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The role of C-reactive protein ratio in predicting mortality in patients with Fournier gangrene
Eray Ismail Cem,Dalci Kubilay,Gumus Serdar,Yalav Orcun,Saritas Ahmet Gokhan,Boz Asli,Rencuzogullari Ahmet 대한대장항문학회 2023 Annals of Coloproctolgy Vol.39 No.3
Purpose: This study aimed to determine the C-reactive protein (CRP) ratio for the survival of patients with Fournier gangrene (FG). Methods: Fifty-two patients with FG between January 2011 and September 2018 were retrospectively analyzed. Data on clinical presentation, Fournier Gangrene Severity Index (FGSI), CRP ratio, management, and outcome were analyzed. The CRP ratio was calculated as preoperative CRP/postoperative CRP value that measured 48 hours after surgical intervention. Possible alternative cutoff points for the FGSI and CRP were determined by receiver operating characteristic (ROC) analyses. The risk factors related to the prognosis were evaluated by univariate and multivariable logistic regression analyses. Results: The mean CRP ratios were 6.7±6.6 in the survivor group and 1.2±0.8 in the nonsurvivor group (P=0.001). FGSI was significantly higher in the non-survivor group compared to survivor group (8.5±2.5 vs. 3.5±2.2, P=0.001). There was a negative correlation between FGSI and CRP ratio (r=–0.51). ROC analysis determined the cutoff value as 1.78 for CRP (sensitivity, 86%; specificity, 82%; area under the ROC curve, 0.90) to predict death. The incidence of death for patients with CRP ratio of ≤1.78 increased 26.7 fold for those with CRP ratio of >1.78 (95% confidence interval [CI], 4.8–146.5; P=0.001). In the multivariable logistic regression model, CRP ratio (odds ratio [OR], 10.3; 95% CI, 1.5–72.2; P=0.019) and FGSI (OR, 17.8; 95% CI, 2.6–121.1; P=0.003) were independent risk factors for death. Conclusion: The CRP ratio is a simple method to use to predict mortality in FG.
Ertem-Eray, Tugce,Ki, Eyun-Jung The Korean Association for Public Diplomacy 2022 Journal of public diplomacy Vol.2 No.1
With globalization and new communication technologies, governments aim to cultivate relationships with their foreign publics. This goal represents the convergence of the public relations and public diplomacy domains. In this regard, this study aims to explore how foreign-born faculty members' attitudes and behaviors toward the U.S. are shaped by their relationships with their universities. Findings confirm a significant link between foreign-born faculty members' perceived relationships with their universities and their attitudes and behavioral intentions toward the U.S. The authors conclude that a positive relationship between universities and foreign faculty members can serve as a soft power resource in U.S. public diplomacy. This study contributes to governments' public diplomacy efforts by analyzing the roles of the foreign-born faculty members as strategic communication channels in cultivating relationships between a host country and their homelands.
Copcu H. Eray,Oztan Sule 한국조직공학과 재생의학회 2021 조직공학과 재생의학 Vol.18 No.1
The most important and greatest source in the body for regenerative cells is fat tissue. Obtaining regenerative cells from adipose tissue can be done in two ways: Enzymatic and mechanical. The regenerative cell cocktail obtained by the enzymatic method, including stem cells, is called Stromal vascular fracture (SVF). In the literature, there is no clear definition of regenerative cells obtained by mechanical method. We systematically searched the techniques and definitions for stromal cells obtained from adipose tissue by scanning different databases. To evaluate the mechanical stromal-cell isolation techniques and end products from adipose tissue. Systematic review of English and non-English articles using Embase, PubMed, Web of Science and Google scholar databases. Search terms included Nanofat, fragmented fat, mechanical stromal / stem cell, mechanical SVF, SVF gel. We screened all peer-reviewed articles related with mechanical stromal-cell isolation. Author performed a literature query with the aforementioned key words and databases. A total of 276 publications containing the keywords we searched were reached. In these publications, there are 46 different definitions used to obtain mechanical stromal cells. The term SVF is only suitable for enzymatic methods. A different definition is required for mechanical. The most used term nanofat is also not suitable because the product is not in both "fat" and in "nanoscale". We think that the term total stromal-cells would be the most appropriate definition since both extracellular matrix and all stromal cells are protected in mechanical methods.