충수주위 농양의 임상적 고찰

김동환,정우식,류성열,장태수 대한대장항문학회 1997 Annals of Coloproctolgy Vol.13 No.2

외란관측기를 이용한 커플링구조의 동기제어계 구성에 관한 연구

변정환,여동준 여수대학교 2002 論文集 Vol.17 No.-

In this study, a methodology of synchronous control which can be applied to position synchronization of a two-axes rotating system is developed. Based on coupling structure, the synchronous control system is composed of disturbance observer, speed and synchronous controllers. The speed controller is designed to follow speed reference. And the disturbance observer is designed to restrain synchronous error generated by torque disturbance. In addition, the synchronous controller is designed for a viewpoint of accurate synchronization. The effectiveness of the proposed method is verified through various simulation

릴레이 작동 전압 조정 자동화 방법 안출 및 평가

최동엽,국금환 국립경상대학교 공과대학 부설 첨단소재연구소 1992 尖端素材 Vol.2 No.-

The objectives of this study are not only improving the international competition of the relay itself but also partially solving the technical and financial problems featured by common bottlenecks of the SME(small and medium sized enterprises) for efficient assembly automation. For the purpose of these objectives, several topics are studied as followings. -. Analyzing the adjustment process and determining the specification of the automation system. -. Determining the layout for the automation system to meet the determined specification. -. Detail design of the automation system for relay adjustment and inspection. -. Control system design. -. Automation system development and performance test.

소설의 영원한 내적 형식 : 길 그리고 여행

김동환 한성대학교 인문과학연구원 2010 소통과 인문학 Vol.11 No.-

This article aims to examine the journey form which is important on the development stage of novels. The discussion begins from the question journey form still will have validity in korean modern novels. For the discussion, I divide the journey form into three type - returning to starting point type, opened linear type, closed linear type. The analysis is focused on the texts won the Lee-Sang Literature Awards Grand Prize. The award representatives award systems in korea novels. The conclusions are as follows, 1. In korean modern novels, journey form is still meaningful device. Over Half of the targets contain the form. 2. The space that is essential factor of the form, appears very multiply. After 1990's specific city and place in foreign country is embodied more meaningful device than domestic. 3. In returning to starting point type it tend to be based on the epistemology as the individual’s approach, by comparison in linear type as the social collective’s approach. 4. The novelistic critical mind is more deeply embodied in closed linear type than returning to starting point type.

장기 알콜투여가 생쥐의 간 및 신장, 위장 조직 손상에 미치는 영향

김진택,김동환,안상현 東國大學校韓醫學硏究所 1994 東國韓醫學硏究所論文集 Vol.3 No.-

Alcohol is a major risk factor for several diseases and excessive, long-term alcohol consumption are cause physical alteration-fatty liver, hepatitis, cirrhosis, breaking down, Wernicke-karasakoffs syndrome, weight loss, and poor immunity-in virtually all organ and tissue, This study was observed that liver, kindney, and stomach were altered in mouse by the effect of chronic alcohol administration. The mouse were sacrificed to obtain the tissue after mouse were orally injected with 25% ethanol 18㎖/kg/day for 120days. The tissue were stained by hematoxylin and eosun and then obseved by light microscope. The results of this study were as follows : 1. The congestion was appeared in liver after 120days alcohol administration 2. The destruction of glomerulus were increased and parietal cell of Bowman's capsule were swelled such as cuboidal cell after 12days alcohol administration. The congestion was appeared in alcohol administrated group. 3. The mucosa and gasstric pit were destructed and the ulceration was appeared in stomach after 120days administration. The parietal cells and chief cells were damaged. Above results were shown that the tissue were damaged by chronic alcohol administration.

보중익기탕 합 향사육군자탕이 복수암 유발 생쥐 비장의 세포성 면역활성에 미치는 영향에 관한 면역조직화학적 연구

김호현,김동환 세명대학교 한의학연구소 2001 韓醫學硏究所 論文集 Vol.3 No.-

This study investigated that cellular immunity of spleen is effected by administration of Bojungikgitang and Hyangsayukgunjatang extract (BHE) in Sarcoma 180 cells bearing mice (SBA). The BHE was orally administered daily for 21 days at the dose of 0.743 g/㎏ after Sarcoma 180 cells were intraperitonealiy injected with 1.0×106 cells. The specimen was immunohistochemically stained by Avidin biotin complex methods using monoclonal antibody to L3T4 (CD4), Ly-2 (CD8), IL-2R-α (CD25R-α) and NK-1.1 (CD56) after embedding in paraffin. In BHE treated mice, the number of helper T cells, cytotoxic T cells, and IL-2 receptors are remarkaboy increased in the periarterial lymphatic sheath of white pulp (WP) and penicillary artery and trabecular artery in red pulp (RP). The degree of positive reactions is stronger than SBA. The number of natural killer cells is dramatically increased in marginal zone of WP and penicillary artery of RP and degree of positive reactions is stronger than SBA. Above results show that BHE is effective to increase cellular immunity. It can be considered that the BHE may play a role as efficacious antitumor agent.

連翹敗毒散加味方이 알러지성 접촉피부염에 미치는 影響2 : - 알러지성 접촉피부염 유발로 손상된 생쥐 상피세포 완화를 중심으로 -

김호연,김동환 세명대학교 한의학연구소 2001 韓醫學硏究所 論文集 Vol.3 No.-

After allergic contact dermatitis (ACD) elicitated by Dinitrochlorobenzene treatment, BALB/c female mice administered Yunkyopaedocksangamibang (YPGM) extract are observed to investigate the mitigative effect of YPGM on ACD. The BALB/C mice are sensitized by one application of 25 ㎕ of 5% 2,4-dinitrochlorobenzene (DNCB) onto an abdominal skin and 2 weeks later, the mice were challenged with 4 ㎕ of 2.5% DNCB. The YPGM extract (0.51 g/㎏/day) were daily administered to mice suffered from ACD. At obsevation of epidermal morphology, diminishment of hyperplasia, decrease of damaged epithelial cell in stratum spinosum, and decrease of infiltration of lymphocyto are seen in YPGM treated mice. At obsevation of fine epidermal structures, nuclear shrinkage, cytoplasmic vacuolation, and enlarge of intercellular space are diminished in YPGM treated mice. At observation of TUNEL stain, the evoke of apoptosis is decreased in YPGM treated mice. As results indicated that the YPGM extract administration work on the mitigation of epidermal damages in mice with ACD.

NOD/SCID 마우스 모델을 이용한 인간 제대혈 혼합이식에서의 생착 양상 분석

정양조,김동욱,조빈,강영주,박보배,김혜정,김태규,오일환 대한조혈모세포이식학회 2002 대한조혈모세포이식학회지 Vol.7 No.2

연구배경: 제대혈은 골수에 비해 많은 장점을 가지고 있음에도, 이식 후 성적에 있어 총세포수에 의해 좌우되며, 한 개의 태반으로부터 얻을 수 있는 총세포수의 한계가 있어 주로 소아에 국한되고 있다. 따라서 제대혈 응용의 확대를 위해 생착량을 늘이기 위한 방법으로 다중공여자에 의한 제대혈 혼합이식을 늘일 수 있는지 연구하기 위하여, 본 연구에서는 주조직적합성 형별로 조합된 제대혈을 NOD/ SCID 생쥐에 이식하는 방법으로, 혼합생착의 가능성을 연구하였다. 방법: 조합된 2개 공여자로부터 얻어진 제대혈들을 단일이식 및 혼합이식하여, 혼합이식된 숙주에 생착된 세포를 PCR-SSOP 방법을 사용하여 공여자 별로 추적하였다. 또한 각 공여자세포의 상대적 생착비율을 대조군인 단일제대혈 이식에서 얻어진 생착량과 비교하는 정량적 비교도 함께 하였다. 결과: 총단핵구를 혼합이식한 실험군에서는 주조직적합성의 일치도에 관계없이 한쪽공여자의 세포가 다른쪽에 비해 우세한 편향생착을 보였다. 그러나 임파구를 비롯한 Lineage 양성세포를 제거한 실험군에서는 주조직적합성의 불일치에도 불구하고 뚜렸한 생착의 공존이 관찰되었다. 결론: 본 연구는 제대혈의 생착량을 증가를 목적으로 총단핵구를 혼합이식할 경우 한쪽공여자의 세포에 의해 편중되며, 이것을 이식 후 생착과정에서의 두 종류의 세포의 경쟁에 의해 초래된다는 것을 보이고 있다. 또한 이러한 경쟁은 제대혈에 포함되어 있던 임파구들에 의한 것이며, 생착공존을 위하여는 공여자간 주조직적합성의 일치도 보다, 임파구의 제거가 더 중요하다는 것을 보여주고 있다. Background: Although umbilical cord blood (UCB) has been an attractive alternatives for bone marrow cells, application is limited to pediatric case due to limitation in total number of nucleated cells, that is a single most important factor for outcomes of UCB transplantation. Therefore, increasing overall engraftment by mixed transplantation of UCB derived from multiple donor should comprise one strategy to circumvent the posed limitation of UCB transplantation. In order to investigate the feasibility of establishing co-engraftment by multi-donor UCB cells, we carried out a xenotransaplantation study using NOD/SCID mice for systemic analysis of results on the input-based control of single unit transplantation. Methods: UCB units with various extent of HLA-matchings were co-transplanted into NOD/SCID mice along with single unit transplantation control. The relative contributions of engraftment by cells from each donor-derived were analyzed by HLA polymorphism using PCR-SSOP. Results: In all HLA-based mixed transplantation of total nucleated UCB cells, engraftment of one donor predominated over the other despite that equivalent amount of engraftments were achieved by single donor transplantation. When lineage depleted UCB units were co-transplanted, significant degree of co-engraftments were observed regardless of HLA disparity. Conclusion: Our result show that one donor cells dominate over the other in mixed UCB transplantation and that it is due to competition between donor cells during post-transplantation process. Our results suggest that immune cells contained in UCB unit mediate such competitioin and that 6 locus HLA matching would not be sufficient to prevent the competition.

항공기 고장진단에 효율적인 병렬 생성 시스템에 관한 연구

이종성,채수환,송동호 한국항공대학교 1996 論文集 Vol.34 No.-

실시간처리 분야의 전문가 시스템에 있어서 빠른 추론을 통해 응답 시간을 줄이는 것이 가장 중요하다. 최근 생성 시스템의 속도 향상을 위해 병렬처리 기술에 대한 연구가 활발하다. 본 연구는 규칙베이스를 이용하여 구성된 고장진단 시스템에 적합한 병렬후향추론과 병렬후향추론을 효율적으로 수행하는 병렬 생성 시스템을 제안하고, 이를 항공기 공장진단문제 영역중 엔진 고장영역에 적용하여 제안된 시스템의 성능을 평가하였다. 제안된 시스템의 성능평가를 위해 이산사건 시뮬레이션을 기반으로 한 DEVS-Scheme을 이용하여 모델링 및 시뮬레이션을 수행하였고, 그 결과 제안된 시스템이 제안된 병렬후향추론을 사용하는 항공기 고장진단 시스템에 효율적임을 입증하였다. It is most important in expert systems applied to real-time application fields is to reduce the response time by using efficient inference. Recently many researches have been studied on parallel processing technologies for improving the speed of production systems. We propose a parallel production system which efficiently operates fault diagnostic systems constructed by rule-base system with backward chaining inference. We evaluate and analyze performance of the proposed parallel production system by applying it to the aircraft engine fault diagnosis of aircraft fault diagnosis as an example. By using DEVS-Scheme we simulate the proposed system and then evaluate its performance. Simulation results show that the proposed parallel production system is efficient for the fault diagnostic systems with backward chaining inference.

PID제어계에서 신경망의 역전파 알고리즘을 이용한 모형 헬리콥터의 자세 제어

이오걸,박두환,정동일,이준탁,이용길 동의공업대학 1998 論文集 Vol.24 No.1

This paper deals with a PID neural networks control technique that efficiently control, its elevation angle and azimuth. The Helicopter system is taken as the control system in the current paper, and a mathematical model is derived to design the multivariable controller. The coefficients of the controller are automatically adjusted by the back- propagation algorithm of the neural network. The simulation results using MATLAB verified it's usefulness.