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Effect of Ionizing Radiation on Rat Tissue: Proteomic and Biochemical Analysis
Park*, Eui‐,Chul,Yoon, Jong‐,Bok,Seong*, Jin‐,Sil,Choi, Kyoung‐,Soo,Kong, Eung‐,Sik,Kim, Yun‐,Jeong,Park, Young‐,Mee,Park, Eun‐,Mi Taylor Francis 2006 Preparative biochemistry & biotechnology Vol.36 No.1
<P>Reactive oxygen species (ROS), generated by ionizing radiation, has been implicated in its effect on living tissues. We confirmed the changes in the oxidative stress markers upon irradiation. We characterized the changes in the proteome profile in rat liver after administering irradiation, and the affected proteins were identified by MALDI-TOF-MS and ESI-MS/MS. The identified proteins represent diverse sets of proteins participating in the cellular metabolism. Our results demonstrated that proteomics analysis is a useful method for characterization of a global proteome change caused by ionizing radiation to unravel the molecular mechanisms involved in the cellular responses to ionizing radiation.</P>
청각장애인의 유산소성 운동프로그램 참여가 체성분 구성에 미치는 영향
이의수 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.6
The purpose of this study is to find the effect of aerobic exercise program on body composition of students with hearing-impaired students and its research was carried out for 12 weeks and analyzed the body composition of before and after the program. The results are as follows: 1. After 12 weeks of aerobic exercise pr1Jam percent body at was before the program 20.164.79% and after, 16.733.89%, thus showing statistically significant decrease in body at (p<.05). 2. After 12 weeps of aerobic exercise program mass body at was before the program 13.204.04kg, and after, 10.613.09kg, thus showing statistically significant decrease of 2.59 kg, mass body fat. 3. After 12. weeks of aerobic exercise program total body water was before the program 29.050.781 and after. 29.92.1.611, showing statistically insignificant increase of 0.871. 4. After 12 weeks of aerobic exercise program non-fat body weight was before the program 52.432.23kg and after, 52.762.114kg, showing statistically insignificant slight increase. 5. After 12 weeks of aerobic exercise program body weight was before the program 65.533.135kg and after. 63.373.135, thus showing statistically significant decrease of 2.26kg(p<.05). 6. After 1a weeks of aerobic exercise program BMI was before the program. 22.641.45 kg/m² and after, 21.851.33kg/m², thus indicating statistical significance. Asthe above results show, an aerobic exercise program significanty benefits hearing-impaired students in reduction of body fat and by increasing non-fat essentials such as a potassium, calcium. magnesium, etc, which are crucial for the muscle. We, therefore, fimly conclude that the aerobic exercise is an efficient exercise program for the students
공기중의 Radon 방사능 측정에 의한 서울 대기의 혼합높이 결정
김의훈,김필수,김채옥,이건상,권기덕 漢陽大學校 環境科學硏究所 1985 環境科學論文集 Vol.6 No.-
서울 대기의 혼합높이를 1984년1월부터 4월 사이에 지표고도에서 측정한 ??으로부터 결정하였다. ?? 농도로부터 상당혼합높이를 계산하기 위하여 한 수식 모델을 개발하였다. 이로부터 계산한 상당혼합높이는 늦은 오후에 최고 및 밤 또는 이른 아침에 최저값을 가지며 수 십 미터에서 1킬로미터 또는 그 이상의 높이를 보이는 일변화를 나타냈다. 평균혼합높이는 겨울이 낮았다. 이와 같은 변화는 대기의 안정도, 일조시간, 기온 등 대기의 인자와 밀접한 관계가 있었다. The mixing heigt of the atmosphere in Seoul was determined from the measurement of ?? concentration in air at ground level for January 1984 to April 1984. In order to calculate the equivalent mixing height from ?? concentration, a mathematical model was developed. The equivalent mixing heights calculated from this model showed diurnal variation with the highest values in the late afternoon and the lowest during night hours or early morning ranging from several tens to one thousand meters or more. The average heights represented lower values in the winter. These variations were closely related to the atmospheric factors, such as atmospheric stability, daytime hour, and temperature, etc.
슬관절에 히야루론산 주입후 발생한 활막성 연골종증 : 증례 보고
최의성,김용민,김동수,손현철,박경진,조병기,배승환 충북대학교 의과대학 충북대학교 의학연구소 2009 忠北醫大學術誌 Vol.18 No.2
활막성 연골종증은 비교적 드문 양성 종양으로 관절내 활액막 결체조직의 양성 반응성 이형성에 의해 여러 개의 연골성 결절을 형성하고 이것이 관절내로 유리되어 유리체를 형성하는 질환으로 주로 슬관절에 발생한다. 활막성 연골종증의 정확한 발생 기전은 아직 밝혀지지 않았으나 외상, 감염 등이 원인으로 제시되고 있다. 저자들은 슬관절 내 히야루론산 주입후 발생한 슬관절내 활막성 연골종증을 1 례 경험하였으며, 관절경적 제거술을 통해 만족스런 결과를 얻었다. As a relatively rare benign tumor, synovial chondromatosis forms several cartilaginous nodules by the benign reactive metaplasia of synovial connective tissues within joints, which are loosed into the joints and cause a disease forming loose body mainly in knee joint. Accurate mechanism of synovial chondromatosis has not been clarified yet; however, trauma, infections and others have been suggested as its possible causes. The authors of this study experienced an example of a patient with synovial chondromatosis in knee joint occurred after the injection of hyaluronic acid in the joints and had a satisfactory outcome through the arthroscopic resection.
서의수,박매자,김덕훈,주강 慶北大學校 醫科大學 1990 慶北醫大誌 Vol.31 No.3
주령(週齡)의 증가에 따른 생쥐 Leydig세포의 광학현미경형태와 초미세구조에 관한 변화는 다음과 같다. 1. 생후 1주군에서 미분화된 Leydig세포는 정세관 주위에서 관찰할 수 있었고, 핵은 방추형이며, 핵질과 핵막에는 이염색질이 많이 분포하고, 세포질에는 소포체와 사립체가 조금 분포하나 그 이외의 세포소기관은 거의 없었다. 2. 3주군에서의 Leydig세포는 아직 완전히 분화되지는 않았으나 정세관 주위에서 관찰되었다. 핵은 난형이며, 핵막의 일부 함입과 이염색질의 부착이 있고 세포질에는 잘 발달된 무과립성 내형질망과 membrane whorl이 있으나 그 이외 세포소기관의 발달은 미약하였다. 3. 5주군에서는 완전히 분화한 Leydig세포들의 군집이 정세관 주위에서 관찰되었다. 핵은 거의 원형이며, 핵에는 진염색질이 분포하며, 세포질에는 사립체의 발달이 현저하고, 그 이외의 세포소기관은 약간 증가하였다. 4. 7주군에서는 잘 발달된 정세관의 구조와 잘 분화된 Leydig세포들의 군집을 tubule의 각 공간에서 관찰할 수 있었다. 세포는 핵이 원형으로, 핵막은 뚜렷하고 세포질에는 무과립성 내형질망, 지방소적, 용해소체, 사립체, 당원입자 등이 아주 잘 발달되어 있었다. This study was performed to investigate the ultrastructure of the Leydig cell on aging of the mouse. The results obtained were as follows. One week after birth: The undifferentiated Leydig cells are found around seminiferous tubules. The nucleus showed the fusiform shape. The heterochromatin was found to be adherent to the nuclear membrane and to be dispersed in the nucleoplasm. The smooth endoplasmic reticulum and mitochondria were poorly developed, and the other cell organelles did not appear at this stage. The cytoplasmic vacuolations began to appear. After 3 weeks: Not fully differentiated Leydig cells are present around tubules. The nucleus had oval shape, and some nuclear membrane was caved and adhered to the heterochromatin. The smooth endoplasmic reticulum and membrane was caved and adhered to the heterochromatin. The smooth endoplasmic reticulum and membrane whorl were well developed. But the other cell organelles were poorly developed. After 5 weeks: Clusters of fully differentiated Leydig cells are found around the tubules. The nucleus had round shape, and the nucleoplasm included an euchromatin. Numerous mitochondria were ovserbed at this stage. After 7 weeks: Clusters of fully differentiated Leydig cells are located in the interspace of each tubules. The shape of nucleus was round, and nuclear membrane was prominent. The smooth endoplasmic reticulum, lipid droplets, lysosomal dense body, mitochondria, ribosome and glycogen were increased markedly in number.
14세 여환에서 쇄골에 발생한 동맥류성 골 낭종 : 증례보고
김동수,김용민,최의성,손현철,박경진,조병기,홍경호 충북대학교 의과대학 충북대학교 의학연구소 2010 忠北醫大學術誌 Vol.20 No.1
동맥류성 골낭종(aneurysmal bone cyst)은 Jaffe와 Lichtenstein(1942)에 의해 처음 기술된 이래 많은 증례가 보고되었다. 동맥류성 골낭종은 주로 장관 골의 골간단과 척추에서 발생한다. 병인은 정확히 밝혀지지 않았으나, 반응성 현상으로 생각되며, 원발성 또는 다른 병변과 동반될 수 있다. 쇄골 등 기타 골에서 발생하는 경우는 매우 드물다. 저자들은 우측 쇄골에서 동맥류성 골낭종 1예를 경험하여 보고하는 바이다. 14세 여자환자가 우측 견갑부의 우연히 발견된 종괴를 주소로 내원하였다. 환자는 종괴에 대해 이학적 검사 및 혈액 검사상 측이한 소견을 보이지 않았다. 방사선 검사상, 쇄골 내측부에 골 용해성으로 팽윤된 병변이 관찰되었고, 동맥류성 골낭종, 단순 골낭종, 전이성 골종양 등의 의증 하에 절제술을 시행하였다. 절제된 종괴의 육안 소견상, 얇은피질 골로 쌓여 있으며, 노란색 액체로 차있는 4x5cm 종괴가 관찰되었고, 완전 절제술을 시행하였다. 광학현미경상, 혈액으로 차있는 다양한 크기의 낭성 구조가 보였고, 여러 개의 거대세포가 격막을 이루고 있었다. 조직학적 소견과 MRI소견, 임상 소견을 종합하였을 때, 쇄골에서 원발성으로 발생한 동맥류성 골낭종을 진단할 수 있었다. Many cases of aneurysmal bone cyst(ABC) have been reported since Jaffe and Lichtenstein(1942) first reported. Aneurysmal bone cyst mostly occurs in metaphysis of the long bones and vertebral column. The reason for this disease has not be clearly explained yet, but it is estimated as reactive change and can be accompanied with primary lesion or another lesion. It rarely occurs in clavicle or other bones. We report one case of ABC in right clavicle. 14-year-old female patient who accidentally found palpable mass on right shoulder visited hospital. We did not find any specifics regarding this patient's mass after physical exam and blood test. Radiologic exam showed a large expansile mass with osteolytic lesion, The differential diagnosis includes ABC, simple bone cyst, metastatic bone tumor, etc. Based on visual observation on excised 4×5 cm mass, it was covered by thin cortical bone and filled with yellow fluid, and complete excision was done. On histological examination, the mass consist of various size of cystic structures. and several giant cells comprised septae. Based on histological examination, MRI, clinical examination, we made a diagnosis that it was primary anuerysmal bone cyst in clavicle
박의수 안암교육학회 2010 한국교육학연구 Vol.16 No.3
기초주의는 한국 교육철학의 정립을 위하여 한기언이 제창하고 발전시킨 “전통과 개혁의 조화를 통한 인간형성의 논리”이다. 이 논문은 기초주의의 개념과 구조를 명료화 하고, 기초주의의 전체 구조 속에서 ‘인격’이 차지하는 위상과 교육적 의미를 밝히고, 아울러 기초주의의 틀과 관점에서 인격교육의 과제와 방향을 모색하는데 목적이 있다. 이를 위하여 먼저 기초주의의 개념과 구조를 명료화하고 다음으로 기초주의 구조 속에서의 인격의 위상을 고찰한 후에 기초주의의 관점에서 한국교육의 본질적 문제를 진단하고 기초로서의 인격교육의 방향을 탐구하여 다음 몇 가지 결론을 얻었다. 첫째, 복잡한 기초주의 이념체계를 하나의 표로 정리함으로써 일목요연하게 기초주의의 개념과 구조를 이해할 수 있게 되었다. 둘째, 인격은 사람됨의 기초인 동시에 교육의 기초이며 최종 목표이다. 셋째, 오늘날 한국교육의 본질적 문제는 결국 총체적인 기초의 부실, 즉 기초학력의 부실과 인격적 기초의 부실에서 비롯되는 것이며, 따라서 그 해법은 지적․인격적 측면에서 기초 교육을 공고히 하는데서 찾아야 한다는 것이다. Foundationism(Kichojuii) is widely known as "a human shaping logic through a harmony of tradition and reformation" that Hahn, Ki-Un initiated and developed in order to establish Korean Educational Philosophy. The purpose of this study is to clarify the concept and structure of Foundationism and to disclose the position and educational meaning of character in the context of Foundationism and to research the tasks and directions of character education from the viewpoint of Foundationism. For these purposes, clarifying the meaning and structure of Foundationism was proceeded first and investigating the position and meaning of character was carried out and examining the essential problems of Korea education from the viewpoint of Foundationism and searching the direction of character education as a foundation was finally proceeded. The conclusions of this study are as followings: First, a table that can clearly understand the whole complex system of Foundationism was completed. Second, character is the base of human being, as well as education, and also the eternal goal of education. Third, the essential problems of contemporary Korea education were derived from the weakness of basic scholastic ability and sincerity. So the sure method of solving the problems is to strengthen the foundation of knowledge education, as well as character education.
최의환,하정완,김수관,정태영,김수흥 대한악안면성형재건외과학회 2001 Maxillofacial Plastic Reconstructive Surgery Vol.23 No.3
Modified surgical technique for transposition of the inferior alveolar nerve followed by immediate placement of endosseous implants in mandibles with moderate to severe atrophy are presented. Five transpositions of the inferior alveolar nerve together with the installation of 10 implants were performed in four patients. The mean postoperative follow-up time was 17 months, with a range of 8 to 20 months. All implants with functioning pontics remained stable, with no mobility or symptoms of pain and infection during the follow-up period. Neurosensory evaluation was performed using the two-point discrimination test. Two patients had objective neurosensory dysfunction at postoperative, but all the nerve function were reported as normal by the patients 4 months postoperatively.
제2형 당뇨병 환자에서의 지속적 피하 인슐린 주입 치료시 관해
최의광,최수봉,박선민 건국대학교 의과학연구소 2001 건국의과학학술지 Vol.11 No.-
Background: It is well known that chronic hyperglycemia can deteriorate pancreatic beta cell function and insulin sensitivity in animal and human studies, and the normalization of blood glucose can reverse them. Our purpose of the study was to investigate the remission pattern after treating patients with continuous subcutaneous insulin infusion (CSII) therapy, and compare the clinical characteristics of remitted and non-remitted patients in a retrospective way. Methods: We selected 91 type 2 diabetic patients who had been admitted to KonKuk University hospital from January 1993 to August 1993. After hospitalization, all subjects were treated with insulin pump (Sooil, Seoul, Korea) for intensive blood glucose control until remission occurred. Remission is defined as long-term good glycemic control without any medication. After fifteen to seventeen months of CSII therapy, the induction of remission was examined. Serum c-peptide levels, hemoglobin A1c, and serum lipid profiles were measured after hospitalization and before discharge. Results: Overall 34.4% of all subjects had remission after 53.6±38.9 days of CSII therapy and remission lasted for average 13.6 ± 8.9 months during the study periods. Some clinical characteristics of the patients prior to CSII therapy influenced the remission occurrence. The remission was more frequently induced when patients started CSII therapy with insulin pump in younger age, higher body mass index, shorter diabetic duration, lower post-prandial blood glucose levels, higher post-pandial serum c-peptide levels, and less chronic diabetic complications. Conculsion: These findings suggest that long-term CSII therapy can induce remission in a significant proportion of mild type 2 diabetic patients. Thus, it is desirable that the intensive insulin treatment by CSII is considered as not the last treatment., but an initial management of mild type 2 diabetic patients.