HOMOTHETIC MOTIONS WITH GENERALIZED TRICOMPLEX NUMBERS

( Siddika Özkaldi Karakuş ),( Ferdağ Kahraman Aksoyak ),( Gülşah Özaydin ) 호남수학회 2024 호남수학학술지 Vol.46 No.1

In this paper, we define the generalized tricomplex numbers and give some algebraic properties of them. By using the matrix representation of generalized tricomplex numbers, we determine a motion on the hypersurface M in eight dimensional generalized linear space ℝ⁸_α_βγ and show that this is a homothetic motion. Also, for some special cases of the real numbers α, β and γ, we give some examples of homothetic motions in ℝ⁸ and ℝ⁸₄ and obtain some rotational matrices in these spaces, too.

Preparation of magnetic activated carbon-chitosan nanocomposite for crystal violet adsorption

Ferda Civan Çavuşoğlu,Seher Akan,Ezgi Aleyna Arı,Ezgi Çetinkaya,Elif Çolak,Gamze Nur Daştan,Semina Deniz,Damla Erdem,Melda Köksal,Sevgi Korkmaz,Nursena Onsekiz,Betül Oruçoğlu,Didem Özkaya,Hamdi Buğra 한국화학공학회 2019 Korean Journal of Chemical Engineering Vol.36 No.11

Magnetic, cheap and versatile adsorbents were developed for crystal violet (CV) adsorption in this study. These adsorbents are magnetic activated carbon (AC-Fe3O4) and chitosan grafted magnetic activated carbon (Chitosan- AC-Fe3O4). Fe3O4 and chitosan were also used for adsorption. X-ray diffraction (XRD), scanning electron microscopy (SEM), vibrating sample magnetometer (VSM), zeta potential analysis and Fourier transform infrared spectroscopy (FTIR) methods were used for characterization of adsorbents. Adsorption parameters for CV were investigated. Raw chitosan and Fe3O4 were also used for CV adsorption to compare the results of composites. The chosen adsorption parameters are amount of adsorbent, contact time, initial CV concentration, and temperature. The equilibrium period was observed to be very short for chitosan and Fe3O4 nanoparticles. The adsorption efficiencies of these adsorbents are very low. AC-Fe3O4 and AC-Fe3O4-Chitosan nanoparticles reached equilibrium at 80min. The all adsorbent-CV systems followed pseudo second-order kinetic model. AC-Fe3O4 and AC-Fe3O4-Chitosan composites suited non-linear Freundlich isotherm for all temperatures (298, 308 and 318 K). Regeneration of adsorbents was also investigated. 1M of acetic acid and 0.1M of NaOH solutions were tested. Acetic acid solution desorbed CV better than NaOH solution at 6 hours.

Protease-Activated Receptors-2: Role in Skin Biology and Barrier Function

Ferda Cevikbas,Akihiko Ikoma,Martin Steinhoff 한국피부장벽학회 2009 한국피부장벽학회지 Vol.11 No.2

Proteinases play an essential role in skin homeostasis and various disease states. This is -at least in part-mediated via activation of proteinase-activated receptors (PARs). These are G-protein-coupled receptors with seven transmembrane domains that are activated by specific proteolytic cleavage of the extracellular N-terminus. To date, four PARs are cloned and characterized (PAR1-4). They are stimulated by a variety of serine proteinases. PAR1, PAR3 and PAR4 are cleaved by thrombin, for example. Both PAR1 and PAR4 can be activated by trypsin as well; PAR4 can be also activated by cathepsin G and PAR1 can also be triggered by matrix metalloproteinase-1. PAR2 can be activated by a variety of endogenous serine proteinases like tryptase, matriptase or certain kallikreins. The latter have an important impact in the regulation of skin barrier and may thus be involved in its malfunction during disease state. This receptor can additionally be stimulated by various exogenous proteinases produced by pathogenic organisms like mites, bacteria or fungi, which are capable of modulating epidermal barrier function. It can also be inactivated by certain proteinases which may be of pathophysiological releavance; these mechanisms, however, are poorly understood as of yet. PAR2 is expressed by many cell types present in the skin including keratinocytes in the higher epidermal layers, fibroblasts, endothelial cells as well as by sensory neurons. Moreover, functional PAR2 is expressed by cells crucially involved in innate and adaptive immunity such as eosinophils, neutrophils, monocytes, macrophages, dendritic cells, mast cells and T cells, which may affect skin barrier function during inflammation and immune responses. Activation of the receptor leads to the production of various cytokines, chemokines or growth factors thereby modulating skin homeostasis, barrier function, immune and inflammatory responses as well as tumor surveillance. Thus, aiming at proteases and PARs may be beneficial for the treatrment of various skin diseases and barrier dysfunction.

Are women with small endometriomas who undergo intracytoplasmic sperm injection at an elevated risk for adverse pregnancy, obstetric, and neonatal outcomes?

Fatma Ferda Verit,Ayse Seyma Ozsuer Kucukakca 대한생식의학회 2021 Clinical and Experimental Reproductive Medicine Vol.48 No.1

Objective: The aim of the study was to investigate pregnancy, obstetric, and neonatal outcomes in women with small (<4 cm) unilateral endometriomas. Methods: This retrospective study included 177 patients: 91 patients with small endometriomas and 86 controls with unexplained or tubal factor infertility who were treated at the Süleymaniye Gynecology and Maternity Training and Research Hospital Infertility Unit between January 2010 and July 2015. The groups were matched with regards to demographic characteristics such as age, body mass index, and infertility duration. All of the women in this study conceived via intracytoplasmic sperm injection. We compared pregnancy, obstetric, and neonatal outcomes between these groups. Results: Women with endometriomas had a higher biochemical pregnancy rate, but lower clinical pregnancy and live birth rates than women with unexplained and tubal factor infertility (p<0.05 for all). However no significant differences were found in terms of obstetric and neonatal complications between the two groups (p>0.05 for all).Conclusion: In this study, we found that women with endometriomas less than 4 cm were more prone to early pregnancy complications. We also showed that this group did not have any increased risks of late pregnancy, obstetric, and neonatal complications.

Does bilateral uterine artery ligation have negative effects on ovarian reserve markers and ovarian artery blood flow in women with postpartum hemorrhage?

Verit, Fatma Ferda,Cetin, Orkun,Keskin, Seda,Akyol, Hurkan,Zebitay, Ali Galip The Korean Society for Reproductive Medicine 2019 Clinical and Experimental Reproductive Medicine Vol.46 No.1

Objective: Bilateral uterine artery ligation (UAL) is a fertility-preserving procedure used in women experiencing postpartum hemorrhage (PPH). However, the long-term effects of this procedure on ovarian function remain unclear. The aim of this study was to investigate whether bilateral UAL compromised ovarian reserve and ovarian blood supply. Methods: This prospective study included 49 women aged between 21 and 36 years who had undergone a cesarean section for obstetric indications. Of these, 25 underwent uterine bilateral UAL to control intractable atonic PPH. The control group consisted of 24 women who had not undergone bilateral UAL. Standard clinical parameters, the results of color Doppler screening, and ovarian reserve markers were assessed in all participants at 6 months after surgery. The clinical parameters included age, parity, cycle history, body mass index, and previous medication and/or surgery. Color Doppler screening findings included the pulsatility index (PI) and resistance index (RI) for both the uterine and ovarian arteries. The ovarian reserve markers included day 3 follicle-stimulating hormone (FSH) levels, antral follicle count, and $anti-M\ddot{u}llerian$ hormone (AMH) levels. Results: There were no significant differences in the ovarian reserve markers of day 3 FSH levels, antral follicle count, and AMH levels between the study and control groups (p> 0.05 for all). In addition, no significant differences were observed in the PI and RI indices of the uterine and ovarian arteries (p> 0.05 for all). Conclusion: In this study, we showed that bilateral UAL had no negative effects on ovarian reserve or ovarian blood supply, so this treatment should be used as a fertility preservation technique to avoid hysterectomy in patients experiencing PPH.

Cardiovascular risk may be increased in women with unexplained infertility

Verit, Fatma Ferda,Zeyrek, Fadile Yildiz,Zebitay, Ali Galip,Akyol, Hurkan The Korean Society for Reproductive Medicine 2017 Clinical and Experimental Reproductive Medicine Vol.44 No.1

Objective: Growing evidence suggests that increased cardiovascular disease (CVD) risk is associated with female infertility caused by conditions such as polycystic ovarian disease, obesity, thyroid dysfunction, and endometriosis. The aim of this study was to evaluate whether any relationship exists between CVD and unexplained infertility. Methods: Sixty-five women with unexplained infertility and 65 fertile controls were enrolled in the study. CVD risk markers such as low-density lipoprotein (LDL), high-density lipoprotein (HDL), total cholesterol (TC), triglycerides (TG), insulin resistance (defined by the homeostasis model assessment ratio), and high-sensitivity C-reactive protein (hs-CRP) were assessed. Results: TG, TC, LDL, and hs-CRP levels were higher and HDL levels were lower in patients with unexplained infertility than in fertile controls (p<0.05 for all). Positive associations were found between unexplained infertility and TG, TC, LDL, and hs-CRP levels, and a negative correlation was found for HDL (p<0.05 for all). Multivariate logistic regression analysis showed that TG, HDL, and hs-CRP were independent variables associated with unexplained infertility. Conclusion: Our study showed that women with unexplained infertility had an atherogenic lipid profile and elevated hs-CRP levels, suggesting a higher risk of developing CVD in the future. Further studies with larger groups are needed to investigate the nature of this link.

Endometriosis, Leiomyoma and Adenomyosis: the Risk of Gynecologic Malignancy

Verit, Fatma Ferda,Yucel, Oguz Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.10

The aim of this review article was to evaluate the relationship and the possible etiological mechanisms between endometriosis, leiomyoma (LM) and adenomyosis and gynecological cancers, such as ovarian and endometrial cancer and leiomyosarcoma (LMS). MEDLINE was searched for all articles written in the English literature from July 1966 to May 2013. Reports were collected systematically and all the references were also reviewed. Malignant transformation of gynecologic benign diseases such as endometriosis, adenomyosis and LM to ovarian and endometrial cancer remains unclear. Hormonal factors, inflammation, familial predisposition, genetic alterations, growth factors, diet, altered immune system, environmental factors and oxidative stress may be causative factors in carcinogenesis. Early menarche, low parity, late menopause and infertility have also been implicated in the pathogenesis of these cancers. Ovarian cancers and endometriosis have been shown to have common genetic alterations such as loss of heterozygosity (LOH), PTEN, p53, ARID1A mutations. MicroRNAs have also been implicated in malignant transformation. Inflammation releases proinflammatory cytokines, and activates tumor associated macrophages (TAMS) and nuclear factor kappa b (NF-KB) signaling pathways that promote genetic mutations and carcinogenesis. MED12 mutations in LM and smooth muscle tumors of undetermined malignant potential (STUMP) may contribute to malignant transformation to LMS. A hyperestrogenic state may be shared in common with pathogenesis of adenomyosis, LM and endometrial cancer. However, the effect of these benign gynecologic diseases on endometrial cancer should be studied in detail. This review study indicates that endometriosis, LM, adenomyosis may be associated with increased risk of gynecological cancers such as endometrial and ovarian cancers. The patients who have these gynecological benign diseases should be counseled about the future risks of developing cancer. Further studies are needed to investigate the relationship between STUMPs, LMS and LM and characteristics and outcome endometrial carcinoma in adenomyotic patients.

Gait Dyspraxia due to Right Occipital Infarct

Halil Onder,Ferda Buyuk 대한파킨슨병및이상운동질환학회 2019 Journal Of Movement Disorders Vol.12 No.1

Synthesis, characterization, and antimicrobial activities of 3-HPAA-Alg-Chi nanoparticles

Ozdemir, Ozgun O.,Soyer, Ferda Techno-Press 2021 Advances in nano research Vol.11 No.3

Encapsulation of bioactive compounds (e.g., phenolic acids) into nanoparticles is a well-received technique in the searching for new antimicrobial agents against multidrug-resistant pathogens. Encapsulation can be a good technique to maintain the stability of phenolic acids against environmental conditions. In this study, 3-hydroxyphenylacetic acid (3-HPAA) was encapsulated into alginate-chitosan nanoparticles with the ion gelation technique. The characterization of loaded and unloaded nanoparticles was performed via dynamic light scattering, Fourier transform infrared spectroscopy, and scanning electron microscopy. According to the results, 3-HPAA loaded nanoparticles have spherical shapes with a diameter range of 40-80 nm and an average hydrodynamic diameter of 361.0 ± 69.8 nm. The loading of 3-HPAA was successfully achieved based on the Fourier transform infrared spectra and encapsulation percentage studies. The antimicrobial effect of the nanoparticles in solution forms was tested on P. aeruginosa, S. epidermidis, MRSA, and MSSA. The results demonstrated that the 3-HPAA loaded alginate chitosan nanoparticle solution showed elevated antimicrobial effect due to the pH change by treatment with 1% acetic acid, and it displayed bacteriocidal effects in a strain-specific and dose-dependent manner. Therefore, the 3-HPAA loaded alginate chitosan nanoparticle solution was produced successfully with the bacteriocidal effect against serious pathogenic bacteria.

Obestatin is present in saliva: alterations in obestatin and ghrelin Levels of saliva and serum in ischemic heart disease

Yilmaz Ozbay,Suleyman Aydin,A. Ferda Dag1i,Mehmet Akbulut,Necati Dagli,Nermin Kilic,Ali Rahman,Ibrahim Sahin,Veli Polat,H. Ibrahim Ozercan,Nadi Arslan,Dogan Sensoy 한국생화학분자생물학회 2008 BMB Reports Vol.41 No.1