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      • KCI등재

        갑상선기능저하증에 기인한 내인성 급사 1예 보고

        이정규,전지현,김민정,이규재,김한겸,조현득,채양석 大韓法醫學會 1999 대한법의학회지 Vol.23 No.2

        Although it is known that hypothyroidism can cause cardiac dysfunction, it is very hard to find a case report on sudden death due to hypothyroidism. There are only two reported cases on mediline; one is about a 15-year-old girl who died suddenly of Hashimoto's thyroiditis and the other is about a 31-year-old man who also died suddenly of hypothyroidism associated with chronic lymphocytic thyroiditis. Recently we found a young woman who unexpectedly died while she was sleeping. She was diagnosed as hypothyroidism when she went to hospital about a month before she died. At autopsy there were roughly four abnormal findings; Hashimoto's thyroiditis, mild chronic active hepatitis, diverticulosis and accessory spleen. Trace of chlorpheniramine was detected in gastric remains and blood alcohol level was 0.37 percent. To our knowledge, this is the first case reporting sudden and unexpected natural death associated with hypothyroidism in Korea.

      • 랫드에서 l-muscone의 급성독성 및 아급성독성시험 연구

        오승민,연제덕,남혜운,박대규,조명행,정규혁 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1

        l-Muscone is synthesized for use as substitutive material of musk which is the active ingredient of woohwangchungsimwon. The objective of this investigation was to evaluate the acute and subacute toxicity of l-muscone in rats. In oral acute toxicity test, SPF Sprague-Dawley male and female rats were gavaged with l-muscone of two doses(0, 5.0g/㎏). No dead animal and abnormal autopsy findings were found in control and treated group. Body weights were slightly decreased in both sexes of rats treated with 5.0g/㎏. Therefore, oral LD_50 of l-muscone was consider to be higher than 5.0g/㎏ in male and female rats. In intraperitoneal acute toxicity test, rats were injected intraperitoneally with dosages of 0, 1,000, 1,316, 1,732, 2,279 and 3,000 ㎎/㎏. Decreased body weights and motor activities were observed at high dose group. Intraperitoneal LD_50 of l-muscone were 1,920 ㎎/㎏ in male and female rats. In the subacute study. l-muscone was administrated orally to both sexes of rats for 4 weeks as several doses(0, 10, 100 and 1,000 ㎎/㎏). There were neither dead animals nor significant changes of body weights during the experimental period. In addition, no differences were found between control and treated groups in clinical signs, urinalysis, hematology, serum biochemical analysis, and other findings. Above data suggest that no observed adverse effect level of l-muscone in rats might be over 1,000 ㎎/㎏/day in this study.

      • 척추 전방 전위증 환자의 자기공명 영상 소견에서 보이는 추체종판의 변화

        안재성,이준규,황득수,이원석 충남대학교 의과대학 지역사회의학연구소 1997 충남의대잡지 Vol.24 No.2

        We reviewed the 156 magnetic resonance of lumbar spine with spondylolisthesis in simple X-ray and analysed relationship of the type of spondylolisthesis with bone marrow change in lumbar MRI and low back pain, instability of lumbar spine and prognosis. The patients with no bone marrow change were excluded in our study. Bone marrow changes were classified into 3 types by Moddic methods. Type I is low signal in T1 image and high signal in T2 image, type Ⅱ is high signal in T1 image and isodense or slight increased signal in T2 and type 2Ⅲ is decreased signal in both T1 and T2 image. Displacement over 3㎜ in motion view is defined as instability. Pain was scored by JOA scoring system. 22(14.1%) of 156 patients had local bone marrow change of vertebral end-plate. Of 22 patients, levels of lesion were 28 levels. 14 levels were isthmic type, 6 levels were degenerative type and 8 levels were retrolisthesis, respectively. Isthmic type had type Ⅰ or Ⅲ In 8(57.1%) levels, instability in 7(50.0%) levels and significant pain(0 of 1 point) in 9(69.2%) patients. Degenerative or retrolisthesis had type Ⅱ in 10(71.4%) levels, instability in 1(7.1%) level and significant pain in 4(44.4%) patients. Unstable and more symptomatic type of spondylolisthesis was associated with type Ⅰ or Ⅲ change of bone marrow in MRIm and may be teated more aggressively. Type Ⅰ or Ⅲ of bone marrow change is associated with segmental instability and low back pain and has a poor prognosis, but type Ⅱ are present in more stable and chronic disease. We concluded that isthmic type was more associated with pain, instability and type Ⅰor Ⅲ change, while degenerative or retrolisthesis type were more stable and painful and associated with type Ⅱ change.

      • 생체 세라믹스용 마모시험장비의 제작 및 정방정지르코니아의 마모특성

        김성호,류득배,문병규,이수완 선문대학교 중소기업기술지원연구소 2001 선문공대 연구/기술 논문집 Vol.6 No.1

        생체 세라믹스용 마모시험장비를 제작하였다. 마모시험기는 lever system을 이용하여 하중인가가 되게 설계되었으며 step motor를 사용하여 회전수 조절이 용이하게 하였다. DAQ (Data Acquisition System)을 이용하여 하중을 측정하여 마찰계수를 측정할 수 있게 하였다. 성능평가를 위해 정방정지르코니아를 Ringer's solution에서 선속도 40 mm/s, 인가하중 10, 20, 30 N에서 마모시험 하였다. Grooving, crack networking등의 마모기구가 관찰되었다. A wear testing machine for bioceramics was designed and made, which loading and rotating parts consisted of a lower systemed and a step motor, respectively. Friction coefficient was determined by DAQ(Data Acquisition System). Wear resistance of tetragonal zirconia was measured under linear velocity of 40 mm/sec, applied load of 10, 20, 30 N in Ringer's solution, which showed grooving, crack networking on worn surfaces.

      • 도시하천의 환경 친화적 개선방안에 관한 조사연구

        이길영,권득용,김영안,한천규 대전대학교 산업기술연구소 1999 산업기술연구소 論文集 Vol.10 No.1

        The three main steams flowing through Taejon have some serious problems to be solved or improved. They are : First, the uniform cross section of the rivers should be changed. Second, the extension of the riverside road should be reconsidered. Third. the neighborhood parks on the flood plain should be modified. Fourth, the flood plain parking place must not be constructed. Fifth, the ecosystem will be destroyed by the structure constructed along the rivers. In this study, we suggest that the investment and research on the development of the new technology for the setting the rivers in natural condition should be needed now and the continuous investigation and long-term plan to preserve the ecosystem of the rivers should be required. The environmental conditions of Taejon-stream, Yudung-stream and Kap-stream are indicators of the standard of living of the citizens in Taejon. Now is the time to reconsider the careless construction around the rivers and to prepare the long-term plan for the protection of the ecosystem and natural environment.

      • 남자 초·중학생의 무산소성 작업능력과 무산소성 파워의 관계

        정동식,정덕조,정성태,이병근,전태원,김은혜,이동규,정동춘 師範大學 體育硏究所 1998 서울大學校 體育硏究所論集 Vol.19 No.2

        The critical power(CP) is the highest intensity to sustain for a long time without a fatigue. The anaerobic work capacity(AWC) is the highest anaerobic capacity to be provided by anaerobic energy system without the infection of hypoxia. The purpose of this study was to determine the relationship between AWC and AnP and to verify the validity of AWC. The subjects were consisted of 10 elementary and 10 middle school male students(12.8±1.3yrs, 159.3±12.1㎝, 49.4±11.8㎏). The critical power and anaerobic work capacity were calculated by work-time relationship after four cycle ergometry test to fatigue from 1 to 10 minute. The anaerobic power included Margaria-Kalmen test, Sargent jump and Wingate test. The main finding were as follows. The AWC of elementary and middle school students. were 6.47±2.63KJ and 11.10±3.01KJ. The AWC of elementary students was 58.3% of the middle school students's one. The AnP of elementary students were 47.2∼66.5% of the middle school students's one. And there were high correlation between AWC and AnP(0.64∼0.87, P<0.01). This study showed that AWC is useful index on AnP both elementary and middle school students.

      • KCI등재

        Chlorpyrifos 및 Chlorothalonil의 사과 생산단계별 잔류특성

        김영숙,박주황,박종우,이영득,이규승,김장억 한국환경농학회 2003 한국환경농학회지 Vol.22 No.2

        사과의 생산단계에서의 잔류허용기준 설정과 최종 소비단계에서의 안전성 평가자료로 활용하기 위하여 사과에 많이 살포되는 살충제 chlorpyrifos 및 살균제 chlorothalonil의 사과 재배기간 중 생물학적 반감기, 보관방법에 따른 잔류량 변화 그리고 부위별 잔류량 분포를 조사하였다. 사과 재배단계에서의 생물학적반감기는 chlorpyrifos 살포 후 15일, chlorothalonil 살포 후 30일까지의 잔류량 변화를 조사한 결과 chlorpyrifos 9.3일, chlorothalonil 32.2일로 나타났다. 사과의 유통과정중에서 일어날 수 있는 두 약제의 잔류량 변화는 실온저장시 chlorpyrifos 35일, chlorothalonil 56.3일이었고, 냉장 저장시에는 chlorpyrifos 120.7일, chlorothalonil 182.2일의 반감기를 나타내었다. 사과의 부의별 잔류량을 조사한 결과 chlorpyrifos의 경우 움푹 파인 부위의 과피 77.1%, 나머지 과피 22.8%, 과육 부위에서는 0.1%로 나타났고, chlorothalonil의 경우 움푹 파인 부위의 과피 85.2%, 나머지 과피 10.4%, 과육 부위에서 4.4%로 나타났다. 사과 중 두 약제의 잔류량은 대부분인 95~99%과 과피에 잔류하는 것으로 나타났다. An organophosphorus insecticide, chlorpyrifos and an arylnitrile fungicide, chlorothalonil commonly used for apple were subjected to a residual investigation under field conditions to ensure safety of terminal residues at harvest. After pesticides were applied at standard rate in apple tree for 15 days for chlorpyrifos and 30 days for chlorothalonil, persistence of their residues in apple was investigated by several interval. At harvest, residual concentrations of chlorpyrifos and chlorothalonil in apple were 1.3 and 2.4 ㎎/㎏, respectively, and the residue levels were higher than MRL, 1.0 ㎎/㎏ in Korea. As well fitted by the first -oder kinetics, biological half-lives of the pesticide residues in apple were 9.3 days for chlorpyrifos and 32.2 days for chlorothalonil. During the storage, half-lives of chlorpyrifos and chlorothalonil were 35.0 and 56.3 days at room temperature, and 120.7 and 182.8 days at 4℃, respectively. Distribution of chlorpyrifos residue in flesh, fruit skin and stalk cavity of each apple corresponded to 0.1% 22.8% and 77.1% respectively. In case of chlorothalonil, residue in flesh, fruit skin and stalk cavity was 4.4%, 10.4% and 85.2%, respectively.

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