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      • Survival Results and Prognostic Factors in T4 N0-3 Non-small Cell Lung Cancer Patients According to the AJCC 7<sup>th</sup> Edition Staging System

        Arslan,,Deniz,Bozcuk,,Hakan,Gunduz,,Seyda,Tural,,Deniz,Tattli,,Ali,Murat,Uysal,,Mukremin,Goksu,,Sema,Sezgin,Bassorgun,,Cumhur,Ibrahim,Koral,,Lokman,Coskun,,Hasan,Senol,Ozdogan,,Mustafa,Savas,,Burhan Asian Pacific Organization for Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.6

        Background: The American Joint Committee on Cancer (AJCC) published a new staging system ($7^{th}$ edition) in 2009. In our study, we evaluated the survival results and prognostic factors among T4 local advanced non-small cell lung cancer (LA-NSCLC) patients in a large heterogeneous group, in accordance with this new system. Materials and Methods: We retrospectively evaluated the files of 122 T4 N0-3 M0 LA-NSCLC patients, identified according to the new staging system, treated at two centers between November 2003 and June 2012. Variables correlating with univariate survival at p<0.20 were later included in multivariate Cox regression analysis. Here, selection of relevant predictors of survival was carried out in accordance with the likelihood ratio formula with p<0.05 regarded as significant. Results: The median age was 60 and the median follow-up period was 17.4 months. Median overall survival (OS) was 18.3 months, the 1 year overall survival (OS) rate was 72%, and the 5 year OS rate was 28%. Statistically significant predictors of survival were (p<0.20) ECOG-PS (Eastern Cooperative Oncology Group Performance Status), age, T4 factor subgroup, stage and primary treatment in OS univariate analysis. On multivariate analysis for OS ECOG-PS (p=0.001), diagnostic stage (p=0.021), and primary treatment (p=0.004) were significant. In the group receiving non-curative treatment, the median OS was 11.0 months, while it was 19.0 months in the definitive RT group and 26.6 months in the curative treatment group. There was a significant difference between the non-curative group and the groups which had definitive RT and curative operations (respectively p<0.001 and p=0.001) in terms of OS, but not between the groups which had definitive RT and curative operations. The median event free survival (EFS) rate was 9.9 months, with rates of 46% and 19% at 3 and 5 years, respectively. On univariate analysis of EFS rate with ECOG-PS, weight loss and staging, statistical significance was found only for thorax computerized tomography (CT)+18F-fluorodeoxy-glucose positron emission tomography-CT (PET-CT) use, stage and primary treatment (p<0.20). In multivariate analysis with EFS, only the primary treatment was statistically significant (p=0.001). In the group receiving non-curative treatment, the median EFS was 10.5 months while in the curative operation group it was 14.7 months. When all the primary treatment groups were taken into consideration, grade III/IV side effect swas observed in 57 patients (46.6%). Esophagitis was most prominent among those that received definitive radiotherapy. Conclusions: Independent prognostic factors among these 122 heterogeneous LA-NSCLC T4 N0-3 M0 patients were age at diagnosis, ECOG-PS, stage and primary treatment, the last also being a significant prognostic indicator of EFS. Our findings point to the importance of appropriate staging and a multidisciplinary approach with modern imaging methods in this patient group. In those with T4 lesions, treatment selection and the effective use of curative potential should be the most important goal of clinical care.

      • Increase in the Rate of HPV Positive Oropharyngeal Cancers During 1996-2011 in a Case Study in Turkey

        Tural,,Deniz,Elicin,,Olgun,Batur,,Sebnem,Arslan,,Deniz,Oz,,Buge,Serdengecti,,Suheyla,Uzel,,Omer Asian Pacific Organization for Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.10

        Background: Primary aim of this study is to assess whether or not there is an increase at rate of HPV positive oropharyngeal cancers during 1996-2011 in Turkey, for comparison with prior reports from Western countries. Materials and Methods: A total of 138 newly diagnosed patients with oropharyngeal cancer were identified, 39 of which had no primary tumor specimen available and 18 patients with invalid HPV status, therefore HPV status for remaining 81 patients was evaluated. The presence and type of HPV DNA were determined with formalin-fixed paraffin embedded specimens, using an HPV DNA-based multiplex PCR assay. Associations between HPV status and clinicopathological characteristics were evaluated using a two-sample t-test for the continuous variables and the categorical variables were compared by chi-square test. Overall survival (OS) periods were calculated with Kaplan-Meier method. Results: The proportion of HPV-positive cancer has continued to increase during 2004-2011 as compared with 1996-2003. Notably, 33% (6/18) of the cases were HPV-positive in 1996-1999, 43% (9/21) in 2000-2003, 55% (11/20) in 2004-2007 and 70% (16/23) in 2008-2011. Thus, when we compared the results obtained during the 2004-2011with results of 1996-2003 period, we found that increase at HPV-positivity ratio was statistically significant (38% vs 64% p=0.012). Conclusions: This study demonstrated that HPV positive oropharyngeal cancers are increasing in Turkish patients as in the Western world.

      • Cancer Pain Prevalence and its Management

        Arslan,,Deniz,Koca,,Timur,Akar,,Emre,Tural,,Deniz,Ozdogan,,Mustafa Asian Pacific Organization for Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.20

        Pain is a public health problem affecting more than half of cancer patients. Despite the success of the protocols currently used, pain cannot still be reduced satisfactorily in the large majority of patients. In order to improve pain management, all healthcare professionals involved with pain should have sufficient knowledge on pain assessment and treatment, and should inform patients to prevent patient-related barriers. In this compilation, the prevalence values and the treatment methods of cancer pain, and the barriers to pain management have been assessed.

      • KCI등재

        Antinociceptive Effect of Chlorogenic Acid in Rats with Painful Diabetic Neuropathy

        Deniz,Bagdas,Hasret,Yucel,Ozboluk,Nilufer,Cinkilic,Mine,Sibel,Gurun 한국식품영양과학회 2014 Journal of medicinal food Vol.17 No.6

        The present study aimed to evaluate possible antinociceptive effects of chlorogenic acid in streptozotocininduced diabetic neuropathic pain in rats. Chlorogenic acid (100 mg/kg) was administered daily for 14 days. Our study showed for the first time that both single and chronic chlorogenic acid treatments produced significant antinociceptive effects in diabetic rats. In contrast, single dose of chlorogenic acid showed no signs of an antinociceptive effect, but chronic treatment exerted antinociceptive potential in nondiabetic rats. Additionally, chronic treatment effectively reduced hyperglycemia that induced by diabetes. In conclusion, chlorogenic acid has beneficial effects for the management of diabetic neuropathic pain.

      • Examining The Spatial Distribution of Festivals in Turkey

        Deniz,,NCÜ,Semra,,NAY,AKTAŞ 세계문화관광학회 2015 International Journal of Culture and tourism Resea Vol.8 No.1

        '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

        Festivals have become a strong demand generating factor in recent years. They not only contribute to tourism, travel, leisure and hospitality industries but also act as an important tool to attain social, economical, environmental objectives of communities. This study investigates the spatial dependence of festivals (cultural, agricultural, ethnic etc.) in 81 provinces and 955 subprovinces of Turkey for the 2013- 2014 time period by using spatial statistics and mapping analysis. Exploratory Spatial Data Analysis (ESDA) was used to determine whether there is a spatial pattern of festivals in Turkey or not. Spatial correlation analysis which covers global and local spatial autocorrelation is conducted to determine meaningful patterns. Results shows that there is a moderate positive spatial autocorrelation, which suggests a clustered spatial pattern in the distribution of the number of festivals across Turkey. In addition, in terms of festival themes, there is no spatial autocorrelation in Turkey. In other words, festivals are randomly assigned to clusters.

      • SCOPUSKCI등재

        Determination and classification of intraoral phosphor storage plate artifacts and errors

        Deniz,,Yesim,Kaya,,Seher Korean Academy of Oral and Maxillofacial Radiology 2019 Imaging Science in Dentistry Vol.49 No.3

        Purpose: The aim of this study was to determine the reasons and solutions for intraoral phosphor storage plate (PSP) image artifacts and errors, and to develop an appropriate classification of the artifacts. Materials and Methods: This study involved the retrospective examination of 5,000 intraoral images that had been obtained using a phosphor plate system. Image artifacts were examined on the radiographs and classified according to possible causative factors. Results: Artifacts were observed in 1,822 of the 5,000 images. After examination of the images, the errors were divided into 6 groups based on their causes, as follows: images with operator errors, superposition of undesirable structures, ambient light errors, plate artifacts (physical deformations and contamination), scanner artifacts, and software artifacts. The groups were then re-examined and divided into 45 subheadings. Conclusion: Identification of image artifacts can help to improve the quality of the radiographic image and control the radiation dose. Knowledge of the basic physics and technology of PSP systems could aid to reduce the need for repeated radiography.

      • SCOPUSKCI등재

        The Fekete-Szego Problem for a Generalized Subclass of Analytic Functions

        Deniz,,Erhan,Orhan,,Halit Department of Mathematics 2010 Kyungpook mathematical journal Vol.50 No.1

        In this present work, the authors obtain Fekete-Szeg$\ddot{o}$ inequality for certain normalized analytic function f(z) defined on the open unit disk for which $\frac{(1-{\alpha})z(D^m_{{\lambda},{\mu}}f(z))'+{\alpha}z(D^{m+1}_{{\lambda},{\mu}}f(z))'}{(1-{\alpha})D^m_{{\lambda},{\mu}}f(z)+{\alpha}D^{m+1}_{{\lambda},{\mu}}f(z)}$ ${\alpha}{\geq}0$) lies in a region starlike with respect to 1 and is symmetric with respect to the real axis. Also certain applications of the main result for a class of functions defined by Hadamard product (or convolution) are given. As a special case of this result, Fekete-Szeg$\ddot{o}$ inequality for a class of functions defined through fractional derivatives is obtained. The motivation of this paper is to generalize the Fekete-Szeg$\ddot{o}$ inequalities obtained by Srivastava et al., Orhan et al. and Shanmugam et al., by making use of the generalized differential operator $D^m_{{\lambda},{\mu}}$.

      • KCI등재SCOPUS

        Methacryloylamidohistidine in Affinity Ligands for Immobilized Metal-ion Affinity Chromatography of Ferritin

        Deniz,Akta,Uygun,Nevra,Öztürk,Sinan,Akgöl,Adil,Denizli 한국생물공학회 2011 Biotechnology and Bioprocess Engineering Vol.16 No.1

        A new metal-chelate adsorbent utilizing 2-methacryloylamidohistidine (MAH) was prepared as a metalchelating ligand. MAH was synthesized using methacryloly chloride and histidine. Monosize nanospheres with an average diameter of 450 nm were produced by emulsion polymerization of 2-hydroxyetylmethacrylate (HEMA) and MAH. Then, Fe^(3+) ions were chelated directly onto the monosize nanospheres. Mon-poly(HEMA-MAH) nanospheres were characterized by Fourier transform infrared spectroscopy,scanning electron microscopy, and elemental analysis. Fe^(3+) chelated monosize nanospheres were used in ferritin adsorption from an aqueous solution. The maximum ferritin adsorption capacity of Fe^(3+)-chelated mon-poly(HEMAMAH)nanospheres was 202 mg/g at pH 4.0 in acetate buffer. The non-specific ferritin adsorption on the monpoly(HEMA-MAH) nanospheres was 20 mg/g. The adsorption behavior of ferritin could be modeled using both Langmuir and Freundlich isotherms. The adsorption capacity decreased with increasing ionic strength of the binding buffer. High desorption ratios (> 95% of the adsorbed ferritin) were achieved with 1.0 M NaCl at pH 7.0. Ferritin could be repeatedly adsorbed and desorbed with the Fe^(3+)-chelated mon-poly(HEMA-MAH) nanospheres without significant loss of adsorption capacity.

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