후두 및 하인두 편평세포암종에서 E-cadherin의 면역조직화학적 발현

도남용,나한조,이도용,허준,최지윤,이홍영,임성철 조선대학교 2000 The Medical Journal of Chosun University Vol.25 No.2

Background and Objectives : The cell-cell adhesion molecule E-cadherin is necessary for the maintenance of the epithelial cellular structure. We were designed to confirm the significance of E-cadherin as a marker for differentiation and invasiveness of squamous cell carcinoma of the larynx and hypopharynx. Materials and Methods : Our study was investigated for the immunohistochemical expression of the epithelium-specific cell adhesion molecule E-cadherin in formalin fixed paraffin embedded tissue specimen of 32 cases of squamous cell carcinoma of larynx and hypopharynx. Results : The positive expression of E-cadherin was 56.3%(18 cases) in squamous cell carcinoma of the larynx and hypopharynx. Decreased E-cadherin expression was a stastistically significant correlation with a increased grade of lymph node stage and clinical stage. Reduced expression was seen in the large tumor size and poorly differentiated tumors, but these result was not statistically significant. Conclusion : The expression of E-cadherin may be related with progression of squamous cell carcinoma of the larynx and hypopharynx. But these correlation were not sufficient for the prognostic indicators in squamous cell carcinomas of the larynx and hypopharynx.

우리말 '몸'의 의미 확장 연구

배도용(Do Yong Bai) 언어과학회 2003 언어과학연구 Vol.24 No.-

The purpose of this study is to examine how form and meaning extension of the human body term `mom` in Korean is composed and how the direction of the meaning extension is realized on the assumption that various meanings of a word constitute a category. It is important how central meanings should be prescribed in the meaning extension, which has been frequently neglected in previous studies. Until the accurate prescription of central meanings is made, it has been impossible to understand which constituents of a central meaning extend to marginal meanings and how they do. Also we can not confirm that marginal meanings extend orderly and systematically, even though they look scattered in disorder. As a result, the semantic field of `mom` makes it possible to establish a section of the lexical system in the Korean language and the conception network of `mom` to explain a section of the Korean national spirit.

후두 및 하인두 암종에서 p53단백 발현과 Espstein-Barr Virus 검출

최영환,도남용,나한조,이도용,노용훈,김완수,최종선 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.2

Background and Objectives : When p53 cancer suppressor gene, occurs gene deletion or point mutation, malignancy develops by loss of p53 function with abnormal p53 protein. The Epstein-Barr virus (EBV) is the causative agent of certain type of lymphoma and undifferentiated nasopharyngeal carcinoma. However, the role of EBV as a causative factor in other head &eck tumors is not fully elucidated except nasopharyngeal carcinoma. This study, the author examined that p53 expression and detection rate of EBV correlate to development of laryngeal and hypopharyngeal squamous cell carcinoma(SCC) and play the possible role of prognostic indicators. Materials and Methods : Formalin-fixed, paraffin-embedded tissue specimen from 32 cases of larynx and hypopharyngeal squamous cell carcinomas were studied by immunohistochemical staining for p53 and EBV. The results of analysis were compared with clinicopathological parameters. Results : p53 expression was 56.3% (18 cases) and the detection rate of EBV was 43.6% (14 cases) of 32 cases in laryngeal and hypopharyngeal squamous cell carcinomas. p53 expression was correlate with histologic grade (p<05) only. Detection of EBV was not correlate with clinicopathological parmeters. Conclusion : These results suggest p53 expression and the detection of EBV may be related with development of laryngeal and hypopharyngeal squamous cell carcinoma. And, the expression of p53 protein can be used as a prognosticator in laryngeal and hypopharyngeal squamous cell carcinoma under certain limitation.

大學英語 敎授法 開發에 관한 硏究

李昌希,李容晟,金龍度 부산외국어대학 1984 논문집 Vol.2 No.-

This thesis aimed at studying about the effect teaching method in college English (College Cultral English) in general view of educational fields with reference to the established theories and methods of language learning. 1) It is claimed that College English education, which is the important and last level, takes the merits from both the Empiricist Approach of Structural Linguistics and the Rationalist Approach to language learning. So it is needed that instructor teaches students to comprehend the rules of grammar and sentence structures, and that he must guide them to create many new sentences in each situation and to have the habits of language through patten practices. 2) It is rather effect that instructor teaches English language with dividing skill-fields to written language and spoken language. And it is good that spoken language is taught by native speaker and written language, by Korean English instructor. If Korean English instructor teaches spoken language because of educational conditions, it is effect that the uses audio-visual and materials in language laboratory. 3) In case of teaching in classroom which is regular classwork by instructor, English teaching must be focused to students. That is, it is that students study positively English, and instructor helps them. Also it must be to develop comprehension power and writing ability. In order to do that, it must be focused for student to comprehend and catch the ideas of the materials. 4) Also, in case of outer classwork which is not regular classwork, English teaching is very important in college. College authority must not limit the use of labs in the only special subjects of regular classwork, must open the Language Labs for the more possible time for students to study English by themselves for their free times. And in order to make the effect use of Labs, authority and instructor make special learning program by use of audio-video materials.

만성중이염의 골도청력변화

박선홍,노용훈,이도용,나한조,김용기,최봉남,도남용 朝鮮大學校 附設 醫學硏究所 1996 The Medical Journal of Chosun University Vol.21 No.1

We have usually experienced bone conduction impairment in chronic otitis media, but it is unclear that raised bone conduction threshold is due to the reflection of cochlear dam- age and / or Carhart effect ( an artificial elevation of bone conduction threshold due to conductive defect ) or both. The purpose of this study is to verify the influence of the artificial elevation of the bone conduction threshold in chronic otitis media and to estimate Carhart effect. A total of 336 cases of tympanoplasty with unilateral chronic otitis media without any other causes of sensorineural hearing loss was studied. The average threshold levels of the bone conduction in diseased ears ranged from 18.5dB at 4kHz to 12.1dB at 250Hz The longer duration of the disease, the larger perforation size, the more severe damage of the middle ear structure and the presence of the cholesteatoma made bone conduction threshold increased. The postoperative thresholds of bone conduction were Improved in 36 cases (40.4%) of the 89 cases that underwent operation with type I tympanoplasty technique without electrie drilling. The degree of the maximal improvement was 14.3dB at 2000Hz and the minimum was 8.8dB at 250Hz. but these result did differ from a statistically significant degree. The result suggest that the bone conduction threshold in chronic otitis media is elevated artificially by conductive defect and improved by successful reconstructive surgery.

장애인 태권도 선수의 여가활동에 대한 실태 분석

이성훈(Lee Sung Hoon),김용국(Kim Yong Kook),정현도(Jung Hyun Do) 세계태권도문화학회 2014 세계태권도문화학회지 Vol.- No.9

The purpose of this research is to provide basic data suggesting the direction of disabled taekwondo player's healthy leisure activity through the analysis on actual status of disabled taekwondo players' leisure activity. The subject was 41 maleㆍfemale players participating in the 32th national athlete meet for the disabled. Data of this research was analyzed by SPSS WIN 18.0 program. For the concrete statistical method, frequency analysis and cross analysis were done so as to examine general characteristics of research subject and differences of awareness on leisure activity. To examine interests in leisure activity and differences of satisfaction, t-test and one-way Anova were conducted. And, a positive analysis was verified in significance standard p<.05, p<.01, p<.001. As a result of Scheffe method as a post-hoc test, following conclusions were obtained. First, interests in leisure activity were higher as the time of participation in contest was higher and they learned taekwondo because they want to do. For the motives of participation in leisure activity, main factors were pleasure of life, relief of stress and emotional stability. Satisfaction for leisure activity was generally more than medium level, 3 scores. What are the most necessary for leisure activity were leisure of time, money(costs), friends to enjoy together and facility/location. Obstacles of leisure activity were insufficient money(costs), insufficient time, insufficient location/facility, so they had an awareness similar to the necessary of leisure activity. Therefore, players who have lots of times to participate in taekwondo contest and learned taekwondo because they wanted to do can be the group with active tendency. And, active group showed high demands of interests and satisfaction in leisure activity. Second, costs of monthly leisure activity were increased as current grade was higher and the number of participation in contest was more. Daily taekwondo training time was longer as they were women and the number of participation in contest was more. Daily leisure time of weekdays was longer as the number of participation in contest was more. Leisure time of weekends and holidays was less than 4 hours in more than half players. For the location of leisure activity, male players preferred leisure sports center and internet cafe and female players preferred leisure sports center and shopping/department store. Especially, group with lot of times of participation in contest showed long training time, much leisure activity time and high activity costs. It means disabled taekwondo players participating in many times showed long activity time of taekwondo, but participated in various leisure activities. Third, for the form of leisure activity, they mainly preferred rest/sleeping and leisure sports. For the favorite sports as leisure activities, male players preferred soccer, basketball and swimming and female players preferred soccer, inline skating and balling. For the people they enjoy leisure activity together, there were friends, colleagues and alone in may cases. Therefore, there were various activities preferred by gender. Fourth, for the activation measures of leisure activity, there were leisure of time, facility/location and cultivation of professional instructor in order. Therefore, leisure of time was insufficient as a factor which is the most necessary for leisure activity and hinders leisure activity. So, activity program which can be approached easily around us on weekdays and holidays should be developed.

혈관질환 정보관리 시스템

김동익,김덕경,허세호,이병붕,김용신,김은숙,문지영,도영수,신성욱,김동수,김만태,진재욱,김용신 대한혈관외과학회 2002 Vascular Specialist International Vol.18 No.1

As medical technology progresses rapidly, there is a rise in the average age along with the Korean dietary lifestyle becoming more westernized, which leads to an increase in the number of vascular disease patients in Korea. Thus, we need to manage the medical information of a disease systematically in order to diagnose and treat constructively. However, since there has been no standardized method of man agement to date, a great deal of information could not be properly utilized nor studied. Therefore, the departments of Cardiology, Radiology and Neurology of Samsung Seoul Hospital recently got together to develop an information management system called the Vascular Data System. This program was developed to be run on win98 O/S, upper Pentium Ⅲ, and upper 128 MB Memory, and its source code is Dephi 4.0. It was configured for the user to set the configurations as well as do a variety of search and analysis. If this program were to be updated continuously, it may be used extensively as well as in various parts of clinical research activities.

비강 및 부비동 종양에서의 종양혈관형성에 관한 면역조직화학적 연구

도남용,노용훈,박선홍 조선대학교 부설 의학연구소 2002 The Medical Journal of Chosun University Vol.27 No.1

Background and Objectives : Angiogenesis is essential for the growth of solid tumors. Microvessel density(MVD), which represent a measure of tumor angiogenesis, have been found to have prognostic significance in many tumor types for predicting an increased risk of metastasis. However, the significance of angiogenesis in sinonasal malignant tumor remains controversial. The purpose of this study was to asses the tumor vascularity using the highly specific endothelial cell marker CD34, and the expression of its related protein p53, in sinonasal malignant tumors. Materials and Methods : The study samples were obtained after surgical removal of 27 cases of inverted papilloma(IPs), 5 cases of IPs with malignant transformation(IP-MT), 16 cases of squamous cell carcinoma(SCC) in sinonasal cavity. Microvessels were stained with anti-CD34 and p53 expressions were assessed by immunohistochemical staining. Results : The degree of tumor angiogenesis in squamous cell carcinoma group was higher than in inverted papilloma group, and which reached at highest level in IP-MT(p<05). The p53 expressions were increased as tumor progressed, which was statistically significant also(p<05). Significant correlation between MVD and p53 expressions was observed in IP(p<05) but there were no correlation in IP-MT and SCC. Conclusions : These results suggest that overexpression of p53 and MVD in the sinonasal tumors seemed to be associated with tumorigenesis but further studies on tumor angiogenesis of sinonasal tumors are needed before it can be adopted as a prognostic marker.

알파-1 아드레날 차단제에 의한 만성골반통증후군의 치료 효과 증진

이용성,김경도 중앙대학교 의과대학 의학연구소 2004 中央醫大誌 Vol.29 No.3·4

This study was undertaken to evaluate the effects of the combination of alpha-1 adrenergic blocker (doxazosin XL 4 mg) and antibiotics (fluoroquinolones) in the treatment of chronic pelvic pain syndrome. A total of 40 patients with chronic pelvic pain syndrome were assigned to 2 groups (20 patients respectively). Antibiotics was administered to all patients of group 1 and 2. Alpha-1 adrenergic blocker was given to patients of group 2. Mean followup was 4 weeks. The assessment of the treatment effects was analysed with National Institutes of Health-Chronic Prostatitis Symptom Index (NIH-CPSI). A Wilcoxon matched pairs test was used for statistical analysis of data. The pre-treatment symptom index, as measured by total NIH-CPSI were 29.5±12.5 (group 1) and 30.2± 13.0 (group 2) respectively. After administering antibiotics and alpha-1 adrenergic blocker, the total NIH-CPSI were 20.5±9.2 (group 1) and 12.2±4.2 (group 2, p<0.001) respectively. The alpha-1 adrenergic blocker appeared the positive effect in treating patients with chronic pelvic pain syndrome. The patients treated with a combination use of alpha-1 adrenergic blocker and antibiotics caused better enhanced clinical improvement in comparison with patients receiving only antibiotics.

영국의 아동보육제도 연구

도미향,이용복 남서울대학교 2001 남서울대학교 논문집 Vol.7 No.-

The objective of this article lies in examining the problems and seeking the solutions of child care in Korea through the study of the UK day care system. The UK introduced the concept of education or care for two-to-seven year children in the 19th century. Robert Owen established day care center for the first time in 1816, and made foundation for social adaptaion of children in poverty. But the child care system in the UK was in a primitive development stage until 1870, when the debate on the school age began. Even after the Second World War the conditions for child did not improve much. Most married working women were paid by the hour, and children were looked after by their father, relatives, or private childminder. In 1990s the shortage of labor force grew worse, increasing the number of working women who had little infants. This situation put the child care to top priority of all the political and economic issues. Nonetheless, public care service was provided limitedly children and families with special welfare needs. As a result, the public financial support for child care continued to be at a standstill. In this way the governmental intervention has been minimized, letting the employers and private markets provide the greater par of care services for working women whose percentage of employment ascending steadily. At the background of such passive governmental policy is the philosophy that the best place for a child is his or her home and that child care is primarily a personal problem which can be solved effectively by the market mechanism.