Development of Scientific Reasoning in College Biology : Do Two Levels of General HypothesisTesting Skills Exist?

Lawson, Anton E.,Clark, Brian,CramerMeldrum, Erin,Falconer, Kathleen A.,Sequist, Jeffrey M.,Kwon, Yong Ju 한국교원대학교 과학교육연구소 2000 청람과학교육연구논총 Vol.10 No.1

The primary purpose of the present study was to test the hypothesis that two general developmentally based levels of hypothesis-testing skills exist. The first hypothesized level presumably involves skills associated with testing hypotheses about observable causal agents; the second presumably involves skills associated with testing hypotheses involving unobservable entities. To test this hypothesis, a hypothesis-testing skills test was developed and administered to a large sample of college students both at the start and at the end of a biology course in which several hypotheses at each level were generated and tested. The predicted positive relationship between level of hypothesis-testing skill and performance on a transfer problem involving the test of a hypothesis involving unobservable entities was found. The predicted positive relationship between level of hypothesis-testing skill and course performance was also found. Both theoretical and practical implications of the findings are discussed. ⓒ 2000 John Wiley & Sons, Inc. J Res Sci Teach 37: 81-101, 2000

Portal Vein Thrombosis in Minimal Change Disease

Gyuri Kim,Gyuri Kim,Su Jin Heo,Yoen Kyung Kee,Seung Hyeok Han 이화여자대학교 의과학연구소 2014 EMJ (Ewha medical journal) Vol.37 No.2

Among the possible venous thromboembolic events in nephrotic syndrome, renal vein thrombosis and pulmonary embolism are common, while portal vein thrombosis (PVT) is rare. This report describes a 26-year-old man with histologically proven minimal change disease (MCD) complicated by PVT. The patient presented with epigastric pain and edema. He had been diagnosed with MCD five months earlier and achieved complete remission with corticosteroids, which were discontinued one month before the visit. Full-blown relapsing nephrotic syndrome was evident on laboratory and clinical findings, and an abdominal computed tomography revealed PVT. He immediately received immunosuppressants and anticoagulation therapy. An eight-week treatment resulted in complete remission, and a follow-up abdominal ultrasonography showed disappearance of PVT. In conclusion, PVT is rare and may not be easily diagnosed in patients with nephrotic syndrome suffering from abdominal pain. Early recognition of this rare complication and prompt immunosuppression and anticoagulation therapy are encouraged to avoid a fatal outcome.

MIXED CHORD-INTEGRALS OF STAR BODIES

Department of Mathematics 대한수학회 2010 대한수학회지 Vol.47 No.2

The mixed chord-integrals are defined. The Fenchel-Aleksandrov inequality and a general isoperimetric inequality for the mixed chordintegrals are established. Furthermore, the dual general Bieberbach inequality is presented. As an application of the dual form, a Brunn-Minkowski type inequality for mixed intersection bodies is given.

Synthesis and Characterization of Isotopically-Labelled Cystenine and Glutathione Conjugates of Methylisocyanate

Han, Deog Hwa,Person, Paul G,Baillie Thomas A. 중앙대학교 약학연구소 1990 약학 논총 Vol.4 No.-

Four isotopically labelled analogs of S-(N-methylcarbamoyl) glutathione(SMG), the glutathione conjugate of methylisocyanate, and three isotopically-labelled derivatives of S-(N-methylcarbamoyl) cysteine (SMC), the corresponding cysteine adduct, have been prepared by reaction of glutathione and cysteine, respectively, with [1-^13C]-, [3-^13C]-, [3-14^C]- or [3, 3, 3-^2H_3]methylisocyanate. The latter species, which served as key intermediates in the syntheses, were obtained either by reaction of [1-^13C]acetylchloride with sodium azide [to give [1-^13C]methylisocyanate), or by reaction of silver cyanate with iodomethane labelled with ^13C, ^14C or deterium (to give the methyl-substituted compounds). Condensation of labelled methylisocyanate with glutathione or cysteine proceeded smoothly and in high yield in aqueous acetonitrile solution, and afforded the target conjugates in high isotopic purity. The structures of the products were confirmed by fast atom bombardment tandem mass spectrometry (FAB / MS / MS) and by ^1H- and ^13C-NMR spectroscopy.

Detection of Tumor-specific mRNA Species in the Blood of Stomach Cancer Patients with Immunobead RT-PCR

Chung, Jun Ho 가톨릭 의과학연구원 2002 가톨릭 의과학연구원 국제학술대회 Vol.6 No.-

The use of RT-PCR to identify tumor-associated mRNA is currently believed to be the most sensitive means of identifying circulating tumor cells in cancer patients. One of the newer areas being explored in the management of cancer is the use of RT-PCR to analyze the blood of cancer patients for the detection of mRNA expressed in tumor cells. This technology may aid in three major areas in the management of cancer: 1) predicting which patients will have a favorable outcome following removal/treatment of the primary lesion, 2) more efficiently analyzing ways to follow the efficacy of therapy, and 3) detecting relapsing tumors at its very early stage.

Effects of stress on scuticociliate killing activity of olive flounder (Paralichthys olivaceus) Plasma in relation to humoral immunity

Kwon, Se Ryun,Kim, Chun Soo,Kim Ki Hong 한국어병학회 2002 한국어병학회지 Vol.15 No.2

Effects of stress-induced suppression of humoral immunity on seuticoculiated killing activity of olive flounder plasma were investigated. Changes in glucose level, alternative complement activity and lysozyme activity of plasma by handling stress were analysed in relation to in virto parasiticidal activity of plasma. The plasma glucose level was about two times higher in fish after a handling stress than in control fish. Plasma lysozyme activity and natural haemolytic activity were decreased in stressed fish. The scuticociliate killing activity of plasma was significantly lower in stressed fish than in non-stressed fish. The scuticociliated killing activity of plasma was significantly lower in stressed fish than in non-stressed control fish. The present results indicated that stress-induced immunodepression could be a cause of scuticociliatosis occurrence in olive flounder.

TOTALLY REAL SUBMANIFOLDS WITH PARALLEL MEAN CURVATURE VECTOR IN A COMPLEX SPACE FORM

KI, U-HANG,KIM, BYUNG HAK,KIM, HE-JIM 경북대학교 위상수학 기하학연구센터 1995 硏究論文集 Vol.3 No.-

Preliminary Experiments on Cloning of Collagenase from C. histolyticum

Han, Song,Seifter, Sam The Official Publication of Korean Academy of Oral 1993 International Journal of Oral Biology Vol.17 No.2

Collagenase from Clostridium histolyticum was purified to homogeneity using several column chromatographic methods in the presence of protease inhibitors. The purified enzyme migrated as one band in SDSPAGE with an apparent Mr of 110,000 and in several test systems, did not exhibit any other proteolytic activity. Automatic Edman degradation of the protein revealed that the primary structure of the aminoterminal region of the protein was IANTNSEKYDFEYLNGL. The protein was cleaved with CNBr and the resulting CNBr peptides were separated by HPLC. A polyclonal antibody against the enzyme was raised and its titer determined on a slot blot using an ABC detection method. DNA from C. histolyticum was prepared, digested partially with Sau3AI and inserted onto a multiple cloning site of the vector plasmid pBluescript SK(-). Host E. coli strain XL1 Blue transformed with the recombinant plasmids was screened with an oligonucleotide probe; several positive clones were thereby revealed.

Endoscopic Evaluation of Gastric Cancer

Shim,Chan Sup 순천향대학교 1984 논문집 Vol.7 No.1

All histologically confirmed cases of carcinoma of the stomach seen at Kobe University Hospital and Hyogo Cancer Center from September 1982 to April 1983 have been reviewed. The over-all results of this series compared favorably with those of many other series reported in the literature of gastric cancer, especially between Japan and Korea. This series did not show any significant differences from other series reported in the literature in Japan. However, in Korea the incidence of gastric cancer is the highest among all malignant tumors, but it is lower than that of Japan. Again in Korea, the average life span of both sexes is also lower than that of Japan. The peak decade of age of advanced gastric cancer in Korea was the 6th decaed, while being the 7th decade in Japan. The overall ratio of early gastric cancer to all gastric cancer in Korea was also a little lower than that of Japan. And there were not any significant differences in the sex ratio, location, and type of early and advanced gastric cancer between two countries. A strong plea is made for the improvement of examination method, its propagation and its enlightenment, and more efforts for the early detection of gastric cancer. Acknowlegement: The author wish to express his deep appreciation for valuable advice and help to professor S, Baba, Dr. S. Saeki and Dr. Tomofujiat Kobe University, Dr. Shima, chief of the Department of Gastroenterology at Hyogo Cancer Center, and Dr. Tamada, Chief of the Department of Gastroenterology of Suma Red Cross Hospital.

Induction of DNCB Oral Tolerance in Mice

Department of Dermatology, Catholic University Medical College,Kang, Sung Bum,Lee, Jun Young CATHOLIC MEDICAL CENTER 1986 Bulletin of the Clinical Research Institute Vol.14 No.1

Tolerance to contact hypersensitivity was induced by feeding of different DNCB doses in mice. A total of 40 mice were divided into 4 groups (control group, 6 ㎎ feeding group, 10 ㎎ feeding group, 14 ㎎ feeding group) in experiment 1. Degree of tolerance to contact hypersensitivity was measured by increment rate? of ear swelling after challenge with DNFB. Experiment 2 was performed in the same method of experiment 1 with addition of 3 ㎎ DNCB feeding group. The increment rates were significantly decreased in DNCB feeding groups in experiment 1 and 2(P<0.01). But there were no differences statistically between increment rates of DNCB feeding groups.