미토콘드리아 cytochrome b 유전자 염기서열 분석에 의한 극동지역 송사리의 계통과 지리적 분포의 상관관계

어재영 ( Jae Yong Eah ),유정하 ( Jeong Ha Yoo ),강태욱 ( Tae Wook Kang ),김무상 ( Moo Sang Kim ),김창배 ( Chang Bae Kim ) 한국어류학회 2006 韓國魚類學會誌 Vol.18 No.1

근무력 증후군(Lambert-Eaton Myasthenic syndrome) 1례

어경윤,이재욱,전상신,이영헌 동국대학교 경주대학 1996 東國論集 Vol.15 No.-

근무력 증후군은 운동 초기에 근력 약화를 보이고 최대 수의 운동 후 일시적인 근력 회복을 보이고 주로 상지보다는 하지의 근위부 근력 약화, 심부건반사 감소, 자율신경장애 등을 특징으로 하는 질환이다. 그 기전은 현재 자가 면역증에 의해 신경근 접합부에서 신경종단부 acetylcholine이 원활히 유리되지 않기 때문으로 설명하고 있다. 진단은 주로 임상 양상과 신경 생리학적 검사를 통하여 이루어지며 반복신경자극검사상 빠른(10㎐ 이상)반복 자극에서 증가 반응, 느린(3~7㎐) 반복 자극에서 감소 반응을 보인다. 이 질환은 악성 종양과 동반되는 빈도가 높으며, 종양이 발견되기 전에 특징적인 근력약화증이 선행하는 경향이 있으므로 임상적 의의가 있다 하겠다. 저자들은 최근에 하지 무력감을 주소로 내원하여 소세포폐암을 동반한 근무력 증후군으로 진단된 1례를 경험하였기에 문헌 고찰과 함께 보고하고자 한다. The Lambert-Eaton Myathenic syndome is an autoimmune disease of acetycholine release defect at the level of peripheral neuromuscular synapse, and characterize the proximal muscle weakness, decresed deep tendon reflexes and autonomic nerve dysfunction. The diagnosis is performed with clinical symptoms and the reults of repetitive nerve stimulation which is consists of the incremental response at high rate(above 10Hz) stimulation and decremental response at the low rate(3-7Hz). This disease has a clinical significance that a specific muscle weekness pattern preceds the discovering underlying malignancy. We report a case of Lambert-Eaton myasthenic syndrome combined small cell carcinoma of the lung through the repetitive nerve stimulation test.

Lithium Carbonate로 인한 안구운동발증 1례

어경윤,이광헌 東國大學校 醫學硏究所 1995 東國醫學 Vol.3 No.-

안구운동발증(Oculogyric crisis)은 연축성 공액안구운동을 특징으로 하며 주로 항정신병 약물 사용후 나타나는 추체외로 증후군의 초기 증상으로 관찰되나, 항조증 약물인 lithium 사용으로 인해 이 증상이 생기는 경우는 아주 드문 것으로 알려져 있다. 저자들은 과량의 lithium 사용으로 인하여 안구운동발증이 발현된 환자 1 례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Oculogyric crisis is a form of the acute dystonia consisted with spasmodic conjugate deviation of the eyes, usually upward. Oculogyric crisis has been described as a secondary segmental or focal dystonic contractions of extrapyramidal syndroms, after the use of the neuroleptics. However Oculogyric in association of lithium carbonate use is not common. We report a case in that oculogyric crisis is a prominent symptom induced by lithium carbonate intoxication(serum level; 2.6mEq/L).

추골동맥 폐색과 동반된 경부 척수경색 1예

어경윤,김욱년,최대섭 동국대학교 경주대학 2000 東國論集 Vol.19 No.-

Spinal cord infarction occurs infrequently and may have diverse causes. In the cervical cord, the anterior spinal artery is supplied by anterior radicular arteries arising from vertebral arteries and cervical arteries. Cervical cord infarction in commonly considered to be due to occlusion of the ant spinal artery, but a similar clinical presentation can occur in radicular occlusion. A 77-year-old man presented with sudden onset of right-side neck pain and quadriparesis. On admission he had developed paraplegia and distal motor weakness of both upper limbs, dissociated sensory disturbances, and loss of bladder function. MRI revealed symmetrical infarction of the ventral one third of the spinal cord segment C5 to C7 and severe spondylotic degeneration. MR angiography findings showed right vertebral occlusion. The patients was treated with intravenous steroid, but clinical course was unfavourable. We report a case of anterior cervical cord infarction with typical MRI findings and MR angiography.

Meige 증후군 1 례

전상신,어경윤 동국대학교 경주대학 1997 東國論集 Vol.16 No.2

Meige 증후군은 안검경련, 수명현상, 구안-안면부 근긴장 이상을 주 증상으로 하는 드문 운동장애 증후군으로서 주로 40대이후 여성에서 호발하며 아직 그 원인과 병리학적 소견이 확실히 밝혀져 있지 않다. 최근 본 교실에서는 50대 여자 환자에서 관찰된 Meige 증후군의 임상양상을 경험하였기에 문헌고찰과 함께 보고하는 바이다. Meige syndrome is an idopathic dystonic disorder. The essential features consists of blephalospam, photophobia and oro-madibular dystonia, and may occur together and separately. In 1910, Henri Meige described the "spasme facial median" which is most commonly seen in middle-aged or elderly females. The cause of this disorder is obscure and has been no consistent response to any particular treatment. We present a case of Meige's syndrome with reviewing some of literatures.

경동맥 죽종의 색혈류 도플러 초음파 소견

오연희,김승현,이성우,어경윤 동국대학교 경주대학 1996 東國論集 Vol.15 No.-

한국인의 뇌경색의 가장 중요한 원인은 경동맥 죽종으로 알려져 있다. 저자들은 경동맥 죽종의 복식 초음파 및 색혈류 도플러 초음파영상을 비교·분석 하였다. 죽종 침범의 범위는 총경동맥+내경동맥+외경동맥 혹은 분지부 47.9%, 총경동맥 24.4%, 총경동맥+분지부+내경동맥 11.1%등이었다. 경동맥 협착은 중등도 53.6%, 경도 26.1%, 중도 16.3%, 위험도 3.1%, 완전폐쇠 0.9%. 표면의 형태는 매끄러운 경우 53.1%, 경도 불규칙 41.3%, 심한 불규칙 3.9% 그리고 표면 궤양이 동반된 경우 1.7%였다. 또한 죽종 내부구조의 음영도상 균일한 경우 90.5% 였고 죽종의 음영은 등에코성 40.2% 석회화 25.1%, 저에코서 22.3%등이었다. 결론적으로 복식 초음파와 색혈류 도플러 영상은 경동맥 죽종 진단에 있어서 정확하고 안전한 비침습적인 진단방법이다. Several reports have been documented that carotid atheroma presented as the mostimportant cause of cerebral infarction in Korea. Authors analysed the atheroma imaging of the carotid artery in the patients with cerebral infarction patients using duplex sonography and color flow imaging. The atheroma extents were CCA(common carotid artery)+ICA(intemal carotid artery)+ECA(external carotid artery) or BIF(bifurcation) 47.9%. CCA(common carotid artery) 24.4%, CCA(common carotid artery)+BIF(bifurcation)+ICA(lntemal carotid artery) 11.1 %. The percents of stenosis of carotid arteries were moderate 53.6%, mild 26.1 %. severe 16.3%, critical 3.1 % and occlusive 0.9%. The surface characters were smooth 53.1 %, mild irregular 41.3%, severe irregular 3.9% and ulcerated 1.7%. The atheroma texture was homogenous 90.5%, and the echogenicities of atheroma were isoecboic 40.2%, calcification 25.1 %, hypoechoic 22.3%. We concluded that duplex sonography and color flow imaging were accurate and safe non-invasive method detecting of carotid atheroma.

만성 주관 증후군에서 전기신경학적 진단 및 수술적 치료

황정수,어경윤,문상호,김욱년,하정호,김범,김영성,박소강 동국대학교 경주대학 2000 東國論集 Vol.19 No.-

The results of various treatments for ulnar neuropathy secondary to the chronic cubital tunnel syndrome are some controversial. A prospective study was done to determine the clinical and electrophysiological results of our surgical method which is composed of in situ release, medial epicondylectomy and nerve transposition onto the bony surface on where medial epicondyle was after smoothening. Clinical result was evaluated by scoring system which was made by Adelaar et al, and short segment stimulation test which were designed to localize the more discrete region at elbow. Latency and amplitude changes were determined by stimulating the ulnar nerve at 2㎝ intervals across the elbow. The four patients with chronic ulnar nerve palsy at the elbow level were selected. Average follow-up duration is 11.25 months and the patients had symptoms for an average of 33 months before surgery. All patients had good clinical scores and significant latency changes compared to preoperative nerve conduction studies. According to this study, we think that our operative method is a good treatment for chronic cubital tunnel syndrome.

뇌경색 후 경련발작

전상신,어경윤 대한신경과학회 1998 대한신경과학회지 Vol.16 No.4

DNA barcoding Korean birds.

Yoo, Hye Sook,Eah, Jae-Yong,Kim, Jong Soo,Kim, Young-Jun,Min, Mi-Sook,Paek, Woon Kee,Lee, Hang,Kim, Chang-Bae Korean Society for Molecular Biology 2006 Molecules and cells Vol.22 No.3

<P>DNA barcoding, an inventory of DNA sequences from a standardized genomic region, provides a bio-barcode for identifying and discovering species. Several recent studies suggest that the sequence diversity in a 648 bp region of the mitochondrial gene for cytochrome c oxi- dase I (COI) might serve as a DNA barcode for identify- ing animal species such as North American birds, in- sects and fishes. The present study tested the effective- ness of a COI barcode in discriminating Korean bird species. We determined the 5' terminus of the COI bar- code for 92 species of Korean birds and found that spe- cies identification was unambiguous; the genetic differ- ences between closely related species were, on average, 25 times higher than the differences within species. We identified only one misidentified species out of 239 specimens in a genetic resource bank, so confirming the accuracy of species identification in the banking system. We also identified two potential composite species, calling for further investigation using more samples. The finding of large COI sequence differences between species confirms the effectiveness of COI barcodes for identifying Korean bird species. To bring greater reliability to the identification of species, increased in- tra- and interspecies sampling, as well as supplementa- tion of the mitochondrial barcodes with nuclear ones, is needed.</P>

천마의 GABA-benzodiazepine 수용체 복합체에 대한 조절작용

하정희,이동웅,어경윤,하정상,김현주,용철순,허근 영남대학교 약품개발연구소 1998 영남대학교 약품개발연구소 연구업적집 Vol.8 No.-

Methanol extract of G. elata inhibited the binding of [³H]Ro15-1788, a selective benzodiazepine receptor antagonist, to benzodiazepine receptor of rat cortices. Saturation experiments followed by Scatchard analysis of the results showed that the inhibition of [³H]Ro15-1788 binding by G. elata. appeared to be competitive. These competitive inhibiton of the butanol fraction was observed to be higher than the methanol extract. Methanol extract of G. elata inhibited a [³H]flunitrazepam, a selective benzodiazepine receptor agonist, binding to benzodiazepine receptor. GABA significantly enhanced the inhibition of [³H]flunitrazepam binding by G. elata, and these "positive GABA shift" supported the strong possibility of agonistic activity to benzodiazepine receptor. Butanol fraction was observed to be higher than crude extract by methanol in an agonistic activity to benzodiazepine receptor, furthermore enhanced the binding of [³H]SR95531 to GABA_(A) receptor. Butanol fraction of G. elata significantly diminished the pentylenetetrazole-induced lethality of mice. From these results, it can be concluded that substance or substances with neurochemical properties characteristic of a benzodiazepine receptor agonist may be important components, and contribute to the anticonvulsant property of G. elata.