Cisplatin이 1차 감작된 마우스의 IgM 용혈반 형성 세포수와 임파구 증식능에 미치는 영향

표명윤,강명옥,윤희은,주은영 숙명여자대학교 약학연구소 1996 약학논문집-숙명여자대학교 Vol.12 No.-

The effects of cisplatin on the IgM plaque forming cells and the lymphocyte proliferation in primarily sensitized mice were investigated. Cisplatin was i.p. injected with a single low does (0.825, 1.65, 3.3mg/kg, which is 5, 10, 20% of LD_50) to mice. The splenic IgM antibody plaque forming cell (PEC) was assayed after ICR mice had been treated in vivo with a combination of three different doses of Cisplatin at different time (day-2, day+2) plus SRBC(day 0). IgM PFC was significantly increased when drug was injected prior to immunization with SRBC, but it was decreased when administered after SRBC antigen. Splenocytes from mice injected with Cisplation(1.65, 3.3mg/kg) on the 2nd day before the test day were cultured with Con A and LPS. The splenocyte proliferation to Con A mitogen was slightly increased, but to LPS was significantly and markedly increased. It was found that Cisplatin at low dose showed either immunosuppression or immunostimulation, depending on the time of drug-application in relation to antigenic treatment.

IEEE 802.11기반의 애드 혹 네트워크의 효율적인 동시적 전송

공현표,김은성,김두용 순천향대학교 산업기술연구소 2007 순천향 산업기술연구소논문집 Vol.13 No.1

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톨루엔의 급성 흡입이 마우스의 자발운동량에 미치는 영향

표명윤,주은영 숙명여자대학교 환경과학연구센터 1996 환경과학논문집 Vol.4 No.-

To investigate the effects of acute toluene exposure on the spontaneous locomotor activity. Female ICR mice were exposed for varying periods of time(10, 20, 30min)to 10,000ppm toluene and were tested at intervals during and after exposure. The spontaneous locomotor activity was markedly de­creased at high dose(10,000ppm) toluene inhalation. Rapidity of recovery was dependent upon the time of inhalation.

톨루엔의 급성흡입이 마우스의 1차 체액성 면역반응에 미치는 영향

표명윤,주은영 숙명여자대학교 약학연구소 1998 약학논문집-숙명여자대학교 Vol.15 No.-

Toluene was inhaled at concentration of 10,000ppm to ICR mice for 10, 20, 30min, and mice were sacrificed on day 2, 4, 6 or 8 following inhalation. Acute toluene inhalation didn't change the body weight gains, thymus and kidney weights. Spleen weight was slightly decreased, but there's no significant difference. Liver weight was significantly decreased on the 6th day after inhalation and recovered on the 8th day after. The number of WBC was significantly decreased on the 4th day and recovery from toluene hazard was appeared on the 8th day. Platelets were markedly and significantly decreased only on the 2nd day in every inhaled group. Red blood cells were increased on the 6th day and recovered on the 8th day after. The number of IgM plaque forming cells in splenocytes and IgM level in antiserum were increased in every inhaled group when toluene( 10,000 ppm, 10, 20, 30 min) was exposed to mice prior to primary immunization. When mice were exposed to toluene after immunization, IgM plaque forming cells and IgM level were increased in 10 min inhaled group and similar to PFC of control in 30 min inhaled group. Therefore the acute toluene inhalation at high dose in mice seems to increase the primary humoral immune response irrespective to the time of SRBC-antigen injection.

Caffeine이 지구성 운동 수행능력에 미치는 영향과 억제성 아미노산에 의하여 활성화되는 이온통로의 조절작용

김은경,김영표,천병옥,이계영,김연정,임백빈,조영욱,김창주,김성수 대한스포츠의학회 1999 대한스포츠의학회지 Vol.17 No.1

To investigate the effect and mechanism of caffeine on endurance exercise, two experiments were performed. First, to test caffeine effect on aerobic exercise, 200-300g Sprague-Dawley rats were used and three groups, control group, low caffeine injection group and high caffeine injection group, were divided. Blood smpling by heart puncture were done at rest, after 30 min treadmill exercise, and after maximal exercise. Blood glucose, free fatty acid concentration were detected and following results were obtained. Glucose concentration showed significant difference between groups(p=0.0305) and also significant changes were exhibited between time(p=0.0004). Free fatty acid concentration had no difference between groups. but had significance between times(p=0.00065). Exercise endurance performance time showed significant difference(p=0.02350 in high caffeine injection group compared to control group. In this experiments, endurance exercise capacity was increased by caffeine injection. Therefore, second experiment was performed to investigate the effect of caffeine on ion current induced inhibitory amino acid neurotransmitter. GABA and glycine. Single periaqueductal gray neuron was acutely dissociated and nystatin perforated patch clamp was performed under voltage clamping condition. Caffeine evoked outward current in PAG neuron dose dependent manner. 1mM of caffeine application had no response. but 3mM caffeine evoked about 32.5±8.539pA outward ion current and 10mM caffeine evoked about 215.46±19.4pA outward current. 10^-2mM GABA activated Cl￣current and recorded by inward current. Caffeine inhibited GABA activated Cl￣ current concentration dependent manner. 10^-2mM of caffeine had no effect on 1-^-2mM of GABA response. but 10^-1mM caffeine inhibited GABA activated Cl￣ current about 5.74±2.13%, 1mM caffeine inhibited about 17.25±2.70%, 10mM caffeine inhibited GABA response about 45.31±7.71%. 10^-1mM of glycine activated Cl￣ current and also recorded by inward current. Caffeine inhibited glycine activated Cl￣ current concentration dependent manner. 10^-2mM caffeine decreased glycine activated Cl￣ current about 4.61±1.650%, 10^-1mM caffeine decreased about 6.49±2.24%, 1mM caffeine decreased about 26.82±4.27%, and 10mM caffeine decreased glycine response about 94.47±1.39%. These results suggest that caffeine inhibite inhibitory amino acid, GABA and glycine, this response causes excitation of CNS and this seems to be the basic mechanism of increasing effect to aerobic exercise performance by caffeine.

병원정보시스템의 경영전략적 활용방안에 관한 연구

이은효,신종연,윤병준,김영훈 서울보건대학 1999 서울보건대학 부설 병원경영연구소 논문집 Vol.4 No.2

This study includes an empirical analysis of utilization of strategic management with hospital information system and a policy implication on hospital management. The purposes of this study are to analyze the effects of strategic information and implementation on the major performance factors. For this study. the materials used are mailing survey data of 65 hospitals and related literature was reviewed. Crosstabulation and multiple response analysis were made to find the frequencies by groups. ANOVA and multiple regression analysis were adopted to examine the differences and the relationship between variables involved. The major findings are as follow: 1. Internal information needed for strategic management focuses on the patients' data and the ones of services being delivered. Using portion of financial indices also ranked 2nd by respondents. but financial analysis was not performed frequently. 2. The Effects of strategic information on the hospital management environment were the most in hospital planning and hospital administration and medical support tasks. Ane the effects of assessment of the external factors and rapidity and accuracy of decision making, however. were relatively low. 3. The more computer system group satisfy planning group on the material requested by planning group. the more effects of cost reduction and service promotion have favorable results. Besides. the more computer education and PR are performed. the more efficiencies of hospital management have favorable results. In result of more exploration, the relationship of between computer education and PR item and satisfaction level of planning group on requested material and cost reduction effects was statistically significant. Of the above results. there are favorable effects on the major performance factors. However. there are few results of being performed on systematic strategic planning, action and management. With regard to hospital management information system, there are many challenges in the future when applying strategic management methods. Hospital executives must begin to use information system strategically for survival and growth in the 2000s.

송화분을 이용한 간기능 증진제 개발 연구

하은주,이해경,한준표 대구효성가톨릭대학교 1993 연구논문집 Vol.47 No.1

To investigate the effect of the pine pollen on serum and liver of rat pretreated with carbon tetrachloride. Rats were first administrated CCl₄and then treated orally with the water-washed pine pollen as indicated in the book of "Imperial courtcookery" The results are summarized as follows ; GPT activity of rat administrated the pine pollen was lower than that of rat treated with CCl₄to induce a chronic liver injury and was similar to that of nontreatment group. Totla cholesterol in serum of pine pollen administrated rat decreased significantly compared with that of the CCl₄-treated group. There was a noticeable improvement in the activity of the live protein synthesis of pine polllen-administrated rat, compared with that of CCl₄-treated group. Body weight of non-treated group are increased but that of CCl₄-treated and pine pollen-treated group were retarded according to time.

심상과 기능수행에 관한 이론적 연구

성은지,표내숙 釜山大學校 附設 體育科學硏究所 1994 體育科學硏究所 論文集 Vol.10 No.-

Imagery, called visualization, mental practice, mental rehearsal is a technique that has gained considerable attention in sports and dance in recent years because it is thought to enhance skill performance. In this study, theoretical interpretations of the imagery process and factors influencing imagery are reviewed for further study of imagery. The mechanisms that mediate cognition, imagery and motor movement remain mostly unknown. To gain more academic respect, the research on imagery must use better methodologies and attempt theorizing.

부산시 고령자의 통행행태에 관한 연구

오윤표,안영종,김은정 東亞大學校 建設技術硏究所 2005 硏究論文集 Vol.29 No.1

The purpose of this study os to analyze the elderly's travel behavior and to measure the factors affecting their travel mode choice. Questionnaire survey was conducted for this study. It is assumed that the elderly is over 65 years old for this study. The major results of this study are as follows:(1) Because driving alone is very expensive travel mode, bus is considered as main travel mode for the elderly over 65 years old. (2) The friendship, recreation, an medical treatment are significant travel purpose. It was showed that the elderly's travel pattern is irregular. (3) Going up and down of stairs are the most important restriction for the elderly's travel.

유전자치료를 위한 벡터 개발의 연구 동향 : A Current Research Insight

손은화,손은수,표석능 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.5

The basic concept underlying gene therapy is that human diseases may be treated by the transfer of genetics material into specific cells of a patient in order to correct or supplement defective genes responsible for disease development. There are several systems that can be used to transfer foreign genetic material into the human body. Both viral and non-viral vectors are developed and evaluated for delivering therapeutic genes. Viral vectors are biological systems derived from naturally evolved viruses capable of transferring their genetics materials into host cells. However, the limitations associated with viral vectors, in terms of their safety, particularly immunogenecity, and their limited capacity of transgenic materials, have encouraged researchers to increasingly focus on non-viral vectors as an alternative to viral vectors. Although non-viral vectors are less efficient than viral ones, they have the advantages of safety, simplicity of preparation and high gene encapsulation capability. This article reviews the most recent studies highlighting the advantages and the limitation of gene delivery systems focused on non-viral systems compared to viral systems.