Neuropeptides SP and CGRP Underlie the Electrical Properties of Acupoints

Fan, Yu,Kim, Do-Hee,Ryu, Yeonhee,Chang, Suchan,Lee, Bong Hyo,Yang, Chae Ha,Kim, Hee Young Frontiers Media S.A. 2018 Frontiers in neuroscience Vol.12 No.-

<P>Electrical skin measurements at acupuncture points (acupoints) have been utilized as a diagnostic and therapeutic aid for more than 50 years. Although acupoints are described as having distinct electrical properties, such as high conductance and low impedance, the underlying mechanisms are currently unknown. The present study investigated in a rat model of hypertension whether the high conductance at acupoints is a result of the release of the neuropeptides substance P (SP) and calcitonin gene-related peptide (CGRP) during neurogenic inflammation in the referred pain area. When plasma extravasation from neurogenic inflammation was examined by exploring the leakage of intravenously injected Evans blue dye (EBD) to the skin, extravasated EBD was found most frequently in acupoints on the wrist. The increased conductance and temperature at these acupoints occurred during the development of hypertension. The increase in conductance and plasma extravasation at acupoints in hypertensive rats was ablated by cutting median and ulnar nerves, blocking small diameter afferent fibers with resiniferatoxin (RTX) injection into median and ulnar nerves, or antagonizing SP or CGRP receptors in acupoints. In turn, intradermal injection of SP or CGRP resulted in increased conductance and plasma extravasation in naïve rats. Elevated levels of SP and CGRP were found in the acupoints of hypertensive rats. These findings suggest that the high conductance at acupoints is due to vascular leakage following local release of SP and CGRP during neurogenic inflammation.</P>

Pore Structure Identification Method for Pervious Concrete based on Improved UNet and Fusion Algorithm

Fan Yu,Kailang Li,Hua Zhang,Rui Zhang,Zhang Gao,Yubin Huang 대한토목학회 2023 KSCE Journal of Civil Engineering Vol.27 No.11

This paper aims to establish an automatic and accurate pore identification method for pervious concrete. The residual module and mixed loss functions were introduced to the original UNet network to obtain the improved UNet. CT scanning was conducted on the six groups of pervious concrete samples with different aggregate sizes to obtain the initial dataset. The initial dataset was marked and enhanced, and then the pore recognition model was trained. The influence of image brightness and contrast on pore identification was analyzed. The fusion algorithm was used to improve the robustness of the model. The results show that during model training, R-UNet began to converge 20 epochs earlier than UNet and the loss value was smaller. Moreover, the maximum increase of mIoU and mDice was 10.3% and 11.7% respectively, and the maximum decrease of mHD was 14.1%. The fusion algorithm could improve the segmentation accuracy of pores in brightness anomaly images. Compared with threshold segmentation method, the method proposed in this paper could improve the accuracy of pore edge segmentation and the “fine pores” identification, and reduced the pore identification defects. The value of mHD was decreased by 48.7% − 72.4%, and the efficiency of pore identification was greatly improved.

Fabrication of recyclable UiO-66-NH2/PVDF hybrid fibrous membrane for Cr(VI) removal in wastewater

Fan Yu,Liusha Cen,Caihong Lei,Feichao Zhu,Lan Zhou,Hailin Zhu,Bin Yu 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.123 No.-

Efficient and recyclable water treatment technology plays a vital role in practical application of Cr(Ⅵ)removal. Zr-based metal–organic framework (UiO-66-NH2) is widely used in wastewater treatmentdue to its water stability. Powdery UiO-66-NH2 has disadvantages of easy aggregation, reclamation difficultyand secondary pollution. In this work, UiO-66-NH2 was successfully loaded on electrospunpolyvinylidene fluoride (PVDF) fibers by in-situ growth to achieve efficient adsorption and photoreductionof Cr(Ⅵ). Grooved surface of PVDF fibers and truncated octahedron shape of UiO-66-NH2 ensuredthe loading uniformity and firmness. The loading rate and size of UiO-66-NH2 crystals increased withthe amount of trifluoroacetic acid (TFA) in the preparation process. Meantime, the introduction of TFAin synthesis was conducive to the separation efficiency of photogenerated carries. When the additionamount of TFA was 5 ml, UiO-PVDF-3 with loading rate of 44.8% exhibited best Cr(VI) adsorption andphotocatalysis performance. For the pure adsorption process, the adsorption capacity of UiO-PVDF-3 at90 min was 3.76 mg/cm2, and the corresponding removal rate was 95.8%. When visible light was applied,the Cr(VI) removal rate for UiO-PVDF-3 reached to about 95.0% at 45 min. Furthermore, regenerationexperiments showed UiO-PVDF-3 had excellent adsorption and photocatalysis reusability. Based on thismethod, synthesized UiO-66-NH2/PVDF hybrid membrane as a bifunctional material for adsorption andphotocatalysis realizes the reuse of UiO-66-NH2 crystals conveniently and avoids secondary pollutionduring Cr(VI) wastewater treatment.

Identification and comparative analysis of piRNAs in ovary and testis of Nile tilapia (Oreochromis niloticus)

Fan Yu,Xi Gan,Yi Zhou,Huan Zhong,Jun Xiao,Jinpeng Yan,Yongju Luo 한국유전학회 2016 Genes & Genomics Vol.38 No.6

It has been shown that piRNA is the largest class of small non-coding RNA in germline cells of animals which plays key roles in transposons regulation and transcriptional activities. In the present study, piRNAs from two small RNA libraries including ovary and testis of Nile tilapia were identified and characterized. By length and k-mer based small RNA prediction algorithm, 279,059 and 583,230 small RNA reads were confirmed as piRNA from ovary and testis, respectively. The identified piRNAs showed evolutionarily conserved characterization, such as uridine bias in the 50 ends. The 142,961 and 296,775 piRNAs from ovary and testis were mapped to the draft assembly of the tilapia genome, respectively. Both ovary and testis piRNAs were enriched from linkage (LG)6 and LG7. Meanwhile, the even distribution of ?strand and -strand suggested the Ping–pong pathway (a double-displacement reaction of ?strand and -strand) hypothesis. These piRNAs were derived from the upstream -2 kb and downstream ?2 kb as well as gene regions which suggested a regulatory function on transcription activities. In gene regions, abundant piRNAs were derived from 50UTR, 30UTR and CDS. Furthermore, we characterized the differentially expressed piRNAs between ovary and testis. In total, 1979 and 2453 piRNAs were significantly higher and lower expressed in ovary compared to that in testis, respectively. Thereinto, the most concentrated up-regulate and down-regulate piRNAs were both from serine/threonine– protein kinase PIM genes of different transcripts. These findings will be helpful to facilitate studies on the piRNAs regulation on genes during gonad development of teleosts.

Effect of phenolic acids on temperature-sensitive property of self-assembly of ionic pair of poly(ethylene imine)/(phenylthio)acetic acid

Fanyu Zhao,김진철 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.122 No.-

The ionic pair self-assembly (IPSAM) composed of poly(ethyleneimine) (PEI) and (phenylthio)acetic acid(PTA) was prepared and the effect of phenolic acids (PAs) (e.g. cinnamic acid (CA), hydroxycinnamic acid(HCA), and dihydroxycinnamic acid (DHCA)) on the upper critical solution temperature (UCST) and thetemperature-responsive releasing property of IPSAM were investigated. PEI/PTA ionic pair showed aUCST behavior and the PAs decreased the UCST effectively in the order of DHCA > HCA > CA. The PAs werethought to attach to the PEI chain of PEI/PTA ionic pair as pendants. PEI/PTA(3/7) ionic pair was found tobe air/water interface-active. CA had little effect on the interfacial activity of the ionic pair. HCA andDHCA significantly decreased the interfacial activity. IPSAM was found as nanoparticles whose diameterwas tens of nanometer and PAs had little effect on the shape and the size of IPSAM. The release degree ofcargo loaded in IPSAM increased slowly with time lapse when below UCST. Whereas, the release degreeincreased rapidly with time lapse when above UCST, possibly because of the thermally-induced disintegrationof IPSAM.

Near-infrared and Thermo-sensitive Liposomes Incorporating Thiolated-carboxymethyl Cellulose-capped Gold Nanoparticles and Poly(N-isopropylacrylamide)

Fanyu Zhao,WANGPIMOOL KWANJIRA,김진철 한국생물공학회 2023 Biotechnology and Bioprocess Engineering Vol.28 No.4

Near-infrared (NIR) irradiation-responsive drug carriers are of great interest because the light is tissuepenetrating and the carriers administered into human body can be made to release their payloads at a specific site in an active manner using the external stimulus (i.e., NIR irradiation). In this study, thermo-responsive liposomes bearing gold nanoparticle (GNP) were developed as a NIR irradiation-responsive drug carrier. Dipalmitoylphosphatidylcholine (DPPC) liposome was surface-decorated with hydrophobically modified thiolated carboxymethyl cellulose (Hm TL-CMC)-capped GNP and hydrophobically modified poly(N-isopropylacrylamide) (Hm PNIPAM). GNP was prepared using Hm TL-CMC as a reducing agent for gold ions and a capping material for GNP. DPPC liposomes incorporating Hm TL-CMC-capped GNP and Hm PNIPAM were prepared by a film hydration and sonication method and they exhibited a multi lamellar structure along with GNP on its transmission electron micrograph. The temperatureresponsive release of DPPC liposome was promoted when the liposome was incorporating Hm PNIPAM, possibly due to the thermal contraction of the polymer chains. DPPC liposome incorporating Hm TL-CMC-capped GNP showed a NIR-responsive release, possibly due to the photothermal effect of GNP, and the NIR-responsive release was enhanced when the liposome was bearing Hm PNIPAM.

GLOBAL CHARACTERISTICS ANALYSIS FOR VEHICLE SYSTEM WITH DRIVING TORQUE BASED ON DISSIPATION OF ENERGY

Fanyu Meng,Shuming Shi,Boshi Zhang,Yunxia Li,Nan Lin 한국자동차공학회 2022 International journal of automotive technology Vol.23 No.6

As more and more researchers begin to analyse the dynamics characteristics of high-degree-of-freedom and nonlinear vehicle models, it is very important and valuable to propose a new analysis method for this type of model. Moreover, it is a promising research direction to propose quantitative indicators for analysing global vehicle dynamics. Therefore, on the basis of classic works, this paper proposes and verifies a quantitative analysis method - dissipation of energy method for 5-DOF nonlinear vehicle plane motion model for the first time. The quantitative indicators for vehicle nonlinear dynamics is expanded. The transfer relationship between the energy components is revealed, which shows that the dissipation of energy method can reflect the dynamics characteristics and stable region characteristics of the nonlinear 5-DOF vehicle system. The effects of tire force lateral-longitudinal coupling and driving modes on global dynamics are analysed. Finally, the prospect of this method is discussed.

Implementing 1 → <i>M</i> economical phase-covariant cloning and telecloning in cavity QED

Meng, Fanyu,Zhu, Aidong,Yeon, Kyu-Hwang,Yu, Seong-Cho IOP Pub 2009 Journal of Physics B: Atomic, Molecular and Optica Vol.42 No.16

<P>We propose a scheme to implement 1 → <I>M</I> economical phase-covariant quantum cloning by using <I>N</I> three-level atoms nonresonantly interacting with a cavity assisted by a classical laser field. Using this interaction 1 → <I>M</I> telecloning is also implemented by applying the maximal entangled <I>W</I> state and partial entangled <I>W</I> state as the quantum channel, respectively. It is pointed out by analysing the fidelities and success probabilities that a relatively high fidelity and success probability can be obtained by choosing an appropriate channel in terms of the pre-known information of the input state.</P>

中國的行政訴訟與人權

동번여 아세아태평양공법학회 1991 亞-太公法硏究 Vol.1 No.-

Mechanical properties and neural network prediction of cement fly ash-enhanced roadbed soil in seasonal frozen zones under short-term curing

Gao Hang Cui,Zhuo Cheng,Fanyue Sun,Shuxian Ma,Zhiqiang Liu 대한토목학회 2024 KSCE Journal of Civil Engineering Vol.28 No.1

The freezing and thawing of roadbed soils in seasonal frozen zones can cause uneven settlement and other road problems, which puts road operation at risk. This paper focuses on the rapid construction of expressways and analyzes the effects of using fly ash and cement as modifiers on the physical properties and chemical composition of subgrade soil. The study found that cement admixtures can improve soil mechanical attributes and frost resistance, while also increasing the degree of fly ash hydration.And the freeze-thaw cycle process can enhance the mechanical characteristics of soils with higher cement admixture content. This is due to the development of hydrates in cement fly ash-enhanced soils during freeze?thaw cycles, resulting in a denser interior structure. The use of neural network prediction analysis showed that using ANN4-10-3 to forecast soil mechanical property parameters can produce superior results. Therefore, it is recommended to use cement fly ash-enhanced soil for roadbed construction in seasonal freezing areas, and neural network can be used to predict soil mechanical parameters.