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Are Systemic Voriconazole and Caspofungin Ototoxic? An Experimental Study with Rats
Emine Aydın,Filiz Aydoğan,,Eren Taştan,,Ayşe İriz,Gökhan Karaca,İlknur Haberal Can 대한이비인후과학회 2012 Clinical and Experimental Otorhinolaryngology Vol.5 No.3
Objectives. To determine whether systemic administration of voriconazole and caspofungin causes ototoxicity. Methods. This study was conducted on 32 healthy male Wistar albino rats. The baseline auditory brainstem response (ABR)thresholds of all animals were obtained under general anesthesia. Then, the rats were randomly divided into 4 groups (groups I-IV), each group consisting of 8 rats. Rats in group I were injected intraperitoneally with voriconazole 10 mg/kg/day for 7 days, and the rats in the group II were injected intraperitoneally with caspofungin 5 mg/kg/day for 7 days. Group III received 120 mg/kg/day gentamicin for 7 days. Group IV received saline for 7 days. The animals were then observed for 7 days, and on 14th day of the trial, posttreatment ABRs of both ears were recorded. Results. We did not find any significant differences between pretreatment and posttreatment median ABR thresholds in the voriconazole, caspofungin, or saline groups. In the gentamicin group, there was a statistically significant difference between pretreatment and posttreatment ABR thresholds. Conclusion. Caspofungin and voriconazole did not change ABR thresholds in speech frequencies after a 7-day-period of their administration. We believe that further animal studies must be performed after administration of these agents for a longer time period, and these findings must be consolidated with histopathological investigations. Objectives. To determine whether systemic administration of voriconazole and caspofungin causes ototoxicity. Methods. This study was conducted on 32 healthy male Wistar albino rats. The baseline auditory brainstem response (ABR)thresholds of all animals were obtained under general anesthesia. Then, the rats were randomly divided into 4 groups (groups I-IV), each group consisting of 8 rats. Rats in group I were injected intraperitoneally with voriconazole 10 mg/kg/day for 7 days, and the rats in the group II were injected intraperitoneally with caspofungin 5 mg/kg/day for 7 days. Group III received 120 mg/kg/day gentamicin for 7 days. Group IV received saline for 7 days. The animals were then observed for 7 days, and on 14th day of the trial, posttreatment ABRs of both ears were recorded. Results. We did not find any significant differences between pretreatment and posttreatment median ABR thresholds in the voriconazole, caspofungin, or saline groups. In the gentamicin group, there was a statistically significant difference between pretreatment and posttreatment ABR thresholds. Conclusion. Caspofungin and voriconazole did not change ABR thresholds in speech frequencies after a 7-day-period of their administration. We believe that further animal studies must be performed after administration of these agents for a longer time period, and these findings must be consolidated with histopathological investigations.
Artıstıc studies on desıgn development wıth fabrıc scrapsın the context of sustaınable fashıon
Emine KOCA 복식문화학회 2019 服飾文化硏究 Vol.27 No.6
The process of clothing production creates waste and scrap, which creates environmental, economic, and ethical issues. With this in mind the concept of ethical and sustainable fashion is discussed on many platforms as an important and timely topic. Many solutions have been presented on this subject. For the solution of this problem which has been increasing in the fashion and textile industry, the usage of sustainable materials and production methods is needed. There in a ‘recyclable material cycle’ should be adapted, instead of a ‘traditional material cycle’. New methods and techniques should be developed with multi-disciplinary design approaches to produce creative and high value-added products in the name of fashion and sustainability. This is seen as one of the more effective solutions. This study aims to show that production scraps can be transformed into timely clothing designs with samples. The fabric scraps from different brands were turned into unique clothing designs with up to date trends by designer. In the practices completed while following the design process, collage and patchwork techniques were applied depending on the characteristics of the scrap fabric, artistic figures were hand-stitched onto the design. With this study, the scraps that get thrown into dumping grounds and damage the ecosystem can turn into ethical and economic benefits for the manufacturer. How to choose new high value-added products and create an awareness of social responsibility is also shown with examples in this study.
Detection of Pathotypes and Genetic Diversity of Cercospora beticola
Emine Burcu Turgay,Melike Bak r,P nar Özeren,Yakup Zekai Kat rciog˘ lu,Salih Maden 한국식물병리학회 2010 Plant Pathology Journal Vol.26 No.4
The pathotypes of Cercospora beticola, causal agent of sugar beet leaf spot disease, were identified by application of pathogenicity test using 100 isolates obtained from the provinces with intensive sugar beet cultivation. For the identification of pathotypes, five sugar beet cultivars were used each with different resistance factors. Cultivar reactions were determined by inoculation of cultivars with the isolates under controlled conditions and measuring disease severity on the 15th day according to the 1-9 KWS Scale. Based on the reactions of the five cultivars, a total of 15 pathotypes were detected. All employed sugar beet cultivars were resistant to Pathotype no:1 comprising most of the isolates. Genetic diversity of the causal agent was characterized by AFLP reaction. The products acquired at the end of AFLP reaction were detected by means of Beckman CEQ 8800DNA Capillary Series Analysis and the results obtained were evaluated according to the similarity index UPGMA. For the genetic analysis of C. beticola isolates,9874 polymorphic fragments of sizes between 100 and 500 bp were analysed which were generated by nine primers. The dendrogram derived from AFLP analysis depicted the existence of five different subgroups. The polymorphism rate among isolates was 91.13% and the dendrogram distribution of the pathotypes obtained by pathogenicity indicated that pathotypes were not discriminated and did not compose any groups.
Emine Arman Kandirmaz,Efe N. Gençoğlu,Nilhan Kayaman Apohan 한국고분자학회 2019 Macromolecular Research Vol.27 No.8
Polymeric photoinitiators are widely used in ultraviolet (UV)-curable printing inks because of their low migration behavior. In this study, a new phenylphosphine oxide-polystyrene-thioxanthone (PPO-PSt-TX) polymeric photoinitiator was synthesized. Bis[(4-hydroxy)phenyl]phenyl phosphine oxide (BHPPO) that was synthesized by Grignard technique, was functionalized with 2-bromopropionyl bromide (atom transfer radical polymerization (ATRP) initiator) and then used in styrene polymerization. The bromine end-capped polystyrene was then reacted with 2-thioxanthone-thioacetic acid and final polymeric photoinitiator PPO-PSt-TX was obtained. Proton nuclear magnetic resonance (1H NMR), attenuated total reflectance- Fourier transform infrared spectroscopy (ATR-FTIR), gel permeation chromatography (GPC) and ultraviolet-visible spectroscopy (UV-Vis) confirmed the obtained structure. The curing characteristic of PPO-PSt-TX was compared with a standard flexographic printing varnish formulation containing thioxanthone (TX). The photopolymerization kinetics were determined by photo differential scanning calorimetry (Photo-DSC). The conversion of methylmethacrylate polymerization by using macrophotoinitiator is 78%. The migration behavior of PPO-PSt-TX was identified with liquid chromatography-mass spectrometry (LC-MS). It was shown that PPOPSt- TX macro photoinitiator is suitable for flexographic varnish and the migration level of photoinitiator is reduced by using polymeric photoinitiator.
The Effect of wool in patients with chronic obstructive pulmonary disease
Emine, Kiyak Cellmed Orthocellular Medicine and Pharmaceutical 2017 TANG Vol.7 No.3
The purpose of this study was to analyze the effect wool in patients with chronic obstructive pulmonary disease. The study was conducted experimentally on 53 patients with chronic obstructive pulmonary disease attending the chest diseases polyclinic of a hospital located in Erzurum. A randomized selection method was used to categorize patients into two groups; a treatment (n = 27), and a control group (n = 26). Patients in the treatment group (pre-test measurements were taken) wore wool vests for a period of three months, while patients in the control group wore cotton vests (placebo) for the same duration; post-test measurements were taken for both groups at the end of the three-month period. The Medical Outcomes Study Short Form 36, the St. George's Respiratory Questionnaire, and pulmonary function tests were used to collect data. Results concluded that there was a significant decrease (p < 0.05) in the overall score of the St. George's Respiratory Questionnaire, and the symptom, effect, and activity mean scores, while there was a significant increase (p < 0.05) in the SF-36 physical functioning, general health, bodily pain, role physical, vitality, role emotional, social functioning, mental health, physical and mental component summary mean scores of patients in the treatment group. Results of the study concluded that the symptoms, activity, disease effectiveness, and quality of life improved in patients that wore wool vests.
emine çiloğlu 대한안과학회 2019 Korean Journal of Ophthalmology Vol.33 No.4
Purpose: To investigate the foveal avascular zone (AVZ), superficial and deep foveal and parafoveal vesseldensity (VD) changes related to diabetic retinopathy. Methods: Forty-nine type 2 diabetes mellitus (DM) and 45 healthy control subjects were included in this study. The demographic data (age and sex), disease duration, and level of glycated hemoglobin were collected. SuperficialVD (%), superficial AVZ area (mm2), deep VD (%) and deep AVZ area (mm2) were evaluated via opticcoherence tomography angiography. Results: Superficial AVZ was 0.438 ± 0.05 mm2 in the DM group, 0.246 ± 0.022 mm2 in the control group (p< 0.001). Deep AVZ was 0.732 ± 0.06 mm2 in the DM group, and 0.342 ± 0.022 mm2 in the control group (p< 0.001). Superficial foveal VD was 29.45 ± 0.76 mm2 in the DM group, and 34.86 ± 0.75 mm2 in the controlgroup (p < 0.001). Deep foveal VD was 24.85 ± 1.08 mm2 in the DM group, and 33.47 ± 0.56 mm2 in the controlgroup (p < 0.001). Conclusions: In this study, we demonstrated an enlargement in the foveal AVZ along with a reduction in thevascular density of the superficial and deep capillary network in the foveal and parafoveal area using optic coherencetomography angiography in patients with nonproliferative diabetic retinopathy. This technique can beused to monitor the progression of the disease and to evaluate the response to treatment.
A Simple Enzymatic Method for Quantitation of 2’-Fucosyllactose
( Emine Seydametova ),( Jonghyeok Shin ),( Jiwon Yu ),( Dae-hyuk Kweon ) 한국미생물생명공학회(구 한국산업미생물학회) 2018 Journal of microbiology and biotechnology Vol.28 No.7
2’-Fucosyllactose (2’-FL) is one of the most important human milk oligosaccharides and has several health benefits for infants. The levels of 2’-FL in breast milk or samples from other sources can be quantified by high-performance liquid chromatography. However, this method cannot be used for simultaneous detection of the target compound in numerous samples. Here, we developed a simple method for quantifying 2’-FL in a microplate format. The method involves two steps: (i) release of L-fucose from 2’-FL by α-(1-2,3,4,6)-L-fucosidase and (ii) measurement of NADPH formed during the oxidation of L-fucose by L-fucose dehydrogenase. This method enables measurement of up to 5 g/l 2’-FL in 50 min using a 96- well microplate. The efficiency and simplicity of the proposed method make it suitable for the analyses of a large number of samples simultaneously.
Example of iterative process in upcycled clothing design: Unused neckties and upholstery scraps
Emine Koca,Fatma Koç 복식문화학회 2020 服飾文化硏究 Vol.28 No.6
This study proposed a base framework for creating sustainable designs with textile production waste and unused neckties with the “design thinking” approach, which is an iterative process. It aimed to set an example of how fashion designers can plan and manage their clothing design processes in a more sustainable way by recycling textile production scraps and unused neckties into unique clothing pieces with the upcycling method. Unused neckties and upholstery scraps were turned into skirts, blouses, and dresses by using creative techniques in line with current fashion trends. In addition, the five-stage iterative design process followed was explained, and the way in which the waste textile materials gained value by being converted into unique garments was discussed in terms of the user and the designer. Through the study, it was observed that the smallest amount of textile waste can be transformed into upcycled clothing via the iterative process, and original, value-added products enjoyed by consumers can be created. In addition, it was observed that the design thinking approach improves the understanding of the context of the problem, creativity in the generation of insights and solutions, skills to materialize those solutions through iterative prototyping, and the ability to combine these factors. Promising ideas to help designers develop recycling strategies were also provided.
Artıstıc studies on desıgn development wıth fabrıc scraps ın the context of sustaınable fashıon
Emine KOCA 복식문화학회 2019 服飾文化硏究 Vol.27 No.7
The process of clothing production creates waste and scrap, which creates environmental, economic, and ethical issues. With this in mind the concept of ethical and sustainable fashion is discussed on many platforms as an important and timely topic. Many solutions have been presented on this subject. For the solution of this problem which has been increasing in the fashion and textile industry, the usage of sustainable materials and production methods is needed. There in a ‘recyclable material cycle’ should be adapted, instead of a ‘traditional material cycle’. New methods and techniques should be developed with multi-disciplinary design approaches to produce creative and high value-added products in the name of fashion and sustainability. This is seen as one of the more effective solutions. This study aims to show that production scraps can be transformed into timely clothing designs with samples. The fabric scraps from different brands were turned into unique clothing designs with up to date trends by designer. In the practices completed while following the design process, collage and patchwork techniques were applied depending on the characteristics of the scrap fabric, artistic figures were hand-stitched onto the design. With this study, the scraps that get thrown into dumping grounds and damage the ecosystem can turn into ethical and economic benefits for the manufacturer. How to choose new high value-added products and create an awareness of social responsibility is also shown with examples in this study.
Cooking Quality and Sensorial Properties of Noodle Supplemented with Oat Flour
Emine Aydin,Duygu Gocmen 한국식품과학회 2011 Food Science and Biotechnology Vol.20 No.2
Effects of oat flour addition (10, 20, 30, and 40%) on the quality characteristics of noodle were investigated. Noodles were evaluated in terms of cooking quality, color, chemical, and sensory properties. As oat flour level increased, protein, crude fat, ash, Mn, Fe, Zn,and Mg contents of noodles increased. Oat flour caused increases in cooking loss of noodles. Sensory and cooking characteristics of noodles were negatively effected when oat flour level was increased compared with the control. Noodle with 10% oat flour received the highest sensory scores in all noodle samples containing oat flour. Overall acceptability scores of control and in only the noodle with 10% oat flour were found statistically (p<0.05) similar. Especially, the usage of 10% oat flour in noodle formulation gave satisfactory results in terms of acceptability.