교통사고 발생 추이에 관한 연구

양혁준,최봉근,윤태영,최중명,박순영,유동준 慶熙大學校 醫科大學 1997 慶熙 醫大 論文集 Vol.22 No.1

Small Cell Lung Cancer Cell Line을 이용한 Xenoplanted nude mice에서 방서선 치료후 종양의 변화 관찰에 관한 연구

김동욱,유명상,김재욱,이병돈,장혁순 순천향의학연구소 2002 Journal of Soonchunhyang Medical Science Vol.8 No.1

Recently, combination of ionizing radiation with inhibitors of angiogenesis has been reported to improve tumor eradication compared to treatment with irradiation alone. However, the mechanism of this effect have not been defined. For this pupose we established a non-small cell lung cancer model in nude mice. Tumor vascularization was visualized in vivo by MRI using gadolinium-DTPA as contrast agent. Further, cryosections were produced exactly in the MRI slice positions. Since we were interested to examine formation of recurrent tumor irradiation was performed with a single fraction of 6 Gy. This dose caused a partial remission followed by recurrent tumor growth 25 to 35 days after therapy. The process of partial remission as well as formation of the recurrent tumor was examined in 35 nude mice analysing the following parameters: (1) contrast agent enhancement using high-resolution MRI, (2) proliferation of tumor cells and fibroblast using Ki-67 immunohistochemistry, (3) formation of microvessels using CD31 immunohistochemistry. The latter analyses lead to differentiation of three stages. Stage 1(day 1 to 15 after irradiation) was characterized by increasing area of dead cell mass in hematoxylin-eosin stained slides that corresponded to a decrease in tumor cellproliferation as well as contrast agent enhancement. The percentage of Ki-67 positive tumor cells decreased from initially 45.1 ±6.0 to 1.4 %±1.2 % on day 15. Stage 2(days 6 to 20 after irradiation; overlapping with stage 1) was characterized by proliferation of fibroblast leading to formation of fibrotic septae with abundant microvessels. Already during late stage 2 MRI identified new contrast agent enhancing areas. Stage 3(day 20 to 40 after irradiation) was characterized by new tumor cell proliferation. Interestingly, tumor cells almost exclusively proliferated in the direct neighbourhood of the fibroblasts and blood vessels was a condition prior to foramtion of recurrent tumor tissue. Thus our results are in contrast with the view that tumors or recurrent tumors begin as avascular masses that later induce neovascularization. With respect to clinical practice our results suggest that (1) adjuvant anti-angiogenic therapy should not be limited to the day of irradiation but should cover a critical period until day 5 to day 20 after radiotherapy, (2) adjuvant therapy should also include inhibition of fibroblast proliferation, (3) MRI can identify a recurrent tumor 10 to 15 days before occurrence of new tumor growth.

한국무속의 '신병'에 대한 진단분류연구

서동혁,이부영,신민섭,유희철 大韓神經精神醫學會 1996 신경정신의학 Vol.35 No.6

To study nosologically the Korean shaman's initiation sickness, 'Shin-Byong', the authors investigated 29 shamans with Symptom Check List-90-R(SCL-90-R) and questionnaire without visiting and interviewed 70 shamans using SCL-90-R, questionnaire and The Schedule for Affective Disorder and Schizophrenia-Lifetime(SADS-L). All shamans were located in Seoul. The results were as follows : 1) Among symptom groups of SCL-90-R, 'Shin-Byong' were associated with higher scores in depression, somatization, psychoticism and hostility group in descending order. 2) With DSM-Ⅲ-R classification, 87.2% of 'Shin-Byong' cases were mood disorders, Another 8.6% of cases were somatization and dissociative disorders and two disorders were related with dissociative phenomenon. Considering the diagnosis of manic episodes in this study, it seems to be a part of dissociative phenomenon, 'Shin-Byong' is the syndrome that is mainly composed of depression and disorders, which are related with dissociative phenomenon. 3) Shamans have teleologic thinking that 'Shin-Byong' is the phenomenon to receive spirits and diagnose intuitively. They think the main therapeutic method is recieving spirits, In conclusion, 'Shin-Byong' isn't a real disease entity but it is a shamanistic disease concept transformed during the shamanistic therapeutic process for depression patients with high dissociative tendency and dissociative disorder.

구속된 비행 청소년들의 석방 후 6개월 이내 재범의 예측요인

서동혁,정선주,손창호,김원식,고승희,함봉진,조성진,김영기,이중재 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.3

연구목적 : 본 연구는 범법행위로 인해 검참에 구속된 청소년들의 6개월 이내 재범여부를 예측할 수 있는 요인을 분석함으로써 재범의 가능성이 높은 청소년들을 조기에 선별하여 적절한 중재를 시행하기 위한 목적으로 시행되었다. 방 법 : 검찰에 구속된 후 교도소나 소년원에 수감되지 않고 석박된 남자 청소년 125명을 대상으로 하였다. 범죄기록 검토를 통해 사회인구학적, 범죄관련 변인들에 대해 조사하였고, 가족환경 및 부모양육태도, 정신병리, 성격장애, 도덕발달수준 등과 연관된 변인을 알아보기 위해, 부모-이동 갈등해결척도(CTSPC), 한국판 가정환경척도(FES), 한국형 부모양육행동척도, 간이정신진단검사(SCL-90-R), Beck 우울증척도, Beck 불안 척도, 한국판 청소년용 도덕발달수준 평가도구와 한국판 성격장애검사(PDQ-R)를 시행하였다. 결 과 : 전체 연구대상 125명 중 55명 (44%)이 석방 후 6개월 이내에 1회 이상의 재범을 행하였다. 재범군은 비재범군에 비해 구속당시 나이가 어리고, 신체적 학대력이 높았으며, 도덕발달수준이 낮고, SCL-90-R의 적대감척도점수가 높으며 PDQ-R의 반사회적 인격장애에 해당되는 경우가 많았다. 두 집단간 가족환경이나 부모양육태도에는 유의한 차이가 나타나지 않았다. 재범군은 폭력범죄로 구속된 경우가 비재범군에 비해 적었고 첫 범죄시 연령이 어리고 전과가 있는 경우가 많았다. 로지스틱 회귀분석 결과, 재범에 대한 예측요인으로 첫 범죄당시 연령(오즈비=2.91), 반사회적 성격장애(오즈비=2.85), 신체적 학대력(오즈비=2.65)의 세 변인이 포함되었으며, 재범여부에 대한 판별력은 72.8%로 나타났다. 결 론 : 본 연구결과 구속된 청소년들의 재범률이 매우 높다는 사실과 범죄행위에 가담한 연령이 어릴수록, 반사회적 성격장애가 있고 성장과정 중 부모로부터 학대를 받은 경험이 있을수록 반복적인 범죄를 저지를 위험도가 높다는 것을 알 수 있었다. 향후 비행 청소년들의 재범을 예방하기 위해서는 이러한 특성을 가진 고위험군에 대한 조기개입 및 적응을 돕기 위한 프로그램의 개발이 중요할 것으로 사료된다. Objectives : This study was performed to investigate the factors predicting recidivism within 6months after release in arrested juvenile delinquents for proper screening and intervention of high-risk-subjects. Methods : The subjects consisted of 125 arrested male adolescents who were released after legal procedure in prosecutor office and court. The socio-demographic and crime-related characteristics. Were evaluated by police records, and the familial, psychopathology and personality characteristics, and the level of moral development measured by the Conflict Tactics Scale(CTS), Family Environment Scale(FES), Parental Behavioral Inventory, Symptom Checklist-90-Revised(SCL-90-R), Beck Depression Inventory, Beck Anxiety Inventory, Korean form of Moral Developmental Inventory for adolescents, and Personality Disorder Questionnaire-Revised(PDQ-R). Results : The recidivism rate within 6 months after release was 44% of the initial sample, Recidivists were younger and had higher scores on Anger-hostility scale of SCL-90-R and lower principle morality score than nonrecidivists. More recidivists had history of physical abuse and antisocial personality disorder on PDQ-R than nonrecidivists. They also showed the crime-related characteristics of lower percent of violence crime, higher incidence of previous conviction, younger age of the first crime. Among those variables, logistic regression showed that age of first crime, antisocial personality disorder, and history of physical abuse best predicted the recidivism within 6months after release. Conclusion : These results of present study suggest that the recidivism rate of arrested male adolescents is very high, and the age of first crime, antisocial personality disorder and history of physical abuse were key factors predicting recidivism. To prevent repeated crime of delinquent adolescents, the development of programs for those high-risk groups to help rehabilitation and adaptation in community would be essentil.

한약수치에 관한 연구(제 9보) : 炒甘草 제법의 표준화 및 규격화(1) Preparing Standardization and Regulation of Stir-Frying Glycyrrhzia root(1)

최혁재,이우정,박성환,송보완,김동현,김남재 EAST-WEST MEDICAL RESEARCH INSTITUTE KYUNG HEE UNI 2005 東西醫學硏究所 論文集 Vol.2005 No.-

In this study, We carried out the preparing standardization and regulation of processed Glycyrrhizae Radix(PGR) which have been widely used in oriental medicines. Glycyrrhizae Radix(GR) have been generally prepared by the stir-frying, or mix-frying with honey for purpose of decreasing sweetness and augmenting vitality. Firstly, we tried to standardize PGR prepared by the stir-frying. We purchased 14 kinds of PGR and non-processed GR(NPGR) at oriental physician's offices and oriental pharmacies on a nation scale, respectively. The amounts of dry on loss, water extract, diluted ethanol extract, ether extract, total ash, acid insoluble ash, glycyrrhizin(GL), glycyrrhetic acid(GA) and liquiritin(LQ) of them were examined. The amounts of dray on loss, GL and LQ in commercial PGRs showed remarkable decrease, while GA showed increase as compared with NPGR. In order to standardize preparing method of PGR, the effect of heating time on physico-chemical parameters and biological activities were examined. Physico-chemical parameters such as dry on loss, extract amount, GL and LQ contents in PGRs showed decrease, however, GA was increased with heating time as compared with NPGR. Also, GA obtained form heat-treated GR, was found as an artifact in PGRs. PGR was more effective than NPGR in vitro test of DPPH scavenging effect and TBA-Rs reducing effect. PGR and NPGR showed potent hepatoprotective effect on CCl_(1)-intoxicated rats. Especially, PGR prepared by 80 min of heating was the most effective. Considering these results, the optimal condition for PGR preparation was 150℃ for 80min.

결합재 페이스트 충전에 따른 포러스콘크리트의 물성에 관한 기초적 연구

윤상혁,양동일,정근호,김성식,이영도,정상진 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1(구조계)

Although porous concrete is recently used as a pavement at a parking lot, a public squre and a bicycle road, we use without enough examining. Most the maintenance of quality for porous concrete is only dealt with strength and color tone. Also, there is not et enough fundamental data about dynamical properties for strength, rate of void and water permeability. Even when it is applied to at the scene, it is been a matter. Accordingly in this study analyzed influences through the dynamical properties, combination, and time to vibration. After the analyzation, they investigated peculiar dynamics which are strength of porous concrete, rate of void, and water permeability follow the rate of increase on an admixture making pozzolan reaction. This is purpose to improve capacity of the sidewalk permeable concrete and development of the economical technique for pavement.

석이에서 분리한GE974의 혈당상승억제효과

최혁재,김남재,김동현 경희대학교 동서의학연구소 2001 東西醫學硏究所 論文集 Vol.2000 No.-

GE974, isolated from Gyrophora esculenta, showed significant inhibitory effect on several α-glucosidases in vitro in previous study. In the present study, GE974 showed significant inhibitory effect on blood glucose elevation in mice loaded with maltose, sucrose, starch and lactose. Also, it exhibited similar effect in alloxan and streptozotocin induced diabetic mice, and genetic diabetic mice(db/db mice) loaded with maltose in dose dependent manner. These results suggest that GE974 may possess hypoglycemic effect that inhibit competitively α-glucosidase activities.

경고막적 및 고막외적 전극위치에 따른 와우전위의 비교연구

장동임,박철규,이병돈,장혁순,강주원 순천향의학연구소 1995 Journal of Soonchunhyang Medical Science Vol.1 No.1

Electrocochleography is a method of the measurement of electrical events generated either within the cochlea or by primary afferent neurons. It includes measures of summating potential(SP) and cochlear microphonics(CM) from the cochlea, and action potential(AC) from the auditory nerve. There are severval diffefent ways to measure the potentials, mainly transtympanic and extratympanic methods. The purpose of this study is to provide a normal data of eletrocochleography in adults and compare the results obtained by extratympanic and transtympanic methods. The following results were obstained: 1. As the intensity of sound was increased, the SP amplitude and AP amplitude were increased. There was no significant difference between extratympanic and transtympanic method. 2. As the intensity of sound was increased, the SP latency and AP latency were shortened without significant difference between two different methods. 3. As the intensity of sound was increased, the SP/AP ratio was increased without difference in both methods which was less than o.30. 4. Non-invasive method of electrocohleography, the extratympanic method, can be one of the easy method an can be used widely clinically.

석이에서 분리한 GE974의 α-Glucosidase 저해효과

최혁재,김남재,김동현 경희대학교 동서의학연구소 2001 東西醫學硏究所 論文集 Vol.2000 No.-

This study was conducted to search for the α-glucosidase inhibitor from the natural products. In the previous study, the water extract of Gyrophora esculenta exhibited a potent inhibitory effect on α-glucosidase activities. Then, by bioassay-guided fractionation followed by chromatographic seperation of the water extract of Gyrophora esculenta, α-glucosidase inhibitor was isolated as GE974. GE974 showed significant inhibitory activities on some kinds of α-glucosidases in vitro. Its inhibitory mechanism seemed to be competitive for disaccharides. Also, it markedly inhibited α-glucosidases of intestine separated from both nondiabetics and diabetics.

석이중 오르시놀 정량 및 급성독

최혁재,김남재,김동현 경희대학교 동서의학연구소 2001 東西醫學硏究所 論文集 Vol.2001 No.-

In previous study, Gyrophora esculenta showed significant inhibitory effect on α-glucosidases in vitro and blood glucose elevation in vivo In the isolating process of active substance, orcinol was separated from Gyrophora esculenta. Orcinol is known to be toxic, therefore, in this study, it was analyzed by the TLC densitometry method for quantitative determination from Gyrophora esculenta. The average amount of orcinol of Gyrophora esculenta was 0.2%. For the purpose of removing orcinol, the water extract of Gyrophora esculenta was sequentially fractionated by organic solvents, and the acute toxicity of each fraction was assessed in mice. Among them, the LD50 of butanol fraction was 1.19 g/kg(p.o.) and the weight increase of mice in that group was somewhat retarded.