http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Neelima Dhingra,T. R. Bhardwaj,Neeraj Mehta,Tapas Mukhopadhyay,Ashok Kumar,Manoj Kumar 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.7
A number of 17-oxo-5-androsten-3β-yl esters (9a-9f) and 3β-alkoxy-5-androsten-17-ones (11a-11e) were synthesized from commercially available (25R)-5-spirosten-3β-ol (Diosgenin) (4) as starting material. The synthesized compounds were evaluated for their antiproliferative activity against the prostate-specific cancer cell line DU-145, acute toxicity and effect on serum androgen levels, and compared with finasteride as positive control. Some of the compounds exhibited better cytotoxicity and antiandrogenic activity than the reference control. The detailed synthesis, spectroscopic data and biological activity of the synthesized compounds are reported.
Antidepressant-Like Activity of n-Hexane Extract of Nutmeg (Myristica fragrans) Seeds in Mice
Dinesh Dhingra,Amandeep Sharma 한국식품영양과학회 2006 Journal of medicinal food Vol.9 No.1
The present study was undertaken to investigate the effect of an n-hexane extract of Myristica fragransseedson depression in mice by using the forced swim test (FST) and the tail suspension test (TST). M. fragransextract (5, 10, and20 mg/kg) was administered orally for 3 successive days to different groups of Swiss male young albino mice. M. fragransextract significantly decreased immobility periods of mice in both the FST and the TST. The 10 mg/kg dose was found to bemost potent, as indicated by the greatest decrease in the immobility period compared with the control. Furthermore, this doseof the extract was found to have comparable potency to imipramine (15 mg/kg i.p.) and fluoxetine (20 mg/kg i.p.). The ex-tract did not have a significant effect on locomotor activity of mice. Prazosin (62.5 .g/kg i.p.; an .1-adrenoceptor antago-nist), sulpiride (50 mg/kg i.p.; a selective D2 receptor antagonist), and p-chlorophenylalanine (100 mg/kg i.p.; an inhibitor ofserotonin synthesis) significantly attenuated the M. fragransextract-induced antidepressant-like effect in the TST. Thus, ex-tract of M. fragranselicited a significant antidepressant-like effect in mice, when assessed in both the TST and the FST. Theantidepressant-like effect of the extract seems to be mediated by interaction with the adrenergic, dopaminergic, and seroton-ergic systems.
Sonal Dhingra,C M Marya,Avinash J,Puneet Gupta,Ruchi Nagpal,Nidhi Pruthi 대한예방치과학회 2012 International Journal of Clinical Preventive Denti Vol.8 No.2
Objective: To determine the prevalence, associated risk factors and unmet treatment needs of trauma to permanent anterior teeth in 12 to 15 year old school going children in urban and rural areas of Faridabad, Haryana. Methods: A cross-sectional study was carried out through clinical examination of the upper and lower permanent anterior teeth. Type III examination of 1,090 school children (rural=525, urban=565) was done. Dental trauma was classified according to Ellis and Davey (1960) criteria on a prepared examination form. Results: The prevalence of trauma was observed as 24% and 20.9% in rural and urban schoolchildren respectively; more prevalent in boys. The most common type of injury was the ‘enamel only’ fracture; falls and fights being the main cause of trauma; affecting the maxillary central incisor the most. A high level of untreated traumatized teeth observed in rural and urban schoolchildren was 96.8% and 81.4% respectively. Conclusion: The high prevalence and unmet treatment needs of dental trauma clearly illustrates importance of recognizing anterior tooth trauma as major dental public health problem.
Behl, Jyotsna Dhingra,Verma, Naresh Kumar,Behl, Rahul,Sodhi, Monika Asian Australasian Association of Animal Productio 2009 Animal Bioscience Vol.22 No.11
The major histocompatibility complex (MHC) plays well-defined roles in eliciting immune responses and combating infectious diseases. The major histocompatibility complex of cattle is referred to as BoLA (Bovine Lymphocyte Antigen). This genetic system is among the most polymorphic. In the present study, polymorphism of the BoLA- DRB3.2 locus in three Bos indicus breeds viz., Sahiwal, Rathi and Hariana was studied by polymerase chain reaction restriction fragment length polymorphism technique using the enzymes RsaI, Bst Y1 and Hae III. Both Sahiwal and Rathi are good Indian dairy breeds and survive under tough tropical conditions, while Hariana is a prominent dual-purpose breed reared both as a dairy animal and for bullock production. A total of 30 different BoLADRB3.2 alleles were observed to be present in the 3 Bos indicus breeds. Certain alleles were common amongst the three breeds while there were others that were unique to each breed. Allelic distribution amongst the three breeds showed that each breed had a unique allelic distribution pattern that was different from each other and also different from the earlier breeds studied so far for the existence of allelic variation at this locus. A dendogram was constructed based on the frequencies of the BoLA-DRB3 alleles using the UPGMA method. The Rathi and Hariana animals were genetically the most apart. The Hariana animals clustered on a different branch from the other two breeds viz. the Rathi and the Sahiwal. The smallest genetic distances for the DRB3 alleles were those between Sahiwal and Rathi (0.5461) while genetic distance between Hariana and Sahiwal was 0.6123. A comparison of the allelic frequencies of the BoLADRB3.2 locus in these 3 breeds viz. Sahiwal, Hariana and Rathi with the allelic frequencies present in the previously characterized Bos indicus Kankrej breed, which is a dual purpose breed reared both as a draught and a dairy animal, showed that the Bos indicus Sahiwal and Rathi breeds clustered into one group while the Hariana and Kankrej breeds formed another group. The Rathi and Sahiwal showed the least genetic distance of 0.5461 amongst the breeds whereas the Rathi and Kankrej, with a Nei''s genetic distance of 1.1622, were genetically the most distant apart.
Evaluation of pedicled flaps for type IIIB open fractures of the tibia at a tertiary care center
Vathulya, Madhubari,Dhingra, Mohit,Nongdamba, Hawaibam,Chattopadhyay, Debarati,Kapoor, Akshay,Dhingra, Vandana Kumar,Mago, Vishal,Kandwal, Pankaj Korean Society of Plastic and Reconstructive Surge 2021 Archives of Plastic Surgery Vol.48 No.4
Background Soft tissue coverage plays a vital role in replacing the vascularity of the underlying bone in Gustilo type IIIB fractures. The aim of this article was to evaluate the feasibility of local pedicled flaps in type IIIB fractures at a tertiary care center. Methods We included all cases of open Gustilo-Anderson type IIIB fractures of the tibia treated with local flap coverage from January 2017 to February 2019. We carried out a retrospective analysis to investigate the relationships of complications, hospital stay, and cost-effectiveness with the choice of flap, infective foci, site and size of the defect, and type of fixation. Results Out of 138 Gustilo type IIIB fractures analyzed in our study, 27 cases had complications, of which 19 (13.76%) involved flap necrosis, four (2.89%) were infections, three (2.17%) involved partial necrosis, and one (0.72%) was related to bone spur development. Flap complications showed a statistically significant association with the perforator flap category (propeller flaps in particular) (P=0.001). Flap necrosis showed a significant positive correlation with cases treated within 3 weeks after trauma (P=0.046). A significant positive correlation was also found between defect size and the duration of hospital stay (P=0.03). Conclusions Although local flaps are harvested from the same leg that underwent trauma, their success rate is at least as high as microvascular flaps as reported from other centers. Amidst the local flaps, complications were predominantly associated with perforator flaps.
Nathala Emmanuel,Dhingra Swaran Korean Society of Applied Entomology 2006 Journal of Asia-Pacific Entomology Vol.9 No.2
Caesalpinia crista seed extracts were investigated in the laboratory against Helicoverpa armigera (Hubner). The extracts exhibited powerful antifeedant and growth disruption activity. The toxic symptoms of the poisoned larvae included reduction in weight gain and mortality of larvae and pupae, larval-pupal intermediates and malformed adults. Maximum antifeedance is caused by methanol extract ($AI_{50}$=0.0186%), followed by hexane extract (0.0212%), ethyl acetate extract (0.0416%), butanol extract (0.0767%) and aqueous extract (0.2199%). The larval mortality ranged from 10.00 to 70.00% in different extracts. The 50% larval growth inhibition recorded at 3DAT was statistically at par by methanol and hexane extract. The percent $I_{50}$ values for inhibiting normal adult emergence were 0.0287, 0.0325, 0.0485, 0.0977 and 0.0547% for methanol, hexane, ethyl acetate, aqueous and butanol extract. The biosafety evaluation of these extracts carried out against the predator, Coccinella septumpunctata showed no mortality of the adults till nine days after treatment. Though the observation taken at 10 DAT, showed slight mortality of adults by methanol extract at both 5.0 and 1.0% concentration.
Milind Parle,Dinesh Dhingra,S.K. Kulkarni 한국식품영양과학회 2006 Journal of medicinal food Vol.9 No.2
The central cholinergic pathways play a prominent role in the learning and memory processes. Acetyl-cholinesterase is an enzyme that inactivates acetylcholine. The present study was undertaken to estimate the acetyl-cholinesterase-inhibiting activity of extracts of Glycyrrhiza glabra, Myristica fragransseeds, and ascorbic acid and comparethese values with a standard acetylcholinesterase-inhibiting drug, metrifonate. Aqueous extract of G. glabra(150 mg/kg p.o.for 7 successive days), n-hexane extract of M. fragransseeds (5 mg/kg p.o. for 3 successive days), ascorbic acid (60 mg/kgi.p. for 3 successive days), and metrifonate (50 mg/kg i.p.) were administered to young male Swiss albino mice. Acetyl-cholinesterase enzyme was estimated in brains of mice. G. glabra, M. fragrans, ascorbic acid, and metrifonate significantlydecreased acetylcholinesterase activity as compared with their respective vehicle-treated control groups.
Milind Parle,Dinesh Dhingra,S.K. Kulkarni 한국식품영양과학회 2004 Journal of medicinal food Vol.7 No.4
In the traditional system of medicine, the roots and rhizomes of Glycyrrhiza glabrahave been employed clin-ically for centuries for their anti-inflammatory, anti-ulcer, expectorant, antimicrobial, and anxiolytic activities. The presentstudy was undertaken to investigate the effects of G. glabra, popularly known as liquorice (Mulathi), on learning and mem-ory. The elevated plus-maze and passive avoidance paradigm were employed to evaluate learning and memory parameters.Three doses (75, 150, and 300 mg/kg p.o.) of aqueous extract of G. glabrawere administered for 7 successive days in sepa-rate groups of mice. The dose of 150 mg/kg of the aqueous extract of liquorice significantly improved learning and memoryof mice. Furthermore, this dose reversed the amnesia induced by diazepam (1 mg/kg i.p.), scopolamine (0.4 mg/kg i.p.), andethanol (1 g/kg i.p.). Anti-inflammatory and antioxidant properties of liquorice may be contributing favorably to the memoryenhancement effect. Since scopolamine-induced amnesia was reversed by liquorice, it is possible that the beneficial effect onlearning and memory may be because of facilitation of cholinergic transmission in brain. However, further studies are ne-cessitated to identify the exact mechanism of action. In the present investigation, G. glabrahas shown promise as a memoryenhancer in both exteroceptive and interoceptive behavioral models of memory.