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Deepu Singh,B. Sinha,V. P. Rai,M. N. Singh,D. K. Singh,R. Kumar,A. K. Singh 한국식물병리학회 2016 Plant Pathology Journal Vol.32 No.2
Inheritance of resistance to Fusarium wilt (FW) diseasecaused by Fusarium udum was investigated in pigeonpeausing four different long duration FW resistantgenotypes viz., BDN-2004-1, BDN-2001-9, BWR-133and IPA-234. Based on the F2 segregation pattern, FWresistance has been reported to be governed by onedominant gene in BDN-2004-1 and BDN-2001-9, twoduplicate dominant genes in BWR-133 and two dominantcomplimentary genes in resistance source IPA-234. Further, the efficacy of six simple sequence repeat (SSR)markers namely, ASSR-1, ASSR-23, ASSR-148, ASSR-229, ASSR-363 and ASSR-366 reported to be associatedwith FW resistance were also tested and concluded thatmarkers ASSR-1, ASSR-23, ASSR-148 will be used forscreening of parental genotypes in pigeonpea FW resistancebreeding programs. The information on geneticsof FW resistance generated from this study would beused, to introgress FW resistance into susceptible buthighly adopted cultivars through marker-assisted backcrossbreeding and in conventional breeding programs.
Singh, Deepu,Sinha, B.,Rai, V.P.,Singh, M.N.,Singh, D.K.,Kumar, R.,Singh, A.K. The Korean Society of Plant Pathology 2016 Plant Pathology Journal Vol.32 No.2
Inheritance of resistance to Fusarium wilt (FW) disease caused by Fusarium udum was investigated in pigeonpea using four different long duration FW resistant genotypes viz., BDN-2004-1, BDN-2001-9, BWR-133 and IPA-234. Based on the $F_2$ segregation pattern, FW resistance has been reported to be governed by one dominant gene in BDN-2004-1 and BDN-2001-9, two duplicate dominant genes in BWR-133 and two dominant complimentary genes in resistance source IPA-234. Further, the efficacy of six simple sequence repeat (SSR) markers namely, ASSR-1, ASSR-23, ASSR-148, ASSR-229, ASSR-363 and ASSR-366 reported to be associated with FW resistance were also tested and concluded that markers ASSR-1, ASSR-23, ASSR-148 will be used for screening of parental genotypes in pigeonpea FW resistance breeding programs. The information on genetics of FW resistance generated from this study would be used, to introgress FW resistance into susceptible but highly adopted cultivars through marker-assisted backcross breeding and in conventional breeding programs.
( Yogesh V. Joshi ),( Deepu Bhaskar ),( Padmanabh M. Phaltankar ),( Charalambos P. Charalambous ) 대한슬관절학회 2015 대한슬관절학회지 Vol.27 No.4
Tibial cyst formation following the use of bioabsorbable interference screws in anterior cruciate ligament (ACL) reconstruction is well-described; however, cyst formation after the use of metallic interference screws is not well-documented. We describe a case of osteolytic lesion of the proximal tibia presenting to us 20 years after ACL reconstruction using an autologous bone-tendon-bone graft. The original graft fixation technique was interference fixation with a metal screw in the tibial and femoral tunnels. A two-stage revision reconstruction of the ACL was undertaken with curettage and bone grafting of the tibial lesion in the first stage and reconstruction using a four-strand hamstring tendon in the second stage. The patient recovered satisfactorily with complete healing of the cyst and returned to pre-injury level of activities. We have reviewed case reports and case series that describe the aetiology of intra-osseous cyst formation following ACL reconstruction.
Roy, Nabarun,Narayanankutty, Arunaksharan,Nazeem, PA,Valsalan, Ravisankar,Babu, TD,Mathew, Deepu Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.8
Background: Colorectal cancer (CRC) or bowel cancer is one of the most important cancer diseases, needing serious attention. The cell surface receptor gene human epidermal growth factor receptor (EGFR) may have an important role in provoking CRC. In this pharmaceutical era, it is always attempted to identify plant-based drugs for cancer, which will have less side effects for human body, unlike the chemically synthesized marketed drugs having serious side effects. So, in this study the authors tried to assess the activity of two important plant compounds, ferulic acid (FA) and p-coumaric acid (pCA), on CRC. Materials and Methods: FA and pCA were tested for their cytotoxic effects on the human CRC cell line HCT 15 and also checked for the level of gene expression of EGFR by real time PCR analysis. Positive results were confirmed by in silico molecular docking studies using Discovery Studio (DS) 4.0. The drug parallel features of the same compounds were also assessed in silico. Results: Cytotoxicity experiments revealed that both the compounds were efficient in killing CRC cells on a controlled concentration basis. In addition, EGFR expression was down-regulated in the presence of the compounds. Docking studies unveiled that both the compounds were able to inhibit EGFR at its active site. Pharmacokinetic analysis of these compounds opened up their drug like behaviour. Conclusions: The findings of this study emphasize the importance of plant compounds for targeting diseases like CRC.
Epidemiology of Oral Lichen Planus in a Cohort of South Indian Population: A Retrospective Study
Soma Susan Varghese,Giju Baby George,Sreenivasan Bargavan Sarojini1,Sankar Vinod,Philips Mathew,Deepu George Mathew,Joseph Sebastian,Arun George 대한암예방학회 2016 Journal of cancer prevention Vol.21 No.1
Background: Oral lichen planus (OLP) is an immune-mediated potentially malignant disorder of the oral cavity. Dysplastic OLP has an altered cytogenic profile and can progress into oral squamous cell carcinoma. The epidemiology of OLP is well-described in several relatively large series from various geographic locations, whereas such series from southern India is rare. The aim of the present study was to determine the epidemiology of OLP in a cohort of South Indian population. Methods: All the case data records of 29,606 patients who visited Mar Baselios Dental College and Hospital, Kerala, India from 2014 to 2015 were retrospectively reviewed. For data review, 122 patients of OLP were selected Estimated were type, number, and location of lesions, clinical manifestation, age of the patient, gender, onset and duration of lesion, stressful life style, habits, skin involvement and associated systemic illness, and presence/absence of dysplasia. Results: When the distribution of OLP among the gender was considered, we found more prevalence in females than males. Fifty-seven percent of patients were associated with stressful lifestyle. Reticular lichen planus was the most common clinical subtype found. Bilateral buccal mucosal was the common site, when the distribution of sites of OLP were compared (P < 0.05). Hypersensitivity reaction was frequently associated with systemic illness with OLP (P < 0.05). Anaplasia was found among 5% of lichen planus lesions. Conclusions: OLP patients had high incidence of hypersensitivity reactions and 5% of OLP lesions showed anaplasia. Long term follow-up is necessary to monitor the recurrence, prognosis, and malignant transformation of OLP.