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Sah, Edel,Sah, Hongkee Hindawi Limited 2015 Journal of nanomaterials Vol.2015 No.-
<P>In recent years, there have been a plethora of nanoengineering approaches for the development of poly(lactide-<I>co</I>-glycolide) (PLGA) nanoparticulate carrier systems. However, overlooking the multifaceted issues in the preparation and characterization of PLGA-based nanoparticles, many reports have been focused on their<I>in vivo</I>behaviors. It is imperative to fully assess technological aspects of a nanoencapsulation method of choice and to carefully evaluate the nanoparticle quality. The selection of a nanoencapsulation technique should consider drug property, nanoparticle quality, scale-up feasibility, manufacturing costs, personnel safety, environmental impact, waste disposal, and the like. Made in this review are the fundamentals of classical emulsion-templated nanoencapsulation methods used to prepare PLGA nanoparticles. More specifically, this review provides insight into emulsion solvent evaporation/extraction, salting-out, nanoprecipitation, membrane emulsification, microfluidic technology, and flow focusing. Innovative nanoencapsulation techniques are being developed to address many challenges existing in the production of PLGA-based nanoparticles. In addition, there are various out-of-the-box approaches for the development of novel PLGA hybrid systems that could deliver multiple drugs. Latest trends in these areas are also dealt with in this review. Relevant information might be helpful to those who prepare and develop PLGA-based nanoparticles that meet their specific demands.</P>
Interfacial Tension-Mediated Droplet Fusion in Rectangular Microchannels
홍종인,최민석,Joshua B. Edel,Andrew J. deMello 한국바이오칩학회 2009 BioChip Journal Vol.3 No.3
We successfully demonstrate the merging of aqueous droplets within a microfluidic channel mediated by a difference in interfacial tension. Interfacial tension is shown to have a significant influence on the hydrodynamic forces associated with a segmented flow in a rectangular microchannel and results in the possibility of merging multiple droplets in a simple fashion. This facility is important in allowing droplet-based microfluidic systems to be used as synthetic tools in complex reaction processing.
Applicability of non-halogenated methyl propionate to microencapsulation
Kang, Jukyung,Sah, Edel,Sah, Hongkee Informa UK Ltd. 2014 Journal of microencapsulation Vol.31 No.4
<P>Applicability of methyl propionate to microencapsulation was evaluated with regard to volatility, capability of forming emulsions, and their quality. An emulsion-based technique was then developed to encapsulate progesterone into poly-<I><SMALL>D</SMALL>,<SMALL>L</SMALL></I>-lactide-<I>co</I>-glycolide microspheres. Their characteristics were compared with those prepared using ethyl acetate. Our results demonstrated that methyl propionate had greater evaporative tendency and less water miscibility than ethyl acetate did. The former allowed us to prepare good microspheres. Their average volume mean diameter was 68.3 ± 1.7 μm with a span index of 0.91 ± 0.13. Progesterone did not undergo polymorphic transition during microencapsulation, and its encapsulation efficiency ranged from 41.80 ± 1.83 to 85.64 ± 1.95%. Residual methyl propionate in various microspheres was found to be 0.97 ± 0.03 to 1.54 ± 0.07%. Such microsphere characteristics were quite similar to those prepared by the ethyl acetate-based microencapsulation process. Overall, our findings reflect that methyl propionate has a potential to become an invaluable solvent for microencapsulation.</P>
Droplet-Interfaced Microchip and Capillary Electrophoretic Separations
Niu, Xize,Pereira, Fiona,Edel, Joshua B.,de Mello, Andrew J. American Chemical Society 2013 ANALYTICAL CHEMISTRY - Vol.85 No.18
<P>Both capillary and chip-based electrophoresis are powerful separation methods widely used for the separation of complex analytical mixtures in the fields of genomics, proteomics, metabolomics, and cellular analysis. However their utility as basic tools in high-throughput analysis and multidimensional separations has been hampered by inefficient or biased sample injection methods. Herein, we address this problem through the development of a simple separation platform that incorporates droplet-based microfluidic module for the encapsulation of analytes prior to the analytical separation. This method allows for the precise and reproducible injection of pL to nL volume isolated plugs into an electrophoretic separation channel. The developed platform is free from inter sample contamination, allows for small sample size, high-throughput analysis, and can provide quantitative analytical information.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancham/2013/ancham.2013.85.issue-18/ac401383y/production/images/medium/ac-2013-01383y_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ac401383y'>ACS Electronic Supporting Info</A></P>
Imaging Stars by Performing Full-Stokes Optical Interferometric Polarimetry
Elias, Nicholas M. II,Edel, Stanislav S.,Jones, Carol E.,Mackay, Frances E.,Mozurkewich, David,Jorgensen, Anders M.,Schmitt, Henrique R. The Korean Space Science Society 2012 Journal of Astronomy and Space Sciences Vol.29 No.1
Optical interferometry and polarimetry have separately provided new insights into stellar astronomy, especially in the fields of fundamental parameters and atmospheric models. We present: scientific justifications for "full-Stokes" optical interferometric polarimetry (OIP); updated instrument requirements; preliminary beam combiner designs; polarimeter design; end-to-end OIP data reduction; and realistic reimaged full-Stokes models of Be stars with a suitable number of telescopes plus noise sources. All of this work represents preliminary research to construct an OIP beam combiner.
An Overview of Data Security Algorithms in Cloud Computing
D. I. George Amalarethinam,S. Edel Josephine Rajakumari International Journal of Computer ScienceNetwork S 2023 International journal of computer science and netw Vol.23 No.5
Cloud Computing is one of the current research areas in computer science. Recently, Cloud is the buzz word used everywhere in IT industries; It introduced the notion of 'pay as you use' and revolutionized developments in IT. The rapid growth of modernized cloud computing leads to 24×7 accessing of e-resources from anywhere at any time. It offers storage as a service where users' data can be stored on a cloud which is managed by a third party who is called Cloud Service Provider (CSP). Since users' data are managed by a third party, it must be encrypted ensuring confidentiality and privacy of the data. There are different types of cryptographic algorithms used for cloud security; in this article, the algorithms and their security measures are discussed.
Jesus Linares-Flores,Hebertt Sira-Ramirez,Edel F. Cuevas-Lopez,Marco A. Contreras-Ordaz 전력전자학회 2011 JOURNAL OF POWER ELECTRONICS Vol.11 No.5
This article deals with the sensor-less control of a DC Motor via a SEPIC Converter-Full Bridge combination powered through solar panels. We simultaneously regulate, both, the output voltage of the SEPIC-converter to a value larger than the solar panel output voltage, and the shaft angular velocity, in any of the turning senses, so that it tracks a pre-specified constant reference. The main result of our proposed control scheme is an efficient linear controller obtained via Lyapunov. This controller is based on measurements of the converter currents and voltages, and the DC motor armature current. The control law is derived using an exact stabilization error dynamics model, from which a static linear passive feedback control law is derived. All values of the constant references are parameterized in terms of the equilibrium point of the multivariable system: the SEPIC converter desired output voltage, the solar panel output voltage at its Maximun Power Point (MPP), and the DC motor desired constant angular velocity. The switched control realization of the designed average continuous feedback control law is accomplished by means of a, discrete-valued, Pulse Width Modulation (PWM). Experimental results are presented demonstrating the viability of our proposal.
Imaging Stars by Performing Full-Stokes Optical Interferometric Polarimetry
Nicholas M. Elias II,Stanislav S. Edel,Carol E. Jones,Frances E. Mackay,David Mozurkewich,Anders M. Jorgensen,Henrique R. Schmitt 한국우주과학회 2012 Journal of Astronomy and Space Sciences Vol.29 No.1
Optical interferometry and polarimetry have separately provided new insights into stellar astronomy, especially in thefields of fundamental parameters and atmospheric models. We present: scientific justifications for “full-Stokes” opticalinterferometric polarimetry (OIP); updated instrument requirements; preliminary beam combiner designs; polarimeterdesign; end-to-end OIP data reduction; and realistic reimaged full-Stokes models of Be stars with a suitable number oftelescopes plus noise sources. All of this work represents preliminary research to construct an OIP beam combiner.