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인지 과제 및 긍정적 정서 유발에 대한 주요 우울장애 환자의 심장 박동 변이(Heart Rate Variability, 이하 HRV) 양상
이창수,김대석,정명기,김원,우종민,Lee, Chang-Soo,Kim, De-Sok,Jeong, Myeong-Gi,Kim, Won,Woo, Jong-Min 대한불안의학회 2007 대한불안의학회지 Vol.3 No.1
Object : This study was designed to assess the change of heart rate variability (HRV) during stimulation test among the patients with major depressive disorder. Methods : 15 patients with major depressive disorder (MDD) and 15 normal controls were enrolled in this study. We sequentially measured HRV at baseline, during cognitive stimuli and emotional stimuli. Results : There are significant differences between the two groups in HRV index, TINN on baseline state and under cognitive stimulus. Conclusion : Stimulation protocol using HRV can be useful in estimating autonomic nervous function.
공허안 증후군을 동반한 양측성 거대결절성 부신피질 과증식에 의한 쿠싱 증후군 1 예
이경미,김진안,이현철,이은직,김경래,정윤석,정우희,신은택,원욱희,김기황,이희대,허갑범 대한내분비학회 1993 Endocrinology and metabolism Vol.8 No.2
ACTH-dependent bilateral adrenocortical hyperplasia, Known as Cushing's disease, accounts for 60-70% of the cases of Cushing's syndrome. In about 30-40% of patients, manifestations of Cushing's syndrome occur independently of pituitary ACTH secretion due to either ectopic ACTH production or an adrenocortical adenoma or carcinoma. Another rere cause of Cushing's syndrome, also independent of ACTH, is so-called primary adrenocortical nodular dysplasia, in which adjacent areas of the adrenal cortex are atropic. The term bilateral macronodular adrenocortical hyperplasia(MNH) is restricted to the presence of multiple nodules visible to the naked eye and often more than 0.4cm in diameter. Its pathogenesis is still unknown. This report describes a patient with Cushing's syndrome due to ACTH - independenilateral macronodular adrenocortical hyperplasia associated with empty sella syndrome. A 63-year- old woman presented with Cushingoid features, hypertension, diabetes mellitus, dyspnea and chest pain. Urinary free cortisol and 17-hydroxycorticosteroid excretion were 350ug/day and 10.9 mg/day, respectively. Urinary free cortisol didn't decrease after administration of dexamethasone (low and high dose). Plasma ACTH was 4.2pg/ml. Magnetic resonance imaging(MRI) of the sella turcica revealed complete cisternal hernation, suggesting empty sells syndrome. Bilateral total adrenalectomy was perfomed. The right adrenal gland weighed 11 gm and contained two nodules and their sizes are 2.5cm, and 1 cm. The left adrenal gland showed all the features of odular hyperlasia with a 1.5 cm nodule. The postoperative course was uneventful and the patient was discharged to be treated with replacement steroids. (J Kor Soc Endocrinol 8: 203~210, 1993)