Analysis of Indonesian Tuna Fish Export to Twelve Main Destination Countries: A Panel Gravity Model

Wayan Edy Darma PUTRA(Wayan Edy Darma PUTRA ),NASRUDIN(NASRUDIN ) 한국유통과학회 2023 Asian Journal of Business Environment (AJBE) Vol.13 No.1

Purpose: This study purposes to analyze the determinants of the volume of Indonesian tuna exports. Research design, data and methodology: The framework was developed from the gravity model for trade, which was expanded with additional variables of competitiveness, exchange rate, and industrial share of the destination country. The data sources used in this study are UN Comtrade and the World Bank. The data used is yearly data from 12 countries in 2001-2019. The scope of the study is limited to exports to the twelve main export destinations. Panel data regression analysis is used to determine the factors that affect the volume of Indonesian tuna exports. Results: The results show that according to the theory, Indonesia's GDP has a positive effect and economic distance has a negative effect on the volume of the exports. Meanwhile, the GDPs of the destination countries are not proven to have a positive effect. However, the higher the industrial share in the country, the higher the export volume tends to be. Conclusions: The conclusion obtained from this study is that Indonesia's GDP, economic distance, real exchange rate, industrial GDP share of the destination country, and the RCA index affect the volume of Indonesian tuna exports.

THE ADVANTAGE OF LOW GROWTH TEMPERATURE AND V/III RATIO FOR In_xGa_(1-x)As NANOWIRES GROWTH

EDY WIBOWO,ZULKAFLI OTHAMAN,SAMSUDI SAKRANI,IMAM SUMPONO 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2011 NANO Vol.6 No.2

Cylindrical In_xGa_(1-x)As nanowires (NWs) perpendicular to the substrate have been successfully grown using MOCVD. Morphology of In_xGa_(1-x)As NWs has been observed using Field Emission-Scanning Electron Microscopy (FE-SEM) and Transmission Electron Microscopy (TEM). Both FE-SEM and TEM results show that the NWs grown at low growth temperature and V/III ratio were via direct impinging mechanism. Energy Dispersive X-ray spectroscopy (EDX) results confirm that the cylindrical NWs grown via direct impinging mechanism and tends to have uniform chemical composition.

The Effect of Cervical End Preparation Designs on Collarless Metal Ceramic Crown to the Level of IL-1β Gingival Crevice Fluid

Edy Machmud 대한임상예방치과학회 2011 International Journal of Clinical Preventive Denti Vol.7 No.1

Objective: Cervical end preparation is an important procedure in fixed partial denture, because if it is inadequate it will increase dental plaque accumulation which is the beginning of periodontal disease. The aim of this study was to analyze the effect of cervical end preparation design on collarless metal ceramic crown to the level of IL-1β in gingival crevice fluid (GCF). Methods: The study was carried out using by quasi experimental with pre and post test with contol grup design involving 48 subjects. The tooth preparation and the cervical end preparation were made with shoulder, beveled shoulder, and deep chamfer cervical end preparation. The assessment of IL-1β in GCF was measured before and 1, 7, 21 days after insertion of collarless metal ceramic crown. Results: This study showed that the increase of level IL-1β in GCF on bevel shoulder and deep chamfer was significant different compared with control group (p<0.05). Conclusion: Shoulder is a better preparation design for collarless metal ceramic crown.

The improvement of doxorubicin activity on breast cancer cell lines by tangeretin through cell cycle modulation

Edy Meiyanto,Aditya Fitriasari,Adam Hermawan,Sendy Junedi,Ratna Asmah Susidarti 경희대학교 융합한의과학연구소 2011 Oriental Pharmacy and Experimental Medicine Vol.11 No.3

Tangeretin, shows cytotoxic effect on COLO 205colon cancer cells. Combination of tangeretin with tamoxifen showed synergistic effect and increased the cancer cell sensitivity towards tamoxifen on T47D cells. However, the combination of tangeretin with chemotherapeutic agent doxorubicin on breast cancer cells have not been explored yet. Therefore, the aim of this research is to examine the improvement of cytotoxic effect of doxorubicin by tangeretin through cell death induction and cell cycle modulation on MCF-7 and T47D cells. The cytotoxic effect of tangeretin, doxorubicin, and their combination on tested cells were carried out by using MTT assay. Cell cycle distribution was determined by flowcytometer FACSCalibur and the flowcytometry data was analyzed using ModFit LT 3.0 program. Cell death assay were done by double staining method using ethydium bromide-acridin orange. Single treatment of tangeretin 5–100 μM did not show cytotoxic effect on MCF-7 and T47D cells. The combination of tangeretin 50 and 100 μM with doxorubicin 200 nM (MCF-7) and 7.5 nM (T47D) increased the cytotoxic effect of doxorubicin on both breast cancer cell lines. This improvement of cytotoxic effect is due to cell death induction and cell cycle modulation. Furthermore,single treatment of tangeretin showed cell death only on T47D cell and caused G1-phase arrest on MCF-7 cell and G2/M-phase arrest on T47D cell. While doxorubicin induced cell accumulation at G2/M phase in both cancer cell lines. However, combination of tangeretin and doxorubicin increased cell death on both cancer cell lines,compared with doxorubicin by itself. The combination also showed G1-phase arrest on MCF-7 cell and increased cell accumulation at G2/M phase on T47D cell. Based on this result, tangeretin is potential to be developed as cochemotherapeutic agent for breast cancer by inducing apoptosis and cell cycle arrest. However, the molecular mechanism need to be explored further.

The Effect of Cervical End Preparation Designs on Collarless Metal Ceramic Crown to the Level of IL-1β Gingival Crevice Fluid

Edy Machmud 대한예방치과학회 2011 International Journal of Clinical Preventive Denti Vol.7 No.2

Objective: Cervical end preparation is an important procedure in fixed partial denture, because if it is inadequate it will increase dental plaque accumulation which is the beginning of periodontal disease. The aim of this study was to analyze the effect of cervical end preparation design on collarless metal ceramic crown to the level of IL-1β in gingival crevice fluid (GCF). Methods: The study was carried out using by quasi experimental with pre and post test with contol grup design involving 48subjects. The tooth preparation and the cervical end preparation were made with shoulder, beveled shoulder, and deep chamfer cervical end preparation. The assessment of IL-1β in GCF was measured before and 1, 7, 21 days after insertion of collarless metal ceramic crown. Results: This study showed that the increase of level IL-1β in GCF on bevel shoulder and deep chamfer was significant different compared with control group (p<0.05). Conclusion: Shoulder is a better preparation design for collarless metal ceramic crown.

Table 1 showed that on the 7th day, there was a significant difference of the level of IL-1β in GCF between the treatment

Edy Machmud 대한임상예방치과학회 2011 International Journal of Clinical Preventive Denti Vol.7 No.2

Objective: Cervical end preparation is an important porcedure in ficed partial denture, because if it is inadequate it will increase dental plaque accumulation which is the beginning of periodontal disease. The aim of this study was to analyze the effect of cervical end preparation design on collarless metal ceramic crowm to the level of IL-1β in gingival crevice fluid (GCF). Method: The study was carried out using by quasi experimental with pre and post test with control grup design involving 48 subjects. The toothe preparation and the cervical end preparation were made with shoulder, beveled shoulder, and deep chamfer cervical end preparation. The assessment of IL-1β in GCF was measured before and 1, 7, 21 days after insertion of collarless metal ceramic crown. Results: This study showed that the increase of level IL-1β in GCF on bevel shoulder and deep chamfer was significant different compared with control group (p<0.05). Conclusion: Shoulder is a better preparation design for collarless metal ceramic crowm.

Enzymatic glycerolysis–interesterification of palm stearin–olein blend for synthesis structured lipid containing high mono- and diacylglycerol

Edy Subroto,Supriyanto,Tyas Utami,Chusnul Hidayat 한국식품과학회 2019 Food Science and Biotechnology Vol.28 No.2

The objective of this research was to evaluateenzymatic glycerolysis–interesterification to synthesizestructured lipids (SLs) containing high monoacylglycerol(MAG) and diacylglycerol (DAG) from a palm stearin–olein blend (PS–PO blend). The results showed that theoptimum conditions for the solvent to fat ratio, glycerol tofat ratio, and enzyme concentration were 2:1 (v/w), 1.5:1,and 15% (w/w), respectively. The conversion rate of MAGand DAG decreased at a high glycerol to fat ratio, lowsolvent to fat ratio, and high enzyme concentration due toan increase in viscosity and low agitation effectiveness. The emulsion capacity and stability of the SLs were60.19% and 96.80%, respectively. The hardness of the SLsincreased about 3.1-fold. The MAG, DAG, and triacylglycerolconversion rates were 0.45, 0.48, and 1.02%/h,respectively. Thus, glycerolysis–interesterification of a PS–PO blend increased DAG and MAG concentrations andfurther improved the hardness, emulsion capacity, andemulsion stability of the SLs.

Caesalpinia sappan L. heartwood ethanolic extract exerts genotoxic inhibitory and cytotoxic effects

Edy Meiyanto,Beni Lestari,Raisatun Nisa Sugiyanto,Riris Istighfari Jenie,Rohmad Yudi Utomo,Ediati Sasmito,Retno Murwanti 경희대학교 융합한의과학연구소 2019 Oriental Pharmacy and Experimental Medicine Vol.19 No.1

Brazilin and brazilein, the major compounds of Caesalpinia sappan L. (CS) have been reported to possess antioxidant and cytotoxic activities and could potentially be used as an antigenotoxic as well as an anticancer. This study was conducted to investigate the cytotoxic and antigenotoxic effects of CS ethanolic extract (CEE). In vivo mammalian micronucleus test of CEE at the dose of 500 mg/kg BW and 1000 mg/kg BW decreased the number of MNPCE and increased the ratio of PCE to NCE meaning that CEE performed antigenotoxic effect in an in vivo model. In contrast, CEE and doxorubicin (DOXO) performed cytotoxic effect on CHO-K1 cells under MTT assay with IC50 values of 67 μg/mL and 6 μM, respectively. Interestingly, treatment of CEE in combination with DOXO and H2O2 as genotoxic inducer decreased intracellular ROS levels. In addition, in vitro genotoxicity study by using cytokinesis-block micronucleus (CBMN) assay, both of Giemsa staining and flow cytometric analysis showed that the treatment of CEE increased the number of micronuclei and correlated with apoptotic induction results. Moreover, the combination of CEE and DOXO induced cells accumulation in Sub-G1 and G2/M phase. In conclusion, CEE performed antigenotoxic effect in an in vivo model and cytotoxic effect on CHO-K1 cells.

Gastric Electrical Stimulation for Gastroparesis

( Edy E Soffer ) 대한소화기기능성질환·운동학회(구 대한소화관운동학회) 2012 Journal of Neurogastroenterology and Motility (JNM Vol.18 No.2

Gastric electrical stimulation (GES) for gastroparesis has been in use for more than a decade. Multiple publications, consisting almost entirely of open label single center studies, reported a beneficial effect on symptoms, quality of life and nutritional status. Some predictors of better response to GES have been lately identified, primarily diabetic etiology and nausea and vomiting as the predominant symptoms. However, individual response to GES remains difficult to predict. The mechanism of action of GES remains poorly understood. Stimulation parameters approved in clinical practice do not regulate gastric slow wave activity and have inconsistent effect on gastric emptying. Despite such limitations, gastric electrical stimulation remains a helpful intervention in some patients with severe gastroparesis who fail to respond to medical therapy.

Curcumin and its Analogues (PGV-0 and PGV-1) Enhance Sensitivity of Resistant MCF-7 Cells to Doxorubicin through Inhibition of HER2 and NF-kB Activation

Meiyanto, Edy,Putri, Dyaningtyas Dewi Pamungkas,Susidarti, Ratna Asmah,Murwanti, Retno,Sardjiman, Sardjiman,Fitriasari, Aditya,Husnaa, Ulfatul,Purnomo, Hari,Kawaichi, Masashi Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.1

Chemoresistance of breast cancer to doxorubicin is mediated mainly through activation of NF-kB and over expression of HER2. Curcumin and its analogues (PGV-0 and PGV-1) exert cytotoxic effects on T47D breast cancer cells. Suppression of NF-kB activation is suggested to contribute to this activity. The present study aimed to explore the effects of curcumin, PGV-0, and PGV-1 singly and in combination with doxorubicin on MCF-7/Dox cells featuring over-expression of HER2. In MTT assays, curcumin, PGV-0, and PGV-1 showed cytotoxicity effects against MCF-7/Dox with IC50 values of $80{\mu}M$, $21{\mu}M$, and $82{\mu}M$ respectively. These compounds increased MCF-7/Dox sensitivity to doxorubicin. Cell cycle distribution analysis exhibited that the combination of curcumin and its analogues with Dox increased sub G-1 cell populations. Curcumin and PGV-1 but not PGV-0 decreased localization of p65 into the nucleus induced by Dox, indicating that activation of NF-kB was inhibited. Molecular docking of curcumin, PGV-0, and PGV-1 demonstrated high affinity to HER2 at ATP binding site. This interaction were directly comparable with those of ATP and lapatinib. These findings suggested that curcumin, PGV-0 and PGV-1 enhance the Dox cytotoxicity to MCF-7 cells through inhibition of HER2 activity and NF-kB activation.