사람 적혈구 조혈인자 DA-3585 의 토끼에 대한 단회 및 4주 반복투여 독성시험

조현(Hyeon Cho),김동환(Dong Hwan Kim),강경구(Kyung Koo Kang),백남기(Nam Gi Baik),김원배(Won Bae Kim) 한국응용약물학회 1998 Biomolecules & Therapeutics(구 응용약물학회지) Vol.6 No.2

DA-3585, a biosynthetic recombinant human erythropoietin has been developed as a treatment for anemia associated with chronic renal failure in Dong-A pharmaceutical Co. Ltd. This study was carried out to assess its acute and subacute toxicities in rabbits. DA-3585 was intravenously administered to rabbits at dose levels of 6250, 12500 or 25000 IU/kg for single dose toxicity study and at dose levels of 100, 500 or 2500 IU/kg/day for 4-week repeated dose toxicity study. In the acute toxicity study, dose up to 25000 IU/kg had no adverse effect on the behavior or body weight gain. Pathological examinations revealed no abnormal gross lesions related to DA-3585. In the subacute toxicity study, all animals survived until termination of treatment. DA-3585 had no influence on clinical signs, food and water intake or on body weight changes. Hematological examination showed increases in the number of RBC, hemoglobin contents and hematocrit values with a dose dependent manner in the animals treated with DA-3585. Histopathological examination revealed erythroid hyperplasia in the bone marrow and extramedullary hematopoiesis in the liver. The changes detected in the hematological and histopathological examination presumably represent exaggerated pharmacological effects of erythropoietin. The NOAEL (no-observed-adverse-effect-level) of DA-3585 was estimated to be 100 IU/kg/ day under this study condition.

혈우병 소견을 가진 뇌출혈 환자 치험(治驗) 1례(例)

정인태,서병관,이현종,하지영,강미경,홍장무,백용현,박동석,최도영,Jung, In-tae,Seo, Byung-kwan,Lee, Hyun-jong,Ha, Ji-young,Kang, Mi-kyeong,Hong, Jang-moo,Baek, Yong-hyeon,Park, Dong-suk,Choi, Do-young 대한침구의학회 2003 대한침구의학회지 Vol.20 No.4

Objective : Hemophilia, a genetically determined disorder, is characterized by abnormality of the coagulation mechanism due to functional deficiency of a specific factor, namely VIII or IX. In this study, the effect of Dong-Si acupuncture therapy on the cerebral hemorrhage patient with hemophilia was evaluated. Methods : We treated him with acupuncture by stimulating Dong-Si acupuncture point(Yuk Wan) and assessed the effect by using manual dynamic evaluation of MRC(Medical Research Council) and Modified Barthel Index. Results : After treatment, the bleeding tendency was grossly reduced and bleeding lesion was absorbed gradually. And manual dynamic evaluation of the upper extremity increased from 4 grade to 5 grade. Conclusions : This result suggest that Dong-Si acupuncture therapy on the cerebral hemorrhage patient with hemophilia was effective. And futher studies are required to concretely prove the effectiveness of Dong-Si acupuncture therapy for treating hemorrhagic diseases.

심연수 저작물의 서지학적 가치와 활용의 문제

김낙현(金洛炫) ( Kim Nak-hyeon ),유춘동(兪春東) ( Yoo Choon-dong ) 한국어문교육연구회 2021 어문연구(語文硏究) Vol.49 No.4

본고의 목적은 일제강점기 尹東柱와 더불어 대표적인 항일 시인으로 일컬어지는 沈連洙 시인 저작물의 書誌學的 가치와 그 활용의 문제를 논의하는 데 있다. 2000년 7월에 중국 용정에서 발굴된 심연수는 시를 비롯하여 시조, 소설, 수필 등 많은 문학 작품을 남겼다. 심연수가 남긴 문학 사료로는 원고류, 노트와 학습장류, 일기와 수첩류, 편지와 엽서, 도서와 사진, 기타 등으로 구분할 수 있다. 심연수의 자료는 대부분 육필원고로서, 작가의 자취가 고스란히 남아있는 草稿이다. 그가 남긴 이러한 각종 문학 사료는 심연수의 생애를 복원해 볼 수 있는 자료이자, 일제강점기 시인이자 문인으로서의 심연수의 모습을 再構해 볼 수 있는 자료이다. 현재 확인된 근현대문인들의 문학 사료의 경우, 심연수와 같이 다양한 자료, 생애 전반을 재구해 볼 수 있는 자료가 전무한 상황이다. 따라서 심연수의 文學 史料는 상당히 중요한 자료적 가치를 지닌 것으로서, 근현대문학 유산이라는 사실을 인식하고 문화재청의 등록문화재로 등록하여 보존, 관리, 활용할 필요가 있다. 심연수의 사료는 近代登錄文化財 등록을 위한 요건을 모두 갖추고 있기에 등록문화재로 등록할 필요가 있다. 현재 가장 시급하고 중요한 과제는 이미 DB로 구축된 상당수의 심연수 자료를 국가기관과 연계하여 자료를 공개할 필요가 있고, 近現代文獻 正理 및 保存의 관점에서 체계화하며, 차후 등록문화재로의 등록 준비를 하여 자료의 관리 방안과 연구 확대를 위한 노력이다. This paper aims to discuss the bibliographical value of the works of poet Shim Yeon-su, who is said to be a representative anti-Japanese poet along with Yun Dong-ju during the Japanese colonial period, and the problems faced in using his works. Excavated in Yongjeong, China in July 2000, Shim Yeon-su left behind many literary works, including poetry, novels, and essays. Literary materials left by Shim Yeon-su can be I have revised “divided into” to “categorized into” as a word choice revision since manuscripts, notebooks, diaries etc. are categories his work can be classified into. Please check for the intended meaning carefully. categorized into manuscripts, notebooks, study books, diaries, letters and postcards, books and photos, and others. Most of his materials are handwritten manuscripts, drafts in which his traces remain intact. The various literary materials he left behind are works that can reconstruct his life, as well as I have revised “appearance” to “identity” as a word choice revision since appearance only refers to the outward persona, while identity comprises of his thoughts and opinions that he must have produced through his poetry and writing. Kindly check for the intended meaning carefully. his identity as a poet and writer during the Japanese colonial period. I have revised this information heavily for structure, readability, language, grammar, and flow. Kindly check for the intended meaning carefully. In the case of the currently confirmed literary sources of modern and contemporary writers, there is no material available to reconstruct his entire life. Therefore, his literary works have considerable material value, and should be recognized as a modern literary heritage. Since his works meet all the requirements for registration as a modern registered cultural property, it should be registered with the Cultural Heritage Administration. This recognition shall result in its preservation, management, and utilization. The most urgent and important task at present is the disclosure of a considerable volume of deep training data already established as a Do you mean database? Please insert the full form since this is the first mention. DB in connection with national institutions, systematize it from the perspective of organizing and preserving modern and contemporary literature, and prepare for registration as a registered cultural property in the future. This statement is a bit abrupt, since there is no indication of a link to the previous sentence. Please consider providing some context here. It is an effort to manage data and expand research.

수종의 내부연결형 임플란트에서 연결부의 형태에 따른 응력분포의 유한요소 분석

정병현,이경제,강동완 대한치과보철학회 2012 대한치과보철학회지 Vol.50 No.2

Purpose: This study was performed to compare the stress distribution pattern of abutment-fixture connection area using 3-dimensional finite element model analysis when 5 different implant systems which have internal connection. Materials and methods: For the analysis, a finite element model of implant was designed to locate at first molar area. Stress distribution was observed when vertical load of 200 N was applied at several points on the occlusal surfaces of the implants, including center, points 1.5 mm, 3.0 mm away from center and oblique load of 200 N was applied 30º inclined to the implant axis. The finite element model was analyzed by using of 3G. Author (PlassoTech, California, USA). Results: The DAS tech implant (internal step with no taper) showed more favorable stress distribution than other internally connected implants. AS compare to the situations when the loading was applied within the boundary of implants and an oblique loading was applied, it showed higher equivalent stress and equivalent elastic strain when the loading was applied beyond the boundary of implants. Regardless of loading condition, the abutments showed higher equivalent stress and equivalent elastic strain than the fixtures. Conclusion: When the occlusal contact is afforded, the distribution of stress varies depending on the design of connection area and the location of loading. More favorable stress distribution is expected when the contact load was applied within the diameter of fixtures and the DAS tech implant (internal step with no tapering) has more benefits than the other design of internally connected implants. 연구 목적: 본 연구는 3차원 유한요소분석을 통해 특징적인 내부연결구조를 갖는 5종의 임플란트의 고정체와 지대주의 연결방식에 따른 응력분산을 알아보고자 하였다. 연구 재료 및 방법: 본 실험을 위한 유한요소모델은 하악 제1대구치부에 임플란트가 식립되고 상부구조물로 3형 금합금을 사용하는 것으로 가정하였다. 응력분산은 200 N의 하중이 교합면의 중심, 중심에 1.5 mm 외측, 중심에서 3.0 mm 외측에 수직으로 가해지고 임플란트의 장축과 30º의 각도로 경사하중이 가해지도록 하여 분석하였다. 유한요소모델에 대한 해석작업은 3G.Author (PlassoTech, California, USA)를 사용하여 이뤄졌다. 결과: 경사가 없는 내부계단 구조를 가지는 DAS tech의 임플란트의 경우, 내부연결구조를 갖는 다른 임플란트에 더 유리한 응력분산을 보였다. 하중이 임플란트 고정체의 외형선 이내에 가해지는 경우와 비교하여 외형선 바깥이나 경사력으로 전해지는 경우 더 높은 응력을 보였으며 하중조건과 관계없이 임플란트 고정체보다는 지대주에 더 큰 응력이 집중되었다. 결론: 교합력이 가해졌을 때 응력분산은 임플란트의 연결부의 형태와 하중이 가해지는 위치에 따라 달라졌으며 내부계단 구조를 가지는 DAS tech의 임플란트를 사용한 경우와 고정체의 외형선 이내에 하중이 가해졌을 경우에 더 유리한 응력분산을 보였다.

Aging 조건에 의한 SBA-15의 Morphological Control

천종현,김시재,박동호 인제대학교 2003 仁濟論叢 Vol.18 No.1

중간세공 분자체 SBA-15는 tetraethoxysilane을 실리카원으로 하여 triblock copolymer를 구조유지 시약으로 사용하여 합성된다. 이러한 중간 세공 분자체의 응용성은 역시 결정의 외관상 형태에 의 해 좌우되어진다. 규칙적인 모양의 입자를 합성하는 것은 나노 공간의 SBA-15를 이용한 나노물질을 제조하는데 응용되기 때문에 매우 중요하다. SBA-15의 형태는 숙성과정의 온도와 시간을 바꿔 줌으로써 조절된다. 특히 rod 형태의 입자의 길이는 숙성 반응과 수열반응의 조합에 의해 조절된다. Morphology 변화는 형태학적 재 구조화에 의해 설명될 수 있다. Mesoporous molecular sieve SBA-15 using triblock copolymer as a structure directing agent and tetraethoxysilane as a silicon source has been synthesized. The applicability of mesoporous molecular sieve depends also on the external morphology of crystallites. The synthesis of regular shaped particle is very important due to the application for the preparation of nano materials using the nano space of SBA-15. By varying the aging temperature and duration, the morphology of SBA-15 was controlled Especially, the length of rod-shaped particle was controlled with the combination of reaction condition of aging and hydrothermal reaction. The change of morphology could be attribute to the metamorphic reconstruction

신주위 공간 및 요근을 침범한 췌장성 가성낭포 1례 : 진단및 경피적 배액술 Diagnosis and Percutaneous Drainage

이현경,오연희,이원재,한동선,오민구,이성우,박수성 동국대학교 경주대학 1993 東國論集 Vol.12 No.-

Pancretic pseudocyst is a well-known complication of pancreatitis and may occur in unusual locations. Involvement of the left perirenal space and psoas muscle is rare. Radiologic findings and management of a surgically proven case of pancreatic pseudocyst extending to left perirenal space and psoas muscle is described.

稅務計劃과 情報의 不確實性

金東律,吳賢美 釜山外國語大學校國際通商硏究所 1997 國際經營論集 Vol.12 No.-

펄스 옥시미터 시스템 구현에 관한 연구

유동주,허 웅,김근이,이호재,임현수 明知大學校 産業技術硏究所 1992 産業技術硏究所論文集 Vol.11 No.-

In this paper, we implemented a pulse oximeter system which is measured oxygen saturation coefficient of a human blood in vivc We use the Beer-Lambert Law to measure the percentage of hemoglobin is oxygen saturation. The oximeter sensor are consisted of two LED(RED and INFRARED LED) and a single photodiode. The photodiode measures lights which transmitted through the tissue from two light source alternately, We calculated a ratio of light transmittance between two LEDs and then, it applied for the oxygen saturation coefficient calculation to formula. As a result, the oxygen saturation coefficient that measured from normal conditions men was 96.43[%]

5급 복합레진충전된 치아에 있어서의 계면조건과 유지구의 영향에 대한 2차원유한요소법적 연구

김동호,유현미,조병훈 大韓齒科保存學會 1998 Restorative Dentistry & Endodontics Vol.23 No.2

STRESS DISTRIBUTION OF ENDODONTICALLY TREATED MAXILLARY SECOND PREMOLARS RESTORED WITH DIFFERENT METHODS : THREE-DIMENSIONAL FINITE ELEMENT ANALYSIS

임동열,김현철,허복,김광훈,손권,박정길 대한치과보존학회 2009 Restorative Dentistry & Endodontics Vol.34 No.1

본 연구의 목적은 근관치료 된 치아를 구조와 물성이 다른 post와 core 그리고 전장관으로 수복한 후 과도한 교합하중을 가했을 때 치아에 나타나는 응력분포를 조사하기 위함이다. 발치 된 상악 제2소구치를 micro-CT로 단층촬영하고 3D Doctor로 윤곽선을 추출한 다음 HyperMesh Ver. 6으로 삼차원 치아모형을 만들고 다음과 같은 세 가지 방볍으로 수복한 유한요소모형을 제작하였다. 1) 스테인레스 스틸 포스트와 복합레진 코어 그리고 도재소부전장금관으로 수복한 모형 2) fiber 포스트와 복합레전 코어 그리고 전부도재관으로 수복한 모형 . 3)포스트, 코어와 전장관이 일체형인 간접복합레진 EndoCrown으로 수복한 모형. 형성된 모형의 협측 또는 설측교두에 500N의 하중을 가하였으며 하중의 방향은 치아 장축에 대해 45도 이었다. 치관부와 치근부의 von Mises 응력을 ANSYS 9.0 프로그램으로 분석한 결과 포스트와 코어의 형태보다는 전장관 재료의 탄성계수가 근관치료된 상악 소구치의 응력분포를 좌우하였다. 치관부에서는 재료의 탄성계수가 높은 전장관으로 수복한 모형이 낮은 응력분포를 보였다. 치근부에서는 재료의 탄성계수가 낮은 전장관으로 수복한 모형이 낮은 응력분포를 보였다 The purpose of this study was to evaluate the influence of elastic modulus of restorative materials and the number of interfaces of post and core systems on the stress distribution of three differently restored endodontically treatcd maxillary second premolars using 3D FE analysis Model 1, 2 was restored with a stainless steel or glass fiber post and direct composite resin. A PFG or a sintered alumina crown was considered. Model 3 was restored by EndoCrown. An obliquc 500 N was applied on thc buccal (Load A) and palatal (Load B) cusp. The von Mises stresses in the coronal and root structure of each model were analyzed using ANSYS. The elastic modulus of the definitive restorations rather than the type of post and core system was thc primary factor that influenced the stress distribution of endodontically treated maxillary premolars. The stress concentration at thc coronal structure could be lowered through the use of definitive restoration of high elastic modulus The stress concentration at the root structure could be lowered through the use of definitive restoration of low elastic modulus.