解放後 濟州硏究槪觀(Ⅲ) : 社會科學分野

金榮敦,高南旭,夫萬根,申幸澈,金泰保,許鐵洙 제주대학교 탐라문화연구소 1985 탐라문화 Vol.0 No.4

解放後 濟州硏究槪觀 : 國文學 民俗分野

金榮敦,申幸澈,姜榮奉 제주대학교 탐라문화연구소 1982 탐라문화 Vol.0 No.1

1. In this survey, we summarized the general tendency of the researches on Jeju Do's dialect, oral traditional literature and folk-coustom from the Liberation to the late 1970s, as a part of basic preparation for publishing the academic history of Jeju Do. 2. We can look upon the Korean Civil War as the same time like "Renessance" in Jeju Do and the academic world in Jeju Do had begun as Jeju college was opened and had developed according to the growth of it. It is not until the 1960s that books on the dialect and oral traditional literature were published. So the study of those began to be conducted and gradually expanded into even folk-coustom. And around the 1970s, the fields of the investigation and study were expanding and subdivided and also the close investigation were made. The joint investigation and study activities were activated and foreign scholars' visits to Jeju Do increased gradually. 3. The researches on Jeju Do's dialects were made with putting special stress on collection of its vocabularies, morphology and phonology. Their basis had already been implanted in the early 1960s. The researches on its syntax and semantics have still been waste and there are many unsolved problems, such as establishment of study of its part of speech and the system of consonant, systematic researchs on all kinds of suffix, etc. Many Korean and foreign scholars pay consistent attention to such subjects. Nowadays, it seems to be time to refocus on the dialects of Jeju Do from the viewpoint of new accidence which is currently examined by the Korean language circle. Of all these tasks, the collection of the vocabulary of the dialects must be formed on a large scale. 4. The collection and the study of folksongs among the genres of oral traditional literature had been carried out relatively earlier and the results were outstanding. The analyses of the folksongs, however, have been made with putting special stress on only people's consciousness viewpoint in the folksongs rather than on the other many sided points of view. And compared with the development of analysis of their stories, the study of their musical value does not seem to be sufficient and the collection and the study of children's songs do not make special progress any more. Contrary to folktales, the collection and the study of folk religious songs are very active but those of proverbs, riddles, the tales of taboo and so on make slow progress. It is since 1979 that the researches on oral traditional literature had been conducted by the method of investigation through field works. 5. When we classify the field of folk-coustom into that of society, folk religion, folk art, season coustoms and the like, the studies of kinsfolk, family and rites for passage, that is, birth, marriage and death, are relatively active and those of folk religion made considerable progresses. The studies of manufacturing techniques except women divers still stayed behind. And among the studies of food, clothing and housing, that of housing life makes a progress considerably, too. The investigation on folk art and season coustoms makes poor one. It is not until the 1970s that the study of folk-coustom, which have attracted attention from the early 1960s, have become very active and the investigation have done so. 6. There are a lot of tasks worth investigating and researching from the various point of view, such as dialects, oral traditional literature and folk-coustom of Jeju Do. The careful analysis and researches are urgent, but above all, the collection of study materials must be promoted systematically. In addition, we must keep it in mind that we might lose several precious study materials by a rapid change of society.

Lecture 2: Collaborative Research for Clinical Unmet Needs

( Don Haeng Lee ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1

최근 정부과제의 동향은 연구자 수요보다는 의료현장의 수요를 충족하기 위한 제품을 개발하기 위한 과제가 증가되고 있다. 따라서 필요한 컨소시엄 구성이 과제마다 상이하기 때문에 임상의사의 참여가 반드시 요구되는 과제에서 임상의사의 강점을 부각시킬 수 있는 전략이 필요하다. 실제로 과제 지원 시 중요한 평가요소는 연구과제의 창의성, 연구내용 및 추진체계의 우수 성, 연구책임자의 우수성, 기대 및 파급효과 등이다. 이러한 평가요소들 중 임상적 필요성을 개발 초기단계부터 임상의사들의 참여로 제품의 임상적 유용성을 극대화하는 것이 임상의사들의 중요한 역할이라 판단된다. 임상의들의 미충족수요를 해결하기 위해서는 공학자, 약학자 또는 기초의학자 등과의 협력이 필수적이다. 이를 위해서는 임 상의들이 융합연구에 대한 적극적인 자세가 필요한데 연구하고자 하는 분야의 전문가를 찾아보고 초청하여 강의를 듣고 실제 임상현장에서의 개발이 필요한 부분을 설명하고 관련된 국가과제에 같이 지원하는 것 등이 실질적인 방법 중의 하나라고 생각 한다. 임상의는 공학을 모르고 공학자는 임상적 의의를 모르는 경우가 많기 때문에 병원에 초청하여 실제 현장에서의 필요성을 설명 하는 것이 중요하다. 예를 들면 내시경과 관련된 연구개발을 하는데 공학자들이 내시경을 이해하지 못하면 개발이 실패할 가 능성이 높기 때문에 실제 내시경시술 장면을 보게 되면 개발 타겟을 확실히 알게 되므로 성공가능성을 높일 수 있다. 이러한 융합연구에 있어 열린 마음으로 서로 신뢰하는 자세가 연구 못지않게 중요하다.

Hemostatic materials in non-variceal upper gastrointestinal hemorrhage

Don Haeng Lee,Weonjin Ko 소화기인터벤션의학회 2020 Gastrointestinal Intervention Vol.9 No.1

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Hemostatic materials in non-variceal upper gastrointestinal hemorrhage

Don Haeng Lee,Weonjin Ko 소화기인터벤션의학회 2020 International journal of gastrointestinal interven Vol.9 No.1

제 2형 Cirgler-Najjar 증후군

이돈행(Don Haeng Lee),최정현(Jung Hyun Choi),안홍석(Hong Suk Ahnn),윤일국(Il Kuk Youn),장태정(Tae Jung Chang) 대한소화기학회 1995 대한소화기학회지 Vol.27 No.4

Type 2 Crigler-Najjar syndrome is a rare hereditary disorder characterized by chronic, nonhe- molytic and modest unconjugated hyperbilirubinemia. There are currently reported three types ot' syndrome: Gilbert, Type 1 and 2 Crigler-Najjar syndrome. Type 2 Crigler-Najjar syndrome is cau- sed by hereditary glucuronosyl transferase deficiency and it can be differentiated from the Gilbert and Type 1 Crigler-Najjar syndrome by the severity of hyperbilirubinemia and its response to phenobarbital administration. We expierienced a 22 year-old male patient who had shown persistent jaundice and unconjugated hyperbilirubinemia from adolescence. It was noted that several persons had shown jaundice among his maternal family. The plasma bilirubin concentration was elevated after fasting for 48 hours and was decreased dramatically by phenobarbital treatment. (Korean J Gastroenterol 1995;27:4S8 - 492)

원발성 간내 담관세포암의 임상적 고찰

이돈행(Don Haeng Lee),송시영(Si Young Song),전재윤(Chae Yoon Chon),한광협(Kwang Hyub Han),정재복(Jae Bock Chung),문영명(Young Myoung Moon),강진경(Jin Kyung Kang),박인서(In Suh Park) 대한소화기학회 1995 대한소화기학회지 Vol.27 No.6

N/A Background/Aims: Intrahepatic cholangiocellular carcinoma is devided into the peripheral and hilar type according to the location. The clinical features of hilar type is similar to that of extrahe- patic bile duct cancer and the peripheral type similar to the hepatocellular carcinoma. We conducted this study to identify the differences of clinical characteristics and survival rates between the hilar and peripheral type. Methods: We analyzed 42 cases with intrahepatic cholangiocellular carcinoma who were histologically confirmed from January 1981 to December 1990 at Severance Hospital, Yonsei University. Results: The mean age was 57.2 years, the male to female ratio 2.2 to 1. The most common symptom was abdominal pain(83.3%), jaundice was more frequently encountered in hilar type(33.3%) than peripheral type(6.7%) and abdominal mass more common in peripheral type(48.4%) than hilar type(11.1%). Associated diseases were infestation of Clonorchis sinensis(19.0%), liver cirrhosis(19.0%) and intrahepatic bile duct stones(7.1%). The elevation of serum CEA(more than 5 ng/ml) was noted in 52.0%. On abdominal ultrasonography, the hypere- choic pattern in hilar type and the hypoechoic pattern in peripheral type were commonly noted. The hepatic arterial angiography showed mostly hypovascular pattem(72.7%). Local invasion was more frequent in hilar type than peripheral type, however distant metastasis was more common in peripheral type. The overall median survival of 36 cases was 5.5 months, and hilar type 5.3 months and peripheral type 5.9 months. According to the treatment modalities, the survival rates in cases underwent curative resection(median survival; 12.5 months) and in cases with combination of chemotherapy, radiotherapy and hyperthermia(median survival; 9.6 months) were significantly higher than that of no treatment group(median survival; 2.0 months)(pC0.05). Conclusions: To improve the survival in cases with intrahepatic cholangiocellular carcinoma, the efforts to diagnose in early stage should be recommanded, especially in the high risk group such as the patients with Clonorchiasis and intrahepatic bile duct stones. Additionally we should remind the differences including the pattern of metastasis between hilar and peripheral types in the management of these patients. (Korean J Gastroenterol 1995;27: 679 - 689)

Enhancement of a Liver Form of Cytosolic Phospholipase $A_2$ Activity by Methylmercury

Huh, Don-Haeng,Kang, Mi-Sun,Sohn, Dong-Hun,Na, Doe-Sun,Kim, Dae-Kyong Korean Society for Biochemistry and Molecular Biol 1998 Journal of biochemistry and molecular biology Vol.31 No.2

Methylmercury (MeHg), which is widely distributed in the environment, is well known for both its acute and chronic poisoning effects on the human health; however, the precise biochemical mechanisms by which this compound elicits its toxicity in a cellular level are still poorly understood. To examine whether MeHg-induced liver injury involves activation of Phospholipase $A_2$ ($PLA_2$), the $PLA_2$ activity of control and MeHg-administrated livers was measured. MeHg stably enhanced a liver form of cytosolic $PLA_2$ activity, which exhibited several biochemical properties similar to those of the 100 kDa $cPLA_2$, except in its elution profile of a DEAE-5PW HPLC, and it migrated as a molecular weight of 80 kDa in Western blot analysis. This blotting analysis also indicated that the MeHg-induced enhancement of the activity could be due to the increase in the amount of the enzyme protein rather than a stable modification of the enzyme such as phosphorylation. Our data also showed the higher myeloperoxidase activity in MeHg-administrated liver than in the control, suggesting that this increase in the amounts of the 80 kDa $PLA_2$ and its activity may be resulted from infiltration of neutrophils into the liver during a hepatic injury process such as MeHg-induced inflammation. Taken together, these data suggest that MeHg-induced liver injury may be mediated by activation of the 80 kDa form of liver cytosolic $PLA_2$.

융합연구의 실제: From Bench to Bioventure

이돈행 ( Don Haeng Lee ) 대한간학회 2017 임상연구방법론워크숍 Vol.2017 No.1

소화기영역에서의 약물방출스텐트

이돈행 ( Don Haeng Lee ) 대한소화기학회 2007 대한소화기학회지 Vol.49 No.5

Gastrointestinal (GI) cancers cause obstruction of the GI tract including biliary tree. In advanced GI cancer, endoscopic stent insertion is the treatment of choice. However, the current stent allows only mechanical palliation of obstructed GI tract and has no anti-tumor effect. The primary role of a drug eluting stent (DES) in gastrointestinal malignancy is that it decreases the tumor re-growth and sustains the stent patency. This might not be as impressive as the effect of a vascular DES which decreases the incidence of restenosis and thus increases the survival rate of the patient. However, in terms of improving the quality of life of the patient, maintaining the stent patency is one of the most important task of GI doctors. With an advanced technology in stent production, Korea would be able to play an active role in the field of DES especially with more advanced anti-tumor effect. Moreover, advances in this type of drug delivery system will enable the development of local treatment of GI malignancy using endoscopy. (Korean J Gastroenterol 2007;49:294-299)