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Cytotoxic scalarane sesterterpenes from a Korean marine sponge Psammocinia sp.
( Dongyup Hahn ),( Dong Hwan ),( Bora Mun ),( Hiyoung Kim ),( Chulkyeong Han ),( Weihong Wang ),( Taeho Chun ),( Sunhee Park ),( Dajeong Yoon ),( Hyukjae Choi ),( Sang Jip Nam ),( Merrick Ekins ),( Ju 영남대학교 약품개발연구소 2013 영남대학교 약품개발연구소 연구업적집 Vol.23 No.0
Three novel scalarane sesterterpenes were isolated from a Korean marine sponge, Psammocinia sp., along with four known derivatives. Their structures were elucidated on the basis of NMR, MS and IR spectroscopic data. The three new compounds are 12-deacetoxy-23-hydroxyscalaradial (1), 12-dehydroxy-23-hydroxyhyrtiolide (2) and 12-O-acetyl-16-deacetoxy-23-acetoxyscalarafuran (3), respectively, and the four known compounds are 12-deacetoxy-23-hydroxyheteronemin (4), 12-deacetoxy-23-acetoxy-19-O-acetylscalarin (5), 12-deacetoxy-23-O-acetoxyheteronemin (6) and 12-deacetoxyscalaradial (7). They exhibited cytotoxicity against intractable human cancer cell lines A498, ACHN, MIA-paca and PANC-1, with an IC50 range of 0.4-48 μM. ⓒ2013 Elsevier Ltd. All rights reserves.
A Novel Bromoindole Alkaloid from a Korean Colonial Tunicate Didemnum sp.
( Dongyup Hahn ),( Geum Jin Kim ),( Hyukjae Choi ),( Henjoong Kang ) 영남대학교 약품개발연구소 2016 영남대학교 약품개발연구소 연구업적집 Vol.26 No.-
Chemical investigation on a colonial marine tunicate, Didemnum sp. led to the isolation of a series of indole alkaloids including a new (1) and two known metabolites (2-3). Based on the spectroscopic analysis including 1D and 2D NMR along with MS spectra, the structure of 1 (16-epi-18-acetyl herdmanine D) was elucidated as a new amino acid derivative. The absolute configuration of 1 was determined by comparison of specific rotation with the known compound. The structures of compounds 2 and 3 were also identified as bromoindole containing compounds N-(6-bromo-IH-indole- 3-carbonyl)-L-arginine and (6-bromo-IH-indol- 3-yl) oxoacetamide, respectively, based on <sup>1</sup>H and <sup>13</sup>C NMR data, MS data and specific rotation value. Their pharmacological potentials as antibacterial agents and FXR antagonists were investigated, but no significant activity was found. However, the structural similarity of compound 1 to compound 4 suggested the anti-inflammatory potential of compound 1.
( Dongyup Hahn ),( Hiyoung Kim ),( Inho Yang ),( Jungwook Chin ),( Hoosang Hwang ),( Dong Hwan Won ),( Byoungchan Lee ),( Sang Jip Nam ),( Merrick Ekins ),( Hyukjae Choi ),( Heonjoong Kang ) 영남대학교 약품개발연구소 2016 영남대학교 약품개발연구소 연구업적집 Vol.26 No.-
Three new structurally related depsipeptides, halieylindramides F-H (1-3), and two known halieylindra-mides were isolated from a Petrosia sp. marine sponge collected off the shore of Youngdeok-Gun, East Sea, Republic of Korea. Their planar structures were elucidated by extensive spectroscopic data analyses including ID and 2D NMR data as well as MS data. The absolute configurations of halicylin-drarnides F-H (1-3) were determined by Marfey``s method in combination with Edman degradation. The absolute config-urations at C-4 of the dioxyindolyl alanine (Dioia) residues of halieylindramides G (2) and H (3) were determined as 4S and 4R, respectively, based on ECD spectroscopy. The C-2 configurations of Dioia in 2 and 3 were speculated to both be 2R based on the shared biogenesis of the halicylindramides. Halieylindrarnides F (1), A (4), and C (5) showed human farnesoid X receptor (hFXR) antagonistic activities, but did not bind directly to hFXR.
이동엽(Dongyup Lee),손용훈(Yonghoon Son),신영찬(Youngchan Shin),박찬흥(Chanheung Park),김영록(Youngroc Kim) 전력전자학회 2008 전력전자학술대회 논문집 Vol.- No.-
국내에서 개발되어 판매되고 있는 풍력발전용 계통연계형 삼상 인버터는 대부분 대용량 인버터이다. 이 인버터의 경우 크기도 크고 설치하기가 어려워서 주로 발전 사업용으로 사용되고, 공장 및 산업현장에 설치하기에는 많은 단점을 가지고 있다. 본 논문에서는 이러한 단점을 해결하고 풍력발전의 보급을 위하여 소 용량 풍력발전용 계통연계형 삼상 인버터 시스템을 개발하였다.
근거 중심의 학습을 통한 학생들의 임상 실무 능력 개선에 관한 연구
이동엽 ( Dongyup Lee ) 대한통합의학회 2014 대한통합의학회지 Vol.2 No.2
Purpose : The purpose of this study was to investigate the effect that the academic achievement of the students about the evidence based learning investigates the learning utility value about and the request. Method : The agreement of college students explaining the purpose of research for 12 weeks against 17 students and investigate through a questionnaire. The level of academic achievement according to the sex and claim showed a characteristic with a percentage. An utility investigate the descriptive epidemiologic characteristic about the class of the evidence based learning. Result : The most of college students the level of academic achievement and requests the expected grade of the students about the evidence based learning wanted the ‘high’ grade of 9 persons, ‘middle’ grade of 8 persons in the part and the expectation for the class taken so much was high(p<.05). There was the significant different in the utility aspect in the need of the evidence based learning, homework solution, learning synergy effect improvement, and reference search ability improvement(p<.05). Conclusion : These finding revealed that the evidence based learning the satisfaction with class raises the improvement and utility value, and provided the need and the has to develop the educational model which the college students contentment raises an improvement after this opportunity for the new recognition.
Safety and Lung Damage Reduction Activity of Morinda citrifolia (noni) seed
Hyeongjin Eom,Dongyup Hahn 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
Noni used in food and folk remedies for over 2000 years. Recently, the consumption of noni products has increased, as there is a growing interest in noni as various bioactivity has been revealed. But, anthraquinone, one of the components of noni, causes side effects like hepatotoxicity in some papers. It was present in the husk and seeds. Accordingly, it is important to explore bioactive components while excluding anthraquinone. Meanwhile, it is considered that fine dust is the cause of respiratory disease. It consists of minerals, nitrogen oxide, sulfur oxide, and volatile organic compounds. 1-Nitropropane (1-NP), constituting fine dust, have toxicity to lung cells. In this study, Noni seed was extracted with dichloromethane: methanol (1: 1) solution and then fractionated hexane, ethyl acetate, butanol, and water layer. The ethyl acetate layer was subdivided by size exclusion chromatography, and some components were separated using preparative HPLC. 1H-NMR and 13C-NMR were used for components structure elucidation isolated from noni seed. 1-NP had been tested into lung cells with lignans from noni seed, and cell viability was analyzed compared to those not treated.
Quantification of Allantoin in Yams (Dioscorea sp.) Using a <sup>1</sup>H NMR Spectroscopic Method
( Thao Quyen Cao ),( Dongyup Hahn ) 한국미생물생명공학회 2023 Journal of microbiology and biotechnology Vol.33 No.5
Allantoin is an abundant component of yams and has been known as a skin protectant due to its pharmacological activities. In previous methods for allantoin determination using high-performance liquid chromatography (HPLC), the separation was unsatisfactory. We herein developed a 1H quantitative nuclear magnetic resonance (qNMR) method for quantification of allantoin in the flesh and peel of yams. The method was carried out based on the relative ratio of signals integration of allantoin to a certain amount of the internal standard dimethyl sulfone (DMSO<sub>2</sub>) and validated in terms of specificity, linearity (range 62.5-2000 μg/ml), sensitivity (limit of detection (LOD) and quantification (LOQ) 4.63 and 14.03 μg/ml, respectively), precision (RSD% 0.02-0.26), and recovery (86.35-92.11%). The method was then applied for the evaluation of allantoin in flesh and peel extracts of four different yams cultivated in Korea.