사람 적혈구 조혈인자 DA-3585 의 토끼에 대한 단회 및 4주 반복투여 독성시험

조현(Hyeon Cho),김동환(Dong Hwan Kim),강경구(Kyung Koo Kang),백남기(Nam Gi Baik),김원배(Won Bae Kim) 한국응용약물학회 1998 Biomolecules & Therapeutics(구 응용약물학회지) Vol.6 No.2

DA-3585, a biosynthetic recombinant human erythropoietin has been developed as a treatment for anemia associated with chronic renal failure in Dong-A pharmaceutical Co. Ltd. This study was carried out to assess its acute and subacute toxicities in rabbits. DA-3585 was intravenously administered to rabbits at dose levels of 6250, 12500 or 25000 IU/kg for single dose toxicity study and at dose levels of 100, 500 or 2500 IU/kg/day for 4-week repeated dose toxicity study. In the acute toxicity study, dose up to 25000 IU/kg had no adverse effect on the behavior or body weight gain. Pathological examinations revealed no abnormal gross lesions related to DA-3585. In the subacute toxicity study, all animals survived until termination of treatment. DA-3585 had no influence on clinical signs, food and water intake or on body weight changes. Hematological examination showed increases in the number of RBC, hemoglobin contents and hematocrit values with a dose dependent manner in the animals treated with DA-3585. Histopathological examination revealed erythroid hyperplasia in the bone marrow and extramedullary hematopoiesis in the liver. The changes detected in the hematological and histopathological examination presumably represent exaggerated pharmacological effects of erythropoietin. The NOAEL (no-observed-adverse-effect-level) of DA-3585 was estimated to be 100 IU/kg/ day under this study condition.

심연수 저작물의 서지학적 가치와 활용의 문제

김낙현(金洛炫) ( Kim Nak-hyeon ),유춘동(兪春東) ( Yoo Choon-dong ) 한국어문교육연구회 2021 어문연구(語文硏究) Vol.49 No.4

본고의 목적은 일제강점기 尹東柱와 더불어 대표적인 항일 시인으로 일컬어지는 沈連洙 시인 저작물의 書誌學的 가치와 그 활용의 문제를 논의하는 데 있다. 2000년 7월에 중국 용정에서 발굴된 심연수는 시를 비롯하여 시조, 소설, 수필 등 많은 문학 작품을 남겼다. 심연수가 남긴 문학 사료로는 원고류, 노트와 학습장류, 일기와 수첩류, 편지와 엽서, 도서와 사진, 기타 등으로 구분할 수 있다. 심연수의 자료는 대부분 육필원고로서, 작가의 자취가 고스란히 남아있는 草稿이다. 그가 남긴 이러한 각종 문학 사료는 심연수의 생애를 복원해 볼 수 있는 자료이자, 일제강점기 시인이자 문인으로서의 심연수의 모습을 再構해 볼 수 있는 자료이다. 현재 확인된 근현대문인들의 문학 사료의 경우, 심연수와 같이 다양한 자료, 생애 전반을 재구해 볼 수 있는 자료가 전무한 상황이다. 따라서 심연수의 文學 史料는 상당히 중요한 자료적 가치를 지닌 것으로서, 근현대문학 유산이라는 사실을 인식하고 문화재청의 등록문화재로 등록하여 보존, 관리, 활용할 필요가 있다. 심연수의 사료는 近代登錄文化財 등록을 위한 요건을 모두 갖추고 있기에 등록문화재로 등록할 필요가 있다. 현재 가장 시급하고 중요한 과제는 이미 DB로 구축된 상당수의 심연수 자료를 국가기관과 연계하여 자료를 공개할 필요가 있고, 近現代文獻 正理 및 保存의 관점에서 체계화하며, 차후 등록문화재로의 등록 준비를 하여 자료의 관리 방안과 연구 확대를 위한 노력이다. This paper aims to discuss the bibliographical value of the works of poet Shim Yeon-su, who is said to be a representative anti-Japanese poet along with Yun Dong-ju during the Japanese colonial period, and the problems faced in using his works. Excavated in Yongjeong, China in July 2000, Shim Yeon-su left behind many literary works, including poetry, novels, and essays. Literary materials left by Shim Yeon-su can be I have revised “divided into” to “categorized into” as a word choice revision since manuscripts, notebooks, diaries etc. are categories his work can be classified into. Please check for the intended meaning carefully. categorized into manuscripts, notebooks, study books, diaries, letters and postcards, books and photos, and others. Most of his materials are handwritten manuscripts, drafts in which his traces remain intact. The various literary materials he left behind are works that can reconstruct his life, as well as I have revised “appearance” to “identity” as a word choice revision since appearance only refers to the outward persona, while identity comprises of his thoughts and opinions that he must have produced through his poetry and writing. Kindly check for the intended meaning carefully. his identity as a poet and writer during the Japanese colonial period. I have revised this information heavily for structure, readability, language, grammar, and flow. Kindly check for the intended meaning carefully. In the case of the currently confirmed literary sources of modern and contemporary writers, there is no material available to reconstruct his entire life. Therefore, his literary works have considerable material value, and should be recognized as a modern literary heritage. Since his works meet all the requirements for registration as a modern registered cultural property, it should be registered with the Cultural Heritage Administration. This recognition shall result in its preservation, management, and utilization. The most urgent and important task at present is the disclosure of a considerable volume of deep training data already established as a Do you mean database? Please insert the full form since this is the first mention. DB in connection with national institutions, systematize it from the perspective of organizing and preserving modern and contemporary literature, and prepare for registration as a registered cultural property in the future. This statement is a bit abrupt, since there is no indication of a link to the previous sentence. Please consider providing some context here. It is an effort to manage data and expand research.

혈우병 소견을 가진 뇌출혈 환자 치험(治驗) 1례(例)

정인태,서병관,이현종,하지영,강미경,홍장무,백용현,박동석,최도영,Jung, In-tae,Seo, Byung-kwan,Lee, Hyun-jong,Ha, Ji-young,Kang, Mi-kyeong,Hong, Jang-moo,Baek, Yong-hyeon,Park, Dong-suk,Choi, Do-young 대한침구의학회 2003 대한침구의학회지 Vol.20 No.4

Objective : Hemophilia, a genetically determined disorder, is characterized by abnormality of the coagulation mechanism due to functional deficiency of a specific factor, namely VIII or IX. In this study, the effect of Dong-Si acupuncture therapy on the cerebral hemorrhage patient with hemophilia was evaluated. Methods : We treated him with acupuncture by stimulating Dong-Si acupuncture point(Yuk Wan) and assessed the effect by using manual dynamic evaluation of MRC(Medical Research Council) and Modified Barthel Index. Results : After treatment, the bleeding tendency was grossly reduced and bleeding lesion was absorbed gradually. And manual dynamic evaluation of the upper extremity increased from 4 grade to 5 grade. Conclusions : This result suggest that Dong-Si acupuncture therapy on the cerebral hemorrhage patient with hemophilia was effective. And futher studies are required to concretely prove the effectiveness of Dong-Si acupuncture therapy for treating hemorrhagic diseases.

수종의 내부연결형 임플란트에서 연결부의 형태에 따른 응력분포의 유한요소 분석

정병현,이경제,강동완 대한치과보철학회 2012 대한치과보철학회지 Vol.50 No.2

Purpose: This study was performed to compare the stress distribution pattern of abutment-fixture connection area using 3-dimensional finite element model analysis when 5 different implant systems which have internal connection. Materials and methods: For the analysis, a finite element model of implant was designed to locate at first molar area. Stress distribution was observed when vertical load of 200 N was applied at several points on the occlusal surfaces of the implants, including center, points 1.5 mm, 3.0 mm away from center and oblique load of 200 N was applied 30º inclined to the implant axis. The finite element model was analyzed by using of 3G. Author (PlassoTech, California, USA). Results: The DAS tech implant (internal step with no taper) showed more favorable stress distribution than other internally connected implants. AS compare to the situations when the loading was applied within the boundary of implants and an oblique loading was applied, it showed higher equivalent stress and equivalent elastic strain when the loading was applied beyond the boundary of implants. Regardless of loading condition, the abutments showed higher equivalent stress and equivalent elastic strain than the fixtures. Conclusion: When the occlusal contact is afforded, the distribution of stress varies depending on the design of connection area and the location of loading. More favorable stress distribution is expected when the contact load was applied within the diameter of fixtures and the DAS tech implant (internal step with no tapering) has more benefits than the other design of internally connected implants. 연구 목적: 본 연구는 3차원 유한요소분석을 통해 특징적인 내부연결구조를 갖는 5종의 임플란트의 고정체와 지대주의 연결방식에 따른 응력분산을 알아보고자 하였다. 연구 재료 및 방법: 본 실험을 위한 유한요소모델은 하악 제1대구치부에 임플란트가 식립되고 상부구조물로 3형 금합금을 사용하는 것으로 가정하였다. 응력분산은 200 N의 하중이 교합면의 중심, 중심에 1.5 mm 외측, 중심에서 3.0 mm 외측에 수직으로 가해지고 임플란트의 장축과 30º의 각도로 경사하중이 가해지도록 하여 분석하였다. 유한요소모델에 대한 해석작업은 3G.Author (PlassoTech, California, USA)를 사용하여 이뤄졌다. 결과: 경사가 없는 내부계단 구조를 가지는 DAS tech의 임플란트의 경우, 내부연결구조를 갖는 다른 임플란트에 더 유리한 응력분산을 보였다. 하중이 임플란트 고정체의 외형선 이내에 가해지는 경우와 비교하여 외형선 바깥이나 경사력으로 전해지는 경우 더 높은 응력을 보였으며 하중조건과 관계없이 임플란트 고정체보다는 지대주에 더 큰 응력이 집중되었다. 결론: 교합력이 가해졌을 때 응력분산은 임플란트의 연결부의 형태와 하중이 가해지는 위치에 따라 달라졌으며 내부계단 구조를 가지는 DAS tech의 임플란트를 사용한 경우와 고정체의 외형선 이내에 하중이 가해졌을 경우에 더 유리한 응력분산을 보였다.

개별의사결정과 집단의사결정의 성과비교

김동헌,유성용 홍익대학교 동북아연구소 1999 東北亞硏究 Vol.3 No.-

5급 복합레진충전된 치아에 있어서의 계면조건과 유지구의 영향에 대한 2차원유한요소법적 연구

김동호,유현미,조병훈 大韓齒科保存學會 1998 Restorative Dentistry & Endodontics Vol.23 No.2

한국 경제위기와 경제체질의 전환 : 정부 개입에서 시장원리로

정동현 釜山 大學校 經營 經濟 硏究所 2007 經營 經濟 硏究 Vol.26 No.1

현대인의 죽음 : Well-Ending에 대한 종교학적 접근

송현동 한신인문학연구소 2008 종교문화연구 Vol.- No.10

The purpose of this article is to examine the relation between thanatology and religious studies in contemporary Korea and, based on that examination, it tries to explore a new trend in religious studies. People generally trend to avoid talking about issues related to death. Perhaps this is because we are afraid of death. On the one hand, in vein well-being, well-ending become the center of public interest in korea society Well-ending culture modify attitudes on death in Korea. With the result that, thanatology and death education attract an academic attention in psycholoay, medical science, philosophy, the science of nursing, and anthropology. The results of this study can be summarized as follows: Religious Studies make death an object of scientific study and must be discussed separately from theology. Thanatology, the scientific study of death, is the research of related with dying, death, and cure. In view of this, Thanatology and Religious studies have an common interests in study on death.

다발성으로 피부절을 수반한 대상포진 뇌수막염 1예

한동철,박종호,신원철,이영배,박현미,신동진 대한노인병학회 2004 대한노인병학회지 Vol.8 No.1

소기업 경영실태 및 생산구조 분석 : 부산지역 제조업을 중심으로

주수현,이동철 한국중소기업학회 2003 中小企業硏究 Vol.25 No.1

본 고에서는 소기업의 국민경제적 역할과 중요성 그리고 지역경제에서 차지하는 비중은 부산을 중심으로 살펴보았다 츠뭡로그비용함수를 설정하여 추정한 결과 규모의 경제가 존재하였다. 알렌편대체탄력성은 1보다 낮아 비탄력적이었으며 소기업이 대기업보다 탄력성이 높아 요소간의 대응이 더 신속한 것으로 나타났다 한편 가격탄력성의 경우도 비탄력적이었으며 소기업이 대기업보다 민감하게 반응하는 것으로 나타났다. 싫증분석의 결과 요소간 상호관계와 가격에 대한 요소간 대체정도가 기업규모별로 상이하게 나타나 기업규모에 따라 차별적인 정책이 필요함을 보여 주었다. The economic roles and importance of small businesses in a nation, and proportional importance of the regional economy were examined in this paper, specially focused on Busan area, The effects of economies of scale in all sized companies were also appeared as a result of the inference based on the translog cost function in this paper. The Allen's Partial Elasticities of Substitution, less than 1, was inelastic, And adaptations among factors of small businesses were more fast than those of big companies by the higher coefficient of the Allen's Partial Elasticities of Substitution. The Price elasticities of factor demand was also inelastic, and small businesses were more sensitively responsible to the substitution among production factors than that of big companies As the results of substantial analyses, the difference of relatedness in production factors and the level of substitutions among factors at the price were differently appeared by the size of company. Therefore it is suggested that administrative policies were executed differently according to the company's size.