Case Report : Physical Therapy and Rehabilitation of Complex Regional Pain Syndrome in Shoulder Prosthesis

Derya Celik,Mehmet Demirhan 대한통증학회 2010 The Korean Journal of Pain Vol.23 No.4

Synthesis and characterization of hydrothermally grown potassium titanate nanowires

Derya Kapusuz,Y. Eren Kalay,박종이,Abdullah Ozturk 한양대학교 세라믹연구소 2015 Journal of Ceramic Processing Research Vol.16 No.3

Potassium titanate (KT) nanowires were synthesized by a one-step hydrothermal reaction between TiO2 and aqueous KOH solution. The effects of KOH concentration and reaction time on hydrothermal formation and KT nanowire growth were investigated. The nanowire growth mechanism was elucidated using a combined study of powder X-ray diffraction, and scanning and transmission electron microscopy. The results revealed that hydrothermal growth was initiated by the formation of amorphous-like Ti-O-K sheets in anatase. Increasing hydrothermal reaction time caused the transformation of anatase to Ti-O-K sheets, from which potassium hexa-titanate (K2Ti6O13) nuclei formed and grew to establish one-dimensional morphology through preferential growth along the b-axis. It was revealed that the hydrothermal reactions followed a quite different mechanism than the well-known calcination route. Potassium tetra-titanate (K2Ti4O9) crystals formed in the amorphous region using the hexa-titanate phase as a nucleation site for heterogeneous crystallization. Increasing the KOH concentration in the solution accelerated the hydrothermal reaction rate.

Retinal Nerve Fiber Layer Thickness and Its Relationship With Executive Functions in Adult Attention Deficit Hyperactivity Disorder Patients

Derya Kaymak,I˙brahim Gü,ndog˘mus¸,Mihriban Dalkıran,Murat Kü,ç,ü,kevciliog˘ lu,Ö,zcan Uzun 대한신경정신의학회 2021 PSYCHIATRY INVESTIGATION Vol.18 No.12

Objective The aim of this study was to compare the thickness of the retinal nerve fiber layer (RNFL) with controls in individuals with attention deficit hyperactivity disorder (ADHD) and to examine the relationship between RNFL thickness and the level of performance in disease severity and executive function tests in ADHD cases.Methods The study included 38 volunteer patients diagnosed with ADHD and 30 healthy volunteers. Adult ADHD self-report scale was used for ADHD symptom severity. Executive functions were evaluated by Digit Span Test, Verbal Fluency Test, Stroop Test, and Trail Making Test. RNFL thickness of all participants was evaluated using optical coherence tomography (OCT).Results In the comparison of RNFL values, it was found that right mean, right temporal, right temporal inferior, left mean, left nasal, and left nasal inferior quadrant values were statistically thinner in ADHD cases compared to the control group (p<0.05). There was no statistically significant correlation between the mean RNFL thickness values of the right and left eyes of ADHD cases and the symptom severity and performance levels in executive function tests.Conclusion This study is a guide in terms of being the first study investigating the relationship between RNFL thickness, symptom severity, and various neuropsychological tests in adults with ADHD.

CASE REPORT : Two Cases of Unilateral Lichen Planus Following the Lines of Blaschko

( Derya Yayla ),( Seray Kulcu Cakmak ),( Isıl Deniz Oguz ),( Muzeyyen Gonul ),( Esra Ozhamam ),( Aysel Colak ),( Ulker Gul ) 대한피부과학회 2014 Annals of Dermatology Vol.26 No.5

A 50-year-old man and 71-year-old woman presented to ourclinic with unilateral, linear, erythematous, pruritic lesions along the lines of Blaschko. On the basis of clinical andhistopathological findings, the lesions were diagnosed as lichen planus with a Blaschkoian distribution, which is a rare form of lichen planus. The patients were treated with topical corticosteroids and antihistamines. (Ann Dermatol 26(5) 636 ∼638, 2014)

Naringenin Ameliorate Carbon Tetrachloride-Induced Hepatic Damage Through Inhibition of Endoplasmic Reticulum Stress and Autophagy in Rats

Derya Ustuner,Umut Kerem Kolac,Mehmet Cengiz Ustuner,Cihan Tanrikut,Zeynep Ozdemir Koroglu,Dilek Burukoglu Donmez,Hulya Ozen,Hilmi Ozden 한국식품영양과학회 2020 Journal of medicinal food Vol.23 No.11

Hepatic fibrosis emerges upon exposure of liver to various chemicals and if not treated, it develops various diseases such as cirrhosis and cancer. Carbon tetrachloride (CCl4) is a widely used toxin in animal models to develop hepatic fibrosis. Accumulation of unfolded proteins in cells causes stress in the endoplasmic reticulum (ER) and various mechanisms are involved in the cell to reduce the damage caused by these unfolding proteins. The most well known of these is the unfolded protein response. Further, autophagy works to remove these proteins if the damage cannot be repaired and is permanent. In our study, we investigated the effects of naringenin (NRG), a flavanon abundant in citrus fruits, on ER stress and autophagy in CCl4-injured rat liver. The animals were given 0.2 mL/kg of CCl4 for 10 days and treatment group was administered 100 mg/kg of NRG for 14 days. Histopathological examination was performed to show liver damage and to determine the therapeutic properties of the active substance. Transmission electron microscopy (TEM) analysis was carried out to establish cell level damage and effect of treatment. In addition, levels of ER stress and autophagy markers of liver were measured. According to our findings, TEM demonstrated positive effect of NRG and histological examinations reported ameliorative effects. In addition, NRG reduced levels of ER stress markers and inhibited autophagy significantly compared to CCl4-treated group. As a result, NRG significantly reduced damage in hepatocytes and provided a significant amelioration.

The outcome of epiduroscopy treatment in patients with chronic low back pain and radicular pain, operated or non-operated for lumbar disc herniation: a retrospective study in 88 patients

( Derya Burcu Hazer ),( Arsal Acarbas ),( Hans Eric Rosberg ) 대한통증학회 2018 The Korean Journal of Pain Vol.31 No.2

Background: Patients with lumbar disc herniation are treated with physiotherapy/medication and some with surgery. However, even after technically successful surgery some develop a failed back syndrome with persistent pain. Our aim was to evaluate the efficacy of epiduroscopy in patients who suffer chronic low back pain and/or radicular pain with or without surgery and the gender difference in outcome. Methods: A total of 88 patients were included with a mean age of 52 years (27-82), 54 women and 34 men. 66 of them were operated previously and 22 were non-operated. They all had persistent chronic back pain and radicular pain despite of medication and physical rehabilitation. Visual Analog Scale (VAS) for pain and Oswestry Disability Index (ODI) were evaluated preoperatively, after one month, six months and one-year after the epiduroscopy. Results: All patients, and also the subgroups (gender and operated/non-operated) improved significantly in pain (VAS) and disability (ODI) at one month. A significant improvement was also seen at one year. No differences were found between men and woman at the different follow-up times. A slight worsening in VAS and ODI was noticed over time except for the non-operated group. Conclusions: Epiduroscopy helps to improve the back and leg pain due to lumbar disc herniation in the early stage. At one year an improvement still exists, and the non-operated group seems to benefit most of the procedure. (Korean J Pain 2018; 31: 109-15)

Posttreatment Effects of Olea Europaea L. Leaf Extract on Carbon Tetrachloride-Induced Liver Injury and Oxidative Stress in Rats

Derya Ustuner,Emine Colak,Murat Dincer,Neslihan Tekin,Dilek Burukoglu Donmez,Fahrettin Akyuz,Ertugrul Colak,Umut Kerem Kolac,Emre Entok,Mehmet Cengiz Ustuner 한국식품영양과학회 2018 Journal of medicinal food Vol.21 No.9

The aim of this study is to examine the therapeutic effects of Olea europaea L. leaf extract on carbon tetrachloride (CCl4)-induced liver damage in rats. In the experiments, 3- to 4-month-old 28 male Sprague–Dawley rats were divided into four groups: control, O. europaea leaf extract, CCl4, and curative. The CCl4 and curative groups received CCl4 (0.2 mL/kg) intraperitoneally for 10 days to form hepatic injury. O. europaea (80 mg/kg) leaf extract was given orally to the curative group dissolved in distilled water the following 14 days. Hepatic and antioxidant enzyme levels, p53, caspase 3, lipid peroxidation marker malondialdehyde (MDA), and also DNA fragmentation levels were determined to establish oxidative stress in hepatic cell damage and its consequences. After formation of liver damage, oral administration of the O. europaea significantly reduced CCl4-induced elevations of serum alkaline phosphatase, aspartate aminotransferase and alanine aminotransferase levels (P < .001), MDA levels of both blood (P < .001) and liver tissues (P < .001), DNA fragmentation (P < .001), p53 (P < .001), and caspase 3 (P < .001) levels of liver tissues. Also this administration in curative group significantly increased CCl4-induced reductions of superoxide dismutase (SOD) (P < .001) and catalase (CAT) (P < .001) activity of blood samples and decreased SOD (P < .001) and CAT (P < .05) activity observed in liver tissue curative groups compared with CCl4 curative group. In CCl4 group, liver tissue samples exhibited remarkable damage because of CCl4 and reduction of these damages were observed in the curative group. Our results showed that O. europaea leaf extract was effective in reducing hepatic damage caused by CCl4 by reducing lipid peroxidation, regulating antioxidant enzymes, and minimizing DNA damage.

Fabrication and Application of Silicotungstic Acid/Polyvinyl Alcohol and Phosphomolybdic Acid/Polyvinyl Alcohol Hybrid Membrane for Pervaporative Dehydration of Isopropanol Solution

Derya Unlu 한국고분자학회 2019 Macromolecular Research Vol.27 No.10

Hybrid membranes were prepared by loading silicotungstic acid (STA) and phosphomolybdic acid (PMA), into polyvinyl alcohol (PVA) matrix. The membranes were characterized by Scanning electron microscopy (SEM), Fourier transform infrared (FTIR), contact angle meter, thermogravimetric analysis (TGA), and X-ray diffraction (XRD). Separation performance of hybrid PVA membranes was compared over that of neat PVA membrane, for dehydration of aqueous isopropanol mixtures by using the pervaporation (PV) process. The PV experiments were conducted over the feed water composition of 5-20 wt.%, temperature range of 30- 60 oC, and heteropolyacid amount of 5-20 wt%. Usage of hybrid membranes for separating water from the organic solvents, results in high flux and selectivity values. Of all the membranes studied, 5 wt% STA loaded hybrid PVA membrane and 5 wt% PMA loaded hybrid PVA membrane, exhibited best separation performance. While flux and selectivity values are 0.499 kg/m2h and 12848 for 5 wt% STA loaded hybrid PVA membrane, these values are 0.471 kg/m2h and 74991 for 5 wt% PMA loaded hybrid PVA membrane. Flux and selectivity values of neat PVA membrane are quite lower, as compared to the hybrid membranes. Neat PVA membrane has 0.360 kg/m2h of flux, and 36 of selectivity values. From this study, it is concluded that the selectivity and flux values of hybrid membranes, are rather higher than the neat PVA membrane.

The Effects of Cold Application to the Perineum on Pain Relief After Vaginal Birth

Derya K. Senol,Ergul Aslan 한국간호과학회 2017 Asian Nursing Research Vol.11 No.4

Purpose: Perineal pain developing during the postpartum period affects women's relationships with their families and infants. The aim of this study was to determine the efficacy of cold gel pad application for relieving perineal pain and possibly increasing mothers' comfort after vaginal delivery. Methods: This experimental randomized controlled study was conducted in the postpartum department of obstetrics and gynecology hospital. A total of 200 mothers were included in the study. Cold gel pads were applied to the perineum of mothers in the experimental group for 20 minutes in the postpartum first 2 hours and 4 hours after the first application. All the data were collected by using an information form, the visual analog scale, and the postpartum comfort questionnaire. Results: In the experimental group, the first visual analog scale score was 6.73 ± 1.68; after cold gel pad application, the pain levels decreased to 2.59 ± 1.20 in both primiparous and multiparous mothers. In addition, the postpartum comfort questionnaire score increased from 2.58 ± 0.14 to 2.69 ± 0.14 in the second assessment after the cold gel pad application and the difference was statistically significant (p < .001). Conclusion: The application of the cold gel pad to the perineum relieved perineal pain and increased postpartum comfort in all the women. The pain felt by the women during the recovery and the daily activities decreased. Postpartum perineal pain adversely affected daily activities such as lying down, sitting, and walking; infant care, breastfeeding, and urination; and comfort levels of the postpartum women.

Production of Lipase-catalyzed Structured Lipid from Olive Oil with Omega-3 Polyunsaturated Fatty Acids

Derya Kahveci,Aslı Can,Beraat Ozcelik 한국식품과학회 2009 Food Science and Biotechnology Vol.18 No.1

Acidolysis of olive oil with omega-3 (n-3) polyunsaturated fatty acids (PUFAs) was carried out to produce a structured lipid. Novozym 435<SUP>®</SUP> from Candida antarctica was used as the biocatalyst. Response surface methodology (RSM) was used to determine optimum conditions for lipase-catalyzed enrichment of olive oil. Three factors, 5 levels, central composite design was used. The effects of incubation time, temperature, and substrate mole ratio on incorporation ratio (n-3 fatty acids/total fatty acids, %) were investigated. From the evaluation of response surface graphs, the optimal conditions for incorporation of long chain n-3 PUFAs into olive oil were 40-60℃ for temperature, 30-45 hr for reaction time, and 3:1-5:1 (n-3 fatty acids/olive oil) for substrate mole ratio. Experiments conducted under optimized conditions predicted by the model equation obtained from RSM yielded structured lipids with 50.8% n-3 PUFAs. This value agreed well with that predicted by the model. Oxidative stability tests showed that the product was more susceptible to oxidation than unmodified olive oil. Antioxidant addition improved the oxidative stability of the product.