플라이애쉬 콘크리트의 特性에 미치는 굵은 骨材 最大値數의 影響에 관한 實驗的 硏究

김덕현,유영주,이상수,송하영,김을용 한밭대학교 2004 한밭대학교 논문집 Vol.21 No.-

In this study, the experiment was carried out to investigate and analyze the influence of coarse aggregate's maximum size and Fly Ash replacements ratio on the properties of concrete. The main experimental variables were water/cement ratio 45 and 65(%), maximum size of coarse aggregate 15, 25 and 40(mm), Fly Ash replacements ratio 0, 10, 20(%). According to the test results, the principal conclusions are summarized as follows. 1) The slump and flow of fresh concrete were found to be higher in the order of maximum size of coarse aggregate 15, 25 and 40(mm), also in the order of Fly Ash replacements ratio 0, 10, 20(%). 2) The compressive strength of hardened concrete were found to be lower in the order of maximum size of coarse aggregate 15, 25 and 40(mm). While, Fly Ash replacements ratio increases in age 7days, showed tendency that compressive strength increases together. but, age 28, 56(day) were showed opposite tendency.

22q11 Deletion Syndrome을 동반한 정신분열병 1예

방수영,김창윤,주연호,서을주,유한욱 大韓神經精神醫學會 2003 신경정신의학 Vol.42 No.4

It has been well known that 22q deletion syndrome (22qDS), encompasses several genetic syndromes associated with microdeletions at chromosome 22q11.2 became relatively generally identified in the 1990s through the availability of specialized chromosomal studies, and it includes such syndromes as velocardiofacial syndrome (VCFS), DiGeorge syndrome (DGS), Shprintzen syndrome, CATCH 22. The syndrome is characterized by distinctive dysmorphology, congenital heart disease, athymia, parathyroid disease, other congenital diseases, learning difficulties and various psychiatric illnesses. This syndrome is a common genetic condition often accompanied by mild cognitive impairment. Learning difficulties and anger outburst are also common in adolescence with this syndrome, In addition, a prevalence of major psychiatric disorders in adults' individuals are high, especially schizophrenia, schizoaffective disorder, bipolar disorder and other psychiatric illnesses, including simple or social phobia, depression, obsessive-compulsive disorder. We report a patient with facial dysmorphology, cleft lip and palate, ventricular septal defect, borderline IQ, poor impulse control and psychotic symptoms who was diagnosed schizophrenia and 22qDS by FISH analysis which finds 22q11.2 microdeletion.

상피성 난소암 217 례의 임상병리학적 특징과 생존율 분석

문을주(Eul Ju Moon),전우진(Woo Jin Jeon),이재규(Jae Kyu Lee),윤병선(Byoung Sun Youn),유상영(Sang Young Ryu),김종훈(Jong Hoon Kim),김병기(Byoung Gie Kim),박상윤(Sang Yoon Park),이의돈(Eui Don Lee),김경희(Kyung Hee Kim) 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.9

목적 : 난소암은 우리 나라에서 점차 증가하고 있는 악성 부인종양으로 진단시 대부분 진행성으로 발견되어 예후가 매우 불량하다고 알려져 있으나 우리 나라에서의 상피성 난소암 환자의 예후 및 예후인자에 관하여 알려진 바가 많지 않다. 이에 본 연구에서는 상피성 난소암 환자의 임상병리학적 특징, 5년 생존율과 생존율에 영향을 미치는 예후인자 등을 평가하고자 하였다. 연구 방법 : 1990년 1월부터 1996년 12월까지 원자력병원 산부인과에서 치료를 받았던 상피성 난소암 환자 266명 중 경계성 종양과 일차 중복 종양을 제외한 217명을 대상으로 임상병리학적 특성 및 생존율을 분석하였으며 생존율에 영향을 미치는 예후인자 평가를 위해 단변량 및 다변량 분석을 시행하였다. 결과 : 평균 연령은 49세(연령 분포 13-85세)였으며 임상 증상으로는 복강내 종괴 촉지가 가장 많았다. FIGO 분류에 따른 병기별 분포는 제 1기가 34.0%, 제 2기가 6.4%, 제 3기가 43.6%, 제 4기가 10.1%로 대부분 진행성으로 발견되었으며, 병리학적 분포는 장액성 낭선암이 39.2%로 가장 많았고 점액성 낭선암, 자궁내막양 선암, Brenner 종양 및 투명세포암 순이었다. 상피성 난소암의 5년 생존율은 42.3%였으며 FIGO 수술적 병기에 따른 생존율은 1기가 78.2%, 2기가 53.5%, 3기가 21.1%, 4기가 8.3%였다. 상피성 난소암 환자에서 단변량 분석을 시행해 본 결과 연령, FIGO 수술적 병기, 수술 후 잔류 종괴 크기가 생존율에 영향을 미쳤으나 다변량 분석상 FIGO 수술적 병기(p=0.0002)와 수술 후 잔류 종괴 크기(p=0.0116)가 유의한 예후인자로 확인되었다.결론 : 본 연구에서 상피성 난소암 환자의 평균 연령은 49세로 기존의 보고보다 진단 연령이 10여년 낮게 나타났으며 대부분 FIGO 병기 3, 4기에 발견되었고 상대적으로 1기의 환자가 많은 분포를 보였다. 상피성 난소암의 5년 생존율은 42.3%이었으며 FIGO 병기와 수술 후 잔류 종괴가 생존율에 영향을 미치는 예후인자로서 유의하였다. Objective : Ovarian cancer usually presents with already advanced disease at the time of diagnosis and is known to have a poor prognosis. But the prognosis and prognostic factors of patients with epithelial ovarian cancer are still inconclusive. This study is performed to evaluate the clinicopathologic characteristics, overall 5-year survival rate and prognostic factors affecting survival in patients with epithelial ovarian cancer. Methods : We retrospectively investigated the outcome of 266 patients with epithelial ovarian cancer, who had been treated at the Korea Cancer Center Hospital from Jan. 1990 to Dec. 1996. Among 266 cases of the epithelial ovarian cancer, 49 cases were excluded due to borderline tumor or double primary cancer. Univariate and multivariate analysis for survival were conducted to test the prognostic significance of several clinicopathologic factors among subjects. Results : The median age of the patients with epithelial ovarian cancer was 49 years (range 13-85) and the most common subjective symptom was abdominal mass sensation (31.3%). The FIGO stage distribution was 34.0% for stage I, 6.4% for stage II, 43.6% for stage III, and 10.1% for stage IV. Serous carcinoma was the most common histologic type (39.2%), followed by mucinous (29.5%), endometrioid (12.9%), Brenner tumor and clear cell carcinoma (1.8%, respectively). The overall 5-year survival rate was 42.3%. The 5-year survival rates of stage I were 78.2%, stage II 53.5%, stage III 21.1% and stage IV 8.3%. In multivariate analysis, stage and residual disease were found to be significant independent prognostic factors (p=0.0002, p=0.0116 respectively), but age (< 50 vs. 50) was not significant (p=0.1099). Conclusion : In this study, the median age of the patients with epithelial ovarian cancer was 49 years, which is 10 years younger than that of other reports. Most patients were with advanced stage but the proportion of patients with stage I was relatively higher. The overall 5-year survival rate of patients with epithelial ovarian cancer was 42.3% and the survival depends on two most important prognostic factors, stage and residual tumor after primary surgery.

염색체 Microarray 검사의 임상적 적용

서을주(Eul-Ju Seo) 대한의학유전학회 2010 대한의학유전학회지 Vol.7 No.2

염색체 microarray 검사는 유전체 전체를 한번에 검색하여 초현미경적인 염색체 이상을 매우 정밀하고 정확하게 검출할 수 있다. 외국에서는 현재 자주 활용되는 임상 진단 검사로 자리잡았고, 염색체 검사 또는 표적 부위를 검출하는 FISH 검사나 PCR 기반의 분자유전학적 방법을 대체하고 있다. 최근 발표된 consensus 들은 염색체 microarray 검사를 비특이적인 다발성 기형, 발달지연 또는 정신지체, 자폐증상질환의 환자에서는 염색체 검사보다 먼저 시행할 수 있는 검사로 제안하였다. 염색체 microarray 검사는 핵형 분석에서 검출된 염색체 불균형을 검증하기 위해 염색체 검사에 보조적으로 활용할 수 있고, 염색체 이상에 대한 보다 정확하고 종합적인 분석이 가능하다. 그러나 염색체 microarray 검사는 균형재배열의 염색체 이상과 low-level 모자이시즘을 검출하기 어렵고, 임상적 중요성이 불명확한 CNV에 대한 해석과 검사비용이 고가라는 한계점이 있다. 이러한 이유로 인해 현재로서는 염색체 microarray 검사가 산전 진단 목적으로는 고식적인 염색체 검사를 대신할 수는 없다는 의견이다. 임상검사실에서 염색체 microarray 검사 시행 시, 유전학적 및 세포유전학적 지식과 경험이 결과 분석과 해석 과정에서 요구되며, 적절한 검증 과정 단계와 유전상담이 동반되어야 한다. Chromosomal microarray analysis (CMA) enables the genome-wide detection of submicroscopic chromosomal imbalances with greater precision and accuracy. In most other countries, CMA is now a commonly used clinical diagnostic test, replacing conventional cytogenetics or targeted detection such as FISH or PCR-based methods. Recently, some consensus statements have proposed utilization of CMA as a first-line test in patients with multiple congenital anomalies not specific to a welldelineated genetic syndrome, developmental delay/intellectual disability, or autism spectrum disorders. CMA can be used as an adjunct to conventional cytogenetics to identify chromosomal abnormalities observed in G-banding analysis in constitutional or acquired cases, leading to a more accurate and comprehensive assessment of chromosomal aberrations. Although CMA has distinct advantages, there are several limitations, including its inability to detect balanced chromosomal rearrangements and low-level mosaicism, its interpretation of copy number variants of uncertain clinical significance, and significantly higher costs. For these reasons, CMA is not currently a replacement for conventional cytogenetics in prenatal diagnosis. In clinical applications of CMA, knowledge and experience based on genetics and cytogenetics are required for data analysis and interpretation, and appropriate follow-up with genetic counseling is recommended.

5-year Survival of 266 Patients with Epithelial Ovarian Cancer

문을주 ( Eul Ju Moon ),( Byoung Sun Youn ),( Sang Young Ryu ),( Jong Hoon Kim ),( Byoung Gie Kim ),( Sang Yoon Park ),( Eui Don Lee ),( Kyung Hee Lee ),( Soo Yong Choi ) 대한산부인과학회 1999 대한산부인과학회 학술대회 Vol.84 No.-

부인암에서 전인병소절제술 (Metastasectomy) 6예의 보고

문을주 ( Mun Eul Ju ),박연진 ( Park Yeon Jin ),정희환 ( Jeong Hui Hwan ),노주원 ( No Ju Won ),심정석 ( Sim Jeong Seog ),박상재 ( Park Sang Jae ),박종림 ( Park Jong Lim ),이종목 ( Lee Jong Mog ),조재일 ( Jo Jae Il ),조대순 ( Jo Dae 대한산부인과학회 2003 Obstetrics & Gynecology Science Vol.46 No.5

To report cases of metastasectomy for metastatic gynecologic malignancies, we reviewed the medical records of all patients who have undergone metastasectomy for metastatic gynecologic malignancies in Center for Uterine Cancer from June 2001 to October 2002. Six patients were identified with median age of 55 years (range 52-66 years). The metastatic sites and primary sites were as follows : 3 liver metastasis from ovary ; 1 abdominal wall metastasis from uterus (endometrial cancer), 1 brain metastasis from ovary, 1 lung metastasis from uterus (sarcoma). The median disease free interval was 48 months (range 10 months-13 years). There was no perioperative mortality. Postoperative morbidity was tolerable with 1 case of bile leakage. In three patients with hepatectomy, one patient was dead of disease after 15 months, one patient is alive with disease at 20 months of follow up, one patient have no evidence of recurrence at 7 months follow up. The patient with brai metastasis was dead due to lung metastsis after 9 months later postoperatively. Remaining two patients with abdominal wall and lung metastasis have no evidence of tumor recurrence at 4, 7 months follow up respectively. Metastasectomy for metastatic gynecologic malignancies can be performed safely and may help prologn survival in carefully selected patients.

座瘡型 Democidiosis 6例

朴旭和,金在柱,金乙聲,禹泰河 대한의학협회 1969 대한의학협회지 Vol.12 No.5

Comparison between high dose and Low dose dexamethasone regimen in combination with aprepitant and granisetron after cisplatin chemotherapy (초)

Ju Young Yoon,Dae Eun Kim,Dae Ho Cho,Jun Eul Hwang,Hyun Jung Sim,Sang Hee Cho,Ik Joo Jung,Woo Kyun Bae 대한내과학회 2009 대한내과학회지 Vol.77 No.4S

Identification of MicroRNAs and Their Putative Targets that Respond to Drought Stress in Solanum tuberosum

( Eul Won Hwang ),( Seon Ju Shin ),( Hawk Bin Kwon ) 한국응용생명화학회 2011 Applied Biological Chemistry (Appl Biol Chem) Vol.54 No.3

MicroRNAs (miRNAs) are small noncoding RNAs that are found in both animals and plants. miRNAs function as negative post-transcriptional regulators during plant development and in response to biotic and abiotic stresses. In present study, high-throughput DNA sequencing and alignments with sequences from microRNA database (miRBase), a microRNA database, were used to identify drought stress-related miRNAs. This method is useful for identifying miRNAs and determining their expression profiles when genomic sequences are not available. Three droughtinduced miRNAs, stu-miR396, stu-miR156a, and stu-miR157a were identified in potato (Solanum tuberosum). Effects of drought stress on their expression profiles were demonstrated, and their target mRNAs were predicted.

Guillain-Barre syndrome in a patient with carcinoma of unknown primary site (CUPS), receiving oxaliplatin-based chemotherapy (초)

( Ju Young Yoon ),( Woo Kyun Bae ),( Jun Eul Hwang ),( Hyun Jeong Shim ),( Sang Hee Cho ),( Ik Joo Chung ),( Tai Seung Nam ) 대한내과학회 2010 대한내과학회 추계학술대회 Vol.2010 No.-