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Novel Molecular Mechanisms in the Development of Non-Alcoholic Steatohepatitis
Davide Povero,Ariel E. Feldstein 대한당뇨병학회 2016 Diabetes and Metabolism Journal Vol.40 No.1
Non-alcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease in adults and children worldwide. NAFLD has become a severe health issue and it can progress towards a more severe form of the disease, the non-alcoholic steatohepatitis (NASH). A combination of environmental factors, host genetics, and gut microbiota leads to excessive accumulation of lipids in the liver (steatosis), which may result in lipotoxicity and trigger hepatocyte cell death, liver inflammation, fibrosis, and pathological angiogenesis. NASH can further progress towards liver cirrhosis and cancer. Over the last few years, cell-derived extracellular vesicles (EVs) have been identified as effective cell-to-cell messengers that transfer several bioactive molecules in target cells, modulating the pathogenesis and progression of NASH. In this review, we focused on recently highlighted aspects of molecular pathogenesis of NASH, mediated by EVs via their bioactive components. The studies included in this review summarize the state of art regarding the role of EVs during the progression of NASH and bring novel insight about the potential use of EVs for diagnosis and therapeutic strategies for patients with this disease.
Lukens, Katherine E.,Feldstein, Steven B.,Yoo, Changhyun,Lee, Sukyoung Wiley Blackwell (John WileySons) 2017 Quarterly journal of the Royal Meteorological Soci Vol.143 No.703
<P>For all eight MJO phases, it is found that the extratropical response over the North Pacific and North America is almost entirely due to the MJO convection over the western tropical Pacific. The RWS is excited within the first 24 h after the model heating is turned on. For MJO phases 1-3 and 8, the RWS leads to the development of a cyclonic anomaly over southeast Asia via advection of the climatological absolute vorticity by the anomalous divergent wind in the subtropics and by horizontal convergence in the Tropics. MJO phases 4-7 show opposite features. The resulting anomaly is then advected eastward by the climatological zonal wind toward the central Pacific, after which dispersion into the extratropics and the excitation of a Pacific/North American teleconnection pattern takes place.</P>