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Jang, Eue-Soon Korean Chemical Society 2012 대한화학회지 Vol.56 No.4
We successfully synthesized $Fe_3O_4/SiO_2$ nanoparticles with ultrathin silica layer of $1.0{\pm}0.5$ nm that was fine controlled by changing concentration of $Fe_3O_4$. Among various reaction conditions for silica coating, increasing concentration of $Fe_3O_4$ was more effective approach to decrease silica thickness compared to water-to-surfactant ratio control. Moreover, we found that concentration of the 1-octanol is also important factor to produce the homogeneous $Fe_3O_4/SiO_2$ nanoparticles. The present approach could be available to apply on preparation of other core/shell nanoparticles with ultrathin silica layer.
바이오 물질 분석을 위한 금속 나노입자를 이용한 SERS 분석 연구동향
장의순(Eue-Soon Jang) 한국세라믹학회 2019 세라미스트 Vol.22 No.3
Surface enhanced Raman scattering (SERS) was first discovered in 1974 by an unexpected Raman signal increase from Pyridine adsorbed on rough Ag electrode surfaces by the M. Fleishmann group. 1) M. Moskovits group suggested that this phenomenon could be caused by surface plasmon resonance (SPR), which is a collective oscillation of free electrons at the surface of metal nanostructures by an external light source. 2-14) After about 40 years, the SERS study has attracted great attention as a biomolecule analysis technology, and more than 2500 new papers and 500 review papers related to SERS topic have been published each year in recently. 15) The advantages of biomaterials analysis using SERS are as follows; ① Molecular level analysis is possible based on unique fingerprint information of biomolecule, 16-20) ② There is no photo-bleaching effect of the Raman reporters, allowing long-term monitoring of biomaterials compared to fluorescence microscopy, ③ SERS peak bandwidth is approximately 10 to 100 times narrower than fluorescence emission from organic phosphor or quantum dot, resulting in higher analysis accuracy, 21), 22) ④ Single excitation wavelength allows analysis of various biomaterials, ⑤ By utilizing near-infrared (NIR) SERSactivated nanostructures and NIR excitation lasers, auto-fluorescence noise in the visible wavelength range can be avoided from in vivo experiment and light damage in living cells can be minimized compared to visible lasers, ⑥ The weak Raman signal of the water molecule makes it easy to analyze biomaterials in aqueous solutions. For this reason, SERS is attracting attention as a next-generation non-invasive medical diagnostic device as well as substance analysis. In this review, the principles of SERS and various biomaterial analysis principles using SERS analysis will be introduced through recent research papers.
Jang Eue‐Soon 대한화학회 2021 Bulletin of the Korean Chemical Society Vol.42 No.6
This is the first study that elucidates the effect of alcohol alkyl chain length on the formation of mesoporous silica (mSiO2) layers on cetyltrimethylammonium bromide (CTAB)-stabilized gold nanorods (CGNRs). The growth tendencies of the mSiO2 layers on the CGNRs (CGNR@mSiO2) in various alcohol solvents differed quite substantially from those observed for previously reported spherical silica particles. The formation of the mSiO2 layer was closely related to the interaction between the CTAB bilayer and alcohol.
Jang, Eue-Soon,Park, Kyeong-Soon Korean Chemical Society 2012 Bulletin of the Korean Chemical Society Vol.33 No.8
We successfully synthesized $Fe_3O_4@SiO_2$ nanoparticles with ultrathin silica layer of $1.0{\pm}0.5$ nm that polyethyleneimine (PEI) with low molecular weight of 2.0-4.0 kDa was covalently conjugated with the resulting $Fe_3O_4@SiO_2$ nanoparticles by silane coupling reaction. The PEI-$Fe_3O_4@SiO_2$ nanoparticles were further used as gene delivery vector for a human fibroblast cell (IMR-90) line. Gene transfection efficiency of the PEI-$Fe_3O_4@SiO_2$ complexes did not increase remarkably after magnetofection; however, the addition of Lipofectamine 2000 significantly increased the transfection efficiency of the PEI-$Fe_3O_4@SiO_2$ complexes. We believe that the present approach could be utilized for magnetofection as alternative to $Fe_3O_4$ nanoparticles conjugated with the PEI of high molecular weight thanks to its relatively low cytotoxicity and high transfection efficiency.
Recent Progress in Synthesis of Plate-like ZnO and its Applications: A Review
Jang, Eue-Soon The Korean Ceramic Society 2017 한국세라믹학회지 Vol.54 No.3
Zinc oxide (ZnO) is one of the most versatile semiconductors, and one-dimensional (1D) ZnO nanostructures have attracted significant interest for use in ultraviolet (UV) lasers, photochemical sensors, and photocatalysts, among other applications. It is known that 1D ZnO nanowires can be fabricated readily owing to the anisotropic growth of ZnO along the [0001] direction. However, this type of growth results in a decrease in the surface area of the (0001) plane, which plays a vital role not only in UV lasing but also in the photocatalytic process. Thus, we attempted to synthesize ZnO crystals with an increased polar surface area by controlling the crystal growth process. The purpose of this review is to propose a simple route for the synthesis of plate-like ZnO crystals with highly enhanced polar surfaces and to explore their feasibility for use in UV lasers as well as as a photocatalyst and antibacterial agent. In addition, we highlight the recent progress made in the pilot-scale synthesis of plate-like ZnO crystals for industrial applications.
구의본,이순용,서강석 인제대학교 1985 仁濟醫學 Vol.6 No.3
저자들은 1979년 7월부터 1984년 6월까지 만 5년간 부산백병원에 입원한 만 15세 이하의 소아 악성 종양 99예를 임상 통계적으로 관찰하고 그 결과를 보고하고자 한다. A clinical study was carried out on 99 cases of children with malignant tumors admitted to Pusan Paik Hospital during a period of 5 years, from July 1, 1979 to June 30, 1984, and the following results were obtianed. 1.The incidence of malignant tumors among total inpatients under 15 years of age was 0.62 percent. 2.The most common malignant tumor was leukemia(57.6%), and the next were brain tumor(8.1%), retinoblastoma (8.171), and neuroblastoma (7.1%)) in decreasing order of frequency. 3.The male to female ratio was 1.5:1. But the ratio of patients with malignant tumors to total inpatients was nearly equal in broth sexes. 4.A bout a half of the cases with malignant tumors in children (51.5%) were under 5 years of age. Most of the cases of neuroblastoma, Wilms tumor, and retinoblastoma were under 5 years of age. 5.A mong leukemia acute lymphoblastic leukemia was 59.6%, acute nonlymphblastic leukemia was 36.8% and chronic myelocytic leukemia was 3.5%. 6.Among brain turmors astrocytoma (37.5%) was the most common.
J-curve relationship between corrected QT interval and mortality in acute heart failure patients
Chan Soon Park,Hyun-Jai Cho,Eue-Keun Choi,이상은,김민석,김재중,Jin-Oh Choi,Eun-Seok Jeon,Kyung-Kuk Hwang,Shung Chull Chae,Sang Hong Baek,Seok-Min Kang,Byung-Su Yoo,Dong-Ju Choi,Youngkeun Ahn,Kye-Hoon Kim,Myeon 대한내과학회 2020 The Korean Journal of Internal Medicine Vol.35 No.6
Background/Aims: This study investigated the prognostic power of corrected QT (QTc) interval in patients with acute heart failure (AHF) according to sex. Methods: We analyzed multicenter Korean Acute Heart Failure registry with patients with AHF admitted from 2011 to 2014. Among them, we analyzed 4,990 patients who were followed up to 5 years. Regarding QTc interval based on 12 lead electrocardiogram, patients were classified into quartiles according to sex. Results: During follow-up with median 43.7 months, 2,243 (44.9%) patients died. The relationship between corrected QT interval and all-cause mortality followed a J-curve relationship. In Kaplan-Meier analysis, both sex had lowest mortality in the second QTc quartile. There were significant prognostic differences between the second and the fourth quartiles in male (log-rank p = 0.002), but not in female (log-rank p = 0.338). After adjusting covariates, the third (hazard ratio [HR], 1.185; 95% confidence interval [CI], 1.001 to 1.404; p = 0.049) and the fourth (HR, 1.404; 95% CI, 1.091 to 1.535; p = 0.003) quartiles demonstrated increased risk of mortality compared to the second quartile in male. In female, however, there was no significant difference across quartiles. QTc interval was associated with 5-year all-cause mortality in J-shape with nadir of 440 to 450 ms in male and 470 to 480 ms in female. Conclusions: QTc interval was an independent predictor of overall death in male, but its significance decreased in female. The relationship between QTc interval and all-cause mortality was J-shaped in both sex.
Park, Chan Soon,Choi, Eue-Keun,Han, Kyung-Do,Lee, Hyun Jung,Rhee, Tae-Min,Lee, So-Ryoung,Cha, Myung-Jin,Lim, Woo-Hyun,Kang, Si-Hyuck,Oh, Seil Oxford University Press 2018 International journal of epidemiology Vol.47 No.1
<P>Conclusions: Shorter height in adulthood was strongly related to an increased risk of MI, HF, stroke and all-cause death. A suitable environment and appropriate nutrition early in life could influence adult height and eventually reduce the risk of CV events and mortality.</P>