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- 저자 : Demirel-Yilmaz (검색결과 5 건)
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Berber, Ufuk,Yilmaz, Ismail,Yilmaz, Omer,Haholu, Aptullah,Kucukodaci, Zafer,Ates, Ferhat,Demirel, Dilaver Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.6
We aimed to investigate bladder cancer risk with reference to polymorphic variants of cytochrome p450 (CYP) 1A1, CYP1B1, glutathione S-transferase (GST) M1, and GSTT1 genes in a case control study. Polymorphisms were examined in 114 bladder cancer patients and 114 age and sex-matched cancer-free subjects. Genotypes were determined using allele specific PCR for CYP1A1 and CYP1B1 genes, and by multiplex PCR and melting curve analysis for GSTM1 and GSTT1 genes. Our results revealed a statistically significant increased bladder cancer risk for GSTT1 null genotype carriers with an odds ratio of 3.06 (95% confidence interval=1.39-6.74, p=0.006). Differences of CYP1A1, CYP1B1 and GSTM1 genotype frequencies were not statistically significant between patients and controls. However, the specific combination of GSTM1 null, GSTT1 null, and CYP1B1 codon 119 risk allele carriers and specific combination of GSTM1 present, GSTT1 null, and CYP1B1 432 risk allele carriers exhibited increased cancer risk in the combined analysis. We did not observe any association between different genotype groups and prognostic tumor characteristics of bladder cancer. Our results indicate that inherited absence of GSTT1 gene may be associated with bladder cancer susceptibility, and specific combinations of GSTM1, GSTT1 and CYP1B1 gene polymorphisms may modify bladder cancer risk in the Turkish population, without any association being observed for CYP1A1 gene polymorphism and bladder cancer risk.
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Ufuk Berber,Ismail Yilmaz,Gizem Narli,Aptullah Haholu,Zafer Kucukodaci,Dilaver Demirel 한국유방암학회 2014 Journal of breast cancer Vol.17 No.2
Purpose: We examined expression profiles of 16 micro RNAs(miRNAs) in triple negative breast cancers to identify their potentialas biomarkers for lymph node metastasis. Methods: The expressionprofiles of miR-9, miR-21, miR-30a, miR-30d, miR-31,miR-34a, miR-34c, miR-100, miR-122, miR-125b, miR-146a,miR-146b, miR-155, miR-181a, miR-200c, and miR-205 wereexamined by using real-time quantitative reverse transcriptionpolymerase chain reaction in tumor samples and correspondingbenign breast tissues. Their associations with histopathologicalfeatures and prognostic parameters were assessed. Results:When compared with the expression in benign breast tissues,seven of the miRNAs (miR-31, miR-205, miR-34a, miR-146a,miR-125b, miR-34c, and miR-181a) were downregulated morethan 1.5-fold in tumor tissues, whereas, only miR-21 was foundto be upregulated more than 1.5-fold in tumor tissues. AlthoughmiR-200c levels were decreased only 1.12-fold in tumor tissues,the reduced expressions of miR-200c and miR-205 were significantlyassociated with lymph node metastasis (p=0.021 and p=0.016, respectively). Conclusion: Our results demonstrate thatmiR-205 and miR-200c expression levels may be useful in predictinglymph node metastasis in triple negative breast cancerpatients.
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Palaz Esra Bulunuz,Demirel Fatih,Adali Sümeyye,Demirel Serap,Yilmaz Abdurrahim 한국식물생명공학회 2023 Plant biotechnology reports Vol.17 No.2
Orchids are naturally grown in many countries of the Eastern Mediterranean. Salep, produced from orchid tubers via grinding and used as a hot drink, is an essential ingredient of ice cream. Salep orchid species are in danger of extinction due to the absence of cultivation and over-harvesting from nature. In this study, the genetic diversity and population structure between salep orchid species, their hybrids, and commercial species of Phalenopsis sp. were first investigated using inter-Primer Binding Site (iPBS) Retrotransposon markers. A total of 854 bands were scored with a 100% polymorphism rate. Neighbor-joining, model-based structure, and PCoA (Principal Coordinate Analysis) algorithms clustered the 30 salep orchids into three main populations. The analysis of molecular variance revealed variations within and among the populations as 71% and 29%, respectively. Anacamptis morio and Serapias vomeracea had the furthest genetic distances, and F1 hybrids of S. vomeracea and A. morio had great genetic diversity. The study results will provide helpful information for orchid breeding by eliciting the genetic distances of salep orchids.
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Mesut Buluc,Murat Ayaz,Belma Turan,Emine Demirel-Yilmaz 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.5
Resveratrol, a natural phytoalexin found in wine, has been suggested to have benefits in preventing cardiovascular diseases. However, the direct effects of resveratrol on the activity of cardiac tissues and its mechanism of action have not been determined. This study examined the effects of resveratrol on the right and left atrium and left papillary muscle isolated from the rat heart. The contractile responses of the right atrium and papillary muscle and the action potential from the left atrium were recorded and the effects of resveratrol on these responses were observed. The resting force of the isolated right atrium and the peak developed force of the left papillary muscle were depressed by resveratrol (0.1 nM - 0.1 mM). Exposure to the KATP channel blocker glyburide (3 µM) prevented significantly the resveratrol-induced decrease. Resveratrol (0.1 mM) shortened the repolarization phase of action potential recorded from the left atrium and this effect of resveratrol was reversed by glyburide (3 µM). These results indicated that resveratrol depressed cardiac muscle contraction and shortened action potential duration probably due to the activation of KATP channels in the rat heart.
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Ozbay, Pelin Ozun,Ekinci, Tekin,Caltekin, Melike Demir,Yilmaz, Hasan Taylan,Temur, Muzaffer,Yilmaz, Ozgur,Uysal, Selda,Demirel, Emine,Kelekci, Sefa Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.1
Background: To determine the cut-off values of the preoperative risk of malignancy index (RMI) used in differentiating benign or malignant adnexal masses and to determine their significance in differential diagnosis by comparison of different systems. Materials and Methods: 191 operated women were assessed retrospectively. RMI of 1, 2, 3 and 4; cut-off values for an effective benign or malignant differentiation together with sensitivity, specificity, negative and positive predictive values were calculated. Results: Cut-off value for RMI 1 was found to be 250; there was significant (p<0.001) compatibility at this level with sensitivity of 60%, positive predictive value (PPV) of 75%, specificity of 93%, negative predictive value (NPV) of 88% and an overall compliance rate of 85%. When RMI 2 and 3 was obtained with a cut-off value of 200, there was significant (p<0.001) compatibility at this level for RMI 2 with sensitivity of 67%, PPV of 67%, specificity of 89%, NPV of 89%, histopathologic correlation of 84% while RMI 3 had significant (p<0.001) compatibility at the same level with sensitivity of 63%, PPV of 69%, specificity of 91%, NPV of 88% and a histopathologic correlation of 84%. Significant (p<0.001) compatibility for RMI 4 with a sensitivity of 67%, PPV of 73%, specificity of 92%, NPV of 89% and a histopathologic correlation of 86% was obtained at the cut-off level 400. Conclusions: RMI have a significant predictability in differentiating benign and malignant adnexal masses, thus can effectively be used in clinical practice.
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