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이연숙,오승혜,이의준 연세대학교 대학원 1986 延世論叢 Vol.22 No.1
The purpose of this study was to identify developmental phase of the color concept of Korean children according to age, sex. The present experiment was conducted during June, 1985. Subjects were 616children ranged form 3-year old to 15-year old, who were attending to Child Development Research Institute of Y University, E indergarten,E Demonstration Elementary School College of E Womans University, A Middle School. The materials used in the experiment were 24 colored papers selected through a pilot study. The experiment was designed to identify the children's color concepts by presenting the 24 colored papers.
Insert type 총형공구 여유각 영향에 따른 베어링 Rubber Seal 금형의 가공성 평가
Li, Li-Hai,김연술,김도형,양균의,문상돈 한국공작기계학회 2004 한국공작기계학회 춘계학술대회논문집 Vol.2004 No.-
Formed insert type tool satisfy both the surface roughness and geometric accuracy, so that cutting edge of formed tool can duplicate final feature. For experiment, the formed tools with various clearance angles are machined. And the tools are evaluated with respect cutting force, flank wear and surface roughness to optimistic condition.
Extract of Balloon-flower Inhibited In Vitro Angiogenesis in Human Umbilical Vein Endothelial Cells
Eui-Yeun Yi(이의연),Yung-Jin Kim(김영진) 한국생명과학회 2017 생명과학회지 Vol.27 No.9
혈관신생과정은 종양 형성과 이동에 필수적인 과정으로 촉진제와 저해제에 의하여 조절되며, 이러한 혈관신생과정의 저해는 새로운 항암치료 기법으로 이용하고 있다. 최근, 한약재와 식료품으로부터 추출한 천연물을 새로운 치료 물질로 널리 이용하고 있으며, 실제 in vitro 뿐만 아니라 in vivo 상에서도 항암 효과가 나타나는 것을 확인하였다. 그 중 도라지는 아시아에서 한약재와 식료품으로 오랫동안 사용 되어왔다. 본 연구에서는 도라지 추출물이 in vitro 상에서 인간 제대 정맥 내피 세포의 혈관신생을 억제하는 효과에 대해 조사하였다. 도라지 추출물은 세포독성 없이, 혈관 형성 및 이동, 침윤 현상을 모두 억제하는 효과를 보였다. 특히, 세포 이동은 80% 정도 감소 시켰으며 침윤 현상이 거의 나타나지 않는 것을 확인하였다. 이러한 결과를 토대로 도라지 추출물은 혈관신생 억제제로 이용할 수 있으며, 더 나아가 항암제로 개발될 수 있을 것이라 사료된다. Angiogenesis is an essential step in tumoral growth and metastasis and is regulated by a balance between stimulators and inhibitors. Recently, antiangiogenic target therapy has shown promise as a new type of chemotherapy. Natural products have attracted widespread attention worldwide as a useful source of novel therapeutic compounds. The balloon-flower has long been used as a traditional medicinal material and food in Asia. In this study, we investigated whether extract of balloon-flower would inhibit in vitro angiogenesis and vascular-like network formation in human umbilical vein endothelial cells (HUVECs). The extract of Balloon-flower did not affect the viability of HUVECs. However, treatment with the Balloon-flower extract suppressed tube formation of HUVECs. In addition, after treatment with the Balloon-flower extract, cell migration decreased about 80%, and cell invasion was almost completely inhibited. Taken together, these results suggest that extract of Balloon-flower may have potential as an angiogenic inhibitor and that it could be developed as an anticancer agent.
nhibition of Vascular Network Formation on Human Microvessel Endothelial Cell by Betaine
Eui-Yeun Yi,Yung-Jin Kim 대한암예방학회 2008 Journal of cancer prevention Vol.13 No.4
Angiogenesis, the sprouting and remodeling of capillaries, plays a central role in a variety of physiologic and pathologic processes. Anti-angiogenesis therapy has recently been found to be one of the most promising new anti-cancer therapeutic strategies. Natural products comprise a major source of small molecular weight angiogenesis inhibitors. Angiogenesis and inflammation often share common pathways, and these two biological processes are also closely coupled with cancer. Both angiogenesis and inflammation are exacerbated by increased production of cytokines, growth factors and proteolytic enzymes. Betaine has been shown to have anti-inflammatory effects. In this study, we investigated the possibility that betaine inhibit angiogenesis. Therefore, we examined the effect of betaine on the vascular network formation of HMEC-1. Although betaine does not show any effect on the viability of HMEC-1, the treatment of betaine inhibited the tube formation of human microvessel endothelial cells (HMEC-1). This result suggests that betaine act for an angiogenic inhibitor.
YI, EUI-YEUN,KIM, YUNG-JIN Spandidos Publications 2013 International journal of oncology Vol.43 No.1
<P>Angiogenesis is an important process involved in tumor growth and metastasis. Many studies have investigated the use of natural compounds such as angiogenic inhibitors. Xylitol is a 5-carbon sugar alcohol and is an artificial sweetener that has been used in chewing gums to prevent tooth decay. Xylitol has been also known to inhibit inflammatory cytokine expression induced by lipopolysaccharide (LPS). Since angiogenesis and inflammation share a common signaling pathway, we investigated the role of xylitol in angiogenesis. Xylitol inhibited the migration, invasion and tube formation of human umbilical vein endothelial cells (HUVECs). Xylitol also inhibited in vivo angiogenesis in a mouse Matrigel plug assay. Furthermore, mRNA expression of vascular endothelial growth factor (VEGF), VEGFR-II (KDR), basic fibroblast growth factor (bFGF), bFGFR-II, matrix metalloproteinase-2 (MMP-2) and MMP-9 of HUVECs decreased following treatment with xylitol. These anti-angiogenic effects of xylitol are exerted through inhibition of NF-κB and Akt activation. Taken together, these results suggest that xylitol acts as a beneficial angiogenesis inhibitor.</P>
A Novel Anti-cancer Agent, SJ-8029, Inhibits Angiogenesis and Induces Apoptosis
Yi Eui-Yeun,Jeong Eun-Joo,Song Hyun-Seok,Kang Dong-Wook,Joo Jeong-Ho,Kwon Ho-Seok,Lee Sun-Hwan,Park Si-Kyung,Chung Sun-Gan,Cho Eui-Hwan,Kim Yung-Jin The Korean Society for Biomedical Laboratory Scien 2006 Journal of biomedical laboratory sciences Vol.12 No.3
A new piperazine derivative, 8J-8029, is a synthetic anti-cancer agent which exhibits both microtubule and topoisomerase II inhibiting activities. In this study, we investigated the ability of 8J-8029 for anti-angiogenesis and apoptosis. 8J-8029 decreased the bFGF-induced angiogenesis in the CAM and the mouse Matrigel implants, in vivo. 8J-8029 inhibited the proliferation, migration, invasion, tube fonnation, and expression of MMP-2 in BAECs. In addition, 8J-8029 reduced the cell viability in HepG2 cells, caused the production of fragmented DNA and the morphological changes corresponding to apoptosis. 8J-8029 also elicited the release of cytochrome c and the activation of caspase-3. Taken together, these results suggest 8J-8029 may be a candidate for anti-cancer agent with the ability to inhibit the angiogenesis of endothelial cells and to induce the apoptosis of tumor cells.
Yi, Eui-Yeun,Kim, Yung-Jin Lychnia 2012 International journal of oncology Vol.41 No.5
<P>Angiogenesis is defined as the formation of new blood vessels form existing vessels surrounding a tumor. The process of angiogenesis is an important step for tumor growth and metastasis, as is inflammation. Thus, angiogenesis inhibitors that suppress inflammation have been studied as an anticancer treatment. Recently, many research groups have investigated the anti-angiogenic activity of natural compounds since some have been demonstrated to have anticancer properties. Among many natural compounds, we focused on betaine, which is known to suppress inflammation. Betaine, trimethylglycine (TMG), was first discovered in the juice of sugar beets and was later shown to be present in wheat, shellfish and spinach. In Southeast Asia, betaine is used in traditional oriental medicine for the treatment of hepatic disorders. Here, we report the anti-angiogenic action of betaine. Betaine inhibited in?vitro angiogenic cascade, tube formation, migration and invasion of human umbilical vein endothelial cells (HUVECs). Betaine also inhibited in?vivo angiogenesis in the mouse Matrigel plug assay. The mRNA expression levels of basic fibroblast growth factor (bFGF), matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) in HUVECs were decreased by betaine treatment. In addition, betaine suppressed NF-κB and Akt activation.</P>
Geometrical Compensation of Injection-Molded Thin-Walled Parts in Reverse Engineering
Yeun Sul Kim,Hi Koan Lee,Jing Chung Huang,Young Sik Kong,Gyun Eui Yang 한국정밀공학회 2005 International Journal of Precision Engineering and Vol.6 No.2
A geometric compensation of thin-walled molded parts in reverse engineering is presented. Researches in reverse engineering have focused on the fitting of points to curves and surfaces. However, the reconstructed model is not the geometric model because the molded parts have some dimensional errors in measurements and deformation during molding. Geometric information can give an improved accuracy in reverse engineering. Thus, measurement data must be compensated with geometric information to reconstruct the mathematical model. The functional and geometric concepts of the part can be derived from geometric information. LSM (Least square method) is adopted to determine the geometric information. Also, an example of geometric compensation is given to improve the accuracy of geometric model and to inspect the reconstructed model.