A Silent and Late Embolization of Atrial Septal Defect Occluder Device Into the Right Pulmonary Artery: A Case Report

Durmus¸ Yıldıray S¸ahin,,Mevlüt Koc,Habib C¸akır,Osman Ziya Arık,Zafer Elbasan,Murat C¸aylı 대한심장학회 2012 Korean Circulation Journal Vol.42 No.11

Percutaneous device closure of atrial septal defect (ASD) is an alternative treatment to surgery. The main advantages of the percutaneous approach include avoidance of surgery, short procedure time and hospital length, in addition to comparable rates of complications. However,percutaneous device closure is associated with infrequent early and late complications including device embolization, air embolism,cardiac tamponade and thrombotic complications. We report a rare complication of silent and late device embolization of the ASD occluder device into the right pulmonary artery, three months after implantation.

The effect of Hericium erinaceum on the prevention of chemically induced experimental colitis in rats

( Ali Durmus ),( Ilgim Durmus ),( Omer Bender ),( Oguzhan Karatepe ) 대한내과학회 2021 The Korean Journal of Internal Medicine Vol.36 No.0

Background/Aims: The aim of this study is to investigate the effects of the Hericium erinaceum on an experimental colitis model. Methods: Twenty-four Wistar albino were included in this study. Rats were divided into three groups. Group 1 (n = 8) was sham group. Group 2 is the group of chemically induced by intrarectal administration of trinitrobenzene sulfonic acid (TNBS) resulting in colitis. Group 3 (n = 8) is the group that was treated 7 days before and 7 days after with H. erinaceum resulting in colitis. The activity of colitis was evaluated macroscopically and microscopically in rats. In other words, nitric oxide (NO) levels, malondialdehyde (MDA), interleukin 6 (IL-6), nuclear factor-kappa B (NF-κB) and, tumor necrosis factor-α (TNF-α) in addition to the myeloperoxidasem (MPO) activities was determined. Results: The rate of TNBS-induced colitis caused to increase the level of MDA activities meaningfully in the colitis group than the control group. The results indicated that MDA (p = 0.001), NO (p = 0.001), IL-6 (p = 0.001), MPO (p = 0.878), TNF-α (p = 0.001), and NF-κB levels of treatment group decreased in the blood and colon tissues because of the H. erinaceum treatment when compared to the colitis group. H. erinaceum treatment was related to the declining of MDA, NF-κB, NO, IL-6, and TNF-α levels. Conclusions: H. erinaceum had a positive effect on the colitis by reducing oxidative damage in blood and tissue.

The Effectiveness of Community-based Social Distancing for Mitigating the Spread of the COVID-19 Pandemic in Turkey

Durmus, Hasan,Gokler, Mehmet Enes,Metintas, Selma The Korean Society for Preventive Medicine 2020 예방의학회지 Vol.53 No.6

Objectives: The objective of this study was to demonstrate the effects of community-based social distancing interventions after the first coronavirus disease 2019 (COVID-19) case in Turkey on the course of the pandemic and to determine the number of prevented cases. Methods: In this ecological study, the interventions implemented in response to the first COVID-19 cases in Turkey were evaluated and the effect of the interventions was demonstrated by calculating the effective reproduction number (R_t) of severe acute respiratory syndrome coro navirus 2 (SARS-CoV-2) when people complied with community-based social distancing rules. Results: Google mobility scores decreased by an average of 36.33±22.41 points (range, 2.60 to 84.80) and a median of 43.80 points (interquartile range [IQR], 24.90 to 50.25). The interventions caused the calculated R_t to decrease to 1.88 (95% confidence interval, 1.87 to 1.89). The median growth rate was 19.90% (IQR, 10.90 to 53.90). A positive correlation was found between Google mobility data and R_t (r=0.783; p<0.001). The expected number of cases if the growth rate had not changed was predicted according to Google mobility categories, and it was estimated to be 1 381 922 in total. Thus, community-based interventions were estimated to have prevented 1 299 593 people from being infected. Conclusions: Community-based social distancing interventions significantly decreased the R_t of COVID-19 by reducing human mobility, and thereby prevented many people from becoming infected. Another important result of this study is that it shows health policymakers that data on human mobility in the community obtained via mobile phones can be a guide for measures to be taken.

Effects of Ensiling Alfalfa with Whole-crop Maize on the Chemical Composition and Nutritive Value of Silage Mixtures

Ozturk, Durmus,Kizilsimsek, Mustafa,Kamalak, Adem,Canbolat, Onder,Ozkan, Cagri Ozgur Asian Australasian Association of Animal Productio 2006 Animal Bioscience Vol.19 No.4

The aim of this study was to evaluate the chemical composition, in vitro DM degradability, ME and OMD of alfalfa-maize silage mixtures in comparison to pure maize and alfalfa silages, and to test the existence of associative effects of ensiling alfalfa forage with whole-crop maize using the in vitro gas production technique. Ensiling alfalfa with whole-crop maize had a significant (p<0.001) effect on chemical composition, pH, in vitro DM degradability, OMD and estimated ME values of mixtures. DM content of the resultant silages significantly increased with increasing proportion of whole-crop maize in the mixtures, whereas the pH value, crude protein (CP), acid detergent fibre (ADF) and ash contents of mixtures decreased due to the dilution effect of whole-crop maize which was low in CP, ADF and ash. The pH values of all alfalfa-maize silage mixtures were at the desired level for quality silage. Gas production of alfalfa-maize silage mixtures at all incubation times except 12 h increased with increasing proportion of whole-crop maize. When alfalfa was mixed with whole-crop maize in the ratio 40:60, ME and OMD values were significantly (p<0.001) higher than other silages. Maximum gas production ($A_{gas}$) ranged from 65.7 to 78.1 with alfalfa silage showing the lowest maximum gas production. The results obtained in this study clearly showed that maximum gas production increased with increased percentage of whole-crop maize in the silage mixtures (r = 0.940, p<0.001). It was concluded that ensiling alfalfa with whole-crop maize improved the pH, OMD and ME values. However, trials with animals are required to see how these differences in silage mixtures affect animal performance.

Prognostic Value of Osteopontin in Patients Treated with Primary Radiotherapy for Head and Neck Cancer

Etiz, Durmus,Ataizi, Fulya Colak,Bayman, Evrim,Akcay, Melek,Acikalin, Mustafa Fuat,Colak, Ertugrul,Ciftci, Evrim Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.9

Background: The prognostic value of tumor osteopontin (OPN) in patients with squamous-cell head and neck cancer (SCHNC) was investigated. Materials and Methods: OPN expression was assessed by immunohistochemical methods in 50 patients, who were treated with primary radiotherapy (RT) for locally advanced SCHNC. The effects of OPN on clinical parameters, local-regional control after RT and metastasis-free survival, was assessed. Results: The rate of OPN expression in tumor tissue was 76%. OPN positive cases had lower Hb levels (p=0.088). Mean time to local recurrence was 53.8 months (SE 3.9) in OPN-negative cases and 39.1 months (SE 4.7) in OPN-positive cases (p=0.047). OPN increased the risk of local recurrence 5.9 times (p=0.085). It had no effect on metastasis-free (p=0.116) or overall survival (p=0.123). OPN was positive in 12 of 19 cases that developed grade 3-4 acute radiation dermatitis (p=0.096). Conclusions: OPN expression is associated with an increase in local recurrence in patients who were treated with primary RT for locally advanced SCHNC.

Controlling the electrical characteristics of Al/p-Si structures through Bi4Ti3O12 interfacial layer

P. Durmus,M. Yıldırım,S. Altındal 한국물리학회 2013 Current Applied Physics Vol.13 No.8

In this study, the effects of high permittivity interfacial Bi4Ti3O12 (BTO) layer deposition on the main electrical parameters; such as barrier height, series resistance, rectifying ratio, interface states and shunt resistance, of Al/p-Si structures are investigated using the currentevoltage (I-V) and admittance measurements (capacitanceevoltage, CeV and conductanceevoltage, G/ω-V) at 1 MHz and room temperature. IeV characteristics revealed that, due to BTO layer deposition, series resistance values that were calculated by both Ohm’s law and Cheung’s method decreased whereas shunt resistance values increased. Therefore, leakage current value decreased significantly by almost 35 times as a result of high permittivity interfacial BTO layer. Moreover, rectifying ratio was improved through BTO interfacial layer deposition. I-V data indicated that high permittivity interfacial BTO layer also led to an increase in barrier height. Same result was also obtained through C-V data. Obtained results showed that the performance of the device is considerably dependent on high permittivity BTO interfacial layer.

Investigation of rheological behaviors of polyolefin blend type thermoplastic elastomers for quantifying microstructure-property relationships

Ali Durmus,Mine Begum Alanalp,Ismail Aydin 한국유변학회 2019 Korea-Australia rheology journal Vol.31 No.2

Polyolefin blend type thermoplastic elastomers (TPEs) were prepared via melt blending method in a twin screw extruder by using isotactic polypropylene (i-PP), three different styrene-olefin triblock copolymers (SEBS-1 and SEBS-2 having a styrene content of 30 wt.% and 60 wt.%, respectively and SEEPS having a styrene content of 30 wt.%) and paraffinic oil. Composition-dependent and time-dependent viscoelastic properties of compounds were determined by various test procedures conducted in a rotational rheometer in melt state. It was found that the content of polystyrene blocks (or hard segment) in copolymers governed the rheological behaviors of compounds. It can be concluded that the increasing amount of styrene-olefin block copolymer or content of glassy domains into blend composition reduces miscibility between polyolefin and elastomer phases and also yields higher melt elasticity and viscosity, longer relaxation times, lower creep strain and compliance values at relatively longer time scale.

Dosimetric and Clinical Predictors of Acute Esophagitis in Lung Cancer Patients in Turkey Treated with Radiotherapy

Etiz, Durmus,Bayman, Evrim,Akcay, Melek,Sahin, Bilgehan,Bal, Cengiz Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.7

Background: The purpose of this study was to determine the clinical and dosimetric factors associated with acute esophagitis (AE) in lung cancer patients treated with conformal radiotherapy (RT) in Turkey. Materials and Methods: In this retrospective review 104 lung cancer patients were examined. Esophagitis grades were verified weekly during treatment, and at 1 week, and 1 and 2 months afterwards. The clinical parameters included patient age, gender, tumor pathology, number of chemotherapy treatments before RT, concurrent chemotherapy, radiation dose, tumor response to RT, tumor localization, interruption of RT, weight loss, tumor and nodal stage and tumor volume. The following dosimetric parameters were analyzed for correlation of AE: The maximum ($D_{max}$) and mean ($D_{mean}$) doses delivered to the esophagus, the percentage of esophagus volume receiving ${\geq}10$ Gy ($V_{10}$), ${\geq}20$ Gy ($V_{20}$), ${\geq}30$ Gy ($V_{30}$), ${\geq}35$ Gy ($V_{35}$), ${\geq}40$ Gy ($V_{40}$), ${\geq}45$ Gy ($V_{45}$), ${\geq}50$ Gy ($V_{50}$) and ${\geq}60$ Gy ($V_{60}$). Results: Fifty-five patients (52.9%) developed AE. Maximum grades of AE were recorded: Grade 1 in 51 patients (49%), and Grade 2 in 4 patients (3.8%). Clinical factors had no statistically significant influence on the incidence of AE. In terms of dosimetric findings, correlation analyses demonstrated a significant association between AE and $D_{max}$ (>5117 cGy), $D_{mean}$ (>1487 cGy) and $V_{10-60}$ (percentage of volume receiving >10 to 60 Gy). The most significant relationship between RT and esophagitis were in $D_{max}$ (>5117 cGy) (p=0.002) and percentage of esophageal volume receiving >30 Gy ($V_{30}$ >31%) (p=0.008) in the logistic regression analysis. Conclusions: The maximum dose esophagus greater than 5117 cGy and approximately one third (31%) of the esophageal volume receiving >30 Gy was the most statistically significant predictive factor associated with esophagitis due to RT.

The role of slenderness on the seismic behavior of ground-supported cylindrical silos

Demir, Aysegul Durmus,Livaoglu, Ramazan Techno-Press 2019 Advances in concrete construction Vol.7 No.2

This paper reports on the results of a parametric study, which examines the effects of varying aspect ratios on the dynamic response of cylindrical silos directly supported on the ground under earthquake loading. Previous research has shown that numerical models can provide considerably realistic simulations when it comes to the behavior of silos by using correct boundary conditions, appropriate element types and material models. To this end, a three dimensional numerical model, taking into account the bulk material-silo wall interaction, was produced by the ANSYS commercial program, which is in turn based on the finite element method. The results obtained from the numerical analysis are discussed comparatively in terms of dynamic material pressure, horizontal displacement, equivalent base shear force and equivalent bending moment responses for considered aspect ratios. The effects experienced because of the slenderness of the silo in regards to the seismic response were evaluated along with the effectiveness of the classification system proposed by Eurocode in evaluating the loads on the vertical walls. Results clearly show that slenderness directly affects the seismic response of such structures especially in terms of behavior and the magnitude of the responses. Furthermore the aspect ratio value of 2.0, given as a behavioral changing limit in the technical literature, can be used as a valid limit for seismic behavior.

Investigation of wall flexibility effects on seismic behavior of cylindrical silos

Livaoglu, Ramazan,Durmus, Aysegul Techno-Press 2015 Structural Engineering and Mechanics, An Int'l Jou Vol.53 No.1

This paper is concerned with effects of the wall flexibility on the seismic behavior of ground-supported cylindrical silos. It is a well-known fact that almost all analytical approximations in the literature to determine the dynamic pressure stemming from the bulk material assume silo structure as rigid. However, it is expected that the horizontal dynamic material pressures can be modified due to varying horizontal extensional stiffness of the bulk material which depends on the wall stiffness. In this study, finite element analyses were performed for six different slenderness ratios according to both rigid and flexible wall approximations. A three dimensional numerical model, taking into account bulk material-silo wall interaction, constituted by ANSYS commercial program was used. The findings obtained from the numerical analyses were discussed comparatively for rigid and flexible wall approximations in terms of the dynamic material pressure, equivalent base shear and bending moment. The numerical results clearly show that the wall flexibility may significantly affects the characteristics behavior of the reinforced concrete (RC) cylindrical silos and magnitudes of the responses under strong ground motions.