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- 저자 : Demiralay (검색결과 2 건)
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Unal, Hakan Umit,Demiralay, Ebru,Tepeoglu, Merih,Fidan, Cihan,Kilickap, Saadettin Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.5
Introduction: Colorectal cancers are in the top of the cancer-related causes of death in the world and lymph node metastasis is accepted as the primary prognostic factor. In this study, correlations of FGF19 staining pattern with local invasion and lymph node metastasis in a series of colorectal cancers were investigated. Methods: This studyincluded 81 colorectal cancer patients who underwent surgery in our hospital with no evidence of preoperative radiological distant metastasis. Routine pathological examination of the resection material was performed in order to identify vascular, perineural and serosal infiltration, regional lymph node metastasis and the degree of differentiation. Tumor tissue samples were stained with an immunohistochemistry method for FGF 19 evaluation and the staining pattern was statistically compared with the above mentioned characteristics of the tumors. Results: The patient population consisted of 47 females and 34 males with a median age of 70 years. In 40 patients regional lymph nodes were positive and 51%, 32% and 38% had serosal, perineural and vascular invasion. While 64 cases were moderately-differentiated, 11 cases were well-differentiated and 6 poorlydifferentiated, there was no association with FGF 19 staining, including intensity. Conclusion: No evidence of significant statistically correlation was found between FGF 19 staining pattern and serosal, perineural, vascular invasion, lymph node involvement and degree of differentiation.
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Aykut Saglam,Ebru Kalaycioglu,Funda Gul Guven,Neslihan Saruhan,Asım Kadioglu,Mehmet Demiralay 한국원예학회 2014 Horticulture, Environment, and Biotechnology Vol.55 No.4
Reducing effects of exogenous hydrogen peroxide on leaf rolling in detached leaves of Ctenanthe setosawere studied. The leaves were kept in H2O2 solutions ranging from 0 to 1 mM for 48 h and then, osmotic stresswas applied for 4 h by polyethylene glycol (PEG). Degree of leaf rolling, loss of leaf water, and malondialdehyde(MDA) content were reduced by 0.2 mM H2O2. Antioxidant enzymes were induced by 0.2 mM H2O2. EndogenousH2O2 content was increased after the 0.5 and 1 mM H2O2 treatments but was decreased after 0.2 mM H2O2 treatment. Proline was decreased after exogenous H2O2 applications. Total soluble sugar content was increased as compared tothe control after 0.2 mM H2O2 treatment. In conclusion, low-dose exogenous H2O2 treatment could delay leaf rollingby inducing tolerance to osmotic stress due to modulation of the antioxidant system, soluble sugar accumulation, andmaintenance of leaf hydration. Therefore, postharvest life of C. setosa cut foliage could be extended by 0.2 mMH2O2 treatments.
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