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Ekanayake Waruni,Dinh Phuong Thanh N.,이준헌,이승환 한국동물유전육종학회 2024 한국동물유전육종학회지 Vol.8 No.1
The present study deploys a comparison of Gradient Boosting Machine (GBM), Extreme Gradient Boosting (XGBoost), and Genome Wide Association Studies (GWAS) in selecting optimum subsets of single nucleotide polymorphisms (SNPs) to be used in genomic prediction in cattle. The data simulation was carried out for 6,000 animals and 47,841 SNPs which include 43,633 polygenic markers and 4208 quantitative trait loci (QTL) using QMSim software. The genomic prediction was conducted with the best linear unbiased prediction (BLUP) method using the BLUPF90 program. The accuracy of prediction was computed in three different types, namely, Empirical all SNPs, Empirical QTL, and theoretical accuracy, Accuracy PEV . Among the three models, the highest Empirical all SNPs accuracy 0.79 was derived for GBM followed by 0.77 for XGBoost and 0.76 for GWAS. The Empirical QTL accuracy was almost equal for all three models. The maximum theoretical accuracy was obtained for GWAS which was 0.93, whereas GBM and XGBoost obtained 0.86 and 0.85 accuracy levels respectively. Our results indicate that all three models comparably performed in genomic predictions; however, subsets selected by both GBM and GWAS reported higher prediction accuracies compared to the whole SNP set. The number of QTL selected as a proportion of the total number of SNPs was superior in GWAS. These observations can be validated using real data which could enable further optimization of the analysis process.
Ekanayake, Chandima,Gubanski, Stanislaw M.,Fernando, M.A.R.M. The Korean Institute of Electrical Engineers 2004 KIEE International Transactions on Electrophysics Vol.4C No.3
Frequency Domain Spectroscopy (FDS) measurements were performed on pressboard samples containing different moisture contents and on insulation system of power transformers. The results were used for evaluating sensitivity of the so-called X - Y model, which is applied for estimating moisture content in transformer insulation using the results of FDS measurements. Based on the observations of this analysis a simplified model, called X model, was introduced in which the presence of spacers in transformer insulation has been neglected. Finally, reliability of the X model was assessed by comparing estimates of moisture contents based on FDS measurements on field installed power transformers with moisture contents obtained from chemical analyses of their oil samples.
Cloning, characterization and tissue expression of disk abalone (Haliotis discus discus) catalase
Ekanayake, P.M.,De Zoysa, M.,Kang, H.S.,Wan, Q.,Jee, Y.,Lee, Y.H.,Kim, S.J.,Lee, J. Academic Press 2008 FISH AND SHELLFISH IMMUNOLOGY Vol.24 No.3
Catalase is an antioxidant enzyme that plays a significant role in protection against oxidative stress by detoxification of hydrogen peroxide (H<SUB>2</SUB>O<SUB>2</SUB>). A gene coding for a putative catalase was isolated from the disk abalone (Haliotis discus discus) cDNA library and denoted as Ab-catalase. The full-length (2864bp) Ab-catalase cDNA contained 1,503bp open reading frame (ORF), encoding 501 amino acid residues with 56kDa predicted molecular weight. The deduced amino acid sequence of Ab-catalase has characteristic features of catalase family such as catalytic site motif (<SUP>61</SUP>FNRERIPERVVHAKGAG<SUP>77</SUP>), heme-ligand signature motif (<SUP>351</SUP>RLYSYSDT<SUP>358</SUP>), NADPH and heme binding residues. Phylogenetic and pairwise identity results indicated that Ab-catalase is more similar to scallop (Chlamys farreri) catalase with 80% amino acid identity except for other reported disk abalone catalase sequences. Constitutive Ab-catalase expression was detected in gill, mantle, gonad, hemocytes, abductor muscle and digestive tract in tissue specific manner. Ab-catalase mRNA was up-regulated in gill and digestive tract tissues for the first 3h post injection of H<SUB>2</SUB>O<SUB>2</SUB>, showing the inducible ability of abalone catalase against oxidative stress generated by H<SUB>2</SUB>O<SUB>2</SUB>. The purified recombinant catalase showed 30,000U/mg enzymatic activity against H<SUB>2</SUB>O<SUB>2</SUB> and biochemical properties of higher thermal stability and broad spectrum of pH. Our results suggest that abalone catalase may play an important role in regulating oxidative stress by scavenging H<SUB>2</SUB>O<SUB>2</SUB>.
Gihan Ekanayake,Mahesh Suresh Patil,서재형,이무연 대한기계학회 2019 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.33 No.3
This study aimed to numerically investigate the parametric effects of fin geometry on the heat transfer characteristics of 72 V electronic control unit (ECU) heatsink for an electric three-wheeler. The temperature distribution, fin efficiency, and thermal resistance of the 72 V ECU heatsink were compared by varying the fin geometry parameters, including fin thickness, number, height, and depth. The maximum cooling performance was observed for the proposed fin arrangement with a fin thickness of 2.1 mm, fin number of 60, fin height of 16 mm, and fin depth of 8 mm, in comparison with the existing heatsink model. The proposed 72 V ECU heatsink model was validated with the experimental results of the existing heatsink model and indicated a good agreement within ±4.97 %. The optimized ECU heatsink enhanced the heat transfer performance, thereby decreasing the temperatures of the heatsink, capacitor, and metal-oxidesemiconductor field-effect transistor for the proposed 72 V ECU heatsink model by 16.88 %, 12.71 % and 18.95 %, respectively, in comparison with the existing heatsink model.
Immunohistochemical localization of nerve injury-induced protein-1 in mouse tissues
Poornima Ekanayake,Meejung Ahn,김정태,Taekyun Shin 대한해부학회 2019 Anatomy & Cell Biology Vol.52 No.4
Nerve injury-induced protein (Ninjurin)-1 is a cell adhesion molecule that is upregulated in neurons and Schwann cells after transection injury in rats. In this study, we investigated the localization of Ninjurin-1 in various tissues, including the cerebrum, sciatic nerve, spleen, lung, stomach, ileum, colon, liver, pancreas, kidney, testis, and skin in C57BL/6 mice, using Western blotting and immunohistochemistry. Western blot analysis showed that Ninjurin-1 was differentially expressed among organs. Ninjurin-1 was abundant in skin and ileum, weakly expressed in cerebrum, and moderately expressed in the other organs studied. Immunohistochemical analysis largely confirmed the results of the western blot analysis with often localization of Ninjurin-1 in the regions with abundant connective tissues. In addition, Ninjurin-1 was differentially expressed in various cell types in the tissues under the investigation. These findings suggest that Ninjurin-1 may play organ-specific roles in development and homeostasis of many organs.
Design of nanocapacitors and associated materials challenges
S. Ramesh Ekanayake,Michael J. Ford,Michael B. Cortie 한국물리학회 2004 Current Applied Physics Vol.4 No.2-4
The International Technology Roadmap for Semiconductors (ITRS) projects that the spatial resolution of feature sizes inintegrated circuits is rapidly approaching nanoscopic dimensions. Consequently, there is an active interest in the design of nanoscalecircuit elements such as transistors, resistors, andcapacitors. The properties of materials used to fabricate capacitors pose animportant design factor, as with all circuit elements. We analyze the critical materials properties that would inuence engineeringnanocapacitors (nanoscopic capacitors), and show that at nanoscale, dielectric properties (dielectric constant, dielectric strength,and dielectric relaxation) determine the practicality of such capacitors.