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Propamidine decreas mitochondrial complex 3 activity of Botrytis cinerea
( Fangli Wu ),( Weibo Jin ),( Juntao Feng ),( Anliang Chen ),( Zhiqing Ma ),( Xing Zhang ) 생화학분자생물학회 (구 한국생화학분자생물학회) 2010 BMB Reports Vol.43 No.9
Propamidine, an aromatic diamidine compound, is widely used as an antimicrobial agent. To uncover its mechanism on pathogenetic fungi, Botrytis cinerea as an object was used to investigate effects of propamidine in this paper. The transmission electron microscope results showed that the mitochondrial membranes were collapsed after propamidine treatment, followed that mitochondria were disrupted. Inhibition of whole-cell and mitochondrial respiration by propamidine suggested that Propamidine is most likely an inhibitor of electron transport within Botrytis cinerea mitochondria. Furthermore, the mitochondrial complex 3 activity were inhibited by propamidine. [BMB reports 2010; 43(9): 614-621]
Fangli Qiao,Jian Ma,Yongzeng Yang,Yeli Yuan 한국해양과학기술원 2004 Ocean science journal Vol.39 No.1
Based on the MASNUM wave-current coupled model, the temperature and salinity structures along 36°N in the Yellow Sea are simulated and compared with observations. Both the position and strength of the simulated thermocline are similar to data analysis. The wave-induced mixing is strongest in winter and plays a key role in the formation of the upper mixed layer in spring and summer. Numerical experiments suggest that in the coastal area, wave-induced mixing and tidal mixing control the vertical structure of temperature and salinity.
Qiao, Fangli,Ma, Ji-An,Yang, Yong-Zeng,Yuan, Yeli The Korean Society of Oceanography 2004 Journal of the Korean Society of Oceanography Vol.39 No.1
Based on the MASNUM wave-current coupled model, the temperature and salinity structures along $36^{\circ}N$ in the Yellow Sea are simulated and compared with observations. Both the position and strength of the simulated thermocline are similar to data analysis. The wave-induced mixing is strongest in winter and plays a key role in the formation of the upper mixed layer in spring and summer. Numerical experiments suggest that in the coastal area, wave-induced mixing and tidal mixing control the vertical structure of temperature and salinity.
A Node Importance Measuring Method based on Hypernetwork
Quan Xiao,Fangli Yang,Song Luo,Lihong Zhang,Hua Zhao,Wei Shu 보안공학연구지원센터 2016 International Journal of Future Generation Communi Vol.9 No.12
Measuring the importance of nodes in network is an important issue in the study of complex networks. The networks in current researches are mostly based on classical graph theory, which have limitations on describing certain complex relations. In this work, we introduce hypernetwork, taking hypergraph as representation foundation, to describe relations. Hypernetwork is able to extend the modeling and describing capability of traditional network and may be a promising representation model of complex relations. However, a general lack of attention to the node importance measuring in hypernetwork, an important fundamental issue for its further application, has been noted across the majority of related published works. In this paper, we utilize the idea of deleting method, to measure the importance of node in hypernetwork through investigating the influence on the whole network when deleting it. Specifically, the influence is measured by direct loss and indirect loss. Through a calculating example, our method is compared with node degree, betweenness, closeness centrality, degree of neighbor nodes etc., the result shows this method has better adaptability and accuracy.
Melatonin prevents lung injury by regulating apelin 13 to improve mitochondrial dysfunction
Lu Zhang,Fangli Liu,Xiaomin Su,Yue Li,Yining Wang,Ruonan Fang,Yingying Guo,Tongzhu Jin,Huitong Shan,Xiaoguang Zhao,Rui Yang,Hongli Shan,Haihai Liang 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-
Pulmonary fibrosis is a progressive disease characterized by epithelial cell damage, fibroblast proliferation, excessive extracellular matrix (ECM) deposition, and lung tissue scarring. Melatonin, a hormone produced by the pineal gland, plays an important role in multiple physiological and pathological responses in organisms. However, the function of melatonin in the development of bleomycin-induced pulmonary injury is poorly understood. In the present study, we found that melatonin significantly decreased mortality and restored the function of the alveolar epithelium in bleomycin-treated mice. However, pulmonary function mainly depends on type II alveolar epithelial cells (AECIIs) and is linked to mitochondrial integrity. We also found that melatonin reduced the production of reactive oxygen species (ROS) and prevented apoptosis and senescence in AECIIs. Luzindole, a nonselective melatonin receptor antagonist, blocked the protective action of melatonin. Interestingly, we found that the expression of apelin 13 was significantly downregulated in vitro and in vivo and that this downregulation was reversed by melatonin. Furthermore, ML221, an apelin inhibitor, disrupted the beneficial effects of melatonin on alveolar epithelial cells. Taken together, these results suggest that melatonin alleviates lung injury through regulating apelin 13 to improve mitochondrial dysfunction in the process of bleomycin-induced pulmonary injury.
Noise Reduction-Oriented Flight Aircraft Type
Xia Feng,Fangli Sun,Min Lu 보안공학연구지원센터 2015 International Journal of Database Theory and Appli Vol.8 No.5
With the rapid development of civil aviation and raising public awareness of environmental issues, it is extremely crucial to reduce airport noise impact in the vicinity of airports. Reduction of noise at source and operation restrictions are two prominent noise abatement approaches, both of which reduce aircraft noise impact by selecting appropriate aircraft types for flights. However, reduction of noise at source requires high cost while operation restrictions would restrict the ability of full operation of the airport. To tackle with the above issue, the paper studies the problem of aircraft type selection for noise reduction, the target of which is to select aircraft type with the lowest noise from a variety of candidate types. To this end, the paper employs weighted equivalent continuous perceived noise level to measure the noise level, and then utilizes Integrated Noise Model (INM) to calculate noise impact area at the interval of noise level. Experimental results on Beijing International Airport noise monitoring dataset show that the proposed algorithm can indeed obtain the aircraft type with minimal aircraft noise impact.
Zhe Wu,Yuying Zhang,Yong Liu,Fangli Mo,Chengwu Wang,Huizong Lu,Julong Yuan,Zhifeng Liu 한국정밀공학회 2024 International Journal of Precision Engineering and Vol.25 No.1
Aiming to green machining of single crystal sapphire, polysaccharide-bonded soft abrasive tool using hydrothermal gelatinisation method was proposed. Mechanical properties of prepared polysaccharide films show that when the weight ratio of natural polysaccharide to cross-linked polysaccharide is 1:1, the tensile strength and extension rate of the film are relatively optimal. Composition and making process of polysaccharide bonded abrasive tool was built. Samples of polysaccharide bonded soft abrasive tools were made by which the single crystal sapphire substrates were machined. It is found that by adopting guar gum as dispersion agent and hydrothermal gelatinisation, the abrasive sedimentation during making process of abrasive tool is substantially eliminated, and better abrasive holding ability is attained. XPS and Raman microscope analysis showed that material of single crystal sapphire was removed by mechano-chemical reaction with good surface integrity. Abrasive tools with abrasive to binder ratio of 4:1 presented relatively better self-sharpening and machining performance, and the material removal rate reached 0.427 μm/min. More interesting, XPS and FT-IR analyses both indicated that the polysaccharide binder dehydrated by the friction heat during machining process.
Wu Tao,Ren Yan,Wang Wei,Cheng Wei,Zhou Fangli,He Shuai,Liu Xiumin,Li Lei,Tang Lu,Deng Qiao,Zhou Xiaoyue,Chen Yucheng,Sun Jiayu 대한영상의학회 2021 Korean Journal of Radiology Vol.22 No.10
Objective: This study used cardiac magnetic resonance imaging (MRI) to compare the characteristics of left ventricular remodeling in patients with primary aldosteronism (PA) with those of patients with essential hypertension (EH) and healthy controls (HCs). Materials and Methods: This prospective study enrolled 35 patients with PA, in addition to 35 age- and sex-matched patients with EH, and 35 age- and sex-matched HCs, all of whom underwent comprehensive clinical and cardiac MRI examinations. The analysis of variance was used to detect the differences in the characteristics of left ventricular remodeling among the three groups. Univariable and multivariable linear regression analyses were used to determine the relationships between left ventricular remodeling and the physiological variables. Results: The left ventricular end-diastolic volume index (EDVi) (mean ± standard deviation [SD]: 85.1 ± 13.0 mL/m2 for PA, 75.9 ± 14.3 mL/m2 for EH, and 77.3 ± 12.8 mL/m2 for HC; p = 0.010), left ventricular end-systolic volume index (ESVi) (mean ± SD: 35.2 ± 9.8 mL/m2 for PA, 30.7 ± 8.1 mL/m2 for EH, and 29.5 ± 7.0 mL/m2 for HC; p = 0.013), left ventricular mass index (mean ± SD: 65.8 ± 16.5 g/m2 for PA, 56.9 ± 12.1 g/m2 for EH, and 44.1 ± 8.9 g/m2 for HC; p < 0.001), and native T1 (mean ± SD: 1224 ± 39 ms for PA, 1201 ± 47 ms for EH, and 1200 ± 44 ms for HC; p = 0.041) values were higher in the PA group compared to the EH and HC groups. Multivariable linear regression demonstrated that log (plasma aldosteroneto- renin ratio) was independently correlated with EDVi and ESVi. Plasma aldosterone was independently correlated with native T1. Conclusion: Patients with PA showed a greater degree of ventricular hypertrophy and enlargement, as well as myocardial fibrosis, compared to those with EH. Cardiac MRI T1 mapping can detect left ventricular myocardial fibrosis in patients with PA.
Chongwen Xu,Yuan Shao,Wanli Ren,Hao Dai,Fangli Yang,Xiang Li,Shaoqiang Zhang,Junsong Liu,Xiaobao Yao,Qian Zhao,Xin Sun,Zhiwei Zheng 한국분자세포생물학회 2023 Molecules and cells Vol.46 No.6
Papillary thyroid carcinoma (PTC) is the most common subtype of thyroid carcinoma. Despite a good prognosis, approximately a quarter of PTC patients are likely to relapse. Previous reports suggest an association between S-phase kinase-associated protein 2 (SKP2) and the prognosis of thyroid cancer. SKP1 is related to apoptosis of PTC cells; however, its role in PTC remains largely elusive. This study aimed to understand the expression and molecular mechanism of SKP2 in PTC. SKP2 expression was upregulated in PTC tissues and closely associated with clinical diagnosis. In vitro and in vivo knockdown of SKP2 expression in PTC cells suppressed cell growth and proliferation and induced apoptosis. SKP2 depletion promoted cell autophagy under glucose deprivation. SKP2 interacted with PH domain leucine-rich repeat protein phosphatase-1 (PHLPP1), triggering its degradation by ubiquitination. Furthermore, SKP2 activates the AKT-related pathways via PHLPP1, which leads to the cytoplasmic translocation of SKP2, indicating a reciprocal regulation between SKP2 and AKT. In conclusion, the upregulation of SKP2 leads to PTC proliferation and survival, and the regulatory network among SKP2, PHLPP1, and AKT provides novel insight into the molecular basis of SKP2 in tumor progression.