Determination of the Effect of Diameter of the Sac on Prognosis in 64 Cases Operated for Meningomyelocele

Metehan Eseoğlu,Ahmet Eroğlu,Serkan Kemer,Mehmet Arslan 대한척추신경외과학회 2017 Neurospine Vol.14 No.1

Objective: To examine the effect of meningomyelocele sac size on prognosis by retrospective review of 64 cases operated for meningomyelocele between January 2009 and December 2012. Methods: We evaluated newborn babies operated for meningomyelocele by retrospectively reviewing their files for head circumference, location and with of the defect, accompanying anomalies, treatments administered, drugs that mother used during pregnancy. Based on the defect size, 3 patient groups were created as 0-24 cm2 (group I), 25-39 cm2 (group II), and 40 cm2 and above (group III). Results: Throughout the study, 64 babies were evaluated. Mean head circumference was 37.4 cm (range, 30.7-50 cm). Based on their location, 49 of the defects (76.5%) were lumbar, 7 (10.9%) were thoracolumbar, 4 (6.2%) were thoracic, 3 (3.1%) were sacral, 1 (1.5%) was cervical. Mean size of the meningomyelocele sac was 4.7 cm×5.8 cm (range, 1 cm×1 cm—10 cm×8 cm), 13 of the babies (20.3%) had skin defect requiring flap. According to accompanying anomalies, 47 of the babies (73.4%) had hydrocephalus, 7 (10.9%) had club foot, 1 (1.5%) had diastematomyelia, 1 (1.5%) had tethered cord. Thirty-nine of the babies (60.9%) had paraplegia, 10 (15.6%) had paraparesis, 8 (12.5%) had monoplegia; neurological examination in the remaining 7 babies was normal. Conclusion: In our study, increased diameter of meningomyelocele sac was associated with greater amount of neural tissue within the sac, which worsens the prognosis. Sac localization was not changing prognosis but infection rates, hospitalization duration were increased in babies with bigger diameter of sacs.

Successive Chemical Modification of Poly(acrylonitrile) Fibers with Glycidyl Methacrylate and Poly(p-phenylenediamine)/Ag Particles for an Efficient Antibacterial Activity

Nihan Seven Eroğlu 한국섬유공학회 2022 Fibers and polymers Vol.23 No.3

One of the most industrially-prominent fibers, polyacrylonitrile (PAN), was chemically modified with the twospecific steps to gain new functional groups that enable the surface chemically attractive. First, the chemically-susceptibleepoxy groups were introduced to the PAN through graft copolymerization of glycidyl methacrylate using benzoyl peroxide(Bz2O2) as an initiator. Secondly, the surface of GMA grafted-PAN fibers (PAN-g-GMA) was decorated by the poly(pphenylenediamine)(PFDA) and Ag nanoparticles through the in-situ oxidative polymerization of p-phenylenediamine (p-FDA) using AgNO3. The changes in the PAN fiber's weights were monitored by changing the experimental conditions suchas Bz2O2 and GMA concentrations, polymerization temperature-time, and AgNO3/p-FDA mol ratio. The usage of 5×10-3 Mof Bz2O2 and 0.5 M of GMA at 85 ºC for 1 h ensured over 95 % of GMA graft yields to the PAN-g-GMA fibers. Structural,thermal, and morphological changes that occurred in the PAN fiber were examined in detail using ATR-FTIR, XRD, TGA,Optical Microscope, and SEM techniques, respectively. A grey metallic shine was detected by optic microscopy on thecomposite surface after the PFDA/Ag nanoparticles deposition. Finally, the antibacterial activity performance of the Agparticles anchored-composite fiber was determined against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli)by the zone inhibition test. The Ag particles decorated-composite showed high antibacterial activity, especially against E. coli(16.5 cm inhibition) compared to Ag-unloaded one. A suitable methodology was presented to develop a fiber composite thatwill potentially be used as an antibacterial textile in the various material preparation fields.

THE LOSSES AND THE GAINS OF FUEL CONSUMERS AND FUEL STATIONS DUE TO DELIVERY TEMPERATURE OF FUEL IN THE COLD WEATHER OR IN THE HOT WEATHER

HUSEY?N ERO?LU 동북아시아문화학회 2017 동북아시아문화학회 국제학술대회 발표자료집 Vol.2017 No.7

Lumbar Disc Herniation in a Patient With Congenital Vertebral Body Anomaly: A Case Report

Cem Atabey,Ahmet Eroğlu,Ali Kivanc Topuz,Murat Velioğlu,Mehmet Nusret Demircan 대한척추신경외과학회 2014 Neurospine Vol.11 No.4

Lumbar disc herniation is characterized with low back and leg pain resulting from the degenerated lumbar disc compressing the spinal nerve root. The etiology of degenerative spine is related to age, smoking, microtrauma, obesity, disorders of familial collagen structure, occupational and sports-related physical activity. However, disc herniations induced by congenital lumbar vertebral anomalies are rarely seen. Vertebral fusion defect is one of the causes of congenital anomalies. The pathogenesis of embryological corpus vertebral fusion anomaly is not fully known. In this paper, a 30- year-old patient who had the complaints of low back and right leg pain after falling from a height is presented. She had right L5-S1 disc herniation that had developed on the basis of S1 vertebra corpus fusion anomaly in Lumbar computed tomography. This case has been discussed in the light of literature based on evaluations of Lumbar Computed Tomography (CT) and Magnetic Resonance Imaging (MRI). This case is unique in that it is the first case with development of lumbar disc herniation associated with S1 vertebral corpus fusion anomaly. Congenital malformations with unusual clinical presentation after trauma shouldbe evaluated through advanced radiological imaging techniques.

Cytogenetic Finding of Breast Cancer Cases and in Their First-Degree Relatives

Dilek Aşcı Çelik,Nurten Özçelik,Erol Eroğlu,Pınar Aslan Koşar 한국유방암학회 2013 Journal of breast cancer Vol.16 No.3

Purpose: The aim of this study was to evaluate and compare the rate of sister chromatid exchange (SCE), the occurrence of micronuclei, and the lymphocyte proliferation rate index (PRI) in patients with breast cancer, their first-degree relatives, and healthy volunteers. Methods: We analyzed the frequency of SCE and micronuclei, and the PRI in the peripheral blood lymphocytes of 30 women with breast cancer, 22 of their female family members,and 20 age-matched healthy female volunteers. Results:SCE occurred significantly more often in the lymphocytes of breast cancer patients (10.84±0.4 per metaphase), compared with their first-degree relatives (7.45±0.54) and controls (5.94±0.2) (p<0.001 for both). The mean SCE frequency was not statistically different between first-degree relatives and controls (p=0.071). Similarly, micronuclei occurred at a significantly higher rate in breast cancer patients (9.6±0.72), and in their first-degree rela tives (7±0.64), compared to controls (3.85±0.4) (p<0.001 and p=0.001, respectively). There was also a significant difference between the occurrence of micronuclei in patients compared to their family members (p=0.021). The PRI was significantly lower in patients (1.61±0.1), compared with both their first-degree relatives (1.75±0.1), and controls (1.74±0.1) (p=0.001 and p=0.002,respectively). Conclusion: Increased SCE and the occurrence of micronuclei, as well as a reduced PRI are associated with breast cancer. Furthermore, increased SCE and the frequency of micronuclei in a first-degree relative suggest that they exhibit greater genetic instability than women of the same age.

A Population-Based Study of Factors Associated With Nocturia in Reproductive-Aged Turkish Women

Haşmet Sarici,Onur Telli,Berat Cem Özgür,Ömer Gökhan Doluoğlu,Muzaffer Eroğlu,Selen Bozkurt 대한비뇨의학회 2014 Investigative and Clinical Urology Vol.55 No.6

Purpose: This study aimed to investigate the prevalence of nocturia according to theInternational Continence Society (ICS) definition in Turkish women and to determinethe associated risk factors and the correlation of other voiding symptoms with nocturia. Materials and Methods: A prospective epidemiological study was carried out by useof self-reported questionnaires in 4,250 reproductive-aged women from January 2013to May 2013. The International Consultation on Incontinence Questionnaire-ShortForm and a questionnaire developed by the researchers according to the ICS were administeredto define nocturia and other lower urinary tract symptoms. Other physical,reproductive, and health characteristics were also recorded concurrently. Results: Overall, 1,636 women were included in the final analyses. The women had anaverage age of 34.4±5.26 years. The overall prevalence of nocturia was 34.7% (567 of1,636 women). Women with nocturia were older (p<0.001), had a higher body massindex (p=0.026), and had more children (p<0.001). Nocturia occurred more frequentlyin women with a history of nocturnal enuresis (p<0.001). Three or more pregnancies,3 or more deliveries, and age >40 years were significant risk factors for nocturia. Wealso found that other lower urinary tract symptoms correlated significantly (p<0.001)with nocturia. Conclusions: Although the prevalence of nocturia is higher with increasing age, youngeradults are also affected. Nocturia may cause sleep disorders, mood disturbances, reducedquality of life, and distractibility. Thus, even if one void nightly causes a patientto experience bother, nocturia should be queried about and should be treated if necessaryaccording to the cause of the disease.

Electrospun Nanofibers for Dual and Local Delivery of Neuroprotective Drugs

Mohammad Karim Haidar,Selin Seda Timur,Gülen Melike Demirbolat,Emirhan Nemutlu,R. Neslihan Gürsoy,Kezban Ulubayram,Levent Öner,Hakan Eroğlu 한국섬유공학회 2021 Fibers and polymers Vol.22 No.2

Drug delivery for neuroprotection/neuroregeneration after traumatic peripheral nerve injuries still remains achallenge. For this purpose, we formulated composite nanofiber formulation for the dual local delivery of alpha lipoic acid(ALA) and atorvastatin (ATR) to enhance regeneration process after peripheral nerve injury. The initial stage involvedencapsulation of ATR into nanosprayed chitosan (CH) nanoparticles after which the CH nanoparticles were embedded intopoly(lactic-co-glycolic acid) (PLGA) nanofibers containing freely dispersed ALA within the fiber structure. Morphologyinvestigations revealed that smooth and randomly aligned nanofibers with mean diameter of 340±69 nm were formed. Encapsulation efficiency for ALA and ATR were calculated as 92.76±3.53 % and 89.27±5.053 %, respectively. DifferentialScanning Calorimetry and FT-IR analysis confirmed successful encapsulation of ALA and ATR into the compositenanofibers; however, XRD results indicated surface localization of ALA within the structure. Porosity and pore volume of thenanofibers increased in accordance with increase in density of the electrospunned solution. Similarly, mechanical strength ofthe nanofibers was found to increase significantly following the incorporation of ALA and ATR with respect to the unloadednanofibers (p<0.05). Dual release of ALA and ATR in different fashions was confirmed by in-vitro release test of thenanofibers. For ALA, an immediate release percentage of 83.90 % within the first hour was observed. On the other hand,ATR exhibited a three-stage release profile which begins with a relatively lower initial release (22.07 %) in comparison toALA followed by an increasing release (82.439 %) up to 150 h. According to cell viability results, blank and loadedformulations were found to have no cytotoxic effect on both L-929 and B35 cell lines after incubation for up to 48 h. Basedon this, composite PLGA nanofibers could be classified as suitable candidates for long-term and local delivery ofneuroprotective drugs in peripheral nerve injury.

Fast and effective methylene blue adsorption onto graphene oxide/amberlite nanocomposite: Evaluation and comparison of optimization techniques

Zeynep Ciğeroğlu,Gürkan Küçükyıldız,Aydın Haşimoğlu,Fulya Taktak,Nazlıcan Açıksöz 한국화학공학회 2020 Korean Journal of Chemical Engineering Vol.37 No.11

Since graphene is a miracle material of the 21st century, a considerable number of researchers have studied the oxidation of graphite to synthesize graphene oxide and its applications. In this study, polymeric resin (amberlite XAD7HP) supported graphene oxide (GO) nanocomposite was synthesized successfully. Analytical methods, namely Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and scanning electron microscopy (SEM) were utilized to characterize the new structure. Methylene blue (MB) solution was selected as a model discharged textile wastewater for adsorption application of synthesized nanocomposite. The adsorption data were modelled by response surface methodology (RSM), random forest (RF) and artificial neural networks (ANN) methods. The optimal condition parameters, which maximize the adsorption uptake capability, were determined by the genetic algorithm. Statistical errors and correlation coefficient values of each developed model were calculated independently to compare models’ performance. According to the results, the developed RF model outperformed the other models. On the other hand, the ANN model had the lowest correlation coefficient value among the models.

Scapular spine base fracture with long outside-in superior or posterior screws with reverse shoulder arthroplasty

Osman Nuri Ero?lu,Bu?ra Husemo?lu,Onur Ba?cı,Mustafa Ozkan,Hasan Havıtcıo?lu,Onur Hapa 대한견주관절의학회 2021 대한견주관절의학회지 Vol.24 No.3

Background: The purpose of the present study was to determine how long superior screws alone or in combination with posterior placement of metaglene screws protruding and penetrating into the scapular spine in reverse total shoulder arthroplasty affect the strength of the scapular spine in a fresh cadaveric scapular model. Methods: Seven fresh cadaver scapulas were allocated to the control group (short posterior and superior screws) and seven scapulars to the study group (spine base fixation with a four long screws, three with both long superior and long posterior screws). Results: The failure load was lower in the spine fixation group (long screw, 869 N vs. short screw, 1,123 N); however, this difference did not reach statistical significance (p>0.05). All outside-in long superior or superior plus posterior screws failed due to scapular spine base fracture; failures in the short screw group were due to acromion fracture. An additional posterior outside-in screw failed to significantly decrease the failure load of the acromion spine. Conclusions: The present study highlights the significance of preventing a cortical breach or an outside-in configuration when a superior or posterior screw is inserted into the scapular spine base.

Maxillary protraction using skeletal anchorage and intermaxillary elastics in Skeletal Class III patients

Elcin Esenlik,Cahide A?larcı,Gayem Ero?lu Albayrak,Yavuz Fındık 대한치과교정학회 2015 대한치과교정학회지 Vol.45 No.2

The aim of this case report is to describe the treatment of a patient with skeletal Class III malocclusion with maxillary retrognathia using skeletal anchorage devices and intermaxillary elastics. Miniplates were inserted between the mandibular lateral incisor and canine teeth on both sides in a male patient aged 14 years 5 months. Self-drilling mini-implants (1.6 mm diameter, 10 mm length) were installed between the maxillary second premolar and molar teeth, and Class III elastics were used between the miniplates and miniscrews. On treatment completion, an increase in the projection of the maxilla relative to the cranial base (2.7 mm) and significant improvement of the facial profile were observed. Slight maxillary counterclockwise (1°) and mandibular clockwise (3.3°) rotations were also observed. Maxillary protraction with skeletal anchorage and intermaxillary elastics was effective in correcting a case of Skeletal Class III malocclusion without dentoalveolar side effects.