New pyrimidine and pyrazole kinase inhibitors as potential anticancer agents : design, synthesis and biological evaluation

El-Deeb, Ibrahim Mustafa Univ. of Science and Technology 2010 국내박사

Burnup Estimation for MTR Fuel Using SCALE6 Code

LUAY MOHAMMAD DEEB ALAWNEH UNIVERSITY OF SCIENCE AND TECHNOLOGY 2014 국내석사

This thesis presents a new simple method to estimate burnup for plate type fuel assemblies of research reactors. Burnup for research reactors can be estimated very accurately through some Monte Carlo method codes such as McCARD and MCNPX. McCARD is a Monte Carlo neutron-photon coupled transport code designed for the analysis of various nuclear systems. It is capable of the burnup analysis of nuclear systems with help of a built-in depletion subroutine which provides solutions to the depletion equation. MCNPX (MCNP eXtended) is a Fortran90 Monte Carlo radiation transport computer code. MCNPX and CINDER’90 have been internally coupled for fuel depletion and burnup calculations. The objective for this thesis is to provide a simple reliable method to estimate burnup for plate type fuel assemblies with a good accuracy. Monte Carlo codes do estimate burnup accurately, however Monte Carlo calculations are really computationally expensive; to apply Monte Carlo calculation for a research reactor a huge parallel computing system is needed, and that is the motivation for this thesis; to provide simple method to calculate burnup for plate type fuel assemblies of research reactors accurately. The method consists of finding fitted formulas to evaluate burnup based on specific power, fuel enrichment and fuel density. Through a couple of Scale 6 code sequences such as TRITON/NEWT and ORIGEN-ARP one fuel assembly is modeled and it is depleted for a long period of time divided into a certain steps. The TRITON control module in SCALE performs 2-D depletion calculations using the New ESC-based Weighting Transport code (NEWT) flexible mesh discrete ordinates code coupled with CENTRM/PMC resonance self-shielding and with ORIGEN-S depletion. TRITON control module is used to generate burnup dependent cross section libraries for the plate type fuel assembly. Different TRITON inputs are made; each input has different input parameters such as power density, fuel enrichment and fuel density. ORIGEN-ARP is a SCALE depletion analysis sequence used to perform point-depletion calculations with the ORIGEN-S code using problem-dependent cross sections. The resulting cross section libraries from TRITON calculation are used with ORIGEN-ARP sequence; ORIGEN-ARP provides nuclides inventories after each time step. Burnup is estimated for different power densities, enrichments and fuel densities after each time step. Least square fitting method is used to estimate general equation for burnup after each time step. Linear least square, second order least square and nonlinear fitting methods are considered to estimate burnup accurately. This approach is applied to three configurations of research reactors, the first one is a 5MW open pool type research reactor that uses U3Si2 as a fuel, the second and the third configurations are suggested simple 3MW cores, U3Si2 is chosen for fuel in the second one and it is switched to UMo in the third one. For the 5 MW research reactor burnup is evaluated using the fitted equations and the results are compared to McCARD results for 18 cycles, each cycle has a different length and the total period of all the cycles is about 681 days, the cycle lengths is determined in such a way that insures that the power peaking factors is within the safety limits, though interpolation is considered to match the time between the equations and McCARD. The results of the proposed approach are in good agreement with McCARD code results; especially for the second order least square fitting results, the average of the errors is within 10% for almost all the cycles. In case of 3MW reactors burnup is evaluated for a period of 350 days of depletion for U3Si2 and UMo loaded cases with a time step of 50 days. The results for the suggested approach and MCNPX are in a good agreement for both first and second order fitting approaches; the average of the errors is within 8% for all the cycles.

Inequalities at work: Health care workers and clients in a community clinic

Deeb-Sossa, Natalia The University of North Carolina at Chapel Hill 2006 해외박사(DDOD)

My dissertation is a study of health care workers and clients in a private, not-for-profit health care center. Through participant observation and in-depth interviews I analyze how workers at a community clinic reproduce or respond to inequalities of race, class, and gender in their interactions with each other and in their daily work with poor clients, especially Latinas/os. As a symbolic interactionist and feminist ethnographer, I studied how health care providers came to act as they did as well as the consequences of their behavior for their clients, other staff, and themselves. I identify how inequality was reproduced, including the interactions, roles, identities, meanings, and emotions that were central to the people at the clinic. In Chapter 1, I explore how the Black female staff draw on racialized and gendered rhetorics to criticize and claim status over Latinas. These rhetorics followed from the discourses constructed and used by white elites to reinforce racism and sexism. Black women used these rhetorics as a way to respond to the changes in the racial make-up of clients and the accompanying hiring of bilingual staff, mostly Latinas. Similarly, Latinas used images of pushy, bossy, and "uppity Black women" against the Black staff. I argue that these strategies divided low-status workers. In Chapter 2, I examine how the Maternity Care Coordinators (MCCs) maintained a moral identity as good health care providers. The MCCs defined Latinas as the "neediest of the needy" and "Americans" as the privileged clients. They thought differently about the Latina, Black, and white women they served. In Chapter 3, I explore how the white high-status staff s solidarity-talk kept them from seeing the significance of race in interactions among staff members. The rhetoric used largely by the white high-status staff protected them from having to "see" their own race and did not help Latina and Black staff develop solidarity. Finally, in the conclusion I highlight how the staff might have come to recognize racism, sexism, and class inequality if organizational arrangements had been different.

Remixing Authorship Copyright and Capital in Hollywood's New Media Age

Deeb, Hadi Nicholas University of California, Los Angeles 2014 해외박사(DDOD)

The explosion in new media technologies and how people use them has ruptured a longstanding model of authorship and ownership behind intellectual property (IP) laws and norms. New media make creating, manipulating, and circulating information much faster, easier, and cheaper. The romantic author entitled to own her expressions of creative genius is being reimagined as a remix author who always borrows, collaborates, and has partial claims over cultural products. Scholars in various fields have used this development to reconsider what authorship is and how it relates to ownership. My approach employs empirically, locally grounded linguistic anthropological methods that have not been applied before to this topic. My aim is to uncover what motivates authorship as a communicative activity that has social value, as evidenced by its link to ownership. I conducted fieldwork among professional storytellers, lawyers, and marketers in Hollywood, an influential industry that relies heavily on copyright, the branch of IP law that regulates the circulation of creative expression. I investigated how people who see remix authorship as both a challenge and an opportunity talk about authorship and, in doing so, talk as authorship. Framing my study in practice theory terms, I analyzed the micro-semiotic and macro-social aspects of that discourse in contexts such as courtroom litigation, professional gatherings, and story production. I argue that authorship and ownership are mutually defining practices driven by a productive tension between the chronological pursuit of authentic experience and a horizonal goal of idealized authenticity. Striving to achieve authenticity is socially mediated, and often occurs through cultural products, including entertainment commodities. For a long time, romantic authorship ideology tailored authenticity to its own terms, mitigating the tension and supporting the modern IP regime. Spurred by new media, remix authorship ideology pries open that loop. More broadly, people constantly remix the nexus of what authenticity, authorship, and ownership mean. My findings further remix authorship theory in order to think beyond the superficial divergence of IP law and social practices; specify the social and institutional consequences of linguistic authorship, including how it can lead to paradigmatic transformation; and describe an experiential motivation behind that practice.

Aerobic biotransformation of BTEX compounds and MTBE in mixtures by enriched and pure cultures

Deeb, Rula Anselmo University of California, Berkeley 1999 해외박사(DDOD)

Substrate interactions during the aerobic biotransformation of mixtures of the gasoline aromatic components benzene, toluene, ethylbenzene and xylene (BTEX) and the fuel oxygenate methyl <italic>tert</italic>-butyl ether (MTBE) were evaluated using mixed and pure cultures. Several patterns of interactions were observed during the biodegradation of BTEX mixtures including enhancement, competitive inhibition, non-competitive inhibition and cometabolism. The most significant interactions included the inhibition of benzene, toluene and the three xylene isomers in the presence of ethylbenzene, and the cometabolism of the xylenes in the presence of benzene, toluene and ethylbenzene. The breakdown of BTEX compounds to CO₂ by the cultures was evaluated. A mixed culture mineralized all six BTEX compounds individually and in mixtures while two <italic>Rhodococcus</italic> isolates, RR1 and RR2, mineralized five of the six BTEX components. <italic>o</italic>-Xylene was transformed by the pure cultures to non-volatile intermediates that persisted in solution. The observed substrate interactions during the biotransformation of BTEX compounds in mixtures had no measurable effect on the final mineralization potentials of BTEX mixture components. Biochemical studies with the pure cultures revealed that the BTEX compounds were being mineralized by a pathway involving a suite of metabolic steps similar to those of the upper route of the TOD pathway. Two lower pathways were found to be expressed by RR1 and RR2, an <italic>ortho</italic> fission and a <italic> meta</italic> fission pathway. It was not clear whether the mineralization of <italic>m</italic>-xylene and <italic>p</italic>-xylene took place by the further breakdown of the dimethycatechols by the <italic>ortho</italic> fission pathway or by an alternate metabolic route. Three toluene-degrading cultures derived from a gasoline-contaminated aquifer were not capable of degrading MTBE. The presence of MTBE in mixtures with BTEX compounds had no effect on BTEX biodegradation rates by these cultures. Substrate interactions during the biodegradation of MTBE and BTEX mixtures by a pure culture capable of utilizing MTBE and benzene for growth (PM1) were then evaluated. PM1 was not capable of degrading ethylbenzene and the xylenes at concentrations of 20 mg/L due to substrate toxicity. Mixtures of benzene and MTBE were readily degraded. Results from mixture studies with benzene and MTBE suggested that the degradation of these two compounds by PM1 occurred by two independent inducible pathways. While the presence of MTBE in a mixture with benzene enhanced benzene degradation, the presence of benzene inhibited MTBE degradation.

The architecture of reception sculpture and gender in the 1950s and 1960s (Lee Bontecou, Louise Bourgeois, Louise Nevelson)

Speaks, Elyse Marie Deeb Brown University 2005 해외박사(DDOD)

This dissertation examines the sculptural reception and production of Lee Bontecou, Louise Bourgeois, and Louise Nevelson during the 1950s and 1960s in order to suggest the terms that precipitated their reputations in the New York art world prior to the feminist movement. I claim that the uprooted, shifting conventions of sculpture---the changes that sculpture underwent as a critical category in terms of scale, materials, and use---produced a climate in which women sculptors were able to make objects that resonated with the work of their peers but which remained critically unresolved and unavailable for classification. The consequent plurality of meanings attached to these objects entailed a critical discourse centered on the key concepts of mystery, unclassifiability, and hidden identities---terms that became positive critical values with which to approach sculpture. The structure of the dissertation proceeds sequentially, the first episode dating to 1950, then 1958, 1963 and 1964. Within the individual chapters, overlapping themes give way to particular analyses of the cultural resonances that informed each artist and her reception, so that, for example, the first chapter examines the use of primitive art; the second explores the relationship between sculpture and modern dance; the third focuses on the terms of art criticism that dominated the discourse of the sixties; and the final chapter focuses more on theoretical conceptions of domestic spaces from the 1950s and 1960s.