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( Qiang Zhang ),( Yujuan Li ),( Fangxue Xu ),( Mengmeng Zheng ),( Xiaozhi Xi ),( Xuelan Zhang ),( Chunchao Han ) 한국균학회 2017 Mycobiology Vol.45 No.2
Different endophytes isolated from the seeds of Sophora flavescens were tested for their ability to produce matrine production. Response surface methodology (RSM) was applied to optimize the medium components for the endophytic fungus. Results indicated that endophyte Aspergillus terreus had the ability to produce matrine. The single factor tests demonstrated that potato starch was the best carbon source and the combination of peptone and NH<sub>4</sub>NO<sub>3</sub> was the optimal nitrogen source for A. terreus. The model of RSM predicted to gain the maximal matrine production at 20.67 μg/L, when the potato starch was 160.68 g/L, peptone was 24.96 g/L and NH<sub>4</sub>NO<sub>3</sub> was 2.11 g/L. When cultured in the optimal medium, the matrine yield was an average of 20.63 ± 0.11 μg/L, which was consistent with the model prediction. This study offered an alternative source for the matrine production by endophytic fungus fermentation and may have far-reaching prospect and value.
Fangxu Li,Hong Zhong,Shuai Wang,Guangyi Liu 한국공업화학회 2016 Journal of Industrial and Engineering Chemistry Vol.37 No.-
In order to get close-packed hydrophobic molecular monolayer, surface modification of ilmenite wascarried out with cupric ions. As it was found by zeta potential and XPS measurement, the cupric ionsmodification occurs via ion exchange, metal hydroxides adsorption, and redox processes. Aftermodifying by cupric ions, ilmenite surface properties became more active and the adsorption amount ofa-hydroxyoctyl phosphinic acid (HPA) increased. As expected, the flotation behaviour of ilmeniteimproved. XPS measurements verified the ability to establish a covalently attached HPA on the surfacesof ilmenite after Cu(II) activation. The findings of this study will provide a fundamental basis forstrengthening flotation.
A 2-40 Gb/s PAM4/NRZ Dual-mode Wireline Transmitter with 4:1 MUX in 65-nm CMOS
Fangxu Lv,Xuqiang Zheng,Feng Zhao,Jianye Wang,Ziqiang Wang,Shuai Yuan,Yajun He,Chun Zhang,Zhihua Wang 대한전자공학회 2018 Journal of semiconductor technology and science Vol.18 No.2
This paper presents a 2-40 Gb/s dual-mode wireline transmitter supporting the four-level pulse amplitude modulation (PAM4) and non-return-tozero (NRZ) modulation with a multiplexer (MUX)-based two-tap feed-forward equalizer (FFE). An edgeacceleration technique is proposed for the 4:1 MUX to increase the bandwidth. By utilizing a dedicated cascode current source, the output swing can achieve 900 mV with a level deviation of only 0.12% for PAM4. Fabricated in a 65-nm CMOS process, the transmitter consumes 117 mW and 89 mW at 40 Gb/s in PAM4 and NRZ at 1.2 V supply.
An analytical model of the additional confining stress in a prestress-reinforced embankment
Xinyu Ye,Fangxu Li,Wuming Leng,Xi Ai,Hossein Moayedi,Qishu Zhang 국제구조공학회 2023 Smart Structures and Systems, An International Jou Vol.31 No.5
Using a device composed of two lateral pressure plates (LPPs) and a steel reinforcement bar to apply horizontal pressure on slope surfaces, a newly developed prestress-reinforced embankment (PRE) is proposed, to which can be adopted in strengthening railway subgrades. In this study, an analytical model, which is available of calculating additional confining stress (<i>σ</i><sub>H</sub>) at any point in a PRE, was established based on the theory of elasticity. In addition, to verify the proposed analytical model, three dimensional (3D) finite element analyses were conducted and the feasibility in application was also identified and discussed. In order to study the performance of the PRE, the propagation of <i>σ</i><sub>H</sub> in a PRE was analyzed and discussed based on the analytical model. For the aim of convenience in application, calculation charts were developed in terms of three dimensionless parameters, and they can be used to accurately and efficiently predict the <i>σ</i><sub>H</sub> in a PRE regardless of the embankment slope ratio and LPP side length ratio. Finally, the potential applications of the proposed analytical model were discussed.
Guanqun Chao,Yingying Wang,Fangxu Ye,Shuo Zhang 연세대학교의과대학 2018 Yonsei medical journal Vol.59 No.8
Purpose: This study aimed to screen for differentially expressed microRNAs (miRNAs) in the colons of rats with visceral hypersensitivityto build the expression profiles of miRNAs therein and to determine the mechanism of Tongxieyaofang use in thetreatment of irritable bowel syndrome (IBS). Materials and Methods: Forty Sprague-Dawley rats were divided randomly into four groups: control group, model control group(induced by rectum stimulus and evaluated by abdominal withdraw reaction), treatment control group (normal saline), andTongxieyaofang group (treated with Tongxieyaofang). We screened for differential expression of colonic mucosal miRNAs usingliquid chip technology and verified the expression thereof using reverse transcription-PCR. Results: The visceral hypersensitivity rat model was successfully established. We found the expression of let-7f, let-7i, miR-130b,miR-29a, miR-132, miR-21, and miR-375 to be up-regulated (p<0.05), while the expression of miR-24, miR-31a, miR-192, miR-221,and miR-223 was down-regulated (p<0.05) in the visceral hypersensitivity rats. After treatment with Tongxieyaofang, the expressionof let-7f, let-7i, miR-130b, miR-29a, miR-132, miR-21, and miR-375 was reduced (p<0.05), whereas the expression of miR-24,miR-31a, miR-192, miR-221, miR-223 was increased, compared to the treatment control group (p<0.05). Conclusion: MiRNAs play a pivotal role in visceral hypersensitivity and might be targets in the treatment of IBS by Tongxieyaofang.