Erythropoietin and Erythropoietin Receptor Levels and Their Diagnostic Values in Drug-naïve Patients with Generalized Anxiety Disorder

Ergul Belge Kurutas(Ergul Belge Kurutas ) 대한정신약물학회 2023 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.21 No.2

Objective: Generalized anxiety disorder (GAD) is a prevalent psychiatric disorder. Diagnosis of GAD depends on subjective complaints of patients, thus the need for biological markers is constantly emerging. In this study, we aimed to the investigate diagnostic values of Erythropoietin (Epo) and its receptor (EpoR) levels in drug-naïve patients with GAD. Methods: This study included 45 newly diagnosed drug-naive patients with GAD, aged and sex-matched 30 healthy controls. Medical histories were obtained, and physical examinations and laboratory tests were conducted. Also, the Hamilton Anxiety Rating Scale (HAM-A) was used for all participants. Serum Epo and EpoR levels were measured by ELISA. Results: HAM-A score was significantly higher in GAD patients versus the controls (p < 0.05). While the levels of Epo in patients with GAD were lower than the control patients, EpoR levels were increased in these patients (p < 0.05). Epo/EpoR ratios were significantly lower in the patients with GAD than in the control subjects (p < 0.05). A positive significant correlation was observed between the EpoR level and the HAM-A score (r = 0.755, p < 0.001). However, there was a negative significant correlation between Epo levels and HAM-A score (r = −0.749, p < 0.001). Receiver operator characteristic curve analysis showed high diagnostic performance for Epo and EpoR, areas under curves were 0.901 and 0.912, respectively. Conclusion: This is the first report to investigate the association between serum Epo and EpoR levels in GAD patients. Our results reveal possible diagnostic value of Epo and EpoR. Moreover, Epo therapy may be a good choice for GAD treatment.

Decompositions of soft continuity and soft AB-continuity

Zehra Guzel Ergul,Naime Tozlu 원광대학교 기초자연과학연구소 2017 ANNALS OF FUZZY MATHEMATICS AND INFORMATICS Vol.14 No.5

In this paper, we introduce soft semi-regular sets, soft AB-sets and soft $% \alpha $AB-sets in soft topological spaces which are defined over an initial universe with a fixed set of parameters. We discuss their relationships with other weaker forms of soft open sets like soft semi-open sets, soft A-sets and soft B-sets. We also introduce the concepts of soft AB-continuous function and soft $\alpha $AB-continuous function. The new decompositions of soft continuity are provided.

Diagnostic Performance of Erythropoietin and Erythropoietin Receptors Levels in Children with Attention Deficit Hyperactivity Disorder

Meltem Gungor,Ergul Belge Kurutas,Erkan Oner,Velid Unsal,Hatice Altun,Ali Erdinc Yalin,Serap Yalin,Ozlem Bozkus,Nilfer Sahin 대한정신약물학회 2021 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.19 No.3

Objective: Attention deficit hyperactivity disorder (ADHD) is a heterogeneous, highly heritable, a common childhood neurobehavioural disorder resulting from complex gene-gene and gene-environment interactions. The erythropoietin (Epo)/erythropoietin receptors (EpoR) system turned out to have additional important functions in nonhematopoietic tissue. In this study, we aimed to investigate the levels of Epo and and EpoR, and also their diagnostic values in children with ADHD. Methods: A total of 70 children were included in the study, 35 drug-naive patients with ADHD (age: 6−12 years; male/female: 20/15) and 35 healthy controls (age: 6−12 years; male/female: 22/13). Serum Epo and EpoR levels was determined using a commercial sandwich enzyme-linked immunosorbent assay kit. Results: The results indicated that the levels of Epo decreased in patients with ADHD compared to control (p < 0.05). On the other hand, EpoR levels increased in these patients (p < 0.05). Furthermore, the ratio of Epo/EpoR was significantly lower in ADHD patients than controls (p < 0.05). Receiver operator characteristic curve analysis showed high diagnostic performance for Epo and EpoR, areas under curve were 0.980 and 1.000, respectively. Conclusion: This is the first report to investigate the association between serum Epo and EpoR levels in ADHD patients. Our results indicated that Epo may play a role in the etiology of ADHD, and Epo therapy may be beneficial in these disorders if given in addition to the routine treatment of children with ADHD. Furthermore, our results reveal possible diagnostic value of Epo and EpoR.

Myoepithelial carcinoma in nasopharynx: an unusual localization

Umit Tuncel,Gulusan Ergul,Samet Ozlugedik,Adnan Unal 연세대학교의과대학 2004 Yonsei medical journal Vol.45 No.1

Myoepithelial carcinoma is an extremely rare, malignant epithelial tumor which is usually encountered in the parotid region. In this report, a myoepithelial carcinoma arising from a minor salivary gland in the nasopharynx is presented, along with a discussion of the clinical, histopathological and immunocytochemical characteristics of this rare disorder. Larger clinical series and longer follow-up periods are needed in order to establish the best therapy option for these patients.

The Effects of Cold Application to the Perineum on Pain Relief After Vaginal Birth

Derya K. Senol,Ergul Aslan 한국간호과학회 2017 Asian Nursing Research Vol.11 No.4

Purpose: Perineal pain developing during the postpartum period affects women's relationships with their families and infants. The aim of this study was to determine the efficacy of cold gel pad application for relieving perineal pain and possibly increasing mothers' comfort after vaginal delivery. Methods: This experimental randomized controlled study was conducted in the postpartum department of obstetrics and gynecology hospital. A total of 200 mothers were included in the study. Cold gel pads were applied to the perineum of mothers in the experimental group for 20 minutes in the postpartum first 2 hours and 4 hours after the first application. All the data were collected by using an information form, the visual analog scale, and the postpartum comfort questionnaire. Results: In the experimental group, the first visual analog scale score was 6.73 ± 1.68; after cold gel pad application, the pain levels decreased to 2.59 ± 1.20 in both primiparous and multiparous mothers. In addition, the postpartum comfort questionnaire score increased from 2.58 ± 0.14 to 2.69 ± 0.14 in the second assessment after the cold gel pad application and the difference was statistically significant (p < .001). Conclusion: The application of the cold gel pad to the perineum relieved perineal pain and increased postpartum comfort in all the women. The pain felt by the women during the recovery and the daily activities decreased. Postpartum perineal pain adversely affected daily activities such as lying down, sitting, and walking; infant care, breastfeeding, and urination; and comfort levels of the postpartum women.

RINGS WITH VARIATIONS OF FLAT COVERS

Demirci, Yilmaz Mehmet,Turkmen, Ergul The Honam Mathematical Society 2019 호남수학학술지 Vol.41 No.4

We introduce flat e-covers of modules and define e-perfect rings as a generalization of perfect rings. We prove that a ring is right perfect if and only if it is semilocal and right e-perfect which generalizes a result due to N. Ding and J. Chen. Moreover, in the light of the fact that a ring R is right perfect if and only if flat covers of any R-module are projective covers, we study on the rings over which flat covers of modules are (generalized) locally projective covers, and obtain some characterizations of (semi) perfect, A-perfect and B-perfect rings.

Rings with variations of flat covers

Yilmaz Mehmet Demirci,Ergul Turkmen 호남수학회 2019 호남수학학술지 Vol.41 No.4

We introduce flat e-covers of modules and define e-perfect rings as a generalization of perfect rings. We prove that a ring is right perfect if and only if it is semilocal and right e-perfect which generalizes a result due to N. Ding and J. Chen. Moreover, in the light of the fact that a ring $R$ is right perfect if and only if flat covers of any $R$-module are projective covers, we study on the rings over which flat covers of modules are (generalized) locally projective covers, and obtain some characterizations of (semi) perfect, $A$-perfect and $B$-perfect rings.

Percutaneous ilioinguinal-iliohypogastric nerve block or step-by-step local infiltration anesthesia for inguinal hernia repair

Hakan Kulacoglu,Zafer Ergul,Ali Firat Esmer,Tulin Sen,Taylan Akkaya,Alaittin Elhan 대한외과학회 2011 Annals of Surgical Treatment and Research(ASRT) Vol.81 No.6

Purpose: The repair of groin hernias with local anesthesia has gained popularity. Two main methods have been described for local anesthesia. This study was aimed at comparing percutaneous truncular ilioinguinal-iliohypogastric block and step-by-step infiltration technique by using cadaver dissections. Methods: The study was performed on an adult male cadaver by using blue dye injection. A percutaneous nerve block simulation was done on right side and the dye was given in between the internal oblique and transversus muscles. On the left side, a skin incision was deepened and the dye was injected under the external oblique aponeurosis. Following the injections, stained areas were investigated superficially and within the deeper tissues with dissection. Results: There was a complete superficial staining covering the iliohypogastric and ilioinguinal nerves in the inguinal floor at both sides. On the right side, intraabdominal observation showed a wide and intense peritoneal staining, while almost no staining was seen on the left side. Preperitoneal dissection displayed a massive staining including testicular vascular pedicule and vas deferens on the right side. The dye solution also infiltrated the area of the femoral nerve prominently. On the contrary, a very limited staining was seen on the left. Conclusion: It may not always be easy to keep the percutaneous block within optimum anatomical limits without causing adverse events. A step-by-step infiltration technique under direct surgical vision seems to be safer than percutaneous inguinal block for patients undergoing inguinal hernia repair.

Synthesis of Multifunctional Organic Nanoparticles Combining Photodynamic Therapy and Chemotherapeutic Drug Release

Fazli Sozmen,Merve Kucukoflaz,Mustafa Ergul,Zeynep Deniz Sahin Inan,Yasemin Bozkurt,Dilsad Taydas 한국고분자학회 2022 Macromolecular Research Vol.30 No.1

Cancer is a group of diseases that are caused by uncontrolled proliferation of cells in various parts of the body and it is one of the most studied diseases worldwide. Photodynamic therapy (PDT) is a treatment that uses photosensitizers called photosensitizing agents in addition to light to kill cancer cells. Photosensitizers work only after they have been activated by certain types of light. PDT contains three basic components, these are a photosensitizer, visible light and molecular oxygen (3O2). The efficiency of the therapeutic action is directly related to the property of the photosensitizer. In this study, chitosan and BODIPY based nanoparticles that were capable of carrying out drug delivery and producing singlet oxygen (1O2) were synthesized for the first time. For this purpose, organic nanoparticles showed PDT feature were synthesized via the formation of ionic complexes formed with opposite charged ionic interactions between the synthesized BODIPY derivative (PDT agent) and chitosan hydrochloride at appropriate pH (pH=6). Later, during the formation of this ionic complex, a chemotherapeutic model drug (Doxorubicin) was added to the medium and chemotherapeutic drug-loaded chitosan and BODIPY-based nanoparticles were synthesized. Finally, while drug-free (Y1-Chitosan nanoparticles) and drug-loaded organic nanoparticles (Y1-Chitosan-Dox nanoparticles) showed very good PDT properties, they were found to be effective on MCF7 cancer cells and less toxic to L929 cells.

Quality of Life in Older Adults with Cochlear Implantation: Can It Be Equal to That of Healthy Older Adults?

Tokat Taskin,Müderris Togay,Bozkurt Ergul Basaran,Ergun Uğurtan,Aysel Abdulhalim,Catli Tolgahan 대한청각학회 2021 Journal of Audiology & Otology Vol.25 No.3

Background and Objectives: This study aimed to evaluate the audiologic results after cochlear implantation (CI) in older patients and the degree of improvement in their quality of life (QoL).Subjects and Methods: Patients over 65 years old who underwent CI at implant center in Bozyaka Training and Research Hospital were included in this study (n=54; 34 males and 20 females). The control group was patient over 65 years old with normal hearing (n=54; 34 males and 20 females). We administered three questionnaires [World Health Organization Quality of Life-BREF (WHOQOL-BREF), World Health Organization Quality of Life-OLD (WHOQOL-OLD)], and Geriatric Depression Scale (GDS) to evaluate the QoL, CIrelated effects on activities of daily life, and social activities in all the subjects. Moreover, correlations between speech recognition and the QoL scores were evaluated. The duration of implant use and comorbidities were also examined as potential factors affecting QoL.Results: The patients had remarkable improvements (the mean score of postoperative speech perception 75.7%) in speech perception after CI. The scores for the WHOQOL-OLD and WHOQOL-BREF questionnaire responses were similar in both the study and control groups, except those for a two subdomains (social relations and social participation). The patients with longer-term CI had higher scores than those with short-term CI use. In general, the changes in GDS scores were not significant (<i>p</i><0.05).Conclusions: The treatment of hearing loss with CI conferred significant improvement in patient’s QoL (p<0.01). The evaluation of QoL can provide multidimensional insights into a geriatric patient’s progress and, therefore, should be considered by audiologists.