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      • Effectiveness and Safety of Pemetrexed Versus Docetaxel as a Treatment for Advanced Non-small Cell Lung Cancer: a Systematic Review and Meta-analysis

        Di, Bao-Shan,Wei, Kong-Ping,Tian, Jin-Hui,Xiao, Xiao-Juan,Li, Yan,Zhang, Xu-Hui,Yu, Qin,Yang, Ke-Hu,Ge, Long,Huang, Wen-Hui,Zhang, Fang-Wa Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.8

        Background: Our aim was to conduct a meta-analysis to compare the efficacy and safety of pemetrexed and docetaxel for non-small cell lung cancer (NSCLC). Materials and Methods: We systematically searched the Cochrane Library, PubMed, Embase, China Biology Medicine Database for randomized controlled trials (RCTs) comparing the efficacy and toxicities of pemetrexed versus docetaxel as a treatment for advanced NSCLC. We limited the languages to English and Chinese. Two reviewers independently screened articles to identify eligible trials according to the inclusion and exclusion criteria and assessed the methodological quality of included trials, and then extracted data. The meta-analysis was performed using STATA12.0. Results: Six RCTs involving 1,414 patients were identified. We found that there was no statistically significant differences in overall response rate, survival time, progression-free survival, disease control rate, and 1-2yr survival rate (p>0.050) but it is worthy of mention that patients in the pemetrexed arms had significantly higher 3-yr survival rate (P=0.002). With regard to the grade 3 or 4 hematological toxicity, compared with docetaxel, pemetrexed led to lower rate of grade 3-4 febrile neutropenia, neutropenia, and leukocyts toxicity (p<0.001). There was no significant difference in anemia between the two arms (p=0.08). In addition, pemetrexed led to higher rate of grade 3-4 thrombocytopenia toxicity (p=0.03). As for the non-hematological toxicities, compared with docetaxel, pemetrexed group had lower rate of grade 3-4 diarrhea and alopecia. Conclusions: Pemetrexed was almost as effective as docetaxel in patients with advanced NSCLC. At the same time, pemetrexed might increase the 3-yr survival rate. As for safety, pemetrexed led to lower rate of grade 3-4 febrile neutropenia, neutropenia, leukocytes, diarrhea and alopecia toxicity. However, it was associated with a higher rate of grade 3-4 thrombocytopenia.

      • KCI등재

        Inactive Fusarium Fungal strains (ZSY and MJY) isolation and application for the removal of Pb(II) ions from aqueous environment

        Jianyou Long,Gutha Yuvaraja,Shuyi Zhou,Jianying Mo,Huosheng Li,Dinggui Luo,Di Yun Chen,Lingjun Kong,Munagapati Venkata Subbaiah,Guda Mallikarjuna Reddy 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.72 No.-

        In this study, two Fusarium strains namely ZSY and MJY were successfully isolated from the contaminatedsoil of Dabaoshan smelter in Shaoguan City, and utilised as a biosorbent for the removal of Pb(II) ions fromaqueous solution. Effect of pH (6), agitation speed (150 rpm), biomass concentration (1 g/L), initial Pb(II)concentration, contact time (60 min), and effect of temperature (323 K) was investigated. Kinetic andisotherm results showed that the removal of Pb(II) ions onto ZSY and MJY werefitted well with thepseudo-second-order and Langmuir isotherm models (232.56 and 263.16 mg/g). In addition thermodynamicstudies were also discussed.

      • Research of Control Strategy on DC Side of Hybrid Energy Storage in Micro Grid

        Tieyan Zhangi,Di Bai,Zheng Yang,Zhibin Long,Baiyu Gao 보안공학연구지원센터 2016 International Journal of Grid and Distributed Comp Vol.9 No.9

        The uncertainty and fluctuation brought by distributed type of intermittent power generation in micro grid bring huge challenges to power quality of micro grid in isolating operation and power control in parallel operation. Nevertheless energy storage is able to well solve this problem. Hybrid energy storage integrates the respective advantages of storage battery and supercapacitor to have improved the performance of energy storage system. Service life of storage battery is tightly related to its charging/discharging times and problem of frequent charging/discharging storage battery still exists in current hybrid energy storage technology. In this paper, it respectively puts forward control strategies for storage battery and supercapacitor. As to control strategy for storage battery, it uses double-layered control strategy, namely, single loop control and power hysteresis control, to feedback low-frequency fluctuation of power and reduce charging/discharging frequency of storage battery. As to control strategy for supercapacitor, it uses inner loop current with power to control voltage in outer loop so as to feedback high-frequency fluctuation of power and it is able to well maintain stability of DC bus voltage. Simulation results suggest the validity of aforesaid control strategies.

      • KCI등재

        Current Status of Etiology, Epidemiology, Clinical Manifestations and Imagings for COVID-19

        Jiang Meng Di,Zu Zi Yue,Schoepf U. Joseph,Savage Rock H.,Zhang Xiao Lei,Lu Guang Ming,Zhang Long Jiang 대한영상의학회 2020 Korean Journal of Radiology Vol.21 No.10

        Coronavirus disease 2019 (COVID-19) is a transmissible respiratory disease that was initially reported in Wuhan, China in December 2019. With the alarming levels of COVID-19 spread worldwide, the World Health Organization characterized COVID-19 as a pandemic. Over the past several months, chest CT has played a vital role in early identification, disease severity assessment, and dynamic disease course monitoring of COVID-19. The published data has enriched our knowledge on the etiology, epidemiology, clinical manifestations, and pathologic findings of COVID-19. Additionally, as the imaging spectrum of the disease continues to be defined, extrapulmonary infections or other complications will require further attention. This review aims to provide an updated framework and essential knowledge with which radiologists can better understand COVID-19.

      • KCI등재

        Characterization of Squamosa Promoter Binding Protein-LIKE genes in wheat

        Bingnan Wang,Shuaifeng Geng,Di Wang,Nan Feng,Dongdong Zhang,Liang Wu,Chenyang Hao,Xueyong Zhang,Aili Li,Long Mao 한국식물학회 2015 Journal of Plant Biology Vol.58 No.4

        Common wheat (Triticum aestivum) is an allohexaploid (AABBDD), with Triticum urartu (AA) and Aegilops tauschii (DD) as its A and D genome donors. Squamosa Promoter Binding Protein-Like (SPL) genes play important roles in plant development; however, a systematic study of this gene family in wheat is still lacking. Here, we mined the wheat genomes for SPLs and found 19 SPL genes each from the T. urartu and Ae. tauschii genomes. We also identified 58 SPL genes from the hexaploid wheat genome. We then compared the conservation and divergence of SPLs between the two diploid species in gene structures, tissuespecific expression patterns and responses to salt stress, drought and low temperature. For functional studies, two hexaploid wheat SPLs, TaSPL3 (with miR156 site mutated) and TaSPL6, were overexpressed in Arabidopsis and found to be involved in flowering time and biomass accumulation. In addition, a mutant allele (TaSPL6-D R ) with a 47 bp duplication upstream of the SBP domain was found to be associated with maturity date and grain number per spike among landraces from a Chinese wheat mini-core collection. Collectively, our work provides useful knowledge on the sequences and functions of wheat SPL genes that may help future functional studies and molecular breeding.

      • KCI등재

        Over expression of the wheat BEL1-like gene TaqSH1 affects floral organ abscission in Arabidopsis thaliana

        Lan Zhang,Danmei Liu,Di Wang,Rongzhi Zhang,Shuaifeng Geng,Liang Wu,Aili Li,Long Mao 한국식물학회 2013 Journal of Plant Biology Vol.56 No.2

        Seed shattering is one of the major domestication traits of crops. In wheat, except for the Q gene whose mutation renders free threshing and changing of rachis fragility, not much is known about the molecular mechanism for this process. We report here the cloning and characterization of TaqSH1, the ortholog of the rice seed shattering gene qSH1. TaqSH1 encodes a BEL1-like protein that is conserved between monocots and eudicots. TaqSH1 was located on the homoeologous group 3, a potential new genetic locus for seed threshability in wheat. Over expression of TaqSH1 in Arabidopsis resulted in dwarfed plants. The inflorescences of transgenic plants were more compact with larger pedicel angles. Scanning Electron Microscopy (SEM) showed that the transgenic siliques had a narrower replum where the dehiscence zone was altered. In addition, abscission of petals was significantly delayed due to delayed abscission zone development. Real-time PCR assays showed that over expression of TaqSH1 down regulated known Arabidopsis abscission related genes IDA, HAESA, KNAT1/6 and SHP1/2 in the transgenic plants. Taken together, our data suggest that TaqSH1 may represent another example of conserved mechanisms across monocots and eudicots for fruit/grain abscission and should have potential application in genetic manipulation of wheat seed shattering.

      • KCI등재

        Effect of H2O2 modification of H3PW12O40@carbon for m-xylene oxidation to isophthalic acid

        Zhou-wen Fang,Di Wen,Zhi-hao Wang,Xiang-li Long 한국화학공학회 2018 Korean Journal of Chemical Engineering Vol.35 No.11

        The production of isophthalic acid (IPA) from the oxidation of m-xylene (MX) by air is catalyzed by H3PW12O40 (HPW) loaded on carbon and cobalt. We used H2O2 solution to oxidize the carbon to improve the catalytic activity of HPW@C catalyst. Experiments reveal that the best carbon sample is obtained by calcining the carbon at 700oC for 4h after being impregnated in the 3.75% H2O2 solution at 40oC for 7h. The surface characterization displays that the H2O2 modification leads to an increase in the acidic groups and a reduction in the basic groups on the carbon surface. The catalytic capability of the HPW@C catalyst depends on its surface chemical characteristics and physical property. The acidic groups play a more important part than the physical property. The MX conversion after 180min reaction acquired by the HPW@C catalysts prepared from the activated carbon modified in the best condition is 3.81% over that obtained by the HPW@C catalysts prepared from the original carbon. The IPA produced by the former is 46.2% over that produced by the latter.

      • Growth, Clonability, and Radiation Resistance of Esophageal Carcinoma-derived Stem-like Cells

        Li, Jian-Cheng,Liu, Di,Yang, Yan,Wang, Xiao-Ying,Pan, Ding-Long,Qiu, Zi-Dan,Su, Ying,Pan, Jian-Ji Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.8

        Objective: To separate/enrich tumor stem-like cells from the human esophageal carcinoma cell line OE-19 by using serum-free suspension culture and to identify their biological characteristics and radiation resistance. Methods: OE-19 cells were cultivated using adherent and suspension culture methods. The tumor stem-like phenotype of CD44 expression was detected using flow cytometry. We examined growth characteristics, cloning capacity in soft agar, and radiation resistance of 2 groups of cells. Results: Suspended cells in serum-free medium formed spheres that were enriched for CD44 expression. CD44 was expressed in 62.5% of suspended cells, but only in 11.7% of adherent cells. The suspended cells had greater capacity for proliferation and colony formation in soft agar than the adherent cells. When the suspended and adherent cells were irradiated at 5 Gy, 10 Gy, or 15 Gy, the proportion of CD44+ suspended cells strongly and weakly positive for CD44 was 77.8%, 66.5%, 57.5%; and 21.7%, 31.6%, 41.4%, respectively. In contrast, the proportion of CD44+ adherent cells strongly positive for CD44 was 18.9%, 14.%, and 9.95%, respectively. When the irradiation dose was increased to 30 Gy, the survival of the suspended and adherent cells was significantly reduced, and viable CD44+ cells were not detected. Conclusion: Suspended cell spheres generated from OE-19 esophageal carcinoma cells in serum-free stem medium are enriched in tumor stem-like cells. CD44 may be a marker for these cells.

      • KCI등재

        A rice White-stripe leaf3 (wsl3) mutant lacking an HD domain-containing protein affects chlorophyll biosynthesis and chloroplast development

        Shaolu Zhao,Wuhua Long,Yihua Wang,Linglong Liu,Yunlong Wang,Mei Niu,Ming Zheng,Di Wang,Jianmin Wan 한국식물학회 2016 Journal of Plant Biology Vol.59 No.3

        Leaf-color mutants are ideal genetic materials for understanding the mechanism of chloroplast development and chlorophyll (Chl) biosynthesis. Here we isolated and identified a new leaf-color mutant of rice, named white-stripe leaf3 (wsl3), from a 60Co-irradiated mutant pool. The wsl3 mutant displayed a visible white-stripe leaf in both young seedlings and flag leaves of mature plant. Chl content in homozygous wsl3 mutant was approximately 47% of that in the wild type. Besides, chloroplast development in the mutant was severely arrested. By a map-based cloning strategy, the wsl3 gene was finely confined to a 50.8 kb region on chromosome 1. Moreover, a 9-bp deletion was identified in the genomic region of LOC_Os01g01920, which encodes an HD (histidine and aspartic acid) domaincontaining protein. Genetic complementation confirmed that LOC_Os01g01920 could recover the lesion of wsl3 mutation. Real-time PCR analyses showed that the expression levels of WSL3 were the highest in young and flag leaves among various tissues, and most of the genes associated with Chl biosynthesis were significantly down-regulated in the wsl3 mutant. Meanwhile, in contrast to many nuclear gene-encoded phage-type RNA polymerase(s) (NEP) transcribed genes were up-regulated, most of plastid-encoded bacterialtype RNA polymerase (PEP) transcribed genes were downregulated. These results demonstrated that the WSL3 gene, as an HD domain-containing protein, is involved in chl biosynthesis and chloroplast development in rice.

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