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Ivonne Domínguez-Martínez,Ofelia Gabriela Meza-Márquez,Guillermo Osorio-Revilla,José Proal-Nájera,Tzayhrí Gallardo-Velázquez 한국응용생명화학회 2014 Applied Biological Chemistry (Appl Biol Chem) Vol.57 No.1
Fourier transform mid-infrared (Mid-FTIR) spectroscopyin conjunction with multivariate analysis was used to predict thecapsaicin content, ascorbic acid, total phenolic compounds, andantioxidant activity of Capsicum annuum L. variety serrano. Twomultivariate calibrations, partial least square (PLS), and principalcomponent regression (PCR) were optimized to construct thecalibration models. The best models used to quantify the abovementioned compounds were obtained with the PLS algorithm andcoefficients of determination (R2) greater than 0.998 as well as astandard error calibration less than 0.098. The results demonstratedthat Mid-FTIR spectroscopy in combination with multivariateanalysis can be effectively used for to quantify the capsaicin,ascorbic acid, total phenol content, and antioxidant activity ofCapsicum annuum var. serrano. Mid-FTIR spectroscopy incombination with multivariate calibration offers rapid, easy samplepreparation, is environmentally friendly, and is operationallyuncomplicated, demonstrating the significant advantages of thechemometric models compared with conventional methods ofanalysis.
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Mechanics Predicts Effective Critical-Size Bone Regeneration Using 3D-Printed Bioceramic Scaffolds
Blázquez-Carmona Pablo,Mora-Macías Juan,Martínez-Vázquez Francisco J.,Morgaz Juan,Domínguez Jaime,Reina-Romo Esther 한국조직공학과 재생의학회 2023 조직공학과 재생의학 Vol.20 No.6
BACKGROUND: 3D-printed bioceramic scaffolds have gained popularity due to their controlled microarchitecture and their proven biocompatibility. However, their high brittleness makes their surgical implementation complex for weightbearing bone treatments. Thus, they would require difficult-to-instrument rigid internal fixations that limit a rigorous evaluation of the regeneration progress through the analysis of mechanic-structural parameters. METHODS: We investigated the compatibility of flexible fixations with fragile ceramic implants, and if mechanical monitoring techniques are applicable to bone tissue engineering applications. Tissue engineering experiments were performed on 8 ovine metatarsi. A 15 mm bone segment was directly replaced with a hydroxyapatite scaffold and stabilized by an instrumented Ilizarov-type external fixator. Several in vivo monitoring techniques were employed to assess the mechanical and structural progress of the tissue. RESULTS: The applied surgical protocol succeeded in combining external fixators and subject-specific bioceramic scaffolds without causing fatal fractures of the implant due to stress concentrator. The bearing capacity of the treated limb was initially altered, quantifying a 28–56% reduction of the ground reaction force, which gradually normalized during the consolidation phase. A faster recovery was reported in the bearing capacity, stiffening and bone mineral density of the callus. It acquired a predominant mechanical role over the fixator in the distribution of internal forces after one postsurgical month. CONCLUSION: The bioceramic scaffold significantly accelerated in vivo the bone formation compared to other traditional alternatives in the literature (e.g., distraction osteogenesis). In addition, the implemented assessment techniques allowed an accurate quantitative evaluation of the bone regeneration through mechanical and imaging parameters.
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Natural products in the research of cholesterol gallstones
Ibrahim Guillermo Castro-Torres,Minarda De la O-Arciniega,Janeth Gallegos-Estudillo,Mariano Martínez-Vázquez,Elia Brosla Naranjo-Rodríguez,Miguel Ángel Domínguez-Ortíz,Jesús Samuel Cruz-Sánchez 셀메드 세포교정의약학회 2013 TANG Vol.3 No.3
Cholesterol gallstones are a digestive disease of high prevalence that has many risk factors; for this reason, research has focused mainly on how to prevent it rather than how to treat it. Many molecules of the hepatic, bile and intestinal systems are involved in the pathophysiology of this disease, making it very difficult to find a therapeutic target. The pharmacological treatment is limited, so when gallstones generate symptoms, medical treatment indicates gallbladder removal. Ursodeoxycholic acid is used to dissolve cholesterol stones, and ezetimibe and statins are other drugs with possible applications in the treatment of this disease. Given the small number of drugs that have been developed for treating this disease, the research of natural products becomes of paramount importance. Resources such as black radish, glucosinolates, fenugreek, capsaicin, curcumin, garlic, and onion, have all shown significant effects in the prevention and treatment of cholesterol gallstones. In this review, we made a synthesis of the scientific reports that deal with these natural products and that can serve as antecedents for finding a way to treat the most common disease of the gallbladder.
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Magnetic field emergence in mesogranular-sized exploding granules observed with sunrise/IMaX data
Palacios, J.,Blanco Rodrí,guez, J.,Vargas Domí,nguez, S.,Domingo, V.,Martí,nez Pillet, V.,Bonet, J. A.,Bellot Rubio, L. R.,Iniesta, J. C. del Toro,Solanki, S. K.,Barthol, P.,Gandorfe EDP Sciences 2012 Astronomy and astrophysics Vol.537 No.-
<P>We report on magnetic field emergences covering significant areas of exploding granules. The balloon-borne mission SUNRISE provided high spatial and temporal resolution images of the solar photosphere. Continuum images, longitudinal and transverse magnetic field maps and Dopplergrams obtained by IMaX onboard SUNRISE are analyzed by local correlation traking (LCT), divergence calculation and time slices, Stokes inversions and numerical simulations are also employed. We characterize two mesogranular-scale exploding granules where~10<SUP>18</SUP> Mx of magnetic flux emerges. The emergence of weak unipolar longitudinal fields (~100 G) start with a single visible magnetic polarity, occupying their respective granules’ top and following the granular splitting. After a while, mixed polarities start appearing, concentrated in downflow lanes. The events last around 20 min. LCT analyses confirm mesogranular scale expansion, displaying a similar pattern for all the physical properties, and divergence centers match between all of them. We found a similar behaviour with the emergence events in a numerical MHD simulation. Granule expansion velocities are around 1 kms<SUP>−1</SUP> while magnetic patches expand at 0.65 kms<SUP>−1</SUP>. One of the analyzed events evidences the emergence of a loop-like structure. Advection of the emerging magnetic flux features is dominated by convective motion resulting from the exploding granule due to the magnetic field frozen in the granular plasma. Intensification of the magnetic field occurs in the intergranular lanes, probably because of being directed by the downflowing plasma.</P>
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