years (range, 10-43) (4 males, 7 females). The most common tumor type and location were squamous cell carcinoma (6 patients) and the orbital region (4 patients), respectively. Free tissue transfer was the most commonly performed surgical intervention (4 patients). The average number of surgical procedures was 5.5 (range, 1-25). Six patients were siblings with each other, 5 patients had local recurrences, and one patient was lost to follow-up. Conclusions Although genetic components of the disease have been elucidated, there is no definitive treatment algorithm. Early surgical intervention and close follow-up are the gold standard modalities due to the tendency toward rapid tumor growth and possible recurrence. Treatment must be individualized for each patient. In addition, the psychological aspect of the disease is an important issue for both patients and families.
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Serhat Sibar,Kemal Findikcioglu,Ayhan Isik Erdal,Ismail Barut,Selahattin Ozmen 대한성형외과학회 2016 Archives of Plastic Surgery Vol.43 No.4
Background Xeroderma pigmentosum (XP) is an autosomal recessive disorder characterized by xerosis, ultraviolet light sensitivity, and cutaneous dyspigmentation. Due to defects in their DNA repair mechanism, genetic mutations and carcinogenesis inevitably occurs in almost all patients. In these patients, reconstruction of cutaneous malignancies in the head and neck area is associated with some challenges such as likelihood of recurrence and an aggressive clinical course. The aim of this study is to discuss the therapeutic options and challenges commonly seen during the course of treatment. Methods Between 2005 and 2015, 11 XP patients with head and neck cutaneous malignancies were included in this study. Demographic data and treatment options of the patients were evaluated. Results The mean age of the patients was 32 years (range, 10–43) (4 males, 7 females). The most common tumor type and location were squamous cell carcinoma (6 patients) and the orbital region (4 patients), respectively. Free tissue transfer was the most commonly performed surgical intervention (4 patients). The average number of surgical procedures was 5.5 (range, 1–25). Six patients were siblings with each other, 5 patients had local recurrences, and one patient was lost to follow-up. Conclusions Although genetic components of the disease have been elucidated, there is no definitive treatment algorithm. Early surgical intervention and close follow-up are the gold standard modalities due to the tendency toward rapid tumor growth and possible recurrence. Treatment must be individualized for each patient. In addition, the psychological aspect of the disease is an important issue for both patients and families.
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Sezgin, Billur,Sibar, Serhat,Bulam, Hakan,Findikcioglu, Kemal,Tuncer, Serhan,Dogan, Bilge Korean Society of Plastic and Reconstructive Surge 2014 Archives of Plastic Surgery Vol.41 No.5
Background Disulfiram implantation is a widely used treatment alternative for alcohol abuse, yet reports on the surgical aspect of disulfiram implantation with respect to patient and drug-related treatment efficacy and wound complications are very limited. We present our clinical experiences with disulfiram implantation and discuss the surgical outcomes obtained with different anatomical planes for implantation. Methods Medical records of all patients referred to our clinic from the psychiatry department between 2007 and 2013 for disulfiram implantation were retrospectively analyzed. Implantation was carried out using 10 sterile Disulfiram tablets (WZF Polfa S.A.), each tablet containing 100 mg of disulfiram. The procedure was carried out by implanting the tablets randomly in either a subcutaneous or an intramuscular plane. The location and the plane of implantation and the complications were recorded for each patient and compared to determine the differences in the outcomes. Results A total of 32 implantation procedures were evaluated for this study. Twenty-five implants were placed in the intramuscular plane (78.2%), while seven implants were placed subcutaneously (21.8%). Exposure was encountered in three of the seven subcutaneous implants (42.9%), while no exposure was seen with the intramuscular implants. Incomplete absorption of the tablets was encountered in one patient with a previous subcutaneous implant who presented 1 year later for re-implantation as part of the continuation of therapy. Conclusions To overcome the issue of treatment continuation in the case of disulfiram therapy, which may be ceased due to frequently encountered wound complications, we believe that implantation in the subscapular intramuscular plane allows both uneventful healing and an out-of-reach implant location.
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Billur Sezgin,Serhat Sibar,Hakan Bulam,Kemal Findikcioglu,Serhan Tuncer,Bilge Dogan 대한성형외과학회 2014 Archives of Plastic Surgery Vol.41 No.5
Background: Disulfiram implantation is a widely used treatment alternative for alcoholabuse, yet reports on the surgical aspect of disulfiram implantation with respect to patientand drug-related treatment efficacy and wound complications are very limited. We presentour clinical experiences with disulfiram implantation and discuss the surgical outcomesobtained with different anatomical planes for implantation. Methods: Medical records of all patients referred to our clinic from the psychiatry departmentbetween 2007 and 2013 for disulfiram implantation were retrospectively analyzed. Implantationwas carried out using 10 sterile Disulfiram tablets (WZF Polfa S.A.), each tablet containing100 mg of disulfiram. The procedure was carried out by implanting the tablets randomly ineither a subcutaneous or an intramuscular plane. The location and the plane of implantationand the complications were recorded for each patient and compared to determine thedifferences in the outcomes. Results: A total of 32 implantation procedures were evaluated for this study. Twenty-fiveimplants were placed in the intramuscular plane (78.2%), while seven implants were placedsubcutaneously (21.8%). Exposure was encountered in three of the seven subcutaneousimplants (42.9%), while no exposure was seen with the intramuscular implants. Incompleteabsorption of the tablets was encountered in one patient with a previous subcutaneousimplant who presented 1 year later for re-implantation as part of the continuation of therapy. Conclusions: To overcome the issue of treatment continuation in the case of disulfiramtherapy, which may be ceased due to frequently encountered wound complications, webelieve that implantation in the subscapular intramuscular plane allows both uneventfulhealing and an out-of-reach implant location.
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