REVIEW : Medical Management of Drug-Resistant Tuberculosis

( Doosoo Jeon ) 대한결핵 및 호흡기학회 2015 Tuberculosis and Respiratory Diseases Vol.78 No.3

Drug-resistant tuberculosis (TB) is still a major threat worldwide. However, recent scientific advances in diagnostic and therapeutic tools have improved the management of drug-resistant TB. The development of rapid molecular testing methods allows for the early detection of drug resistance and prompt initiation of an appropriate treatment. In addition, there has been growing supportive evidence for shorter treatment regimens in multidrug-resistant TB; and for the first time in over 50 years, new anti-TB drugs have been developed. The World Health Organization has recently revised their guidelines, primarily based on evidence from a meta-analysis of individual patient data (n=9,153) derived from 32 observational studies, and outlined the recommended combination and correct use of available anti-TB drugs. This review summarizes the updated guidelines with a focus on the medical management of drug-resistant TB.

Infection Source and Epidemiology of NTM Lung Disease

( Doosoo Jeon ) 대한결핵 및 호흡기학회 2017 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.124 No.-

WHO Treatment Guidelines for Drug- Resistant Tuberculosis, 2016 Update: Applicability in South Korea

( Doosoo Jeon ) 대한결핵 및 호흡기학회 2017 Tuberculosis and Respiratory Diseases Vol.80 No.4

Despite progress made in tuberculosis control worldwide, the disease burden and treatment outcome of multidrug- resistant tuberculosis (MDR-TB) patients have remained virtually unchanged. In 2016, the World Health Organization released new guidelines for the management of MDR-TB. The guidelines are intended to improve detection rate and treatment outcome for MDR-TB through novel, rapid molecular testing and shorter treatment regimens. Key changes include the introduction of a new, shorter MDR-TB treatment regimen, a new classification of medicines and updated recommendations for the conventional MDR-TB regimen. This paper will review these key changes and discuss the potential issues with regard to the implementation of these guidelines in South Korea.

Korean guidelines for treatment of drug-resistant TB, update

( Doosoo Jeon ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-

WHO MDR-TB Guideline, 2016 Update

( Doosoo Jeon ) 대한결핵 및 호흡기학회 2016 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.121 No.-

Diagnosis and constitutional and laboratory features of Korean girls referred for precocious puberty

Doosoo Kim,Sung-Yoon Cho,Se-Hyun Maeng,Eun Sang Yi,Yu Jin Jung,박성원,손영배,진동규 대한소아청소년과학회 2012 Clinical and Experimental Pediatrics (CEP) Vol.55 No.12

Purpose: Precocious puberty is defined as breast development before the age of 8 years in girls. The present study aimed to reveal the diagnosis of Korean girls referred for precocious puberty and to compare the constitutional and endocrinological features among diagnosis groups. Methods: The present study used a retrospective chart review of 988Korean girls who had visited a pediatric endocrinology clinic from 2006 to 2010 for the evaluation of precocious puberty. Study groups comprised fast puberty, true precocious puberty (PP), pseudo PP,premature thelarche, and control. We determined the height standard deviation score (HSDS), weight standard deviation score (WSDS), and body mass index standard deviation score (BMISDS) of each group using the published 2007 Korean growth charts. Hormone tests were performed at our outpatient clinic. Results: The PP groups comprised fast puberty (67%), premature thelarche (17%), true PP (15%), and pseudo PP (1%). Advanced bone age and levels of estradiol, basal luteinizing hormone (LH), and peak LH after gonadotropin-releasing hormone stimulation testing were significantly high in the fast puberty and true PP groups compared with the control group. HSDS, WSDS, and BMISDS were significantly higher in the true PP group than in the control group (P<0.05). Conclusion: The frequent causes of PP were found to be fast puberty,true PP, and premature thelarche. Furthermore, BMISDS were significantly elevated in the true PP group. Therefore, we emphasize the need for regular follow-up of girls who are heavier or taller than others in the same age group.

Infection Source and Epidemiology of Nontuberculous Mycobacterial Lung Disease

( Doosoo Jeon ) 대한결핵 및 호흡기학회 2019 Tuberculosis and Respiratory Diseases Vol.82 No.2

Nontuberculous mycobacteria (NTM) are ubiquitous organisms that are generally found not only in the natural environment but also in the human engineered environment, including water, soil, and dust. These organisms can form biofilms and can be readily aerosolized because they are hydrophobic owing to the presence of the lipidrich outer membrane. Aerosolization and subsequent inhalation were the major route of NTM lung disease. Water distribution systems and household plumbing are ideal habit for NTM and the main transmission route from natural water to household. NTM have been isolated from drinking water, faucets, pipelines, and water tanks. Studies that used genotyping have shown that NTM isolates from patients are identical to those in the environment, that is, from shower water, showerheads, tap water, and gardening soil. Humans are likely to be exposed to NTM in their homes through simple and daily activities, such as drinking, showering, or gardening. In addition to environmental factors, host factors play an important role in the development of NTM lung disease. The incidence and prevalence of NTM lung disease are increasing worldwide, and this disease is rapidly becoming a major public health problem. NTM lung disease is associated with substantially impaired quality of life, increased morbidity and mortality, and high medical costs. A more comprehensive understanding of the infection source and epidemiology of NTM is essential for the development of new strategies that can prevent and control NTM infection.

Automated Monitoring of Airgap Eccentricity for Inverter-Fed Induction Motors Under Standstill Conditions

Doosoo Hyun,Jongman Hong,Sang Bin Lee,Kwonhee Kim,Wiedenbrug, E J,Teska, M,Nandi, S,Chelvan, I T IEEE 2011 IEEE transactions on industry applications Vol.47 No.3

<P>There are many limitations to applying online spectrum analysis techniques for diagnosis of closed-loop inverter-fed induction motors due to variable load or frequency operation, and the masking effect of the current regulator. In this paper, a new automated approach for testing inverter-fed induction machines for airgap eccentricity is proposed. The main concept is to use the inverter to excite the machine with a pulsating field at multiple angular positions to observe the variation of equivalent impedance due to eccentricity, whenever the motor is stopped. It is shown that the increase in the value of the equivalent (leakage) inductance under standstill excitation can be used as an indicator of increasing airgap eccentricity. Standstill testing can provide reliable assessment of eccentricity that is independent of variations in operating conditions, load interferences, or motor type. An experimental study on a 7.5-hp induction motor verifies that eccentricity can be detected with high sensitivity and reliability without additional hardware.</P>

Detection of Airgap Eccentricity for Induction Motors Using the Single-Phase Rotation Test

Doosoo Hyun,Sungho Lee,Jongman Hong,Sang Bin Lee,Nandi, S. IEEE 2012 IEEE transactions on energy conversion Vol.27 No.3

<P>The single-phase rotation test (SPRT) is a simple and reliable offline test frequently used for detecting problems in the rotor cage of induction motors without motor disassembly. Airgap eccentricity due to bearing degradation, shaft flexing, etc., is another problem that is difficult to detect, which can cause catastrophic motor failure. In this paper, the feasibility of using the SPRT for detecting eccentricity, which has not been reported before, is investigated. The variation in the inductive component as a function of rotor position and time under static, dynamic, and mixed eccentricity conditions is analyzed. It is shown that airgap eccentricity can be detected in addition to rotor cage problems with the SPRT. An experimental study on a 7.5-Hp induction motor under controlled eccentricity and broken bar conditions shows that airgap eccentricity can be reliably detected with high sensitivity and distinguished from broken rotor bars.</P>

Infection Source and Epidemiology of Nontuberculous Mycobacterial Lung Disease

Jeon, Doosoo The Korean Academy of Tuberculosis and Respiratory 2019 Tuberculosis and Respiratory Diseases Vol.82 No.2

Nontuberculous mycobacteria (NTM) are ubiquitous organisms that are generally found not only in the natural environment but also in the human engineered environment, including water, soil, and dust. These organisms can form biofilms and can be readily aerosolized because they are hydrophobic owing to the presence of the lipid-rich outer membrane. Aerosolization and subsequent inhalation were the major route of NTM lung disease. Water distribution systems and household plumbing are ideal habit for NTM and the main transmission route from natural water to household. NTM have been isolated from drinking water, faucets, pipelines, and water tanks. Studies that used genotyping have shown that NTM isolates from patients are identical to those in the environment, that is, from shower water, showerheads, tap water, and gardening soil. Humans are likely to be exposed to NTM in their homes through simple and daily activities, such as drinking, showering, or gardening. In addition to environmental factors, host factors play an important role in the development of NTM lung disease. The incidence and prevalence of NTM lung disease are increasing worldwide, and this disease is rapidly becoming a major public health problem. NTM lung disease is associated with substantially impaired quality of life, increased morbidity and mortality, and high medical costs. A more comprehensive understanding of the infection source and epidemiology of NTM is essential for the development of new strategies that can prevent and control NTM infection.