miR-124 Inhibits Growth and Invasion of Gastric Cancer by Targeting ROCK1

Hu, Cong-Bing,Li, Qiao-Lin,Hu, Jian-Fei,Zhang, Qiang,Xie, Jian-Ping,Deng, Li Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.16

MicroRNAs (miRNAs) act as critical regulators of genes involved in many biological processes. Aberrant alteration of miRNAs have been found in many cancers, including gastric cancer (GC), but the molecular mechanisms are not well understood. Herein, we investigated the role of miR-124 in GC. We found that its expression was significantly reduced in both GC tissue samples and cell lines. Forced expression of miR-124 suppressed GC cell proliferation, migration, and invasion. Furthermore, the Rho-associated protein kinase (ROCK1) was identified as a direct target of miR-124 in GC cells. Finally, silencing of ROCK1 showed similar effects as miR-124 overexpression, while supplementation of ROCK1 remarkably restored the cell growth and invasion inhibited by miR-124. Together, our data demonstrate that miR-124 acts as a tumor suppressor by targeting ROCK1, and posit miR-124 as a novel strategy for GC treatment.

Primary Research on Theoretical Performance and Powder Supply Characteristics of Powder Rocket

Deng, Zhe,Hu, Chun-bo,Hu, Song-qi,Xu, Yi-hua The Society for Aerospace System Engineering 2015 International Journal of Aerospace System Engineer Vol.2 No.2

The powder propellant rocket which uses micron-sized particles as fuel is storable and costly. Functions like thrust control and multiple-ignition can be realized by changing powder mass flow rate. In this paper, we discuss the theoretical performance of bi-propellant and mono-propellant powder rocket. When used as the fluidization gas, helium can improve specific impulse dramatically. The stability of the powder feeding device is preliminarily quantified through metal/N2O powder rocket hot fire tests.

Identification of polymorphic loci in the deiodinase 2 gene and their associations with head dimensions in geese

Deng, Yan,Hu, Qian,Tang, Bincheng,Ouyang, Qingyuan,Hu, Shenqiang,Hu, Bo,Hu, Jiwei,He, Hua,Chen, Guohong,Wang, Jiwen Asian Australasian Association of Animal Productio 2022 Animal Bioscience Vol.35 No.5

Objective: This study was conducted to clone and compare the molecular characteristics of the deiodinase 2 (DIO2) gene between Sichuan White geese and Landes geese, and to analyze the association between polymorphisms of the DIO2 gene and head dimensions in Tianfu meat geese. Methods: The coding sequence of the DIO2 gene was cloned by polymerase chain reaction and vector ligation and aligned by DNAMAN software. A total of 350 Tianfu meat geese were used to genotype the polymorphisms of the DIO2 gene and measure the head dimensions. Association analysis between the polymorphisms of the DIO2 gene and head dimensions was carried out. Results: An 840-bp coding sequence of the DIO2 gene was obtained and comparison analysis identified four polymorphic loci between Sichuan White geese and Landes geese. Further analysis showed that the dominant alleles for the four polymorphic loci were G, G, A, and T and the frequency of the heterozygous genotype was higher than that of the homozygous genotype in Tianfu meat geese. Compared to that in the population of non-knob geese of Tianfu meat geese, the head dimensions in the population of knob geese were significantly higher except for nostril height. However, in the non-knob geese, beak width 1, beak width 2, nostril length, cranial width 1, and maxillary length had significant differences among different genotypes or haplotypes/diplotypes. Conclusion: These results suggested that polymorphisms of the DIO2 gene could be considered molecular markers to select larger heads of geese in the population of non-knob geese.

Flexural behaviour of steel plate-masonry composite beams

Deng-Hu Jing,Shuang-Yin Cao,Lei Shi 국제구조공학회 2012 Steel and Composite Structures, An International J Vol.13 No.2

Steel plate-masonry composite structure is a newly-developed type of structural technique applicable to existing masonry buildings by which the load-bearing walls can be removed for large spaces. This kind of structure has been used in practice for its several advantages, but experimental investigation on its elements is nearly unavailable in existing literature. This paper presents an experimental study on the flexural behaviour of four steel plate-masonry composite beams loaded by four-point bending. Test results indicate that failure of the tested beams always starts from the local buckling of steel plate, and that the tested beams can satisfy the requirement of service limit state. In addition, the assumption of plane section is still remained for steel plate prior to local buckling or steel yielding. By comparative analyses, it was also verified that the working performance of the beam is influenced by the cross-section of steel plate, which can be efficiently enhanced by epoxy adhesive rather than cement mortar or nothing at all. Besides, it was also found that the contribution of the encased masonry to the flexural capacity of the composite beam cannot be ignored when the beam is injected with epoxy adhesive.

Experimental investigation of masonry walls supported by steel plate-masonry composite beams

Deng-Hu Jing,Jian-Fei Chen,Giuseppina Amato,Ting Wu,Shuang-Yin Cao 국제구조공학회 2018 Steel and Composite Structures, An International J Vol.28 No.6

Masonry walls are sometimes removed in buildings to either make new passages or increase the usable space. This may change the loading paths in the structure, and require new beams to transfer the loads which are carried by the masonry walls that are to be removed. One possible method of creating such new beams is to attach steel plates onto part of the existing walls to form a steel plate-masonry composite (SPMC) beam, leading to a new structure with part of the masonry wall supported by a new SPMC beam. This paper presents an experimental investigation into the interaction between the SPMC beam and the masonry wall above. Five SPMC beams supporting a masonry wall were tested to study the influence of parameters including the height-to-span ratio of the masonry wall, height of the beam and thickness of the steel plates. The test results, including failure mode, load-carrying capacity, load-deflection curves and strain distribution, are presented and discussed. It is found that for developing better arching effect in the masonry wall the ratio of the in-plane flexural stiffness of the masonry wall to the flexural stiffness of the SPMC beam must be between 2.8 and 7.1.

Stability Analysis and Control of Nonlinear Behavior in V² Switching Buck Converter

Hu, Wei,Zhang, Fangying,Long, Xiaoli,Chen, Xinbing,Deng, Wenting The Korean Institute of Power Electronics 2014 JOURNAL OF POWER ELECTRONICS Vol.14 No.6

Mismatch between switching frequency and circuit parameters often occurs in industrial applications, which would lead to instability phenomena. The bifurcation behavior of $V^2$ controlled buck converter is investigated as the pulse width modulation period is varied. Nonlinear behavior is analyzed based on the monodromy matrix of the system. We observed that the stable period-1 orbit was first transformed to the period-2 bifurcation, which subsequently changed to chaos. The mechanism of the series of period-2 bifurcations shows that the characteristic eigenvalue of the monodromy matrix passes through the unit circle along the negative real axis. Resonant parametric perturbation technique has been applied to prevent the onset of instability. Meanwhile, the extended stability region of the converter is obtained. Simulation and experimental prototypes are built, and the corresponding results verify the theoretical analysis.

Performance Measure of Switched Control Systems Based on Covariance Tensor Approach

Deng-Yin Jiang,Li-Sheng Hu 제어·로봇·시스템학회 2016 International Journal of Control, Automation, and Vol.14 No.6

In this paper, controller performance measure is considered for switched systems. The covariance tensorbasedmethod is proposed for the controller performance measure for this systems evolution with the discrete-valuedswitching dynamics and local models for continuous dynamics. We define a measurement tensor to construct themeasured process outputs data, and employ the data processing technique of higher-order singular value decomposition. Applying the higher-order singular value decomposition, we can obtain the sets of singular values fromthe measurement tensor, which are used jointly to evaluate the controller performance of the overall switched systemssignificantly. We develop the covariance tensor-based performance assessment method for the multivariateswitched control systems with characteristic information being mined from the measurement tensor and derive thecalculation approach base on the sets of singular values from the measurement tensor. It is shown that by applyinghigher-order singular value decomposition for measured outputs tensor data, the performance assessment resultscan exactly reflect the controller performance under the overall dynamical process. Finally, two cases study of thenumerical simulation examples and a typical industrial process system well demonstrate the effectiveness of theproposed method.

Ultrafast dynamics control on ablation of Cu using shaped femtosecond pulse trains

Deng Jiannan,Qi Hongxia,Liu Xinyi,Li Xiaoyi,Tong Qiunan,Lian Zhenzhong,Li Juan,Bo Jinqiu,Fei Dehou,Chen Zhou,Hu Zhan 한국물리학회 2021 Current Applied Physics Vol.26 No.-

The ablation processes of Cu film are investigated using temporal shaped femtosecond pulse trains. The depth is modulated by changing the number and interval of the sub-pulses. The underlying ultrafast dynamic processes are discussed based on plasma shielding and electron multiple heating mechanisms. When the sub-pulse interval is less than 0.4 ps electron multiple heating is the dominant mechanism, while the plasma shielding dominates the subsequent ablation processes when the sub-pulse interval is larger than 0.4 ps. The curve of depth obtained by three pulse trains shows more significant oscillation as the function of sub-pulse interval under the lowfluence. We propose that the oscillation of depth is due to the coherent phonon oscillation excited by the pulse train. The study provides a basis for giving insight into the ultrafast dynamics for improving micromachining and nano-fabrications using shaped femtosecond pulse trains.

Circulating current suppression control for modular multilevel converters based on restricted self-redundant states prediction

Hu, Xing,Zhang, Jianzhong,Deng, Fujin,Chen, Gui,Chen, Qiang,Din, Zaki ud The Korean Institute of Power Electronics 2020 JOURNAL OF POWER ELECTRONICS Vol.20 No.5

Circulating current exists among phases or between the DC link and the three phases in a modular multilevel converter (MMC). Suppression control of the alternating components in circulating current is a critical issue for the stable and efficient operation of an MMC. Due to the redundancy and symmetry of MMCs, some of the self-redundant states of MMCs can be used to suppress the alternating components in circulating current without affecting the output performance of the converter. In this paper, a theoretical derivation of the boundary of redundant states is given. Then a suppression strategy for circulating current is proposed based on prediction control and the boundary of redundant states. The selection range of the redundant states is narrowed in this case, which reduces the computation burden when compared to the original method and ensures excellent performance in the suppression of circulating current. Simulations and experiments are carried out to verify the effectiveness of the proposed strategy.

Model predictive DC-component power control for grid-connected inverters under unbalanced network

Hu, Bihua,Chen, Zhiyong,Zhang, Zhi,Deng, Wenlang,Zhao, Dongdong The Korean Institute of Power Electronics 2021 JOURNAL OF POWER ELECTRONICS Vol.21 No.1

Under an unbalanced network, model predictive control (MPPC) with a new definition of the instantaneous reactive power has attracted a great deal of attention due to its simple control structure and outstanding steady-state performance. However, the reactive power cannot precisely trace the nonzero reference. In this paper, a model predictive DC-component power control (MPDCPC) is proposed to tackle the above-mentioned problem. Additionally, the MPDCPC can eliminate oscillations on the reactive power and the negative-sequence current. Then, the corresponding mathematical formulas are derived to extract the DC-component powers, to calculate the DC-component power derivative and to modify the power reference. By regulating the DC-component power to trace the modified reference, the MPDCPC can reduce the current harmonic and remove the oscillations on the active power, reactive power or negative-sequence current. Simulation and experimental platforms are established to demonstrate the validity of MPDCPC. Results demonstrate that the MPDCPC can effectively suppress current distortion and remove oscillations on active power, reactive power or negative-sequence current. In addition, the MPDCPC can successfully break through the restrictions of the MPPC with a new definition of instantaneous reactive power.