법랑아세포종에서 apoptosis 연관 인자 발현과 apoptitic index

목동진,박진배,윤혜경,김우형,이희철 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.4

Objective : Ameloblastoma is a common odontogenic benign tumor of the jaw bone. However, it might be able to infiltrate into the adjacent tissue, causing bony destruction and high recurrent rate. The aim of this study is to understand the biologic behavior of ameloblastoma through immunohistochemi cal stainings for apoptosis-related markers of bcl-2, box and caspase-3, examining the apoptosis index and simultanecusly. performing the same tests on MIB-1, which is a marker of cell-proliferationg capacity and p53, which is related with tumor malignancy, and also study the differences between the above marker's expressions and their relationships. Methods and Material : The 39 cases of ameloblastoma were used after the surgery conducted at the Pusan Back Hospital and the Pusan University Hospital during the period from January 1991 to June 2001. The clinical parameters were recorded by patent's age, sex, location of tumor, treatment modality, radiologic findings and recurrences. Based on hematoxylin & eosin findings, they were histologicaly subdivided into follicular and non-follicular. Immunohistochemical stainings for bcl-2, bax, caspase-3. p53 and MIB-1 and TdT-mediated dUTP-biotin nick end labelling method for apoptosis were performed and also statistical analyses were conducted between clinicopathologic parameters and expressions for bcl-2, bax, caspase-3, p53 and MIB-1 and apoptosis. Results : six(15.4%) recurrences were found out of 39 cases. For the patient's age of 40 and above, found a higher recurrence rate(p=0.0182) and multilocular on X-ray(p=0.0640), but there were no significant differences between recurrence rate, sex, location of tumor, treatment modality and histologic subtype. Apoptosis was found in 10(25.6%) of 39 cases and bcl-2 was(20.5%), bax was 21(53.8%), caspase-3 was 19(48.7%). the positive reaction for p53 was 13 cases(33.3%) and 5(12.8) cases for MIB-1. In the positive case of apoptosis and MIB=1, both of them have showed an increasing tendency of high recurrence, but there were no statistical significance. It showed no significant relationship between expression rates of bcl-2, bax, caspase-3 and p53 and recurrence rate. In follicular type, bcl-2 and p53 positive reaction revealed increasing tendency, however, no significant relationship between radiological finding, expressions of apoptosis, bax, caspase-3 and MIB-1 and histologic subtype has found. No significant relationship between apoptosis and apoptosis-related markers as bcl-2, bax, and caspase-3 expressions has found. There was a significant relationship between bcl-2 and p53 expressions(p<0.01), but no significant differences of apoptosis and expressions of bax and caspase-3 according to p53 and MIB-1 expressions have noted. Conclusion : Apoptosis-related bcl-2, bax, caspase-3 expressions and p53 and MIB-1 expressions are involved in the development of ameloblastoma and high recurrent rate is related to the age of more than 40 years, multichambered lesion and the positive reaction for apoptosis and MIB-1. These finding suggest that patient's age, radiologic findings, apoptosis and proliferation activity of ameloblastoma could be useful markers to predict recurrence.

Rule-Baed 자동 프로그래밍 시스템의 설계에 관한 연구

정목동,이광우 부산 외국어 대학교 1987 外大論叢 Vol.5 No.1

Automatic Programming (AP) research in AI, refers to systems that assist humans in some aspect of programming. In this paper, we describe a few AP systems, and we suggest a rule-based AP system using knowledge engineering technique. Our rule-based AP system utilizes VHLL (Very High Level Language) as an input specification and produces data flow language program which is based on parallel processing.

하악지 시상분할골절단술시 과두위치 유지를 위한 간편계측의 술후경과

류동목,이상철,김여갑,이백수,박종오 대한악안면성형재건외과학회 2000 Maxillofacial Plastic Reconstructive Surgery Vol.22 No.6

This study was intended to evaluate condyle position using simple ruler method in sagittal split ramus osteotomy for mandibular setback in 15 patients by paired t-test. We used oblique transcranial radiographs taken before operation and immediate after operation. And we concluded as follows ; 1.The joint spaces changed under 0.2mm were 21.2%, 0.2mm to 1.0mm were 67.7%, above 1.0mm were 11.1%. 2.The mean changes of AJS, SJS, PJS were all increased and SJS was most changed of them, but there is no statistically significant change in SJS. 3,Comparing the preop. measurements with the postop. ones, there is no statistically significant changes in over all joint spaces (P>0.05)

대두단백질 가수분해물의 특성

김동수,양승택,문윤희,류병호,김희숙,염동민,김진목 慶星大學校 1998 論文集 Vol.19 No.1

The present study was conducted to elucidate some characteristics of soy protein hydrolysates. The soy protein was obtained from defatted soy power by the treatment of n-hexan. The hydrolysates of soy protein were prepared from hydrolysis by bromelian and pepsin with the two kinds of samples of precooking for 30 min in steam oven and noncooking, and fractionated through Bio-gel P-4 column chromatography. Fractions of hydrolysates separated on the Bio-gel column chromatography were carried out to SDS-PAG electrophoresis, resulting to show some different bends from 66kD to 14.2kD of molecular weight. In addition, the fractions showed different activities of superoxide dismutase. From these results, it was found that the hydrolysates could be available to use in a lot of food industrial fields as new functional food materials because the hydrolysates had different characteristics in electrophoresis and could increase the activity of superoxide dismutase.

지능형 멀티에이전트를 이용한 웹 기반 원격 교육 시스템

정목동 釜慶大學校 1998 釜慶大學校 論文集 Vol.3 No.2

ITS(Intelligent Tutoring System) is an example of the application of artificial intellitence technology to instruction, and the objective of an intelligent Tutor is to enable a machine to understand both the concept to be taught and how the student can learn that concept. Although the students, however, can learn through ITS personally, there are a lot of difficulties when the teacher teach the students some topics without the limitations of time and space. To overcome these problems, we propose a distance learning model using Internet/Intranet, Java applet, and Corba ORB technology. Until now, there are some problems in ITS such as static knowledge exchanges among the modules, the extensibility of the system, and the flexibility in the dynamic environments. We propose an agent-based distance learning system to solve these problems. The software agent is a system situated within and a part of an enviroment that senses that environment and acts on it, over time, in pursuit of its own agenda and so as to effect what it senses in the future. In Corba, the client program does not need to know whether the objects resides on the same computer or it is located on a remote computer somewhere on the network. And this system is implemented on Windows NT server 4.0/Windows 95 using Internet Information Server3.0, Oracle 7.3 DBMS, Inprise's VisiBroker for Java 3.2 and VisiChannel for JDBC 1.0. Finally, the domain experts, such as the high school teachers, could construct the various distance learning systems by providing the domain knowledge with the prototypical distance learning system.

초음파 의료영상에서 탄성 팬텀

안동기,조개영,정목근 대진대학교 첨단소재연구소 2002 첨단소재연구소논문집 Vol.5 No.-

Ultrasound elastography has drawn a lot of attention because it enables one to image the stiffness of soft tissue whose quantification can lead to differentiation of benign and malignant tissues. To start the research of elastography, we fabricated stiffness phantoms using gelatin and agar, and measured the stiffness of each phantom. Measured stiffness value is about tens kPa. and is dependent on the density of agar and gelatin, and n-propanol. We confirmed that agar-gelatin phantom is good for mimicking elasticity of biological tissue.

FGCS에서 Data Machine과 Knowledge Base Machine의 Architecture에 관한 연구

정목동,이광우 釜山 外國語 大學校 1986 外大論叢 Vol.4 No.1

Japan's FGCS(Fifth Generation Computer System)project was establshed to build a prototype of KIPS(Knowledge Information Processing System) capable of efficiently performing knowledge-based problem-solving and inference. There are there basic functions in FGCS machine as follows. 1) problem-solving and inference machine 2) knowledge base machine 3) intelligent interface machine Among them, this paper descirbes the architecture of the Delta machine which is a relational data base machine in FGCS, and that of knowledge base machine. Especially we'll discuss the Delta machine and the knowledge base machine.

비절차적 프로그래밍 명세의 자동프로그래밍

정목동 부산 외국어 대학교 1990 外大論叢 Vol.8 No.1

Nonprofessional programmers found it very difficult to program using very high level languages such as V, REFINE, GIST, and SETL, because the semantic primitives of these languages are very abstract. Even professional programmers may find a lot of difficulties when they write a relatively long program in these languages. In this paper, a method is suggested for reducing such difficulties by programming with declarative, and aggregate constructs. We design a program specification language, called KAPL, which is implemented on the knowledge-based automatic programming system KAPS, and show the mehtod of automatic programming from a specification in KAPL into C code.

자동차 프런트 샤시 모듈 측정을 위한 머신 비전 시스템 개발

이동목,이광일,양승환 한국공작기계학회 2003 한국공작기계학회 춘계학술대회논문집 Vol.2003 No.-

Today, automobile world market is highly competitive. In order to strengthen the competitiveness, quality of automobile is recognized as important and efforts are being made to improve the quality of manufactured components. The directional ability of automobile has influence on driver directly and hence it must be solved on the preferential basis. In the present research, an automated vision system has been developed th inspect the front chassis module. To interpret the inspection data obtained for front chassis module, new interpreting algorithm have been developed. Previously the control of tolerance of front chassis module was done manually. With the help of the new algorithm developed, the dimension is calculated automatically to check whether the front chassis module is within the tolerance limit or not.

초고속 정보통신망에 바탕을 둔 원격 교육 시스템

정목동 釜慶大學校 1996 釜慶大學校 論文集 Vol.1 No.2

In this paper, we design and implement a prototype of the distant ITS (Intelligent Tutoring System): English Tutor which is running on the Information Superhighway. It is designed for the purpose of teaching the English conversation effectively to the students whose mother tongues are not English. And this system is based on the hypermedia interface and thus provide efficient student interfaces to the students compared with the existing ITSs. The Tutor could choose appropriate tutoring strategies and teach the students effectively according to the contents of the student model which represents the learning status of the students. And also it is based on the Remote Data Management Client/Server model and is implemented on SPARCstation using Oracle 7.3 and PowerBuilder5.0.