Minoxidil에 의한 모발절대휴지기 탈출 유도 효과

이은정,조영롱,조경혜 서울여자대학교 자연과학연구소 2011 자연과학연구논문집 Vol.23 No.-

Hair follicle (HF), a small physiological organ in the human body which produces hair, repeats a four-phased hair cycle consisting of anagen, catagen, telogen, and exogen phases and affects the growth, maintenance, and loss of hair. Recent studies revealed that the hair growth and loss are controlled by the balance between bmp and nog expressed from dermal papilla cells (DP cells) which control the physiological characteristics of the hair growth cycle and that a phase transition from refractory telogen phase to competent telogen phase, caused from the reduction in expression of bmp gene in the telogen phase, is indispensible for the regeneration of hair cycle. This study is conducted to verify the effect of minoxidil, a depilatory lotion widely used around the globe on the molecular mechanism in the hair cycle process occurring in the DP cells, especially in the expression of bmp and nog genes. DP-enriched cells were separated and cultured from the back skin of 1 day-old new born rats and observed the effects after processing minoxidil on the cells. Minoxidil reduced the expression of bmp4 and bmp6 genes, which stimulate differentiation but inhibit multiplication of DP cells in the hair cycle control process, and reduced the expression of bmprla gene, as its receptor. Minoxidil also reduced the expression of nog genes known as an antagonist of bmp produced from DP cells and an essential element in the telogen-anagen phase transition. From this results, minoxidil induced the DP cells to stay at the competent telogen phase, a prior phase of the initiation of the anagen phase, and to escape from refractory telogen phase of the hair cycle. Also, minoxidil induced DP cells to an ‘undifferentiated state of hair cell' of competent telogen phase, a prior phase of early anagen phase, rather than that inducing the cell to an initiation phase of hair cycle, the anagen phase. Minoxidil reduced the expression of nog gene which is an essential element in the regeneration of hair cycle, but increased the expression of bfgf gene, a upstream growth factor which stimulates the expression of nog and vegf genes which foster the growth of DP cell. Thus, it can be suggested that there is possibility that minoxidil indirectly affects telogen-anagen phase transition and the initiation of anagen phase. In conclusion, this study verified that minoxidil leads escape from refractory telogen phase of a hair growth cycle and thereby reduces the period of the telogen phase. Key words:dermal papilla cells, minoxidil, bmp, noggin, hair cycle.

리스페달 정(리스페리돈 2㎎)에 대한 리스펜 정의 생물학적 동등성

조혜영,박은자,강현아,백승희,이석,박찬호,문재동,이용복 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.2

The purpose of the present study was to evaluate the bioequivalence of two risperidone tablets, Risperdal (Janssen Korea Co., Ltd) and Rispen (Myung In Pharm. Co., Ltd), according to the guidelines of Korea Food and Drug Administration (KFDA). The risperione release from the two risperidone formulations in vitro was tested using KP Ⅷ Apparatus Ⅱ method with various of dissolution media (pH 1.2, 4.0, 6.8 butter solution and water). Twenty four healthy male subjects, 23.33±2.10 years in age and 69.24±8.05 kg in body weight, were divided into two groups and a randomized 2×2 crossover study was employed. After one tablet containing 2 ㎎ as risperidone was orally administered, blood was taken at predetermined time intervals and the concentration of risperidone in serum were determined using HPLC method with UV detector. The dissolution profiles of two formulations were similar at all dissolution media. Besides, the pharmacokinetic parameters such as AUC_(t), C_(max) were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed AUC_(t), C_(max) and untransformed T_(max). The results showed that the differences between two formulations based on the Risperdal were 0.20, -1.29 and -11.09% for AUC_(t), C_(max) and T_(max), respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log(0.8) to log(1.25) (e.g., log(0.90)∼log(1.03) and log(0.84)∼log(1.09) for AUC_(t) and C_(max), respectively). Thus, the criteria of the KFDA guideline for the bioequivalence were satisfied, indicating Rispen tablet and Risperdal tablet were bioequivalent.

아마릴 정(글리메피리드 2㎎)에 대한 글리메드 정의 생물학적 동등성

조혜영,박은자,강현아,백승희,이석,김세미,문재동,이용복 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.2

The purpose of the present study was to evaluate the bioequivalence of two glimepiride tables, Amaryl^(?)(Handok/Aventis Pharm. Co., Ltd.) and Glimed (Kuhn Ⅱ Pharm. Co., Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). The glimepiride release from the two glimepiride formulations in vitro was tested using KP Ⅷ Apparatus Ⅱ method with a variety of dissolution media (pH 1.2, 4.0, 6.8 buffer solution, water and blend of PSB 80 into each dissolution medium). Twenty six healthy male subjects, 22.65±2.19 years in age and 66.55±8.85 kg in body weight, were divided into two groups and randomized 2×2 cross-over study was employed. After one tablet containing 2 ㎎ as glimepiride was orally administered, blood was taken at predetermined time intervals and the concentrations of glimepiride in serum were determined using HPLC method with UV detctor. The dissolution profiles of two formulations were similar at all dissolution media. Besides, the pharmacokinetic parameters such as AUC_(t), C_(max) and untransformed T_(max). The results showed that the differences between two formulations based on the Amaryl were -3.70, -8.28 and 0.61% for AUC_(t), C_(max) and T_(max), respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log(0.8) to log(1.25)(e.g., log(0.84)∼log(1.04) and log(0.82)∼log(1.03) for AUC_(t) and C_(max), respectively). Thus, the criteria of the KFDA guideline for the bioequivalence were satisfied, indicating Glimed tablet and Amaryl tablet were bioequivalent.

마임 건강식품 홍삼진을 이용한 전통과 모던의 융합적 브랜드 이벤트 프로모션 산업체 연계를 통한 아트, 디자인, 공학, 마케팅 융합 디자인을 중심으로-

길혜경,박민지,이하은,조예린,이진민,장미정,이성애 숙명여자대학교 산업디자인연구소 2017 숙명디자인학 연구 Vol.24 No.-

본 연구는 융합 연출 디자인 이라는 목적에서 출발하여 마임 브랜드 홍삼진 제품을 다각적 측면에서 기획 및 분석하는데 목적이 있다. 이에 본 연구는 2017년 3월~ 6월 15주 동안 숙명여대 환경디자인학과<융합 캡스톤 디자인>수업을 통해 이루어졌다. 또한 본 연구는 마임브랜드 중, 건강식품을 브랜딩하고 있는 <홍삼 진>을 선택하였다. 그 결과 본 연구는 기존 이벤트 프로모션과 전시의 사회적 문제를 도출하였고, 이를 해결하기 위한 방안으로서 전통과 현대의 융합의 오감적 체험 프로모션을 주제로 선정하였다. 아울러 본 연구는 SWOT/STP 마케 팅 분석 방법과 브레인스토밍을 사용하여 아트, 디자인, ICT, Marketing의 융합 브랜드를 구축하였다.끝으로 본 연구는 향후 마케팅을 기반한 융합 브랜드 개발에 있어 기초 자료로 활용될 수 있을 것이라 기대된다.

4.6.9 歲 兒童의 親社會的 行動發達에 關한 硏究

林聖惠,朴銀實 진주여자전문대학 1989 論文集 Vol.11 No.-

The main purpose of the present study was to examine the development of children's prosocial behavior. To achieve this purpose, following problems were put forward. (1) Are there any differences in the level of prosocial behavior according to age? (2) Are thers any differences in the level of prosocial behavior according to sex? (3) Are there any differences in the level of prosocial behavior according to socio-economic leves. Subjects were 60 children(30 boys and 30 girls) in three age groups ; 20 kindergarten children(10 boys and 10 girls) aged 6 ; and 20 third-grade children(10 boys and 10 girls) aged 8. To solve the above problems, 60 subjects were administered a prosocial behavior test by Bar-Tal(l979) and socio-economic level scale. These tools were revised to fit the purpose of this study. The data of the present study were processed with Mean, standard Deviation. ONE-WAY ANOVA, T-test and scheffe'-test by SPSS Program. The findings of this study are summerized as follows : First, there was significant differences in the children's prosocial behavior according to age [F=32.02, P< .01]. That is, children's prosocial behavior increased with age increase. Especially, as result of Scheffe'-test, there were more differences between 6 to 9 years old. second, there was no significant differences in the prosocial behavior according to sex. Third, there was significant differences in the childrens prosocial behavior according to socio-economic levels[t[59]=2.59, p[ .01]. Namely, high socio÷ economic level group was more prosocial than low sociof economic level group.

處容舞服飾에 관한 硏究 : 《樂學軌範》에 수록된 도설을 중심으로

전혜숙,김태은 동아대학교 생활과학연구소 2001 생활과학연구 논문집 Vol.9 No.-

This study was about the costumes of Cheo-Yong dance. The purpose of thesis was to make an analysis of a reflective meaning and construction for Cheo-Yong dance as traditional royal dancing costumes shown in Ak-Hak-Gue-Bum(樂學軌範). Cheo-Yong dancing costumes shown in Ak-Hak-Gue-Bum was consisted of Wei(衣), Gun(裙), Sang(裳), Cyun-Wei(天衣), Kil-Kyoung(吉慶), Han-Sam(汗衫), Sa-mo(紗帽), Dea(帶), and Hye(鞋). Cheo-Yong under the influence of Eum-Yang-Oh-Haeng was composed of Oh-Bang Cheo-Yong dancing costumes have weared clothes each other colored (Blue, Yellow, Black, White, Red). In the Chapter I, I have reviewed the purpose of thesis. In the Chapter II, I have reviewed what means a compilation of Ak-Hak-Gue-Bum. In the Chapter III, I have reviewed characteristics and construction of Cheo-Yong dancing costumes recorded in Ak-Hak-Gue-Bum. In the Chapter IV, I tried to examine a reflective meaning at Cheo-Yong dancing costumes.

일 시설노인에게 나타난 주요 간호진단의 관련요인 분석

허혜경,박소미,김기연,신윤희,임은실 성인간호학회 2003 성인간호학회지 Vol.15 No.1

Purpose: The purpose of this study was to analyze related factors for major nursing diagnoses used in caring for institutionalized elders. Method: This study was a descriptive study. The participants were 92 residents in a long-term care facility in Wonju, selected by convenience sampling. The instrument was a checklist designed on the basis of the related factors suggested by NANDA (1997) and a literature review. Data was collected by chart review, observation, and interviews with the participants. Data was analyzed using descriptive statistics with the SPSS WIN program. Result: The most frequent nursing diagnosis was 'risk for injury', 'self-esteem disturbance', 'activity intolerance', 'impaired physical mobility', and 'powerlessness'. The most frequent component for related factors for the five component for each nursing diagnosis was the physical component, followed by the social component. Common related factors for the nursing diagnoses were 'pain', 'change of emotional state/disorder', 'cognitive disorder', 'change of physical structure and function', and 'physical impairment', and 'immobility'. Conclusion: The results of this study can contribute to the development of appropriate nursing intervention programs for elders (eg. 'Injury Prevention Programs', 'Self-esteem Improvement Programs' etc.). Clinical guidelines that gerontological nurses can use to accurately assess health problems and select appropriate nursing interventions may be developed.

성인 암환자의 질병 특성에 따른 증상발생 정도

허혜경,이은현,이원희,소향숙,정복례,강은실 성인간호학회 2002 성인간호학회지 Vol.14 No.3

Purpose: This study was to investigate symptom occurrence related to the disease characteristics of patients with cancer. Method: A total of 301 patients with cancer participated in this study. The participants were recruited from University Hospitals located in Seoul, Wonju, Kwangju, Daegu, and Pusan. Data collection was performed by using a questionnaire on symptom occurrence. The obtained data was analyzed using SPSS computer program that included descriptive statistics, Pearson correlation, one-way ANOVA, and t-test. Result: The mean score of fatigue was the highest (3.24), followed by loss of appetite, lack of concentration, change in appearance, pain, insomnia, change in bowel pattern, nausea/vomiting, coughing, and dyspnea. Most symptoms were significantly correlated with each other. The level of symptom occurrence in patients with lung cancer or cervix cancer was significantly higher than the level in patients with stomach cancer. Patients receiving radiation therapy or a combined therapy of radiation therapy and chemotherapy experienced significantly higher level of symptom occurrence significantly higher level of symptom occurrence than those receiving chemotherapy only. Also, female patients experienced higher level of symptom occurrence than male patients did. Conclusion: The sites of cancer, types of treatment, and gender influence the level of symptom occurrence of patients with cancer. Thus, these variables should be considered when assessing and planing for symptom occurrence of patients with cancer.

창원대학교 재학생들의 식생활 태도와 영양섭취상태에 관한 연구(II) : On Nutrient intakes 영양섭취상태를 중심으로

허은실,이경혜 창원대학교 생활과학연구소 1997 생활과학연구 Vol.- No.1

The purpose of this survey was to assess nutrient intakes of 648 college students in Changwon National University by anthropometric measurements and estimating dietary intakes. The results obtained were as follows. 1. The averages of height and weight of the students were slightly lower those of Korean standard. 2. Daily energy and protein intake of students were lower than those of Korean RDA. The average energy intake of freshmen was significantly higher than other grades. Students in the boarding home with self cooking among residences and students in college of fine arts among colleges showed the lowest energy intake. 3. Intake of calcium of all students was lower than that of Korean RDA. Intake of iron in male students was higher than that of RDA, however, iron intake of female students was 61.7% of RDA. The lowest intake of calcium and iron showed the boarding home with self cooking. 4. Vitamine C and A intake in vitamins were only enough. Students in boarding home with self cooking also showed the lowest intake of vitamins in residences. Proportion of energy intake from alcohol were 15% in male and 8% in female students. From the above results, it is suggested that nutrition education for college students is needed, and menus of campus cafeterias showed be developed to meet the various needs of students.

창원대학교 신입생의 체중조절에 대한 태도와 식습관 및 영양지식에 관한 연구

허은실,이경혜 창원대학교 생활과학연구소 1998 생활과학연구 Vol.- No.2

The purpose of this survey was to assess attitude toward weight control, food habits and nutrition knowlege by self questionnaire of 1650 freshmans in Changwon National University. The results obtained were summarized as follows: Self-evaluation for weight was found the underestimation in normal weighted male students and the overestimation in underweighted female students. The main reason for meal was to satisfy hungry and to nutrient intake. But the objectives of meal were significantly difference between male and female. compared to male. In sack time, male had more snack after dinner and before sleeping. It showed women had more nutrition knowledge.