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Histone Modifications During DNA Replication
Karina B. Falbo,Xuetong Shen 한국분자세포생물학회 2009 Molecules and cells Vol.28 No.3
Faithful and accurate replication of the DNA molecule is essential for eukaryote organisms. Nonetheless, in the last few years it has become evident that inheritance of the chromatin states associated with different regions of the genome is as important as the faithful inheritance of the DNA sequence itself. Such chromatin states are deter-mined by a multitude of factors that act to modify not only the DNA molecule, but also the histone proteins associ-ated with it. For instance, histones can be posttranslation-ally modified, and it is well established that these post-translational marks are involved in several essential nu-clear processes such as transcription and DNA repair. However, recent evidence indicates that posttranslational modifications of histones might be relevant during DNA replication. Hence, the aim of this review is to describe the most recent publications related to the role of histone posttranslational modifications during DNA replication.
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Blood level of adipokines and nutritional status variables in adolescent pregnancy
Mirela Douradinho Fernandes,Silvia Daher,Luciana Moraes de Sousa,Indiomara Baratto,Thalita Frutuoso Lobo,Edward Araujo Júnior,Cristina Aparecida Falbo Guazzelli 대한산부인과학회 2020 Obstetrics & Gynecology Science Vol.63 No.6
ObjectiveTo evaluate the serum levels of adiponectin and leptin and their relationship with nutritional variables duringpregnancy in adolescents. MethodsThis prospective cohort study evaluated eutrophic pregnant adolescents (body mass index [BMI], 18.5–24.9 kg/m2) during the 3 gestational trimesters (first, 10–14 weeks; second, 24–28 weeks; and third, 30–34 weeks). Serumadiponectin and leptin concentrations were measured using the enzyme-linked immunosorbent assay method. Therelationship of these adipokines with the pre-gestational BMI, gestational weight gain, weight at the time of samplecollection, and newborn weight were evaluated. Analysis of variance and the Kruskal-Wallis test were used forstatistical analysis. ResultsThe study group comprised 62 pregnant adolescents. The serum concentration of adiponectin showed a significantdifference between the first and third trimesters (P=0.003), which decreased during pregnancy, but unrelated tonutritional variables. Serum leptin levels increased throughout the pregnancy (P<0.0001) and showed a positivecorrelation with pre-gestational BMI, total weight gain, pregnancy weight at the time of sample collection, andnewborns’ weight. ConclusionSerum levels of adiponectin and leptin vary inversely throughout pregnancy. This pattern in adolescents is similar tothat observed in adults. Moreover, leptin concentrations increased throughout pregnancy, and they were positivelycorrelated with all variables evaluated.
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