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Edson Marchiori,Taisa Davaus Gasparetto,Daniela Peixoto Considera,Dante L. Escuissato,Tomas Franquet 대한영상의학회 2009 Korean Journal of Radiology Vol.10 No.1
Objective: To describe the pulmonary complications following hematopoietic stem cell transplantation (HSCT) that can present with a “crazy-paving” pattern in high-resolution CT scans. Materials and Methods: Retrospective review of medical records from 2,537 patients who underwent HSCT. The “crazy-paving” pattern consists of interlobular and intralobular septal thickening superimposed on an area of ground-glass attenuation on high-resolution CT scans. The CT scans were retrospectively reviewed by two radiologists, who reached final decisions by consensus. Results: We identified 10 cases (2.02%), seven male and three female, with pulmonary complications following HSCT that presented with the “crazy-paving” pattern. Seven (70%) patients had infectious pneumonia (adenovirus, herpes simplex, influenza virus, cytomegalovirus, respiratory syncytial virus, and toxoplasmosis), and three patients presented with non-infectious complications (idiopathic pneumonia syndrome and acute pulmonary edema). The “crazy-paving” pattern was bilateral in all cases, with diffuse distribution in nine patients (90%), predominantly in the middle and inferior lung regions in seven patients (70%), and involving the anterior and posterior regions of the lungs in nine patients (90%). Conclusion: The “crazy-paving” pattern is rare in HSCT recipients with pulmonary complications and is associated with infectious complications more commonly than non-infectious conditions. Objective: To describe the pulmonary complications following hematopoietic stem cell transplantation (HSCT) that can present with a “crazy-paving” pattern in high-resolution CT scans. Materials and Methods: Retrospective review of medical records from 2,537 patients who underwent HSCT. The “crazy-paving” pattern consists of interlobular and intralobular septal thickening superimposed on an area of ground-glass attenuation on high-resolution CT scans. The CT scans were retrospectively reviewed by two radiologists, who reached final decisions by consensus. Results: We identified 10 cases (2.02%), seven male and three female, with pulmonary complications following HSCT that presented with the “crazy-paving” pattern. Seven (70%) patients had infectious pneumonia (adenovirus, herpes simplex, influenza virus, cytomegalovirus, respiratory syncytial virus, and toxoplasmosis), and three patients presented with non-infectious complications (idiopathic pneumonia syndrome and acute pulmonary edema). The “crazy-paving” pattern was bilateral in all cases, with diffuse distribution in nine patients (90%), predominantly in the middle and inferior lung regions in seven patients (70%), and involving the anterior and posterior regions of the lungs in nine patients (90%). Conclusion: The “crazy-paving” pattern is rare in HSCT recipients with pulmonary complications and is associated with infectious complications more commonly than non-infectious conditions.
Design, challenge, and promise of stimuli-responsive nanoantibiotics
Edson Julius A.,Kwon Young Jik 나노기술연구협의회 2016 Nano Convergence Vol.3 No.25
Over the past few years, there have been calls for novel antimicrobials to combat the rise of drug-resistant bacteria. While some promising new discoveries have met this call, it is not nearly enough. The major problem is that although these new promising antimicrobials serve as a short-term solution, they lack the potential to provide a long-term solution. The conventional method of creating new antibiotics relies heavily on the discovery of an antimicrobial compound from another microbe. This paradigm of development is flawed due to the fact that microbes can easily transfer a resistant mechanism if faced with an environmental pressure. Furthermore, there has been some evidence to indicate that the environment of the microbe can provide a hint as to their virulence. Because of this, the use of materials with antimicrobial properties has been garnering interest. Nanoantibiotics, (nAbts), provide a new way to circumvent the current paradigm of antimicrobial discovery and presents a novel mechanism of attack not found in microbes yet; which may lead to a longer-term solution against drug-resistance formation. This allows for environment-specific activation and efficacy of the nAbts but may also open up and create new design methods for various applications. These nAbts provide promise, but there is still ample work to be done in their development. This review looks at possible ways of improving and optimizing nAbts by making them stimuli-responsive, then consider the challenges ahead, and industrial applications.
Edson Cabral da Silva,Takashi Muraoka,Alefe Viana Souza Bastos,Vinícius Ide Franzin,Salatiér Buzetti,Frederico Antonio Loureiro Soares,Marconi Batista Teixeira,José Alberto Bendassolli 한국작물학회 2020 Journal of crop science and biotechnology Vol.23 No.2
Cover plants are intended to cover the soil, protecting it from erosion, nutrient leaching, and providing nutrients through recycling or biological fixation. The objectives of this study were to evaluate the dry biomass productivity and total accumulation of nutrients in the cover crops shoots and in the upland rice grown in succession; and evaluate the effect of the isolated and combined use of cover crops and urea on upland rice crop, grown under no-tillage system. The field experiment was conducted at Selvíria-MS, Brazil, in an Oxisol (Rhodic Haplustox), cerrado (savannah) phase. The experimental design was randomized blocks, in a 5x3 factorial scheme. The treatments were four cover crops species: sunn hemp (Crotalaria juncea L.), pigeon pea (Cajanus cajan L.), green velvet bean (Mucuna prurens), millet (Pennisetum glaucum L.), and spontaneous vegetation (fallow in off-season) combined with 20 kg N ha-1 applied at sowing, 20 kg N ha-1 applied at sowing + 60 kg N ha-1 at plus topdressing, and without mineral N fertilizer application. The millet recycled large amounts of K, Mg, S, and micronutrients, but negatively influenced the rice grain yield grown in succession. There was no response to topdressed mineral N fertilizer when the crop was grown in rotation to legume cover crops. Upland rice under no-tillage showed a positive response to the N fertilization at seeding and when it is grown in rotation with the use of millet or fallow in the off-season. Upland rice also showed a response to N fertilization applied at topdressing.
( Edson Luck T Gonzales ),( Sung Min Yang ),( Chang Soon Choi ),( Darine Froy N Mabunga ),( Hee Jin Kim ),( Jae Hoon Cheong ),( Jong Hoon Ryu ),( Bon Nyeo Koo ),( Chan Young Shin ) 한국응용약물학회 2015 Biomolecules & Therapeutics(구 응용약물학회지) Vol.23 No.3
Propofol is an anesthetic agent that gained wide use because of its fast induction of anesthesia and rapid recovery post-anesthesia. However, previous studies have reported immediate neurodegeneration and long-term impairment in spatial learning and memory from repeated neonatal propofol administration in animals. Yet, none of those studies has explored the sex-specific long-term physical changes and behavioral alterations such as social (sociability and social preference), emotional (anxiety), and other cognitive functions (spatial working, recognition, and avoidance memory) after neonatal propofol treatment. Seven-day-old Wistar-Kyoto (WKY) rats underwent repeated daily intraperitoneal injections of propofol or normal saline for 7 days. Starting fourth week of age and onwards, rats were subjected to behavior tests including open-field, elevated-plus-maze, Y-maze, 3-chamber social interaction, novel-object-recognition, passive-avoidance, and rotarod. Rats were sacrificed at 9 weeks and hippocampal protein expressions were analyzed by Western blot. Results revealed long-term body weight gain alterations in the growing rats and sex-specific impairments in spatial (female) and recognition (male) learning and memory paradigms. A markedly decreased expression of hippocampal NMDA receptor GluN1 subunit in female- and increased expression of AMPA GluR1 subunit protein expression in male rats were also found. Other aspects of behaviors such as locomotor activity and coordination, anxiety, sociability, social preference and avoidance learning and memory were not generally affected. These results suggest that neonatal repeated propofol administration disrupts normal growth and some aspects of neurodevelopment in rats in a sex-specific manner.
Edson Cabral da Silva,Takashi Muraoka,Alefe Viana Souza Bastos,Vinícius Ide Franzini,Salatiér Buzetti,Frederico Antonio Loureiro Soares,Marconi Batista Teixeira,José Alberto Bendassolli 한국작물학회 2020 Journal of crop science and biotechnology Vol.23 No.3
Erratum to: J. Crop Sci. Biotech. 2020 (March) 23 (2):117–126 https ://doi.org/10.1007/s1289 2-019-0288-0
Supplementation of Korean Red Ginseng improves behavior deviations in animal models of autism
Gonzales, Edson Luck T.,Jang, Jong-Hwa,Mabunga, Darine Froy N.,Kim, Ji-Woon,Ko, Mee Jung,Cho, Kyu Suk,Bahn, Geon Ho,Hong, Minha,Ryu, Jong Hoon,Kim, Hee Jin,Cheong, Jae Hoon,Shin, Chan Young Co-Action Publishing 2016 Food & nutrition research Vol.60 No.-
<P><B>Background</B></P><P>Autism spectrum disorder (ASD) is heterogeneous neurodevelopmental disorders that primarily display social and communication impairments and restricted/repetitive behaviors. ASD prevalence has increased in recent years, yet very limited therapeutic targets and treatments are available to counteract the incapacitating disorder. Korean Red Ginseng (KRG) is a popular herbal plant in South Korea known for its wide range of therapeutic effects and nutritional benefits and has recently been gaining great scientific attention, particularly for its positive effects in the central nervous system.</P><P><B>Objectives</B></P><P>Thus, in this study, we investigated the therapeutic potential of KRG in alleviating the neurobehavioral deficits found in the valproic acid (VPA)-exposed mice models of ASD.</P><P><B>Design</B></P><P>Starting at 21 days old (P21), VPA-exposed mice were given daily oral administrations of KRG solution (100 or 200 mg/kg) until the termination of all experiments. From P28, mice behaviors were assessed in terms of social interaction capacity (P28–29), locomotor activity (P30), repetitive behaviors (P32), short-term spatial working memory (P34), motor coordination (P36), and seizure susceptibility (P38).</P><P><B>Results</B></P><P>VPA-exposed mice showed sociability and social novelty preference deficits, hyperactivity, increased repetitive behavior, impaired spatial working memory, slightly affected motor coordination, and high seizure susceptibility. Remarkably, long-term KRG treatment in both dosages normalized all the ASD-related behaviors in VPA-exposed mice, except motor coordination ability.</P><P><B>Conclusion</B></P><P>As a food and herbal supplement with various known benefits, KRG demonstrated its therapeutic potential in rescuing abnormal behaviors related to autism caused by prenatal environmental exposure to VPA.</P>
Neosiphonia ramirezii sp. nov. (Rhodomelaceae, Rhodophyta) from Peru
Danilo Edson Bustamante,원부연,조태오 한국조류학회I 2013 ALGAE Vol.28 No.1
The genus Neosiphonia Kim and Lee 1999 contains approximately 30 species worldwide. Unidentified samples from Peru are here described as a new species, Neosiphonia ramirezii sp. nov., on the basis of morphological and molecular data. N. ramirezii sp. nov. is characterized by the presence of a limited prostrate system, well-developed erect filaments, rhizoids cut off from pericentral cells by cross walls, four pericentral cells that are completely ecorticate, scarce trichoblasts, inconspicuous scar cells, procarps with three-celled carpogonial branches, spermatangial branches developed from basal cells of forked trichoblasts, and spirally arranged tetrasporangia. Our new species is distinct from N. flaccidissima (Hollenberg) Kim et Lee, N. sphaerocarpa (Børgesen) Kim et Lee, and N. savatieri (Hariot) Kim et Lee from the Pacific temperate coast of South America and from 14 Neosiphonia species reported worldwide by having limited prostrate filaments attached by numerous rhizoids, dichotomous (“Y” shaped) branches in the main axes, and scarce trichoblasts. Phylogenetic rbcL analyses confirm the placement of the new taxon as a distinct species in the genus Neosiphonia.