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박동훈(Piao Dongxun) 전남대학교 글로벌디아스포라연구소 2017 디아스포라 연구 Vol.11 No.1
이 연구는 한중 양국 학계간의 소통과 교류가 보다 심화될 필요가 있음에도 불구하고, 연구주체가 갖고 있는 특유의 지적구조로 인해 두 학문체계사이에는 항상 긴장감이 존재한다는 점을 밝히고, 양자간의 상호 소통과 교류, 그리고 이해의 증진을 위해 중국에서의 한국학의 본거지인 연변대학의 역할에 주목하고자 했다. 비록 연변대학교는 한국학의 학문적 교류를 매개하면서 중국의 한국학 발전을 위해 선도적 역할을 해왔지만, 현재로서는 한국학연구 중심의 전략적 사고의 부재, 전문인력 양성사업의 비체계화, 전문인재양성과 사회적 수요간의 불균형, 과도한 성과중심주의에 의한 학문적 경쟁력 하락 등 문제점들이 존재함을 밝혔다. 결과적으로 대학 자체가 갖고 있는 인적·물적 인프라를 토대로 학과 전문지식과 한국에 대한 정확하고 긍정적인 지식들을 학제적으로 융합시키는 데 중점을 두면서, 궁극적으로 종합적 통찰력과 사고의 유연성을 배양하는 방향으로 전문인력들을 양성해 나가는 것을 목표로 해야 한다는 점을 제시했다. This research elaborates on the role played by Yanbian University in Korean studies in China, in the hope of the promotion of the academic exchange between China and the ROK. Yanbian University has been a pioneer of Korean studies in China and the intermediary of the academic exchange of Korean studies between the two countries. However, problems exist such as absence of strategic focus of Korean studies, and the unsystematic training of specialized personnel which doesn’t meet the demand, as well as decreasing academic competence due to an obsession with achievements. Under the circumstances, the university should systematically integrate the positive and sophisticated Korean studies into its various disciplines by leveraging its infrastructure of human and material resources.
朴東勛(Piao, Dongxun),이성환(Lee, Sunghwan) 동아시아국제정치학회 2015 국제정치연구 Vol.18 No.1
This paper mainly takes the China-North Korea foreign peaks as the main line, exploring the main causes which influence the development of relationship between China and North Korea. On this basis, the paper further analyses the main features of China"s policy toward North Korea during the Xi Jinping era in order to provide policy implications for the Republic of Korea. The results of study shows that although the main variables, such as concepts, politics and so on which support the "special relationship" between China and North Korea, have been weakened, the geopolitical factors are still important variables affecting the relationship between China and North Korea. China will encourage more energy and strive to create order in the peninsula. To further deepen the strategic partnership between China and South Korea is conducive to the correct implementation of the South Korean policy toward North Korea.
Lihua Chen,Dongxun Li,Guosong Zhang,Wei Zhang,Lihua Zhang,Yongmei Guan,Weifeng Zhu,Hongning Liu 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.6
Peimisine, the common ingredient of ‘‘zhebeimu’’groups and ‘‘chuanbeimu’’ groups, is responsiblefor the expectorant and cough relieving effects. The aim ofthis study was to investigate the pharmacokinetics, tissuedistribution and excretion of peimisine in male and femaleSD (Sprague-Dawley) rats by a rapid and sensitive LC-MS/MS (liquid chromatography-tandem mass spectrometry)method used carbamazepine as the internal standard afteroral administration, carbamazepine was stated as an IS. The results showed that peimisine was slowly distributed,and eliminated from rat plasma and manifested lineardynamics in a dose range of 0.26–6.5 mg/kg. Tested byANOVA, there were gender differences in the pharmacokineticparameters of AUC0-t, AUC0-? among a singledose of 0.26, 1.3, 6.5 mg/kg (P\0.05). Drug blood andtissue levels in male rats were significantly higher than thefemale counterparts after oral administration, while boththe males and the females showed high drug levels inspleen, kidney, lung, liver and heart. On the other hand, thepeimisine levels that can be reached in uterus, ovary, testisand brain is low. The excretion study showed that littleadministered peimisine (\0.7 %) was recovered in themale and female bile. Approximately 13.46 and 15.05 %were recovered in female urine and feces, while 43.07 and7.49 % were recovered in male urine and feces, respectively,which indicated that the major elimination route ofmale rats was urine excretion. In addition, there was significantdifferences in total cumulative excretive ratio ofpeimisine in feces (P\0.05) and no significant differencesin the urine (P[0.05) at a dose of 1.3 mg/kg.
김경수,김정현,진성규,김동욱,김동식,김종오,용철순,조관형,Dongxun Li,우종수,최한곤 대한약학회 2016 Archives of Pharmacal Research Vol.39 No.4
To investigate the possibility of developing anovel oral pharmaceutical product using fenofibric acidinstead of choline fenofibrate, the powder properties, solubility,dissolution and pharmacokinetics in rats offenofibrate, choline fenofibrate and fenofibric acid werecompared. Furthermore, the effect of magnesium carbonate,an alkalising agent on the solubility, dissolution andoral bioavailability of fenofibric acid was assessed, amixture of fenofibric acid and magnesium carbonate beingprepared by simple blending at a weight ratio of 2/1. Thethree fenofibrate derivatives showed different particle sizesand melting points with similar crystalline shape. Fenofibric acid had a significantly higher aqueous solubilityand dissolution than fenofibrate, but significantlylower solubility and dissolution than choline fenofibrate. However, the fenofibric acid/magnesium carbonate mixturegreatly improved the solubility and dissolution of fenofibricacid with an enhancement to levels similar with thosefor choline fenofibrate. Fenofibric acid gave lower plasmaconcentrations, AUC and Cmax values compared to cholinefenofibrate in rats. However, the mixture resulted in plasmaconcentrations, AUC and Cmax values levels not significantlydifferent from those for choline fenofibrate. Specifically, magnesium carbonate increased the aqueoussolubility, dissolution and bioavailability of fenofibric acidby about 7.5-, 4- and 1.6-fold, respectively. Thus, themixture of fenofibric acid and magnesium carbonate at theweight ratio of 2/1 might be a candidate for an oral pharmaceuticalproduct with improved oral bioavailability.
김동욱,김영훈,Abid Mehmood Yousaf,김동식,권택관,박정희,김영일,박재현,진성규,김경수,조관형,Dongxun Li,김종오,용철순,우종수,최한곤 대한약학회 2016 Archives of Pharmacal Research Vol.39 No.4
To develop a montelukast sodium–loadedstable oral suspension bioequivalent to the commercialgranules in rats, several montelukast sodium-loaded suspensionswere prepared with a suspending agent, stabilizersand anti-aggregation agents, and their stabilities wereinvestigated by visually observing the sedimentation phenomenonand determining the concentration of the degradationproduct. Moreover, dissolution and pharmacokineticstudies of the optimized formulation were examined in ratscompared to commercial montelukast sodium-loadedgranules. Avicel RC-591 (Avicel), a suspending agent,prevented the sedimentation of these suspensions at[2.496(w/v) per cent composition. Amongst the stabilizers tested,fumaric acid provided the lowest concentration of montelukastsulphoxide (a degradation product) in these suspensionsat 40 C, demonstrating its excellent stabilizingactivity. Furthermore, as an anti-aggregation agent, glyceringave lower amounts of degradation product than thosewith poloxamer 407 and Tween 80. In particular, montelukast-loaded oral suspension, an aqueous suspensioncontaining montelukast sodium/Avicel/fumaric acid/glycerinat a concentration of 312/2496/15.6/62.4 (mg/100 ml),and the commercial granules exhibited similar dissolutionprofiles in 0.5 % (w/v) aqueous solution of sodium laurylsulphate. Moreover, the pharmacokinetics in rats providedby this suspension was comparable to that of the commercialgranules, suggesting that they were bioequivalent. In addition, it was physically and chemically stable at40 C for at least 6 months. Thus, this montelukastsodium-loaded oral suspension, with bioequivalence to thecommercial granules and excellent stability, could be aprospective dosage form for the treatment of asthma.