흰쥐 Kupffer 세포에 대한 Propofol의 작용

박세훈,지대림,성언기,김희선,송인환,박희영,김준수,이덕희,박대팔 대한마취과학회 2002 Korean Journal of Anesthesiology Vol.43 No.4

Background: Propofol has an antioxidant capacity and can be used for ischemia-reperfusion injury of the liver. However, the effects of propofol on the Kupffer cells have not been establisked. Methods: Kupffer cells were isolated and cultured from male Sprague-Dawley rats. The effects of propofol on the Kupffer cells were evaluated by a phagocytosis assay, TNF-α gene expression, and superoxide anion release after administering propofol in different concentrations on the cultured Kuprrer cells. Results: The latex bead phagocytosis by the Kupffer cells was suppressed when the Kupffer cells were exposed to propofol irrespective of concentrations. Higher propofol concentrations decreased the loss of Kupffer cells after latex bead phagocytosis. Propofol induced TNF-α mRNA expression in the Kupffer cells, but the mRNA expression level after 50㎍/ml of propofol decreased. The pattern of TNF-α mRNA expression induced by propofol was different to that induced by LPS: TNF-α mRNA was expressed continuously in the propofol-treated cells until 16 hours after exposure to propofol, whereas the level of TNF-α mRNA expression induced by LPS was evident after 2 hours and was not found thereafter. TNF-α production after propofol treatment was not higher than that of the control. Formazan presipitation did not show any qualitative differences between cells untreated or treated with propofol concentrations of 0.5, 5.0, and 50 ㎍/ml. Conclusions: These results showed that propofol might inhibit Kupffer cells. This suggests that propofol and be used for patients with ischemia-reperfusion injury of the liver. (Korean J Anesthesiol 2002; 43: 475~484)

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

암세포 단백합성기구에 미치는 Nocodazole의 영향

김선희,김주영,성언기,이융창 대한해부학회 1997 Anatomy & Cell Biology Vol.30 No.3

연접 부호화 기법에 의한 무선 ATM의 성능 개선

조성언,박기식,홍희식 順天大學校 1999 論文集 Vol.18 No.1

In this paper, we have analyzed and simulated the BER and CLP of Wireless ATM(WATM) cells adopting the concatenated FEC technique in Rician fading channel. Also, in Rician fading channel, we have contrived the performance improvement by introducing the fading compensation technique of inserting pilot symbols into the concatenated FEC. From the results, in Rician fading channel, it is known that since the superior BER performance in low ?? results in the divergence when the Viterbi decoder is conducted first, the performance difference of about 2 [dB] occurs between the theory analysis and the simulation. Besides, from the only simulation results, it is known that the system performance adopting the concatenated FEC technique by inserting pilot symbols is improved about 1 [dB] better in terms of ?? than the system performance adopting the only concatenated FEC technique.

프리셉터 경험이 간호업무수행과 직무만족에 미치는 영향 연구

류언나,송혜숙,장은희,서효신,추연화,김인선,나명주,지성애,박경숙 중앙대학교 간호과학연구소 2001 중앙간호논문집 Vol.5 No.2

The purpose of this study was to investigate how preceptor experience has an effect upon preceptor nurses. This study was so designed that it could compare the difference between clinical performance and Job satisfaction of preceptor nurses and those of nonpreceptor nurses. Study subjects were sampled out from those nurses who worked with two university hospitals where preceptor programs were implemented. The number of subjects totaled to 134, including 69 preceptor nurses and 70 nonpreceptor nurses. The score of preceptor nurses' clinical performance and job satisfaction revealed a higher value than that of nonpreceptor nurses. A similar result was also shown in the subdomains. However these difference were not statistically significant. Among all of the preceptor nurses, the highest number of preceptor experience was just one time. Except for five times in preceptor experience, the more the number of times of preceptor experience, the higher score in clinical performance. It was manifested that the number of preceptor experience was not related to job satisfaction. The score of preceptor nurses' clinica1 performance and job satisfaction revealed a higher value than that of nonpreceptor nurses. A similar result was also shown in the subdomains. However these difference were not statistically significant. The reward that preceptor nurses wished most was a reduction of the work load assigned to them. Currently preceptor nurses are only receiving a small quantity of financial reward related with their preceptor role. Most of preceptor nurses (96.8%) were not satisfied with their existing reward. Almost half of the preceptor nurses(43.5%) did not want to play a role as preceptor again. The reason why the scores of clinical performance and job satisfaction were low might be attributed to the inadequate preceptor training program and reward system. Appropriate knowledge and clinical skill are expected to enhance the level of preceptor nurses' clinical performance and appropriate internal and external reward to elevate the level of preceptor nurses' Job satisfaction. Therefore, it is needed for us to develop more effective preceptor education program, financial reward, support of colleague nurses and nursing managers, and adjust workload for the purpose of more effective preceptor programs.

계측 장비를 위한 무선 RF모듈의 개발

전희종,서영조,오정언,김병진 崇實大學校 1999 論文集 Vol.29 No.1

The existing equipment with wire communication can expect the stability of data transmission. However, according to increasing a number of Measuring Instruments, wiring work becomes a heavy burden. Restriction to application about portable Measuring Instruments and the lack of flexibility are another drawback of wire communication. This paper presents the scheme of the design and implementation of a RF(Radio Frequency) based module. The RF based module is designed to the multi communication between Measuring Instruments. The RF based module consists of RF circuit and microprocessor. The main properties of RF circuit are maximum 5[Kbps] transmission rate, maximum 90m transmission distance and 433[MHz] frequency band. The microprocessor rearrange the data into AHDLC(Advanced High level Data Link Control) format and then instructs RF circuits to transmit/receive the data. The RF module is expacted to have a wide application field such as fire/security alarm, remote control/measurement etc..

민가 유형의 문화적 해석 : 제주도의 부엌 구조와 생활과의 대응을 바탕으로 Based on Fittness of Kitchen Structure with Life Style in the Cheju Island:

이희봉,송병언 中央大學校 建設環境硏究所 1999 環境科學硏究 Vol.10 No.-

The purpose of this study is to interpret a house as material into culture. Main method is a participant observation, a kind qualitative study, with an ethnographic interview. Two significantly different types of folk housing are discovered in two areas, East and West of the Cheju Island. In the East, kitchen itself form a separated building, Jeogji-gori, whereas in the West, kitchen is within a main building, An-gori. The reason of separated kitchen building is inferred by the different family system, life style, and natural environment, such as soil and wind. In order to explain folk house type, a culture area concept is suggested. Behind a surfacial physical 'type' of architecture, the 'cultural type' is suggested as a new typology.

직류철도급전계통에서의 고장판단 및 고장점표정

梁彦泌,姜相熙 明知大學校 産業技術硏究所 2003 産業技術硏究所論文集 Vol.22 No.-

Abstract - The load starting current increases step by step so the time constant of each step is so smaller than that of fault current. The first aim of the present paper is to detect a fault with a time constant using least squared method. If a fault occurs on the DC railway system it is important to find a fault location to repair the faulted system as soon as possible. The second aim of the present paper is to locate the position of the fault using Kirchhoff's voltage law.

원예치료가 정신 및 지체 장애인의 재활에 미치는 영향

손기철,고언희,엄수진,이상훈,송종은 建國大學校附設農業資源開發硏究所 2002 農資源開發論集 Vol.24 No.-

This study was to investigate the effect of horticulture therapy on the healing and rehabilitation of the mentally retarded (MR) and physical disorder (PD) persons. Horticultural therapy program was carried at S rehabilitation center located in Kyounggi-DO from Jun 29, 1999 to Oct 12, 1999. The participants in this program were 36 clients of MR and PD. They attended 14 times once a week for 1 hour at a time for horticultural therapy. Evaluation of horticultural activities and ADL (Activities of daily living) has been assessed two times, that is, before and after horticultural therapy program (HTP) whereas horticultural therapy group activity treatment procedure and horticulture task skill inventory have been assessed 3 times, that is, before HTP and after each 7 weeks. MR in the evaluation of horticultural activities showed statistically significant in participation, interest and assistance, verbal interaction during activity, self-concept and identity, need-drive adaptation, interpersonal and social relations, cognition and problem solving, exercise perceptivity, life-tasks skill and vocational adjustment. In activities group of MR also showed significant improvement in terms of physical perceptual abilities, cognitive ability, writing ability, social interaction (P<0.001). Additionally, their horticulture task skill were improved significantly in skill and efficiency factor (P<0.008) and their ADL were changed positively but not significant. On the other hand, PD in evaluation of horticultural activities showed significantly positive changes in self-concept and identity, interpersonal and social relations, life-tasks skill and vocational adjustment. However, physical perceptual abilities factor was proven to be effective in horticultural therapy group activities treatment procedure (P<0.002). Only grooming was significantly improved in ADL evaluation of PD (P<0.03). Putting these results together, it was found that horticultural therapy programs would be very useful for rehabilitation and healing method in both MR and PD.

크레아틴 로딩이 지구운동 및 스프린트 파워발휘에 미치는 효과

오이표,김희수,이신언 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.5

A study was conducted on the effect f creatine loading on persistent exercise and outcome in sprint which was performed immediately after such exercise and subjects of this study were 12 cycle load athletes. Persistent exercise for the purpose of experiment was carried out for 2 hours and 30 minutes. Then it was continued until the condition of tiredness and exhaustion was reaching with showing density of lactate in blood of 4mmol/ℓand then immediately thereafter for 10 seconds 5 sets maximum sprint were carried out. The subject athletes carried out C Performance which featured absorption of placebo liquid during the exercise involving creatine loading prior to experiment exercise, CC Performance featuring absorption of creatine liquid during the exercise involving creatine loading and P Performance featuring absorption of placebo liquid during the exercise without creatine loading-thus totally 3 Performances were carried out. Comparing with P Performance C Performance showed significant improvement in all the 5 sets in terms of peak power and average power for maximum sprint. On the other hand in CC Performance it was same as P Performance. Creatine loading and creatine absorption liquid did not have any effect on duration of persisting exercise until reaching to fatigue and exhaustion. From the result of this study it could be observed that creatine loading improved maximum sprint ability within a short period of time after persistent exercise leading to fatigue and exhaustion However such effect declined when creatine liquid was absorbed during the exercise.