대전지방 도시단독주택 지붕ㆍ현관ㆍ창호의 형태에 관한 조사연구

宋容浩,金尙謙,趙原德 忠南大學校 産業技術硏究所 1986 산업기술연구논문집 Vol.1 No.2

Roof, porch and window are important exterior elements which constitute the building envelope. This is a research on these elements of urban detached houses in Taejon area to suggest the basic data for housing design. The research is executed by enquete survey, photographs, sketch, measurement of size and survey sheets. By analyzing the elements according to the building ages, type, size, materials and color, and then comparing them with the traditional elements, the findings extracted the following criteria; 1) the inclination of roof type/color. 2) the tendency of establishing porch. 3) the changing aspects of window type/materials/color as well as those of entrance door.

부산지역 강하먼지 중 불용성 중금속 함유량

이용범,황용식,이창희,박명희,이채관,강동묵,김정원,전병일,문덕환 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.1

■ Objectives The purpose of this study was to estimate qualitatively various bulk deposition flux of insoluble heavy metal components by applying regional and seasonal distribution. our institution from January 1980 to December 31th, 2001. ■ Materials and Methods Dustfall particles were collected by the modified American dust jar (wide inlet bottle type) at 6 sampling sites in Pusan area from March, 1999 to February, 2000. Five chemical species (Cd, Cr, Mn, Ni and Pb) were analyzed by AAS(Perkin-Elmer 4100ZL). ■ Results The mean values of each heavy metal concentrations were Cd for 3.947 g/㎢/month, Cr for 0.191 ㎏/㎢/month, Mn for 0.375 ㎏/㎢/month, Ni for 0.176 ㎏/㎢/month, and Pb for 0.823 ㎏/㎢/month. ■ Conclusions Insoluble heavy metal amount of regional variations were found in order of industrial zone, coastal zone, commercial zone, agricultural zone and residential zone.

냉동 제대혈 세포의 체외 증폭

김삼용,김철희,배광봉,김현수,박상준,김종숙,윤환중,조덕연 충남대학교 암연구소 1998 癌共同硏究所 硏究誌 Vol.2 No.1

Background : Cord blood(CB), which has no HLA restriction, is an alternative to bone marrow for hematopoietic stem cell transplantation. The use of cord blood, however, is limited by the number of progenitor/stem cells necessary to reconstitute the older child or adult. Therefore, ex vivo expansion of CB could have tremendous impact on diverse clinical settings. We studied the ex vivo expansion of isolated population of CD34_(+) cells from cryopreserved CB cells. Methods : CD34 cells were isolated from cryopreserved CB mononuclear cells. Purified cells were cultured with various combinations of hematopoietic growth factors including erythropoietin(EPO), stem cell factor(SCF), granulocyte-colony-stimulating factor(G-CSF), gra-nulocyte, macrophage-colony-stimulating factor(GM-CSF), interleukin-1β(IL-1β), 1L-3, and IL-6. After 7, 10 or 14 days of culture, the fold increases of colony-forming unit- granu-locyte, macrophage(CFU-GM), burst-forming unit-erythroid(BFU-E), colony-forming unit-mix (CFU-Mix), and high proliferative potential colony-forming cell(HPP-CFC) were evaluated. Results : Ten-day culture with the combination of EPO, SCF, G-CSF, IL-1β, and IL-3 resulted in a median of 60-fold increase of CFU-GM, which was greater than those with the combinations of less than 5 growth factors. The addition of IL-6 or GM-CSF to this combination did not enhance CFU-GM expansion. Ten-day culture was significantly superior to 7-day culture for CFU-GM expansion. Prolongation of culture to 14 days, however, revealed decreased expansion of CFU-GM compared to 10 days. BFU-E and CFU-Mix were expanded to 2~5 folds in 7-day culture with the combination of EPO, SCF, and G-CSF. Further expansion was not achieved in 10-day culture and colonies disappeared in 14-day culture. HPP-CFC was expanded to a median of 7.5 folds in 7-day culture with the combination of EPO, SCF, G-CSF, IL-1β, IL-3, and IL-6. Neither 10-day or 14 day-culture enhanced expansion of HPP-CFU. Conclusion : Cryopreserved cord blood cells maintain ex vivo expansion potential. In our system, 10-day culture with the combination consisting of EPO, SCF, G-CSF, IL-1β, and IL-3 seems to be adequate for hematopoietic progenitor/stem cell expansion from cryopreserved cord blood cells.

진행위암에 대한 병합화학요법

김삼용,조덕연 충남대학교 의과대학 지역사회의학연구소 1987 충남의대잡지 Vol.14 No.2

Twenty-three patients with advanced stage metastatic or unresectable gastric cancer were given combination chemotherapy consisting of Fluorouracil, Doxorubicin, and Cisplatin(FAC) or Mitomycin(FAM). 5 patients receiving FAC and 6 patients receiving FAM were evaluable. 3 patients receiving FAC and 3 patients receiving FAM achieved partial response. So, overal response rate was 60% for FAC and 50% for FAM. Median duration of response was 13 weeks for FAC and 20 weeks for FAM. 1 patient receiving FAC and 2 patients receiving FAM who achieved partial response are alive. Median survival was 8 months for FAC and 7 months for FAM. Responders had a longer survival than nonresponder in both regimens. There was no difference in response and median survival between 2 regimens. Toxicities were mainly gastrointesinal and hematologic, but were moderate and well tolerated in both groups. In conclusion, these regimens have substantial effects on advanced or unresectable gastric cancer without severe toxicities.

대량화학요법을 위한 G-CSF를 이용한 말초조혈모세포의 구동

김삼용,조덕연 충남대학교 의과대학 지역사회의학연구소 1999 충남의대잡지 Vol.26 No.2

This study probed the effective and economic method for mobilizing the hemopoietic stem cells for the support of high-dose chemotherapy. Eleven trials of Hemopoietic mobilization was performed in 10 patients. A total of 36 leukapheresis was performed(median; 3, range; 2 - 6). Cytotoxic chemotherapy plus G-CSF(300μg/day x 7 days) or G-CSF alone was given to mobilize hemopoietic stem cells. A median of 5.4 x (3.3 - 9.47) x 10 ^8/kg mononuclear cells and 5.1(1.3 - 43) x 10^4/kg GM-CFU was obtained. Nine courses of high-dose chemotherapy was performed in 8 patients. Days with absolute neutrophil count less than 1000/㎣ was 8.5(range ; 3-26) and days with platelet count less than 50.000/㎣ was 14(range; 0-46). Days G-CSF required was 12.5(range ; 9-27) and a median of 100units(range; 10-250) of platelet transfusion was required. Days with antibiotic coverage was 7. 5(0-30) and days of admission was 24(range; 17-51). We can conclude in this study that cyclophosphamide 2g/㎡ and G-CSF 300μg x 7days, or G-CSF for 7 days arc sufficient for the mobilization of hemopoietic stem cells for the high-dose chemotherapy.

X-Band 용 마이크로스트립 안테나 설계에 관한 연구

김환용,김태형,백덕수 圓光大學校 1992 論文集 Vol.26 No.2

마이크로스트립 안테나는 소형, 경량, 저가격, 평면구성의 장점을 가지므로 여러분야에 응용되고있다. 본 논문에서는 X-BAND용 마이크로스트립 안테나를 해석하고 설계하기위하여 이론적 해석이 용이한 사각형의 마이크로스트립 패치 안테나를 제작하여 전압정재파비(VSWR)와 복사패턴을 측정하여 좋은 결과를 보였다. Microstrip antenna is applied to various fields for his forte of compact-size, light-weight, low-cost and planar configuration. In this paper, rectangular microstrip patch antenna which give easy theoretical analysis is verified by the method of slot-transmission line modeling for the analysis and design of X-Band microstrip antenna. After that, microstrip patch antenna is fabricated and attained good measure results for VSWR and radiation pattern.

제조업 산업장의 유기용제 노출에 관한 연구

문덕환,김정하,김필자,박명희,황용식,이채관,이창희 한국산업위생학회 2001 한국산업보건학회지 Vol.11 No.3

Objective : For the purpose of preparing the fundamental data and health promotion and control program on organic solvents in air of manufacturing industry. Methods : The author surveyed number of organic solvent components which was used in working site and also determined the organic solvents concentration in air of 927 manufacturing industries and 1,267 working process with gas chromatography(NIOSH manual) for five years from 1995 to 1999. Results : Mean numbers of solvents components by type of industry, working process was number of 12. There were exceeded to TLV of 1,2-dichloroethane in textile manufacturing industry N,N-dimethyl furan in tanning and dressing of leather ; luggage, handbags, saddlery, harness and footwear manufacturing industry and chemical and chemical product manufacturing industry by type of industry. There were exceeded to TLV of 1,2-dichloroethane in handwriting and drawing process, cellosolove in adhesive spreading process, N,N-dimethly furan in production of solvent process and adhesion process by working process. Total exceeded rate to threshold limit values of organic solvents mixture were 12.9% for EI(Exposure index) and 10.0% for Em(Estimation of mixture) by type of industry, 11.3% for EI and 8.2% for Em by type of working process. The highest exceed rate was 36.7% for EI in tanning and dressing of leather ; luggage handbags, saddlery, harness and footwear manufacturing industry and 29.0% for Em in textile manufacturing industry. the highest exceeded rate was 23.1% for EI and 12.5% for Em in adhesive spreading process by working process. Mean values of total subjects by type of industry and type of working process were 0.7±1.8 for EI and 0.7±1.7 for Em respectively. Conclusions : As above results, the author suggest that it makes the environmental control program on 1.2-dichloro-ethane, N,N-dimethyl furan, cellosolve by kind of organic solvent and on textile manufacturing industry, tanning and dressing of leather ; luggage, handbags, saddlery harness and footwear manufacturing industry by type of industry, and on handwriting, drawing process and adhesive spreading process and adhesion process by type of working process.

림프절 종창의 임상적 관찰

김삼용,김현수,김종숙,박상준,최지영,윤환중,조덕연 충남대학교 의과대학 지역사회의학연구소 1995 충남의대잡지 Vol.22 No.2

Objectives : Clinical management of patient with lymphadenopathy requires judicious judgement of clinicians. Careful evaluation of lymph node enlargement by various clinical parameters will help to disclose the etiology of lymph node enlargement. This study was conducted to identify the clinical manifestations and etiology of lymphadenopathy in korean patients. Methods : A total 192 patients with lymph node enlargement were studied retrospectively. All patients who underwent excisional lymph node biopsy during the period from January 1992 to July 1994 were included. The lymph node biopsy and clinical records were reviewed and patient characteristics were analyzed by various clinical parameters. Results : A female predominance was noted in lymphadenopathy of tuberculosis (58.5%), Kikuchi's syndrome (70%). In lymphadenopathy of nonspecific, tuberculosis, kikuchi syndrome, per centage of patients younger than 40 years of age were 84.5%, 75.6%, 100%, respectively. In lymphadenopathy of tuberculosis and metastatic cancer, the duration of lymphadenopathy below 30days were 51.2%, 73.9%, respectively. The two most common etiology of cervical lymphadenopathy were nonspecific lymphadenitis (47.7%) and tuberculous (26.8%). The two most frequent etiology of supraclavicular lymphadenopathy were nonspecific lymphadenitis (46.3%) and metastatic lymphadenopathy (26.8%) and the most common etiology of axillary lymphadenopathy was nonspecific lymphadenopathy (34.5%). The most common frequent of lymph node enlargement with size below 1㎠ was nonspecific lymphadenitis, while above 2.25㎠ it was metastatic lymphadenopathy. Conclusion : Careful evaluation regarding patient age, sex, size of lymph node, consistency, location of lymph node, presence or absence of systemic symptoms should be pursued before performing a biopsy and management.

위암에 대한 복합치료 성적

조덕연,김삼용 충남대학교 의과대학 지역사회의학연구소 1988 충남의대잡지 Vol.15 No.1

Combined radiotherapy(RT, 4500-5400 rad) plus systemic chemotherapy(CT) using FAM regimen(5-FU 600 mg/m²iv days 1, 8, 29, 36, Doxorubicin 30mg/m²iv days 1, 29, MitomycinC 10mg/m²iv day 1) 2-6 cycles were given to 5 patients with high risk resected stomach cancer and 2 patients with advanced stomach cancer. 4 of 5 patients with resected stomach cancer fares well 21 months, 16 months, 12 months and. 6 months after diagnosis without evidence of disease. 1 patient with resected cancer died of stomach outlet obstruction (without tumor recurrence by endoscopy) 19 months after diagnosis. 1 patient with recurrent stomach cancer is alive 9 months after diagnosis but shows porgressive disease. 1 case of advanced stomach cancer died of disease at 7 months. The toxicity from combined RT and CT were moderate. In 7 patients, 2 cases showed grade 2 GI toxicity, 4 cases showed grade 1 GI toxicity. For granulocyte level, there was one grade 1 toxicity, 4 with grade 2 toxicity and one with grade 3 toxicity. For platelet level, 4 cases showed grade 1 toxicity and 2 cases showed grade 2 toxicity. The effect of combined adjuvant therapy in high risk resected stomach cancer must be followed by further observations. For selected patients with locally advanced GI cancer, combined RT and CT might be effective measures, without significant toxicities.

도금사업장의 작업환경의 유해인자 노출수준에 관한 연구

문덕환,도수영,이채관,황용식,선병관,손병철,김대환,이창희,김휘동,이채언 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.5

Objective : For the purpose of preparing the fundamental data and assessing the status of exposure level of chemical substances and physical agents. Methods and Material : Such as noise, two types of dust, four types of metals, seventeen types of organic solvents, and four types of other materials classified by specific chemical substances in 21 metal product plating factories classified by 28 processes. The author determined exposure level on those hazardous materials from Jan. to Dec. 2001. Results : The results were as follows: 1. The exposure level for noise was exceeded to Threshold Limit Value(TLV) in the process of 6 cases of Machining, 5 and 4 cases of pre and post-buffing, and 6 cases of waterdrop-removing, the mean noise level of all of processes was not exceeded to compliance level. 2. The exposure level for dust was not exceeded to TLV at all. 3. The exposure level for Chromium(Cr) was exceeded to TLV in Chromium plating process, metal exposure level including Zinc(Zn), Manganese(Mn), and Lead(Pb) was not exceeded to TLV. 4. The exposure level of toluene in case of organic solvents was exceeded to TLV in 1 case of finishing/cleaning, coating/developing process, respectively. 5. The exposure level of four types of other materials classified by specific chemical substances were not exceeded to TLV. 6. The exposure level for dust and metal including Zn, Mn, and Pb was decreased in comparison with two results of air monitoring performed. There was no difference of the exposure level for Cr, noise, and four types of other materials classified by specific chemical substances, and the exposure level for organic solvents was slightly increased. 7. The exposure level for noise in factories employing more than 21 workers was higher than that for noise in foadtories employing less than 20 workers. The more workers, the lower exposure level in metal including Zn, Mn. The exposure level for Cr was increasing in factories employing more than 51 workers, and the more workers the lower exposure level in organic solvents. Conclusion : According to above results, this study suggests positive work environment managements in processes exceeding exposure limit value as well as continuously consecutive work environment management in processes not exceeding exposure limit value and revealing no chronological difference of exposure level should be needed.