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- 저자 : Felekoğlu (검색결과 2 건)
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Endocan and Non-Dipping Circadian Pattern in Newly Diagnosed Essential Hypertension
Tolga Çimen,Murat Bilgin,Ahmet Akyel,Mehmet Ali Felekoğlu,Ali Nallbani,Şeyda Özdemir,Gönül Erden,Alpaslan Öztürk,Mehmet Doğan,Ekrem Yeter 대한심장학회 2016 Korean Circulation Journal Vol.46 No.6
Background and Objectives: Non-dipper hypertension is frequently accompanied by endothelial dysfunction and activation. Previous studies suggested that endocan may be a novel endothelial dysfunction marker. This study aims to investigate the association between circadian blood pressure (BP) pattern and plasma endocan levels together with high-sensitivity C-reactive protein (hsCRP) in patients with newly diagnosed untreated hypertension. Subjects and Methods: Twenty-four hour ambulatory blood pressure monitoring was recorded in 35 dipper, 35 non-dipper hypertensives and 35 healthy controls. Endocan levels were measured by enzyme-linked immunosorbent assay. Serum levels of hsCRP were also recorded. Results: Despite similar daytime and 24-hour average BP values between dippers and non-dippers, statistically significant high nocturnal BP was accompanied by a non-dipping pattern (Systolic BP: 132±9 vs. 147±11 mmHg; Distolic BP: 80±7 vs. 91±9 mmHg, respectively, p<0.001 for both). Non-dipper patients demonstrated higher endocan levels compared to dippers and normotensives (367 (193-844) pg/mL, 254 (182-512) pg/mL and 237 (141-314) pg/ml, respectively, p<0.001). HsCRP levels were significantly higher in non-dippers than the other groups (p=0.013). In a multivariate logistic regression analysis, endocan (p=0.021) and hsCRP (p=0.044) were independently associated with a non-dipping pattern. Conclusion: Elevated endocan levels were found in non-dipper groups. Endocan and hsCRP were found to be independently associated with a non-dipping pattern. We suggest that elevated levels of endocan in non-dipper hypertensive patients might be associated with a longer duration of exposure to high BP. These results point to the possible future role of endocan in selection of hypertensive patients at higher risk or target organ damage
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Su-Tae Kang,Kang-Seok Lee,Jeong-Il Choi,Yun Lee,Burak Feleko?lu,Bang Yeon Lee 한국콘크리트학회 2016 International Journal of Concrete Structures and M Vol.10 No.3
Ultra-high performance concrete (UHPC) is one of the most promising construction materials because it exhibits high performance, such as through high strength, high durability, and proper rheological properties. However, it has low tensile ductility compared with other normal strength grade high ductile fiber-reinforced cementitious composites. This paper presents an experimental study on the tensile behavior, including tensile ductility and crack patterns, of UHPC reinforced by hybrid steel and polyethylene fibers and incorporating plastic beads which have a very weak bond with a cementitious matrix. These beads behave as an artificial flaw under tensile loading. A series of experiments including density, compressive strength, and uniaxial tension tests were performed. Test results showed that the tensile behavior including tensile strain capacity and cracking pattern of UHPC investigated in this study can be controlled by fiber hybridization and artificial flaws.
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